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Tungsten 2025年第1期7卷 32-49页

作者： Li-Rong Xiao Chen Chen Shuo Wang Zi-Yin Dai Hideo Kimura Cui Ni Chuan-xin Hou Xue-Qin Sun Si-Jie guo Wei Du Xiu-Bo Xie School of Environmental and Material Engineering Yantai University Bosch HUAYU Steering Systems (Yantai) Co. Ltd.Ytp/MFE University of Tennessee Knoxville Shandong Key Laboratory of Eco-Environmental Science for the Yellow River Delta Shandong University of Aeronautics

MgH2is considered as a promising hydrogen storage material for its high hydrogen storage capacity,low cost and abundant resource ***,the low kinetics and high enthalpy formation of MgH2limit its wide *** the perspective of adding catalysts to enhance the hydrogen storage properties of Mg-MgH2,this article elaborated the main catalysts based on Ti and Nb transition elements,including single oxide catalysts,binary oxides catalysts（combined with Ni,Na,Sr,V,etc.）,multiple catalysts bound to carbon,and composite catalysts with Ti and Nb elements combined with MXene ***,the main pathways of various catalysts to reduce the reaction activity and broaden the hydrogen desorption channel were also *** Ti-based catalysts can enhance the reactive sites of the matrix by forming multivalent states,while Nb-based catalysts broaden the hydrogen reaction channels by forming tiny *** improving the size structure and enhancing the grain size stability,combined with carbon materials should be the future considerations.

关键词： Catalysts Mg-based hydrogen storage alloys Solid hydrogen storage Transition metal elements

Actin microfilament involved in regulation of pacemaking activity increased by membrane stretch in cultured ICCs from murine intestine

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Actin microfilament involved in regulation of pacemaking act...

Maintaining moderate levels of hypochlorous acid promotes neural stem cell proliferation and differentiation in the recovery phase of stroke

中国生理学会第23届全国会员代表大会暨生理学学术大会

作者： Zuo-Yu WANG,Yan-Fei HAN,Xu HUANG,hong-Li LU,xin guo,Wen-Xie XU Department of Physiology,Shanghai Jiaotong University School of Medicine Shanghai,200240,China

Distension is a regular mechanical stimulus in gastrointestinal(GI) *** study is designed to investigate the effect of membrane stretch on pacemaking activity and whether actin microfilament is involved in its mechanism in cultured murine intestinal interstitial cells of Cajal(ICCs) by using whole-cell patch-clamp and calcium imaging *** stretch induced sustained inward holding current from the baseline to(647.38±105.07) pA and significantly decreased amplitudes of pacemaker current from(222.25±51.76) pA to(141.17±46.45) pA(n=6,P<0.05).Membrane stretch increased the intensity of basal F/F0 from baseline to(1.09±0.03) and significantly increased of Ca oscillation amplitude from(0.08±0.01) to(0.19±0.03)(ΔF/F0)(n=6,P<0.05).20μmol/L cytochalasin-B,a disruptor of actin microfilaments,significantly suppressed amplitude of pacemaker currents and calcium oscillations from(491.32±160.33) pA and(0.30±0.06)(ΔF/F0) to(233.12±92.00) pA and(0.09±0.02) (ΔF/F0)(n=6,P<0.05),***-B blocked membrane stretch-induced increase of pacemaker currents and calcium oscillations.20μmol/L phalloidin,a stabilizer of actin microfilaments,significantly enhanced amplitude of pacemaker currents and calcium oscillations from(751.79±282.82) pA and(0.56±0.13)(ΔF/F0) to (1234.34±607.83) pA and(0.72±0.08)(ΔF/F0)(n=6,P<0.05),*** stretch still induced an inward holding current and increased basal fluorescence intensity from baseline to(1.32±0.07) when pretreatment with *** results suggest that membrane stretch potentiates pacemaking activity via actin microfilaments and the process is mediated by altering intracellular basal calcium concentration and calcium oscillation in cultured intestinal ICCs.

关键词： ICCs membrane stretch actin microfilament pacemaking activity calcium oscillation.

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Neural Regeneration Research 2025年第3期20卷 845-857页

作者： Lin-Yan Huang Yi-De Zhang Jie Chen Hai-Di Fan Wan Wang Bin Wang Ju-Yun Ma Peng-Peng Li Hai-Wei Pu xin-Yian guo Jian-Gang Shen Su-Hua Qi School of Medical Technology Xuzhou Key Laboratory of Laboratory DiagnosticsXuzhou Medical UniversityXuzhouJiangsu ProvinceChina School of Pharmacy Xuzhou Medical UniversityXuzhouJiangsu ProvinceChina Department of Laboratory Medicine Branch Hospital of Huai’an First People’s HospitalHuai’anJiangsu ProvinceChina Department of Laboratory Medicine the Affiliated Hospital of Xuzhou Medical UniversityXuzhouJiangsu ProvinceChina School of Chinese Medicine The University of Hong KongHong Kong Special Administrative RegionChina

It has been shown clinically that continuous removal of ischemia/reperfusion-induced reactive oxygen species is not conducive to the recovery of late ***,previous studies have shown that excessive increases in hypochlorous acid after stroke can cause severe damage to brain *** previous studies have found that a small amount of hypochlorous acid still exists in the later stage of stroke,but its specific role and mechanism are currently *** simulate stroke in vivo,a middle cerebral artery occlusion rat model was established,with an oxygen-glucose deprivation/reoxygenation model established in vitro to mimic *** found that in the early stage(within 24 hours)of ischemic stroke,neutrophils produced a large amount of hypochlorous acid,while in the recovery phase(10 days after stroke),microglia were activated and produced a small amount of hypochlorous ***,in acute stroke in rats,hypochlorous acid production was prevented using a hypochlorous acid scavenger,taurine,or myeloperoxidase inhibitor,4-aminobenzoic acid *** results showed that high levels of hypochlorous acid(200μM)induced neuronal apoptosis after oxygen/glucose deprivation/***,in the recovery phase of the middle cerebral artery occlusion model,a moderate level of hypochlorous acid promoted the proliferation and differentiation of neural stem cells into neurons and *** suggests that hypochlorous acid plays different roles at different phases of cerebral ischemia/reperfusion *** levels of hypochlorous acid(5 and 100μM)promoted nuclear translocation ofβ-*** transfection of single-site mutation plasmids,we found that hypochlorous acid induced chlorination of theβ-catenin tyrosine 30 residue,which promoted nuclear ***,our study indicates that maintaining low levels of hypochlorous acid plays a key role in the recovery of neurological function.

关键词： cell differentiation cerebral ischemia/reperfusion injury chlorination hypochlorous acid microglia neural stem cell neurogenesis nuclear translocation stroke β-catenin

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从风邪致病论述肾病蛋白尿的发生机理

世界中西医结合杂志 2017年第6期12卷 855-857,861页

作者：李鑫洪钦国陈刚毅广州中医药大学广州中医药大学第一附属医院肾内科广东广州510405

蛋白尿是肾病的一个常见临床特征,中医学认为其与多种原因有关。风邪与肾病蛋白尿的关系越来越受到重视。长期以来,多数医家从外风致病出发,阐释其发病机理,由此制定的方药取得了良好的临床疗效。临床观察发现,在肾病蛋白尿中,容易忽略... 详细信息

蛋白尿是肾病的一个常见临床特征,中医学认为其与多种原因有关。风邪与肾病蛋白尿的关系越来越受到重视。长期以来,多数医家从外风致病出发,阐释其发病机理,由此制定的方药取得了良好的临床疗效。临床观察发现,在肾病蛋白尿中,容易忽略内风以及内外风之间的相互影响对其发病的影响。文中分别从外风、内风及内外风的相互影响的角度论述风邪导致肾病蛋白尿的中医发病机理,认为外风袭表,风自内生,内外风邪相召,导致肾脏开泄是风邪引发肾病蛋白尿的中医病机,以期为临床治疗肾病蛋白尿提供有效的中医理论依据。

关键词：肾病蛋白尿风邪内风外风

Palladium installed copper-organic framework for C–C coupling reactions

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Science China Chemistry 2025年

作者： Yu-Mei Wang Mei-Xia Tao Kai-Ming Mo Xu Chen Shu-Hua Zhong Elena S Shubina guo-hong Ning Dan Li College of Chemistry and Materials Science Guangdong Provincial Key Laboratory of Supramolecular Coordination ChemistryJinan University A.N.Nesmeyanov Institute of Organoelement Compounds Russian Academy of Sciences

The formation of C–C bonds is a crucial aspect of organic synthesis. Synthesists' long-term objective is to identify novel catalysts to optimize reaction systems based on traditional transition metal catalysis. This study explores the synthesis and catalytic potential of palladium-installed covalent metal-organic frameworks(CMOFs) based on copper cyclic trinuclear units(Cu-CTUs). By incorporating palladium ions into the imine-based framework JNM-7 through a straightforward immersion method, we achieved a notable enhancement in catalytic activity for critical C–C coupling reactions, including C–H arylation and Sonogashira cross-coupling. The resulting JNM-7-Pd demonstrated remarkable stability and recyclability, maintaining its efficiency over at least three cycles without any decline in efficiency.

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Modulation of the octahedral structure and potential superconductivity of La3Ni2O7 through strain engineering

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Science China(Physics,Mechanics & Astronomy) 2025年

作者： Zihao Huo Zhihui Luo Peng Zhang Aiqin Yang Zhengtao Liu Xiangru Tao Zihan Zhang Shumin guo Qiwen Jiang Wenxuan Chen Dao-xin Yao Defang Duan Tian Cui Key Laboratory of Material Simulation Methods & Software of Ministry of Education State Key Laboratory of Superhard Materials College of Physics Jilin University Center for Neutron Science and Technology Guangdong Provincial Key Laboratory of Magnetoelectric Physics and Devices State Key Laboratory of Optoelectronic Materials and Technologies School of Physics Sun Yat-sen University MOE Key Laboratory for Non-equilibrium Synthesis and Modulation of Condensed Matter Shaanxi Province Key Laboratory of Advanced Functional Materials and Mesoscopic Physics School of Physics Xi'an Jiaotong University Institute of High Pressure Physics School of Physical Science and Technology Ningbo University

The recent transport measurements of La3Ni2O7uncovered a“right-triangle”shape of the superconducting dome in the pressure-temperature （P-T） phase *** by this,we perform theoretical first-principles studies of La3Ni2O7with the pressure ranging from 0 to 100 ***,we reveal a pressure dependence of the Ni-d2zelectron density at the Fermi energy (nE Fz) that highly coincides with such *** this basis,we further explore the electronic structure under uniaxial *** tracking the stress response of nE Fz,we propose that superconductivity can be achieved by applying only～2 GPa of compression along the c *** idea is further exemplified from the perspectives of lattice distortion,band structure,Fermi surface and superconducting phase *** also discuss the possible charge modulation under the stress and provide an insight into the relation between nE Fzand the superconducting Tcin *** study provides new routes to the search of high-Tcsuperconductors in future experiments.

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Deciphering fungal metabolon coupling tandem inverse-electrondemand Diels-Alder reaction and semipinacol rearrangement for the biosynthesis of spiro polycyclic alkaloids

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Science China Chemistry 2025年第1期68卷 288-296页

作者： Shuai Liu Wen-Qiang Xu Ying-Tong Di Man-Cheng Tang Ding-Kang Chen Ming-Ming Cao Yao-Wen Chang hong-Yu Tang Chun-Mao Yuan Jun-Bo Yang Zhi-Li Zuo Han guo Zi-Fei Xu Ying Zeng Yun-Dong Wu Xiao-Jiang Hao Key Laboratory of Phytochemistry and Natural Medicines (Chinese Academy of Sciences) Kunming Institute of Botany Chinese Academy of Sciences University of Chinese Academy of Sciences Lab of Computational Chemistry and Drug Design State Key Laboratory of Chemical Oncogenomics Peking University Shenzhen Graduate School Shenzhen Bay Laboratory State Key Laboratory of Microbial Metabolism School of Life Sciences & Biotechnology Shanghai Jiao Tong University State Key Laboratory of Functions and Applications of Medicinal Plants Guizhou Medical University Molecular Biology Experimental Center Germplasm Bank of Wild Species in Southwest China Kunming Institute of Botany Chinese Academy of Sciences Yunnan Key Laboratory for Wild Plant Resources Kunming Institute of Botany Chinese Academy of Sciences Research Unit of Chemical Biology of Natural Anti-Virus Products Chinese Academy of Medical Sciences

In the intricate process of natural product biosynthesis, a metabolon can enhance metabolic flux by associating sequential enzymes. A fungal metabolon, comprising of flavin-dependent monooxygenase Spe F and P450 monooxygenase Spe G, is identified in the biosynthesis of spiro polycyclic alkaloids(+)-notoamide B and its diastereomer(+)-versicolamide B. Using notoamide E as a substance, Spe F/Spe G metabolon can control the stereoselectivity of its 2,3-epoxidation, followed by hydrogen atom ion at C-17 to generate reactive epoxide tau-m A with dienyl iminium unit. Subsequently,(+)-notoamide B and(+)-versicolamide B are produced via tandem nonenzymatic inverse-electron-demand Diels-Alder reaction and semipinacol rearrangement. This provides the first example of metabolon in the biosynthesis of spiro-prenylated indole alkaloids.

关键词： metabolon Diels-Alder reaction semipinacol rearrangement biosynthesis notoamides spiro polycyclic alkaloids

穿越大落差积水矿坑隧道渗流-应力耦合作用下变形特征研究

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国防交通工程与技术 2025年第1期23卷 14-18,80页

作者：郭鑫中铁十八局集团第三工程有限公司河北涿州072750

为探明穿越大落差积水矿坑的隧道洞口仰坡在渗流作用下的稳定性及变形特征,以西部某隧道为工程背景,首先对隧道在渗流作用下及渗流-应力作用下的解析方程进行分析,其次开展了室内试验对隧道岩土体物理力学参数进行测定,在理论与试验基础... 详细信息

为探明穿越大落差积水矿坑的隧道洞口仰坡在渗流作用下的稳定性及变形特征,以西部某隧道为工程背景,首先对隧道在渗流作用下及渗流-应力作用下的解析方程进行分析,其次开展了室内试验对隧道岩土体物理力学参数进行测定,在理论与试验基础上,采用FLAC3D数值模拟软件建立了隧道渗流数值模型,通过设计两种危险渗流工况对隧道围岩及仰坡变形进行计算分析。研究结果表明:只考虑应力场的影响时,拱顶的变形量最大,仰拱的变形量最小,应力场对隧道顶部的影响较大;只考虑渗流场的影响时,在不同孔隙水压的渗流下,拱顶和拱肩的变形量最大,仰拱变形量最小。在两场耦合的作用下,两积水坑水位不同,对隧道不同部位的影响程度也不相同,因此在开挖隧道时,需要考虑如何阻断其渗流作用、减少渗流对隧道的影响。

关键词：隧道工程流-固耦合围岩变形仰坡滑移力学试验数值模拟

关中-天水经济区对日软件外包人才培养模式研究

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现代计算机 2016年第18期22卷 13-17页

作者：欧阳宏基郭新明葛萌咸阳师范学院计算机学院咸阳712000

对日软件外包已成为我国软件产业外包的一个重要分支,但是人才资源短缺仍然是制约对日软件外包发展的一个重要瓶颈。针对该问题,介绍最近几年我国对日软件外包的新特点,然后分析关中-天水经济区在对日软件外包方面的优势,最后根据对日... 详细信息

对日软件外包已成为我国软件产业外包的一个重要分支,但是人才资源短缺仍然是制约对日软件外包发展的一个重要瓶颈。针对该问题,介绍最近几年我国对日软件外包的新特点,然后分析关中-天水经济区在对日软件外包方面的优势,最后根据对日外包业务的基本流程和低端人才需求情况,提出"日语文化学习+技术平台驱动教学内容+教师日企挂职锻炼+真实外包案例训练"的培养模式,希望能为关中-天水经济区内高等院校以及相关软件企业在对日软件外包人才培养方面起到一定的借鉴作用。

关键词：关中-天水经济区对日软件外包人才培养模式

蝙蝠葛碱对阿尔茨海默病小鼠海马晚期糖基化终产物受体和核转录因子-κBp65的影响

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中国老年学杂志 2017年第19期37卷 4697-4700页

作者：张英博费洪新郭家兴桂华潘思文张晓杰周忠光齐齐哈尔医学院黑龙江齐齐哈尔161006 黑龙江中医药大学

目的探讨蝙蝠葛碱(DAU)对阿尔茨海默病(AD)小鼠海马晚期糖基化终产物受体(RAGE)和核转录因子(NF)-κBp65的影响。方法雄性小鼠随机分成对照组、模型组、多奈哌齐组(0.001 g/kg)及DAU高、中、低剂量组(2.4、1.2、0.6 g/kg)。小鼠双侧海... 详细信息

目的探讨蝙蝠葛碱(DAU)对阿尔茨海默病(AD)小鼠海马晚期糖基化终产物受体(RAGE)和核转录因子(NF)-κBp65的影响。方法雄性小鼠随机分成对照组、模型组、多奈哌齐组(0.001 g/kg)及DAU高、中、低剂量组(2.4、1.2、0.6 g/kg)。小鼠双侧海马微量注射β-淀粉样蛋白(Aβ)_(1~42)(2 g/L)和腹腔注射D-半乳糖(180 mg/kg)诱导AD小鼠,连续治疗35 d后取材。采用Morris水迷宫(MWM)检测AD小鼠学习记忆能力,酶联免疫吸附(ELISA)检测海马白细胞介素(IL)-1β、IL-6含量,免疫组化(IHC)、实时定量(RT)-PCR和Western印迹检测海马RAGE和NF-κBp65表达。结果与模型组比较,DAU高、中剂量明显改善AD小鼠学习记忆能力,明显降低海马IL-1β、IL-6、RAGE和NF-κBp65水平(均P<0.05)。结论 DAU通过抑制海马RAGE和NF-κBp65表达来改善AD小鼠学习记忆能力,以此在AD治疗中发挥重要作用。

关键词：蝙蝠葛碱阿尔茨海默病晚期糖基化终产物受体