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Illuminating dark sirens with CSST

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Science China(Physics,Mechanics & Astronomy) 2024年第3期67卷 165-165页

作者： zong-hong Zhu School of Physics and Technology Wuhan UniversityWuhan 430072China Department of Astronomy Beijing Normal UniversityBeijing 100875China

In recent years, the Hubble tension has emerged as one of the most perplexing enigmas within the realm of cosmology[1]. This incongruity suggests the tantalizing prospect of new physics beyond the standard ΛCDM model, leading to the proposal of diverse extended cosmological models. At the same time, there is a pressing demand for novel cosmological tools to mediate the Hubble tension. The gravitational-wave(GW) standard siren has been put forth as a promising cosmological probe for resolving the Hubble tension, provided that the redshift of the GW source is known, as exemplified in ref. [2].

关键词： gravitational source beyond

Efficacy comparison of fruquintinib,regorafenib monotherapy or plus programmed death-1 inhibitors for microsatellite stable metastatic colorectal cancer

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World Journal of Gastrointestinal Oncology 2024年第6期16卷 2449-2462页

作者： Tian-Qi An Hui Qiu Quan-Bo Zhou hong zong Shuang Hu Yu-Gui Lian Rui-Hua Zhao Department of Oncology The First Affiliated Hospital of Zhengzhou UniversityZhengzhou 450000Henan ProvinceChina Department of Hepato-Pancreato-Biliary Surgery Peking University Cancer Hospital and InstituteBeijing 100000China Department of Colorectal Surgery The First Affiliated Hospital of Zhengzhou UniversityZhengzhou 450000Henan ProvinceChina

BACKGROUND Regorafenib(R)and fruquintinib(F)are the standard third-line regimens for colorectal cancer(CRC)according to the National Comprehensive Cancer Network guidelines,but both have limited *** phase 2 trials have indicated that R or F combined with immune checkpoint inhibitors can reverse immunosuppression and achieve promising efficacy for microsatellite stable or proficient mismatch repair(MSS/pMMR)*** to the lack of studies comparing the efficacy between F,R,F plus programmed death-1(PD-1)inhibitor,and R plus PD-1 inhibitors(RP),it is still unclear whether the combination therapy is more effective than *** To provide critical evidence for selecting the appropriate drugs for MSS/pMMR metastatic CRC(mCRC)patients in clinical *** A total of 2639 CRC patients were enrolled from January 2018 to September 2022 in our hospital,and 313 MSS/pMMR mCRC patients were finally *** A total of 313 eligible patients were divided into F(n=70),R(n=67),F plus PD-1 inhibitor(FP)(n=95)and RP(n=81)*** key clinical characteristics were well balanced among the *** median progression-free survival(PFS)of the F,R,FP,and RP groups was 3.5 months,3.6 months,4.9 months,and 3.0 months,*** median overall survival(OS)was 14.6 months,15.7 months,16.7 months,and 14.1 *** FP regimen had an improved disease control rate(DCR)(P=0.044)and 6-month PFS(P=0.014)and exhibited a better trend in PFS(P=0.057)compared with F,and it was also significantly better in PFS than RP(P=0.030).RP did not confer a significant survival benefit;instead,the R group had a trend toward greater benefit with OS(P=0.080)compared with *** significant differences were observed between the R and F groups in PFS or OS(P>0.05).CONCLUSION FP is superior to F in achieving 6-month PFS and DCR,while RP is not better than *** has an improved PFS and 6-month PFS compared with RP,but F and R had similar clinical ***,FP may be a

关键词： Colorectal cancer Fruquintinib Regorafenib Programmed death-1 inhibitor Real-world

Erratum to:Detecting gravitational wave with an interferometric seismometer array on lunar nearside[***.66,109513(2023)]

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Science China(Physics,Mechanics & Astronomy) 2024年第1期67卷 182-183页

作者： Junlang Li Fangfei Liu Yuan Pan Zijian Wang Mengdi Cao Mengyao Wang Fan Zhang Jinhai Zhang zong-hong Zhu Department of Astronomy Beijing Normal UniversityBeijing 100875China Advanced Institute of Natural Sciences Beijing Normal University at ZhuhaiZhuhai 519087China Institute for Frontiers in Astronomy and Astrophysics Beijing Normal UniversityBeijing 102206China Engineering Laboratory for Deep Resources Equipment and Technology Institute of Geology and GeophysicsChinese Academy of SciencesBeijing 100029China

This paper"Detecting gravitational wave with an interferometric seismometer array on lunar nearside"[1]was published in SCIENCE CHINA Physics,Mechanics&Astronomy(66,109513(2023),doi:10.1007/s11433-023-2179-9).Due to an oversight on our part,some errors were made in the originally published *** apologize for these errors and offer the corresponding explanations and corrections for the readers.

关键词： gravitational seism wave

非缠结苯乙烯-对叔丁基苯乙烯共聚物的非线性拉伸流变行为

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应用化学 2024年第8期41卷 1098-1106页

作者：洪宗昊吴世龙陈全中国科学院长春应用化学研究所高分子物理与化学国家重点实验室长春130022 中国科学技术大学应用化学与工程学院合肥230026

聚焦于苯乙烯和对叔丁基苯乙烯的非缠结聚合物以及其共聚物样品的线性和非线性拉伸流变学性质。所有样品均具有相似的链均库恩链段数(约为30个),表现出相似且符合Rouse模型预测的线性黏弹行为。在单轴拉伸实验中,样品在快速拉伸过程,即... 详细信息

聚焦于苯乙烯和对叔丁基苯乙烯的非缠结聚合物以及其共聚物样品的线性和非线性拉伸流变学性质。所有样品均具有相似的链均库恩链段数(约为30个),表现出相似且符合Rouse模型预测的线性黏弹行为。在单轴拉伸实验中,样品在快速拉伸过程,即韦森堡数大于1的过程中拉伸黏度呈现出随拉伸速率增加先“增稠”后“变稀”的行为,在样品具有相似的最大拉伸比λ_(max)=√n_(K)(≈6)前提下,二者转变的特征韦森堡数随着叔丁基苯乙烯含量的增加而增加。该结果表明,链沿拉伸方向的共同取向导致的链段摩擦系数减少效应随着侧基数量的增加而弱化,侧基具有一定的“溶剂化”作用。

关键词：聚苯乙烯聚对叔丁基苯乙烯非线性拉伸流变学

产甘油假丝酵母25S rRNA甲基转移酶BMT5对乙酸胁迫耐受的影响及应用

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食品与发酵工业 2024年第1期50卷 1-6页

作者：周柳陆信曜宗红诸葛斌江南大学工业生物技术教育部重点实验室江苏无锡214122 江南大学生物工程学院工业微生物及多元醇研究设计中心江苏无锡214122

挖掘功能基因,提升菌株环境胁迫耐受性,对高效利用纤维素水解液产乙醇至关重要。产甘油假丝酵母(Candida glycerinogenes)是具有多重抗逆性的工业菌株,经基因组文库筛选,获得能够提高酵母乙酸耐受性的rRNA甲基转移酶基因CgBmt5。在酿酒... 详细信息

挖掘功能基因,提升菌株环境胁迫耐受性,对高效利用纤维素水解液产乙醇至关重要。产甘油假丝酵母(Candida glycerinogenes)是具有多重抗逆性的工业菌株,经基因组文库筛选,获得能够提高酵母乙酸耐受性的rRNA甲基转移酶基因CgBmt5。在酿酒酵母(Saccharomyces cerevisiae)中表达CgBmt5提高了乙酸耐受性,重组菌在胁迫下乙醇产量为60.5 g/L,提高17.7%。在***中过表达CgBmt5后,乙酸胁迫下乙醇产量提高17.6%,2种过表达的单位菌体产量、底物转化率、生产强度均有提高。进一步将***过表达菌应用于纤维素水解液发酵,乙醇产量提高71.7%,转化率提高65.0%,生产强度提高155.7%。乙酸胁迫下,过表达菌中脂质过氧化水平降低,且过氧化氢酶(catalase,CAT)和超氧化物歧化酶(superoxide dismutase,SOD)活性增加;转录分析发现,Pfk1和Arg3基因上调,Gpd1和Cox3下调,表明CgBmt5可能通过降低脂质过氧化水平、提高SOD和CAT活性及影响糖代谢和精氨酸合成促进菌株的乙酸耐受和胁迫下的发酵能力。该研究为酵母的胁迫耐受机制和纤维素乙醇技术发展提供了新的生物材料。

关键词：产甘油假丝酵母基因筛选环境胁迫纤维素水解液 rRNA甲基转移酶

基因工程改造促进大肠杆菌发酵纤维素水解液合成1,2,4-丁三醇

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化工进展 2024年第2期43卷 1063-1068页

作者：佘丹王舒婷陆信曜宗红诸葛斌江南大学生物工程学院工业生物技术教育部重点实验室工业微生物研究中心江苏无锡214122

1,2,4-丁三醇(BT)是广泛应用于各领域的高附加值化合物之一,利用纤维素水解液发酵生产BT需要一株能够耐受其中抑制物的菌株。在水解液中常见抑制因子糠醛存在下,大肠杆菌的发酵严重受限。本研究首先在含有BT合成途径的大肠杆菌中过表达... 详细信息

1,2,4-丁三醇(BT)是广泛应用于各领域的高附加值化合物之一,利用纤维素水解液发酵生产BT需要一株能够耐受其中抑制物的菌株。在水解液中常见抑制因子糠醛存在下,大肠杆菌的发酵严重受限。本研究首先在含有BT合成途径的大肠杆菌中过表达四种糠醛耐受相关的基因:yghA、thyA、mdtJI和pntAB。在0.4g/L糠醛压力下,所有改造菌株的生长均有不同程度的提升,其中过表达pntAB基因的菌株生长最好,同时有助于BT合成酶的酶活力或转录水平的提高,BT产量达到11.0g/L。当以玉米芯纤维素水解液为底物时,过表达yghA、thyA和pntAB均明显促进了大肠杆菌的生长与BT产量的提高,其中yghA基因表现最好,在摇瓶中获得了3.36g/L的BT,在5L发酵罐中BT产量达到15.3g/L,转化率为63.8%。该策略为玉米芯纤维素水解液发酵生产BT提供了借鉴。

关键词：大肠杆菌玉米芯纤维素水解液糠醛耐受 1 2 4-丁三醇

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Cosmic Wave Functions with the Brans-Dicke Theory

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Chinese Physics Letters 2000年第11期17卷 856-858页

作者： ZHU zong-hong Beijing Astronomical Observatory Chinese Academy of SciencesBeijing 100012 National Astronomical Observatories Chinese Academy of SciencesBeijing 100012 Institute of theoretical Physics Chinese Academy of SciencesBeijing 100080

Using the standard Wentzel-Kramers-Brillouin method,the Wheeler-DeWitt equation for the Brans-Dicke theory is solved under three kinds of boundary conditions(proposed by Hartle-Hawking,Vilenkin and Linde,respectively).It is found that,although the gravitational and cosmological“constants”are dynamical and time-dependent in the classical models,they will acquire constant values when the universe comes from the quantum creation,and that in particular,the amplitude of the resulting wave function under Linde or Vilenkin boundary conditions reaches its maximum if the cosmological constant is the minimum.

关键词： Dicke boundary constants

Quark Loop Effects on Dressed Gluon Propagator in Framework of Global Color Symmetry Model

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Communications in Theoretical Physics 2006年第4X期46卷 717-722页

作者： zong hong-Shi Department of Physics Nanjing University Nanjing 210093 China joint Center for Particle Nuclear Physics and Cosmology Nanjing 210093 China CCAST (World Laboratory) P.O. Box 8730 Beijing 100080 China

Based on the global color symmetry mode/ （GCM）, a method for obtaining the quark loop effects on the dressed gluon propagator in GCM is developed. In the chiral limit, it is found that the dressed gluon propagator containing the quark loop effects in the Nambu-Goldstone and Wigner phases are quite different. In solving the quark self-energy functions in the two different phases and subsequent study of bag constant one shouM use the above dressed gluon propagator as input. The above approach for obtaining the current quark mass effects on the dressed gluon propagator is quite general and can also be used to calculate the chemical potential dependence of the dressed gluon propagator.

关键词： quark loop effects GCM explicit and dynamical chiral symmetry breaking

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空间挠性作动器的可靠性验证试验方法

中国空间科学技术（中英文） 2024年第2期44卷 118-124页

作者：叶田园刘鑫崔赪旻周元子宗红北京卫星环境工程研究所北京100094 北京控制工程研究所北京100094

为了对空间挠性作动器在轨运行的可靠性进行评估,针对作动器在轨工况复杂、小子样、长寿命的特点,给出了作动器可靠性验证试验方法。首先,在分析作动器结构组成及工作原理的基础上,确定了作动器可靠性特征量。然后,以寿命型可靠性试验... 详细信息

为了对空间挠性作动器在轨运行的可靠性进行评估,针对作动器在轨工况复杂、小子样、长寿命的特点,给出了作动器可靠性验证试验方法。首先,在分析作动器结构组成及工作原理的基础上,确定了作动器可靠性特征量。然后,以寿命型可靠性试验为基本思路,针对挠性元件在轨疲劳断裂失效这一主要故障模式,根据在轨典型工况载荷数据进行疲劳试验载荷谱设计,采用试验载荷谱开展挠性元件加速疲劳寿命试验,基于试验结果给出作动器的可靠性评估结果。最后,以某型号空间挠性作动器为例,基于挠性元件加速疲劳试验进行可靠性试验验证,得到作动器可靠性评估结果。研究结果表明,该作动器可靠度满足指标要求,评估结果符合工程实际。运用所提出的可靠性验证试验方法,可为空间挠性作动器在轨运行可靠性的定量评估提供有效的技术途径,可为航天器运动机构的可靠性验证提供参考。

关键词：作动器挠性元件载荷谱加速疲劳试验可靠性评估