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实用口腔医学杂志 2014年第2期30卷 273-275页

作者：孙梅刘红北京大学医院口腔中心 100871 吉林大学口腔医学院

咀嚼肌筋膜痛患者20名,夜间戴用NTI-tss咬合板治疗2个月。治疗后,患者咀嚼时咀嚼肌疼痛的VAS值较治疗前明显减小(P<0.01),主动最大张口度明显增加(P<0.01),疗效良好,可能存在的副作用有待进一步观察。

关键词： NTI-tss 咬合板咀嚼肌筋膜痛

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芩莲正积方水提物中总黄酮提取工艺的优化

化学工程师 2024年第2期38卷 92-96页

作者：孙瑶苏适陈洪玉张晓萌阎力君哈尔滨商业大学药学院黑龙江哈尔滨150076

本文旨在研究芩莲正积方水提物中的总黄酮提取工艺。实验采用水提法,以芩莲正积方总黄酮提取率为指标,通过单因素实验和正交实验考察浸泡时间、提取温度、提取次数、提取时间和料液比对方中总黄酮提取率的影响。芩莲正积方水提物中总黄... 详细信息

本文旨在研究芩莲正积方水提物中的总黄酮提取工艺。实验采用水提法,以芩莲正积方总黄酮提取率为指标,通过单因素实验和正交实验考察浸泡时间、提取温度、提取次数、提取时间和料液比对方中总黄酮提取率的影响。芩莲正积方水提物中总黄酮的最佳提取工艺为:浸泡时间0h、提取次数1次、提取温度90℃、提取时间60min、料液比1∶20,在该提取工艺下得到的芩莲正积方水提物中总黄酮提取率最高为6.76%。

关键词：芩莲正积方总黄酮水提法正交设计

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纳米硒对肥育猪肌肉品质的影响

浙江大学学报（农业与生命科学版） 2005年第3期31卷 263-268页

作者：夏枚生张红梅胡彩虹浙江大学动物科学学院浙江杭州310029

以亚硒酸钠为对照,研究了纳米硒对肥育猪肌肉品质的影响.234头体重45kg左右的杜长大肥育猪按饲养试验要求分为13组,每组3个重复,每个重复6头.将纳米硒和亚硒酸钠2种硒源分别以0.10、0.20、0.30、0.40、0.50、1.00mg/kg6个硒水平添加到... 详细信息

以亚硒酸钠为对照,研究了纳米硒对肥育猪肌肉品质的影响.234头体重45kg左右的杜长大肥育猪按饲养试验要求分为13组,每组3个重复,每个重复6头.将纳米硒和亚硒酸钠2种硒源分别以0.10、0.20、0.30、0.40、0.50、1.00mg/kg6个硒水平添加到基础日粮中,配制成12种试验日粮,基础日粮作对照.结果显示①亚硒酸钠添加浓度在0～0.20mg/kg,背最长肌滴水损失随着硒添加浓度的增加而降低;添加浓度在0.30～1.00mg/kg,滴水损失随着硒添加浓度的增加而升高;1.00mg/kg硒添加水平滴水损失显著高于0.20～0.50mg/kg硒添加水平(P0.05);硒源添加浓度在0.40～1.00mg/kg硒时,纳米硒组GSHPx活性和TAOC显著高于亚硒酸钠组(P<0.05),MDA含量显著低于亚硒酸钠组(P<0.05).③硒源添加浓度在0.10～0.30mg/kg时,两种硒源对背最长肌硒含量的影响无显著差异;在0.40～1.00mg/kg硒添加水平上,纳米硒组背最长肌硒含量显著高于亚硒酸钠组.④空白组背最长肌肌红蛋白含量显著低于加硒组(P<0.

关键词：纳米硒肉质肥育猪

Anticipation,anti-glaucoma drug treatment response and phenotype of a Chinese family with glaucoma caused by the Pro370Leu myocilin mutation

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International Journal of Ophthalmology(English edition) 2014年第1期7卷 44-50页

作者： Chun-mei Li Yue-hong Zhang Rong-Hua Ye Chang-Xian Yi Yi-Min Zhong Dan Cao Xing Liu State Key Laboratory of Ophthalmology Zhongshan Ophthalmic CenterSun Yat-sen University First Municipal People's Hospital of Guangzhou

AIM: To describe the anticipation and anti-glaucoma drugs response of a Chinese family with juvenile-onset open angle glaucoma(JOAG) caused by the Pro370Leu myocilin(MYOC) mutation. ·METHODS: Fifteen members of a three-generation Chinese family with JOAG were recruited to this study. They all underwent ophthalmic common examinations. Patients suspected to have JOAG got an assessment of visual field and optical coherence tomography. Intraocular pressures(IOPs) of four patients were measured at 8,10,12,14,17 o’clock respectively after using anti-glaucoma drugs. Mutation screening of all MYOC gene coding exons of the participants was performed by using direct sequencing of PCR products. ·RESULTS: Clinical examinations and pedigree analysis revealed eight family members were suffered from JOAG. Apparent genetics anticipation phenomenon was observed in this family. Their clinical features included elevated IOP of 35-55mmHg,loss of visual field,thinning of retinal nerve fiber layer,and glaucomatous optic disc damage. Noticeably,their intraocular pressure levels could be controlled within normal range at 8 and 10 o’clock by anti-glaucoma drugs,but their IOPs would elevate >21mmHg after 12 o’clock. Seven patients received trabeculectomy produced thin-walled,pale,and saccate filtering blebs maintaining lower intraocular pressure efficiently. Mutation screening indentified aheterozygous C→T missense mutation in the MYOC gene at position 1 109 in exon 3,corresponding to a substitution of a highly conserved proline to leucine at codon 370 in the olfactomedin domain of MYOC. ·CONCLUSION: The clinical characteristics of JOAG in this family were 1) genetics anticipation; 2) high IOP; 3) temporay response to anti-glaucoma drugs; 4) filtering surgery produced thin-walled and saccate filtering blebs,helping maintain lower IOP.

关键词： phenotype anticipation anti-glaucoma drugs myocilin

Spatio-temporal analysis and simulation on shallow rainfall-induced landslides in China using landslide susceptibility dynamics and rainfall I-D thresholds

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Science China Earth Sciences 2017年第4期60卷 720-732页

作者： LI WeiYue LIU Chun Marco SCAIONI sun WeiWei CHEN Yu YAO DongJing CHEN Sheng hong Yang ZHANG KaiHang CHENG GuoDong Institute of Urban Study Shanghai Normal University Shanghai 200234 China Cold and Arid Region Environmental and Engineering Research Institute Chinese Academy of Sciences Lanzhou 730000 China College of Surveying and Geo-Informatics Tongji University Shanghai 200234 China Department of Architecture Built Environment and Construction Engineering Politecnico Milano Milano 20133 Italy College of Architectural Engineering Civil Engineering and Environment Ningbo University Ningbo 315211 China Shandong Academy of Building Research Jinan 250031 China Department of Geography Shanghai Normal University Shanghai 200234 China School of Atmospheric Sciences Sun Yat-sen University Guangzhou 510275 China Key Laboratory of Beibu Gulf Environmental Evolution and Resources Utilization Guangxi Teachers Education University Nanning 530001 China School of Civil Engineering and Environmental Sciences University of Oklahoma OK 73074 USA Department of Hydraulic Engineering Tsinghua University Beijing 100084 China Institute of Tourism Shanghai Normal University Shanghai 200234 China

An empirical simulation method to simulate the possible position of shallow rainfall-induced landslides in China has been *** study shows that such a simulation may be operated in real-time to highlight those areas that are highly prone to rainfall-induced landslides on the basis of the landslide susceptibility index and the rainfall intensity-duration(I-D) ***,the study on landslide susceptibility in China is *** entire territory has been classified into five categories,among which high-susceptibility regions(Zone 4-'High' and 5-'Very high') account for 4.15%of the total extension of ***,rainfall is considered as an external triggering factor that may induce landslide ***-time satellite-based TMPA3B42 products may provide real rainfall spatial and temporal patterns,which may be used to derive rainfall duration time and *** using a historical record of 60 significant past landslides,the rainfall I-D equation has been *** rainfall duration time that may trigger a landslide has resulted between 3 hours and 45 *** combination of these two aspects can be exploited to simulate the spatiotemporal distribution of rainfall-induced landslide hazards when rainfall events exceed the rainfall I-D thresholds,where the susceptibility category is 'high' or 'very high'.This study shows a useful tool to be part of a systematic landslide simulation methodology,potentially providing useful information for a theoretical basis and practical guide for landslide prediction and mitigation throughout China.

关键词： Surface and subsurface runoff Runoff-produced physical and chemical deposits Precipitated salts and water circulation Groundwater supply mechanism Badain Jaran Desert

俯卧位通气治疗儿童急性呼吸窘迫综合征的效果及安全性评估

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广东医科大学学报 2024年第3期42卷 277-280页

作者：银青梅姚志红周月琼余小惠骆成珠广东医科大学附属医院儿童医学中心广东湛江524000

目的分析俯卧位通气(PPV)治疗儿童急性呼吸窘迫综合征(ARDS)中的效果及评估其安全性。方法回顾性分析儿童重症监护室(PICU)采用俯卧位进行呼吸机辅助呼吸的ARDS患儿50例(俯卧位组),根据患儿基线资料进行配对50例非俯卧位进行呼吸机辅助... 详细信息

目的分析俯卧位通气(PPV)治疗儿童急性呼吸窘迫综合征(ARDS)中的效果及评估其安全性。方法回顾性分析儿童重症监护室(PICU)采用俯卧位进行呼吸机辅助呼吸的ARDS患儿50例(俯卧位组),根据患儿基线资料进行配对50例非俯卧位进行呼吸机辅助呼吸的ARDS患儿(非俯卧位组),比较两组患儿的吸气峰压(PIP)、呼气末正压(PEEP)、呼吸频率(RR)、吸入氧浓度(FiO_(2))、血pH值、动脉氧分压(PaO_(2))、动脉二氧化碳分压(PaCO_(2))、氧合指数、血氧饱和度(SpO_(2))、并发症、病死率、住院时间及机械通气时间等指标。结果治疗后俯卧位组患儿的pH值、PaO_(2)、氧合指数高于治疗前与非俯卧位组(P<0.01),PaCO_(2)、PEEP、RR、FiO_(2)、呼吸机相关性肺炎(VAP)低于非俯卧位组(P<0.01或0.05),面部水肿发生率高于非俯卧位组(P<0.05);PICU住院时间与机械通气时间均短于非俯卧位组(P<0.05)。结论俯卧位通气治疗能够显著改善ARDS患儿的氧合指数,缩短呼吸机使用及PICU住院时间,护理并发症发生率少。

关键词：俯卧位通气儿童急性呼吸窘迫综合征

APPLICATION OF WHOLE BODY DIFFUSION WEIGHTED MR IMAGING FOR DIAGNOSIS AND STAGING OF MALIGNANT LYMPHOMA

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Chinese Medical Sciences Journal 2008年第3期23卷 138-144页

作者： Shuo Li Hua-dan Xue Jian Li Fei sun Bo Jiang Dong Liu hong-yi sun Zheng-yu Jin Department of Radiology Peking Union Medical College HospitalChinese Academy of Medical Sciences ＆ Peking Union Medical College Beijing 100730 Department of Hematology Peking Union Medical College HospitalChinese Academy of Medical Sciences ＆ Peking Union Medical College Beijing 100730 MR Modality General Electric Healthcare China Beijing 100176

Objective To evaluate the clinical impact of whole body diffusion weighted imaging （WB-DWI） on diagnosis and staging of malignant lymphoma. Methods Thirty-one patients with suspected lymphadenopathy were enrolled. WB-DWI was performed by using short TI inversion recovery echo-planar imaging sequence with free breathing and built-in body coil. Axial T2- weighted imaging images of the same location were used as reference. The results of WB-DWI were compared with pathological results and other imaging modalities. The mean apparent diffusion coefficient （ADC） values of different kinds of lymph nodes were compared. Results WB-DWI was positive in all 18 cases with lymphoma, 5 cases with metastatic lymph nodes and 4 of 8 eases with benign lymphadenopathy. The mean ADC value of lymphomatous, metastatic and benign lymph nodes was （0.87 ± 0.17） × 10^3, （0.98± 0.09） × 10^3 and （1.20 ± 0.10） × 10^3 mm^2/s. There was significant difference in ADC value between benign lymph nodes and other two groups （P 〈 0.01）. The sensitivity, specificity and accuracy of WB-DWI in diagnosis of lymphoma were 100% （18/18）, 30.8% （4/13） and 71.0% （22/31）. When an ADC value of 1.08 × 10^-3 mm^2/s was used as the threshold value for differentiating malignant from benign lymph nodes, the best results were obtained with sensitivity of 87.8% and specificity of 91.3%. Sixteen of eighteen cases （88.9%） of lymphoma were accurately staged in accordance with clinical staging. Conclusions WB-DWI is a sensitive, but less specific technique for diagnosis of lymphoma. It is difficult to differentiate lymphnmatous from metastatic lymph nodes using WB-DWI. However, it is a valuable imaging modality for staging of patients with malignant lymphoma.

关键词： diffusion magnetic resonance imaging whole body imaging short TI inversion recovery lymphoma

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医用润滑剂组成结构的红外光谱研究

润滑油 2024年第3期39卷 30-38页

作者：于宏伟常美玲王宁宗鹤宸周子轩李泽腾石家庄学院河北石家庄050035 河北省麻醉药技术创新中心河北石家庄050035

采用中红外(MIR)光谱开展了避孕套中医用润滑剂结构的研究。结果发现:医用润滑剂主要包括固态润滑剂和液态润滑剂,其中固态润滑剂的主要结构是高岭石族物质,而液态润滑剂的主要结构是水溶性硅油。研究为探索计生用品中的医用润滑剂结构... 详细信息

采用中红外(MIR)光谱开展了避孕套中医用润滑剂结构的研究。结果发现:医用润滑剂主要包括固态润滑剂和液态润滑剂,其中固态润滑剂的主要结构是高岭石族物质,而液态润滑剂的主要结构是水溶性硅油。研究为探索计生用品中的医用润滑剂结构建立了一种方法,具有一定的应用价值。

关键词：中红外光谱计生用品医用润滑剂结构

Efficacy and safety of stellate ganglion block in chronic ulcerative colitis

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World Journal of Gastroenterology 2017年第3期23卷 533-539页

作者： hong-Ying Zhao Guo-Tao Yang Ning-Ning sun Yu Kong Yun-Feng Liu Department of Elderly Internal Medicine Cangzhou Central HospitalCangzhou Clinical Medical School of Hebei Medical UniversityCangzhou 061001Hebei ProvinceChina Department of Third Neurology Cangzhou Central HospitalCangzhou Clinical Medical School of Hebei Medical UniversityCangzhou 061001Hebei ProvinceChina Department of First Digestion Cangzhou Central HospitalCangzhou Clinical Medical School of Hebei Medical UniversityCangzhou 061001Hebei ProvinceChina Department of Second Digestion Cangzhou Central HospitalCangzhou Clinical Medical School of Hebei Medical UniversityCangzhou 061001Hebei ProvinceChina

AIM To investigate the efficacy and safety of stellate ganglion block for the treatment of patients with chronic ulcerative *** A total of 120 randomly selected patients with chronic ulcerative colitis treated in Cangzhou Central Hospital from January 2014 to January 2016 were included in this study. These patients were divided into two groups: control group(n = 30), patients received oral sulfasalazine treatment; experimental group(n = 90), patients received stellate ganglion block treatment. Clinical symptoms and disease activity in these two groups were compared before and after treatment using endoscopy. Blood was collected from patients on day 0, 10, 20 and 30 after treatment. Enzyme-linked immunosorbent assay was performed to determine interleukin-8(IL-8) level. The changes in IL-8 level post-treatment in the two groups were compared using repeated measures analysis of *** After treatment, clinical symptoms and disease activity were shown to be alleviated by endoscopy in both the control and experimental groups. However, patients in the control group did not have obvious abdominal pain relief. In addition, the degree of pain relief in the experimental group was statistically better than that in the control group(P < 0.05). Ten days after treatment, IL-8 level was found to be significantly lower in the experimental group than in the control group, and the difference was statistically significant(P < 0.05). In addition, adverse events were significantly higher in the control group than in the experimental group, and the difference was statistically significant(χ~2 = 33.215, P = 0.000).CONCLUSION The application of stellate ganglion block effectively improves treatment efficacy in chronic ulcerative colitis, relieves clinical symptoms in patients, and reduces the level of inflammatory factors. Furthermore, this approach also had a positive impact on the disease to a certain extent.

关键词： Stellate ganglion block Chronic ulcerative colitis

Demographic Characteristics and Environmental Risk Factors Exposure of Birth Defects in Pregnant Women: A Population-based Study

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Biomedical and Environmental Sciences 2019年第1期32卷 51-57页

作者： LIN hong LUO Mi Yang LUO Jia You ZENG Rong LI Ya mei DU Qi Yun FANG Jun Qun Xiangya School of Public Health Central South University Saw Swee Hock School of Public Health National University of Singapore Xiangya Hospital of Central South University Hunan Provincial Maternal and Child Health Care Hospital

Worldwide, the incidence of birth defects in low-income countries is 6.42%, while in middle-income and high-income countries it is 5.57% and 4.72%, respectively;approximately 303, 000 newborns die from birth defects each year. In China, the incidence of birth defects is about 5.6%, and around 8.14 million people have congenital disabilities, accounting for 9.6% of total disabled people[1]. Birth defect remains a major clinical and public health challenge because of its high fatality rate and protracted and severe sequela.

关键词： Birth defects demographics Environmental risk factors