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文旅融合赋能乡村共同富裕:作用机理与路径优化

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艺术百家 2024年第3期40卷 46-51,71页

作者：张祝平中共河南省委党校科技文化教研部河南郑州450002

文旅融合能够促进乡村物质和精神共富、缩小区域和城乡生活差距、保障致富权利机会及规则平等,有效赋能乡村共同富裕。目前文旅融合赋能乡村共同富裕面临着基础设施短板、体制机制障碍、利益联结困境等问题,据此,要加强基础设施建设,夯... 详细信息

文旅融合能够促进乡村物质和精神共富、缩小区域和城乡生活差距、保障致富权利机会及规则平等,有效赋能乡村共同富裕。目前文旅融合赋能乡村共同富裕面临着基础设施短板、体制机制障碍、利益联结困境等问题,据此,要加强基础设施建设,夯实文旅融合赋能乡村共同富裕的基础支撑;创新体制机制,提供文旅融合促进共同富裕的制度保障;优化利益联结机制,彰显文旅融合促进共同富裕的文化经济价值。

关键词：文旅融合乡村共同富裕制度保证乡村振兴

Machine Learning Prediction of Structure-Performance Relationship in Organic Synthesis

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Chinese Journal of Chemistry 2022年第17期40卷 2106-2117页

作者： Li-Cheng Yang Lu-Jing zhu Shuo-Qing Zhang Xin hong Center of Chemistry for Frontier Technologies Department of ChemistryState Key Laboratory of Clean Energy UtilizationZhejiang UniversityHangzhouZhejiang310027 China Beijing National Laboratory for Molecular Sciences Zhongguancun North First Street No.2Beijing100190 China Key Laboratory of Precise Synthesis of Functional Molecules of Zhejiang Province School of ScienceWestlake University18 Shilongshan RoadHangzhouZhejiang310024 China

Data-driven approach has emerged as a powerful strategy in the construction of structure-performance relationships in organic *** close the gap between mechanistic understanding and synthetic prediction,we have made efforts to implement mechanistic knowledge in machine learning modelling of organic transformation,as a way to achieve accurate predictions of reactivity,regio-and *** have constructed a comprehensive and balanced computational database for target radical transformations(arene C—H functionalization and HAT reaction),which laid the foundation for the reactivity and selectivity ***,we found that the combination of computational statistics and physical organic descriptors offers a practical solution to build machine learning structure-performance models for reactivity and *** allow machine learning modelling of stereoselectivity,a structured database of asymmetric hydrogenation of olefins was built,and we designed a chemical heuristics-based hierarchical learning approach to effectively use the big data in the early stage of catalysis *** studies reflect a tiny portion of the exciting developments of machine learning in organic *** synergy between mechanistic knowledge and machine learning will continue to generate a strong momentum to push the limit of reaction performance prediction in organic chemistry.

关键词： Reaction performance prediction Synthesis design Structure-activity relationships Synthetic database Radical reactions

Total hip arthroplasty after core decompression:Time-to-event analysis and risk factors

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Chinese Medical Journal 2024年第16期137卷 1988-1990页

作者： Chengsi Li Tianyu Wang Dongwei Wu Haichuan Guo Zhenbang Yang Xinqun Cheng Yanbin zhu Yingze Zhang Department of Orthopedic Surgery The 3rd HospitalHebei Medical UniversityShijiazhuangHebei 050051China Orthopedic Research Institute of Hebei Province Key Laboratory of Biomechanics of Hebei ProvinceShijiazhuangHebei 050051China

To the Editor:Core decompression(CD),the predominant hip-preserving procedure for pre-collapse osteonecrosis of the femoral head(ONFH),is renowned for its improved short-term outcomes and relatively low postoperative complication rates;however,the reported medium-tolong-term survival rates in the literature vary and are a subject of ***,we conducted a large,prospective cohort study to assess the frequency and timing of conversion from CD to total hip arthroplasty(THA)and the factors associated with it.

关键词： decompression arthroplasty femoral

加巴喷丁联合血液灌流治疗老年维持性血液透析合并中重度不宁腿综合征患者的疗效分析

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中国实用医药 2024年第9期19卷 6-11页

作者：朱虹徐明成闻君君北京市西城区展览路医院血液净化中心 100044

目的观察加巴喷丁联合血液灌流治疗老年维持性血液透析合并中重度不宁腿综合征(RLS)患者的疗效。方法4.例老年维持性血液透析合并中重度RLS患者,随机分为观察组和对照组,各20例。两组患者每周均行2次常规血液透析,1次血液透析联合血液... 详细信息

目的观察加巴喷丁联合血液灌流治疗老年维持性血液透析合并中重度不宁腿综合征(RLS)患者的疗效。方法4.例老年维持性血液透析合并中重度RLS患者,随机分为观察组和对照组,各20例。两组患者每周均行2次常规血液透析,1次血液透析联合血液灌流治疗。观察组每晚口服加巴喷丁。比较两组治疗前后国际不宁腿综合征评定量表(IRLS)评分、匹兹堡睡眠指数量表(PSQI)评分、简明健康状况调查量表(SF-36)评分及实验室检查指标[甲状旁腺激素(iPTH)、血β_(2)微球蛋白(β_(2)-MG)]水平,观察不良反应发生情况。结果对照组治疗1周后IRLS评分较本组治疗前无改善(P>0.05);对照组治疗4.8周后IRLS评分较本组治疗期前降低,差异有统计学意义(P4.8周后IRLS评分均较本组治疗前降低,且观察组治疗1、4.8周后IRLS评分(13.4.±3.17)、(6.4.±2.4.)、(4.60±0.84.分低于对照组的(20.10±5.55)、(16.60±5.02)、(12.20±4.76)分,差异有统计学意义(P0.05)。治疗后,对照组RE、VT评分及总分高于本组治疗前,差异有统计学意义(P4.)、(29.00±7.38)、(72.20±10.17)、(4.7.65±36.73)分,差异有统计学意义(P0.05)。治疗后对照组无不良反应。观察组口服加巴喷丁治疗1周时出现2例嗜睡,1例头晕,症状轻微均可耐受;1例出现嗜睡伴双下肢无力、共济失调,行脑CT检查排除脑血管病,加巴喷丁渐减量,患者症状缓解,继续治疗。治疗4.时观察组1例患者加巴喷丁调整药量至300 mg/次、q.d.后出现嗜睡、头晕、恶心,症状可耐受。结论加巴喷丁联合血液灌流能够快速有效缓解老年维持性血液透析患者RLS症状,并改善患者睡眠和生活质量,且耐受性良好。

关键词：不宁腿综合征加巴喷丁血液灌流血液透析老年

Printable elastic silver nanowire-based conductor for washable electronic textiles

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Nano Research 2020年第10期13卷 2879-2884页

作者： hong-Wu zhu Huai-Ling Gao Hao-Yu Zhao Jin Ge Bi-Cheng Hu Jin Huang Shu-hong Yu Division of Nanomaterials&Chemistry Hefei National Laboratory for Physical Sciences at the MicroscaleInstitute of EnergyHefei Comprehensive National Science CenterCAS Center for Exclilence in NanoscienceDepartment of ChemistryUniversity of Science and Technology of ChinaHefei 230026China

Printable elastic conductors promote the wide application of consumable electronic textiles (e-textiles) for pervasive healthcare monitoring and wearable computation. To assure a clean appearance, the e-textiles require a washing process to clean up the dirt after daily use. Thus, it is crucial to develop low-cost printable elastic conductors with strong adhesion to the textiles. Here, we report a composite elastic conductor based on Ag nanowires (NWs) and polyurethane elastomer. The composite could be dispersed into ink and easily printed onto textiles. One-step print could form robust conductive coatings without sealing on the textiles. Interestingly, the regional concentration of Ag NWs within the polyurethane matrix was observed during phase inversion, endowing the elastic conductor with a low percolation threshold of 0.12 vol.% and high conductivity of 3,668 S·cm^−1. Thanks to the high adhesion of the elastic conductors, the resulted e-textiles could withstand repeated stretching, folding, and machine washing (20 times) without obvious performance decay, which reveals its potential application in consumable e-textiles.

关键词： printable elastic conductor electronic textiles washability phase inversion silver nanowires

奥希替尼在老年非小细胞肺癌患者靶向治疗中的应用效果及对T细胞水平的影响

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中国药物与临床 2024年第8期24卷 491-496页

作者：吴俊沛方权朱晓丹吴洪义乌市中心医院呼吸与危重症医学科浙江义乌322000 浙江中医药大学研究生院浙江杭州310053

目的探讨奥西替尼在老年非小细胞肺癌患者靶向治疗中的效果及对免疫水平的影响。方法回顾性选择2018年1月至2020年12月老年非小细胞肺癌患者116例研究,根据治疗方法不同分为2组,各58例。对照组采用常规放化疗治疗,观察组在对照组基础... 详细信息

目的探讨奥西替尼在老年非小细胞肺癌患者靶向治疗中的效果及对免疫水平的影响。方法回顾性选择2018年1月至2020年12月老年非小细胞肺癌患者116例研究,根据治疗方法不同分为2组,各58例。对照组采用常规放化疗治疗,观察组在对照组基础上联合奥西替尼治疗,3个月治疗后评估患者效果,比较2组总有效率、T细胞水平(CD3^(+)、CD4.(+)、CD8^(+)、CD4.(+)/CD8^(+))、肿瘤标志物水平、不良反应发生率。结果观察组治疗3个月总有效率为4..8%高于对照组25.9%(P4.(+)、CD4.(+)/CD8^(+)水平均低于治疗前(P4.21)%、CD4.(+)(32.59±3.11)%、CD4.(+)/CD8^(+)(1.21±0.22)高于对照组(P4.μg/L及癌胚抗原(CEA)水平(34.5)μg/L均低于对照组(P0.05)。结论奥西替尼用于老年非小细胞肺癌患者靶向治疗中,能获得较好的总有效率,对患者T细胞水平影响较小,可降低肿瘤标志物水平,未增加不良反应发生率,值得临床推广应用。

关键词：癌,非小细胞肺分子靶向治疗 T淋巴细胞生物标记,肿瘤药物相关性副作用和不良反应奥西替尼

HIF-1αpromotes virus replication and cytokine storm in H1N1 virus-induced severe pneumonia through cellular metabolic reprogramming

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Virologica Sinica 2024年第1期39卷 81-96页

作者： Xiaoxiao Meng Yong zhu Wenyu Yang Jiaxiang Zhang Wei Jin Rui Tian Zhengfeng Yang Ruilan Wang Department of Critical Care Medicine Shanghai General HospitalShanghai Jiaotong UniversitySchool of MedicineShanghai201620China Precision Research Center for Refractory Diseases Shanghai General HospitalShanghai Jiaotong UniversitySchool of MedicineShanghai201620China

The mortality of patients with severe pneumonia caused by H1N1 infection is closely related to viral replication and cytokine ***,the specific mechanisms triggering virus replication and cytokine storm are still not fully ***,we identified hypoxia inducible factor-1α(HIF-1α)as one of the major host molecules that facilitates H1N1 virus replication followed by cytokine storm in alveolar epithelial ***,HIF-1αprotein expression is upregulated after H1N1 *** of HIF-1αattenuates pulmonary injury,viral replication and cytokine storm in *** addition,viral replication and cytokine storm were inhibited after HIF-1αknockdown in ***,the invasion of H1N1 virus into alveolar epithelial cells leads to a shift in glucose metabolism to glycolysis,with rapid production of ATP and *** of glycolysis significantly suppresses viral replication and inflammatory *** analysis revealed that H1N1-induced HIF-1αcan promote the expression of hexokinase 2(HK2),the key enzyme of glycolysis,and then not only provide energy for the rapid replication of H1N1 virus but also produce lactate,which reduces the accumulation of the MAVS/RIG-I complex and inhibits IFN-α/β*** conclusion,this study demonstrated that the upregulation of HIF-1αby H1N1 infection augments viral replication and cytokine storm by cellular metabolic reprogramming toward glycolysis mainly through upregulation of HK2,providing a theoretical basis for finding potential targets for the treatment of severe pneumonia caused by H1N1 infection.

关键词： H1N1 Severe pneumonia Virus replication Hypoxia inducible factor-1α Glycolysis

Machine-learning-assisted efficient reconstruction of the quantum states generated from the Sagnac polarization-entangled photon source

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Chinese Physics B 2024年第8期33卷 50-54页

作者：毛梦辉周唯李新慧杨然龚彦晓祝世宁 National Laboratory of Solid State Microstructures and School of Physics Nanjing UniversityNanjing 210093China Author notes

Neural networks are becoming ubiquitous in various areas of physics as a successful machine learning(ML)technique for addressing different *** on ML technique,we propose and experimentally demonstrate an efficient method for state reconstruction of the widely used Sagnac polarization-entangled photon *** properly modeling the target states,a multi-output fully connected neural network is well trained using only six of the sixteen measurement bases in standard tomography technique,and hence our method reduces the resource consumption without loss of *** demonstrate the ability of the neural network to predict state parameters with a high precision by using both simulated and experimental ***,the mean absolute error for all the parameters is below 0.05 for the simulated data and a mean fidelity of 0.99 is achieved for experimentally generated *** method could be generalized to estimate other kinds of states,as well as other quantum information tasks.

关键词： machine learning state estimation quantum state tomography polarization-entangled photon source

“货—款担保”的法律性质及顺位——以《民法典》第4.6条为中心

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河北法学 2024年第9期42卷 45-68页

作者：朱继胜广西民族大学法学院

“货—款担保”系以交付之“货”担保未付之“价款”之清偿，其具有独特的结构方式——“有(牵连关系)+登记(控制方式)”,是一种独立的担保物权类型，其性质为法定担保物权，而非抵押权。现行法将“价款”与“价款之贷款”相混同，进而... 详细信息

“货—款担保”系以交付之“货”担保未付之“价款”之清偿，其具有独特的结构方式——“有(牵连关系)+登记(控制方式)”,是一种独立的担保物权类型，其性质为法定担保物权，而非抵押权。现行法将“价款”与“价款之贷款”相混同，进而将“货—款担保”与“货—贷担保”相混同，导致“货—款担保”被认作抵押权，其顺位规则亦被混同于“货—贷担保”。应区分“货—款担保”与“货—贷担保”,前者可依法优先于浮动抵押权、抵押权和质权，但劣后于留置权，与工程款优先权平等；后者仅可依法优先于浮动抵押权；当两者并存时，“货—款担保”在宽限期内办理登记的，优先于“货—贷担保”,在宽限期届满后办理登记的，清偿顺序依登记的时间先后来确定。

关键词：货—款担保货—贷担保抵押权登记优先权《民法典》第4.6条