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The regulation of Ndfip1 and its role in iron accumulation of Parkinson’s disease

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The regulation of Ndfip1 and its role in iron accumulation o...

中国生理学会第24届全国会员代表大会暨生理学学术大会

作者： Huamin Xu Wenting Jia Qing Chang hong jiang junxia xie department of physiology Shandong Provincial Key Laboratory of Pathogenesis and Prevention of Neurological Disorders and State Key Disciplines:PhysiologyQingdao University

Elevated iron accumulation and increased divalent metal transporter 1（DMT1）expression have been reported in the substantia nigra（SN）of Parkinson’s disease（PD）.Nedd4 family interacting protein 1（Ndfip1）is an adaptor protein for the Nedd4 family of ubiquitin ligases that target proteins for *** studies confirmed the role of Ndfip1 as a regulator of iron metabolism and pointed out that Ndfip1was involved in iron homeostasis by regulating the degradation of iron importer *** this study,we investigated the effect of various stimuli,including iron status and lipopolysaccharide（LPS）on Ndfip1expression in MES23.5 dopaminergic cell *** showed that Ndfip1 expression in these cells was enhanced by ferrous iron overload,but not ferric iron overload,and decreased after iron deprivation by desferoxamine（DFO）.In addition,LPS could significantly increase the expression of *** also demonstrated the expression of Ndfip1 decreased in 6-OHDA-induced PD rats and 6-OHDA treated MES23.5 dopaminergic *** study showed the decrease of Ndfip1 occurred earlier than the increase of DMT1 in 6-OHDA-treated MES23.5 cells,indicating the decrease of Ndfip1 might be involved in the increase of *** addition,we demonstrated that over-expression of Ndfip1 caused DMT1+IRE down-regulation,resulting in the decreased iron influx and iron-induced *** Ndfip1knockdown led to DMT1+IRE up-regulation,partially aggravate iron-induced *** experiments showed 6-OHDA-induced down-regulation of Ndfip1 might be related to proteasomal and lysosomal degradation as well as oxidative stress caused by *** data suggests decreased Ndfip1expression contributed to the pathogenesis of 6-OHDA-induced iron accumulation and neuronal damage.

关键词： Ndfip1 divalent metal transporter 1 iron Parkinson’s disease

Wheat genomic study for genetic improvement of traits in China

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Science China(Life Sciences) 2022年第9期65卷 1718-1775页

作者： jun xiao Bao Liu Yingyin Yao Zifeng Guo Haiyan Jia Lingrang Kong Aimin Zhang Wujun Ma Zhongfu Ni Shengbao Xu Fei Lu Yuannian Jiao Wuyun Yang Xuelei Lin Silong Sun Zefu Lu Lifeng Gao Guangyao Zhao Shuanghe Cao Qian Chen Kunpu Zhang Mengcheng Wang Meng Wang Zhaorong Hu Weilong Guo Guoqiang Li Xin Ma junming Li Fangpu Han xiangdong Fu Zhengqiang Ma Daowen Wang Xueyong Zhang hong-Qing Ling Guangmin xia Yiping Tong Zhiyong Liu Zhonghu He Jizeng Jia Kang Chong key Laboratory of Plant Molecular physiology Institute of BotanyChinese Academy of SciencesBeijing 100093China Institute of Crop Sciences Chinese Academy of Agricultural SciencesBeijing 100081China The state key Laboratory of Plant Cell and Chromosome Engineering Institute of Genetics and Developmental BiologyChinese Academy of SciencesBeijing 100101China state key Laboratory for Agrobiotechnology and key Laboratory of Crop Heterosis and Utilization(MOE)and Beijing key Laboratory of Crop Genetic Improvement China Agricultural UniversityBeijing 100193China The key Laboratory of Plant Development and Environment Adaptation Biology Ministry of EducationSchool of Life ScienceShandong UniversityQingdao 266237China state key Laboratory of Crop Biology College of AgronomyShandong Agricultural UniversityTai’an 271018China Crop Genomics and Bioinformatics Center and National key Laboratory of Crop Genetics and Germplasm Enhancement Nanjing Agricultural UniversityNanjing210095China key Laboratory of Molecular Epigenetics Northeast Normal UniversityChangchun 130024China College of Agronomy State Key Laboratory of Wheat and Maize Crop Scienceand Center for Crop Genome EngineeringHenan Agricultural UniversityZhengzhou 450002China state key Laboratory of Crop Stress Biology for Arid Areas College of AgronomyNorthwest A&F UniversityYangling 712100China College of Agronomy Qingdao Agricultural UniversityQingdao 266109China Ministry of Education key Laboratory of Molecular and Cellular Biology Hebei Collaboration Innovation Center for Cell SignalingHebei Key Laboratory of Molecular and Cellular BiologyCollege of Life SciencesHebei Normal UniversityShijiazhuang 050024China Institute of Crop Research Sichuan Academy of Agricultural SciencesChengdu 610066China state key Laboratory of Systematic and Evolutionary Botany Institute of BotanyChinese Academy of SciencesBeijing 100093China state key Laboratory of Soil and Sustainable Agriculture Institute of Soil ScienceChinese Academy of Sciences

Bread wheat(Triticum aestivum L.)is a major crop that feeds 40%of the world’s *** the past several decades,advances in genomics have led to tremendous achievements in understanding the origin and domestication of wheat,and the genetic basis of agronomically important traits,which promote the breeding of elite *** this review,we focus on progress that has been made in genomic research and genetic improvement of traits such as grain yield,end-use traits,flowering regulation,nutrient use efficiency,and biotic and abiotic stress responses,and various breeding strategies that contributed mainly by Chinese *** genomic research in wheat is entering a new era with the availability of multiple reference wheat genome assemblies and the development of cutting-edge technologies such as precise genome editing tools,highthroughput phenotyping platforms,sequencing-based cloning strategies,high-efficiency genetic transformation systems,and speed-breeding *** insights will further extend our understanding of the molecular mechanisms and regulatory networks underlying agronomic traits and facilitate the breeding process,ultimately contributing to more sustainable agriculture in China and throughout the world.

关键词： wheat genomics genetic improvement China

Nesfatin-1 Decreases Excitability of Dopaminergic Neurons in the Substantia Nigra

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中国生理学会第24届全国会员代表大会暨生理学学术大会

作者： Chen Li Fang Zhang Limin Shi Haoyun Zhang Zibin Tian junxia xie hong jiang department of physiology Shandong Provincial Key Laboratory of Pathogenesis and Prevention of Neurological Disorders and State Key Disciplines:PhysiologyQingdao University

Nesfatin-1,a newly discovered satiety molecule which reduces feeding behavior,has been recognized as a unique regulatory neuropeptide with its multiple roles,both central and ***,whether it had neuronal modulation effect on dopaminergic neurons is largely *** the present study,using whole-cell patch clamp under current-clamp mode,we investigate the effects of nesfatin-1 on the electrical activity of rat nigral dopaminergic ***-1 could produce a resting membrane potential hyperpolarization on the majority of dopaminergic neurons *** spike frequency decreased by 23.13±5.93 and 43.20±5.56%in 5-n M and 10-n M nesfatin-1 groups,*** effects persisted in the presence of ionotropic glutamate and GABA receptor *** study suggests that nesfatin-1 postsynaptically inhibits the electrical activity of nigral dopaminergic neurons.

关键词： Nesfatin-1 dopaminergic neurons excitability

透水/不透水格局特征对汇水单元径流污染的影响

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环境科学 2020年第10期41卷 4599-4606页

作者：姜智绘廖云杰谢文霞李佳房志达赵洪涛李叙勇青岛大学环境科学与工程学院青岛266071 中国科学院生态环境研究中心城市与区域生态国家重点实验室北京100085

深入揭示透水/不透水下垫面格局特征(组成、位置和比例等)对城市地块汇水单元地表径流及污染产生能力的影响,对减轻城市内涝及控制面源污染具有重要意义.利用景观格局指数分析透水/不透水下垫面格局特征与地表径流总量(Q)、溶解态污染... 详细信息

深入揭示透水/不透水下垫面格局特征(组成、位置和比例等)对城市地块汇水单元地表径流及污染产生能力的影响,对减轻城市内涝及控制面源污染具有重要意义.利用景观格局指数分析透水/不透水下垫面格局特征与地表径流总量(Q)、溶解态污染物累积负荷(Ld)和颗粒态污染物累积负荷(Lp)之间的关系.结果表明:(1)表征破碎度的斑块密度(PD)与最大斑块指数(LPI)分别与Q和Ld呈正、负相关,PD与Ld呈显著正相关(r=0.59,P<0.05,以COD计),LPI与Ld呈显著负相关(r=-0.60,P<0.05,以COD计);(2)表征复杂度的景观形状指数(LSI)和平均斑块形状(MSI)分别与Q和Lp呈正、负相关性,LSI与Lp呈显著正相关(r=0.61,P<0.05,以TP计),MSI与Lp呈极显著负相关(r=-0.62,P<0.01,以TP计);(3)表征聚散度的内聚力指数(COHESION)和分散指数(SPLIT)分别与Q和Ld呈负、正相关性,COHESION与Ld呈显著负相关(r=-0.59,P<0.05,以COD计),SPLIT与Ld呈显著正相关(r=0.6,P<0.05,以COD计);(4)在城市小尺度透水面格局规划上,适量减少细小规则斑块的散乱分布,增加较大的不规则斑块或斑块群,对有效调控地表径流及污染有积极影响.通过透水/不透水面的破碎度、复杂度和聚散度与汇水区单元径流产生和污染输出的相关性分析,以期从格局特征(面积、距离和形状等)考虑合理配置LID设施调控径流污染提供新思路.

关键词：城市面源污染景观格局地表径流透水/不透水面地块汇水区

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海绵城市地块汇水区颗粒污染物的传输

环境科学 2020年第9期41卷 4113-4123页

作者：李佳谢文霞姜智绘单溪环廖云杰赵洪涛李叙勇青岛大学环境科学与工程学院青岛266071 中国科学院生态环境研究中心城市与区域生态国家重点实验室北京100085

目前我国海绵工程建设多集中在地块汇水区单元内开展,通过多个低影响开发(LID)设施协同完成地表径流水质水量的调控,但基于地块汇水区尺度下城市面源污染的产生和控制效果鲜有报道.本研究比较分析了不同硬化率地块汇水单元内的面源颗粒... 详细信息

目前我国海绵工程建设多集中在地块汇水区单元内开展,通过多个低影响开发(LID)设施协同完成地表径流水质水量的调控,但基于地块汇水区尺度下城市面源污染的产生和控制效果鲜有报道.本研究比较分析了不同硬化率地块汇水单元内的面源颗粒污染物晴天累积、降雨冲刷、地表径流及径流输出负荷状况.结果表明,地块汇水单元内硬质路面是面源颗粒污染物贡献的最主要的下垫面类型,中硬化率(61.1%)地块和高硬化率(73.6%)地块路面街尘累积量分别约占汇水区单元的88.4%(2.22~12.51 g·m^-2)和90.1%(4.99~33.43 g·m^-2),对径流SS的输出贡献比率分别约为91.7%(0.97~7.34 g·m^-2)和90.5%(0.92~18.77 g·m^-2),降雨径流SS污染负荷占比分别约为95.2%和83.1%,经LID设施处理后输出径流污染负荷约为地表径流的24.0%和40.2%.硬质路面的街尘晴天累积及降雨冲刷以>150μm为主,地表径流及输出径流则以1000μm)和高硬化率地块(250~450μm、1000μm:58.1%和108.5%;250~450μm:72.9%和41.8%;<45μm:59.2%和64.8%).以上结果揭示了颗粒污染物在地块汇水区尺度下的污染全过程(累积-冲刷-输出)分布及LID设施对地块整体SS污染负荷的控制效果,可为地块汇水单元内LID设施工程绩效的科学评估提供重要参考.

关键词：地块汇水区低影响开发街尘降雨径流粒径分布

基于协同创新的“基础-临床相结合、培养学术兼应用型创新人才的医学研究生培养模式”的探索与实践

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高校医学教学研究：电子版 2015年第4期5卷 3-5页

作者：姜宏马泽刚陈蕾陈文芳谢俊霞青岛大学医学院生理学教研室青岛266071

如何加强医学相关学科专业研究生协同创新能力的建设,已经成为现代医学研究生教育面临的新挑战。青岛大学生理学国家重点(培育)学科以协同创新中心为载体,打破学科的壁垒,建立协同创新环境下的研究生导师遴选模式和课程体系,通过加强培... 详细信息

如何加强医学相关学科专业研究生协同创新能力的建设,已经成为现代医学研究生教育面临的新挑战。青岛大学生理学国家重点(培育)学科以协同创新中心为载体,打破学科的壁垒,建立协同创新环境下的研究生导师遴选模式和课程体系,通过加强培养过程管理和临床实践环节,探索出了一种兼具专业特点,同时又有基础和临床专长的研究生培养模式。

关键词：协同创新培养模式研究生培养

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合流制面源污染传输过程与污染源解析

环境科学 2019年第6期40卷 2705-2714页

作者：房金秀谢文霞朱玉玺沈雷马玉坤李佳姜智绘李叙勇赵洪涛青岛大学环境科学与工程学院青岛266071 中国科学院生态环境研究中心城市与区域生态国家重点实验室北京100085 珠海市规划设计研究院珠海519000 北京师范大学环境学院北京100875

科学认识和全面理解合流制面源污染发生路径和污染贡献源对于治理和改善城市水环境至关重要.本研究以珠海市典型老城区的合流制小排水区为例,分析了污染物在地表与管道中的累积-冲刷过程,并运用质量守恒法解析了污染物的贡献源.结果表明... 详细信息

科学认识和全面理解合流制面源污染发生路径和污染贡献源对于治理和改善城市水环境至关重要.本研究以珠海市典型老城区的合流制小排水区为例,分析了污染物在地表与管道中的累积-冲刷过程,并运用质量守恒法解析了污染物的贡献源.结果表明,地表街尘累积量为(28. 81±10. 69) g·m^(-2),多场降雨事件中地表街尘冲刷量为(19. 27±10. 90) g·m^(-2),冲刷率为(52. 69±13. 3)%,其冲刷形成的地表径流中SS场降雨浓度为52～109 mg·L^(-1),管道径流中SS的浓度为68～158mg·L^(-1);地表径流对SS的贡献率为39%～72%,旱流污水对SS的贡献率<20%,管道沉积物再悬浮对SS的贡献率为13%～56%;管道沉积物的厚度在小雨和中雨时增加1～14 cm,大雨和暴雨时,减少7～17 cm;降雨特征影响了污染源贡献比率,其中地表径流对各污染物的贡献范围为2%～52%,旱流污水对各污染物的贡献率范围为9%～65%,管道沉积物对各污染物的贡献范围为8%～81%.基于上述研究结果,为合流制面源污染提出控制措施,以期为我国城市受纳水体污染的解决提供参考.

关键词：合流制排水体制地表径流管道径流管道沉积物源解析污染控制

Deubiquitylase OTUD3 regulates IRP2 stability and iron homeostasis

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Deubiquitylase OTUD3 regulates IRP2 stability and iron homeo...

中国生理学会张锡钧基金第十五届全国青年优秀生理学学术论文交流及评奖会议;中国生理学会第十三届全国青年生理学工作者学术会议

作者： Fengju Jia hongchang Li Qian Jiao Lin Fu Lingling Jiao Pei Zhang Yijun Gao Feifei Mu Yanmin Zhong Chunping Cui Lingqiang Zhang hong jiang department of physiology Shandong Provincial Key Laboratory of Pathogenesis and Prevention of Neurological Disorders and State Key Disciplines:PhysiologyMedical College of Qingdao University state key Laboratory of Proteomics National Center of Protein Sciences (Beijing)Beijing Institute of Lifeomics Institutes of Chronic Disease Medical College of Qingdao University

Iron regulatory protein 2(IRP2) dominates regulation in the context of iron *** two ubiquitin ligases that promote IRP2 degradation have been identified,the deubiquitylase for stabilization of IRP2 remains *** we report OTU domain-containing protein 3(OTUD3) as a deubiquitylase for ***3 interacts with IRP2 in the cytoplasm,de-polyubiquitylates and stabilizes IRP2 *** of OTUD3 results in nigral iron ***3-/-mice display decreased IRP2 protein stability and motor deficits and nigrostriatal dopaminergic neurodegeneration,which resembles the pathology of Parkinson's disease(PD).Consistently,decreased levels of OTUD3 are detected in transgenic PD mice expressing A53 T mutant of human α-*** findings demonstrate that OTUD3 is a bona fide deubiquitylase for IRP2 and plays a critical role in the nigral iron deposits in PD.

关键词： Deubiquitylation/Iron/Iron regulatory protein 2/OTU domain-containing protein 3/Parkinson's disease

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南海三沙永乐龙洞悬浮体组分及其来源

海洋与湖沼 2018年第4期49卷 779-792页

作者：孙晓霞傅亮杨作升毕乃双范德江姚鹏刘光兴陈洪举田元刘瑞志中国海洋大学海底科学与探测技术教育部重点实验室青岛266100 中国航迹三沙珊瑚礁保护研究所三沙573199 中国海洋大学海洋化学理论与工程技术教育部重点实验室青岛266100 中国海洋大学海洋环境与生态教育部重点实验室青岛266100 中国环境科学研究院河口与海岸环境国家重点实验室北京100018

三沙永乐龙洞位于南海北部永乐环礁上,水深达300m,是世界已知最深的海洋蓝洞。采用扫描电镜和能谱仪对2016年10月和2017年3月在永乐龙洞从表层到270m的24个不同深度采集的水体悬浮体组分进行了分析,发现悬浮体组分种类丰富,粒度差异大,... 详细信息

三沙永乐龙洞位于南海北部永乐环礁上,水深达300m,是世界已知最深的海洋蓝洞。采用扫描电镜和能谱仪对2016年10月和2017年3月在永乐龙洞从表层到270m的24个不同深度采集的水体悬浮体组分进行了分析,发现悬浮体组分种类丰富,粒度差异大,来源/成因多样,可分为生源碎屑、陆源碎屑、自生矿物颗粒、有机包膜-海洋雪花和人工产物碎屑等5类。生源碎屑以碳酸盐为主,主要来自现代珊瑚礁的松散沉积物,是悬浮体的主要组分。陆源碎屑主要是造岩矿物如石英和长石,以及一些包括重矿物的副矿物,其中细小的陆源造岩矿物碎屑,有可能来自气溶胶沉降,粗粒碎屑可能来自附近琛航岛工程散落的海南岛沿岸海砂。自生矿物颗粒包括重晶石、球状微粒氧化铁集合体和纳米黄铁矿。纳米黄铁矿及其集合体出现在130m以深水体中,是含硫化氢的无氧极端水体的特定产物。有机包膜在生物降解过程中形成,有时包覆多个不同组分的颗粒,常呈片状漂浮在水体中,形成海洋雪花。人工产物碎屑包括多种金属碎屑、微塑料纤维丝和过硫化铅丝。金属碎屑可能来自船只金属部件耗损,微塑料纤维可能来自渔网残余。本文是首次有关海洋蓝洞悬浮体组分的系统报道。永乐龙洞悬浮体组分特色鲜明,对认识其生态系统和沉积记录有重要意义。

关键词：三沙永乐龙洞悬浮体组分物源珊瑚礁碳酸盐陆源碎屑极端水环境