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Science China Chemistry 2025年第01期 26-34页

作者： Yutao Zhang Juan Li Wei-hong Zhu Zhiqian guo Shanghai Key Laboratory of Functional Materials Chemistry Joint International Research Laboratory of Precision Chemistry and Molecular Engineering Institute of Fine Chemicals School of Chemistry and Molecular Engineering East China University of Science and Technology State Key Laboratory of Bioreactor Engineering Shanghai Frontier Science Research Base of Optogenetic Techniques for Cell MetabolismEast China University of Science & Technology

Sequence-activated chemiluminescence(CL) technique offers a unique approach to detecting specific biomolecules or cellular events with high sensitivity and spatial resolution. The fundamental principle behind sequence-activated CL probes involves tailoring highly-controllable CL signals in response to specific sequences or events of interest, thus enabling high-contrast signals under complex physiological conditions. This sequential activation could be triggered by enzymes, reactive oxygen species(ROS), biothiols or changes in the microenvironment. These unique sequence-activated CL probes bestow several advantages, including minimal background, deep-tissue penetration, and the ability of non-invasive or minimally invasive detection. The sequence-activated CL techniques represent a significant advancement in molecular imaging and diagnostics. In this mini-review, we focus on the latest developments in sequential CL probes, addressing the technical challenges and discussing the future trajectory by harnessing CL signaling and molecular recognition.

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Rock fracture mechanism of buffer blasting with cushion layer at the borehole bottom

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International Journal of Minerals,Metallurgy and Materials 2025年第2期32卷 325-334页

作者： xinguang Zhu Chenxi Ding Zhe Sui hong Su Xu guo School of Civil and Resources Engineering University of Science and Technology BeijingBeijing 100083China Key Laboratory for Mechanics in Fluid Solid Coupling Systems Institute of MechanicsChinese Academy of SciencesBeijing 100190China School of Mechanics and Civil Engineering China University of Mining and Technology(Beijing)Beijing 100083China School of Chemical and Blasting Engineering Anhui University of Science and TechnologyHuainan 232001China

This study primarily investigates the rock fracture mechanism of bottom cushion layer blasting and explores the effects of the bottom cushion layer on rock *** involves analyses of the evolution patterns of blasting stress,characteristics of crack distribution,and rock fracture features in the ***,blasting model experiments were carried out using the dynamic caustics principle to investigate the influence of bottom cushion layers and initiation methods on the integrity of the bottom rock *** experimental results indicate that the combined use of bottom cushion layers and inverse initiation effectively protects the integrity of the bottom rock ***,the process of stress wave propagation and dynamic crack propagation in rocks was simulated using the continuum-discontinuum element method(CDEM)and the Landau explosion source model,with varying thicknesses of bottom cushion *** numerical simulation results indicate that with increasing cushion thickness,the absorption of energy generated by the explosion becomes more pronounced,resulting in fewer cracks in the bottom rock *** illustrates the positive role of the cushion layer in protecting the integrity of the bottom rock mass.

关键词： bottom cushion layer blasting crack propagation continuum-discontinuum element method dynamic stress intensity factor

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改进控制器在多能互补供暖系统中的应用

流体机械 2016年第9期44卷 77-81页

作者：郝红于国鑫薛翔远沈阳建筑大学辽宁沈阳110168

为缓解能源危机、综合利用能源、提高能源利用效率,研究了改进算法后的PSO-PID控制器在太阳能-燃气热泵与热网互补供热系统中的作用。构建太阳能-燃气热泵与热网互补供热仿真模型,并对加入改进控制器前后系统的运行特性进行对比。结果表... 详细信息

为缓解能源危机、综合利用能源、提高能源利用效率,研究了改进算法后的PSO-PID控制器在太阳能-燃气热泵与热网互补供热系统中的作用。构建太阳能-燃气热泵与热网互补供热仿真模型,并对加入改进控制器前后系统的运行特性进行对比。结果表明:加入改进控制器减弱了互补供热系统的滞后性,使得用户的室温更加稳定舒适;其运行过程中的各项参数都得到了较好的控制;热泵机组的COP从3.94上升到4.87,PER从1.62上升到2.25;系统在整个供暖季所消耗的标煤量仅为采用传统控制器下的93%;更好的提升了互补供热系统的性能,并使其在整个供暖季可以更加高效、稳定地运行;更好地提升了互补供热系统的性能,并使其在整个供暖季可以更加高效、稳定的运行。

关键词：太阳能-燃气热泵互补供热 PSO-PID算法改进 MATLAB

Sky location of massive black hole binaries in the foreground of Galactic white dwarf binaries

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Science China(Physics,Mechanics & Astronomy) 2025年第1期Mechanics & Astronomy) .卷 97-108页

作者： Pan guo hong-Bo Jin Cong-Feng Qiao Yue-Liang Wu The International Centre for Theoretical Physics Asia-Pacific University of Chinese Academy of Sciences The School of Physical Sciences University of Chinese Academy of Sciences Institute for Frontiers in Astronomy and Astrophysics Beijing Normal University National Astronomical Observatories Chinese Academy of Sciences Institute of Theoretical Physics Chinese Academy of Sciences

For space-based gravitational wave （GW） detection,the main noise source for massive black hole binaries （MBHBs） is attributed to approximately 10～7double white dwarf binaries in the *** a GW source,the amplitude of the detector response,recorded by a space-based gravitational wave detector,exhibits a modulation effect with a year period when observing the source from various orbital *** the adverse conditions mentioned above,where there is a strong foreground noise and annual modulation in the signals,we employed the wavelet transform and the strong-amplitude relevant orbital position search methods,which allows the weak MBHB sources to achieve higher locating *** detail,for two MBHB sources of lower intensity,the precision of luminosity distance,represented by the ratio ?DL/DLat the 95%confidence level,is enhanced by factors of ～*** angular resolutions,denoted by??s,are enhanced by a factor of ～*** improvements increase the number of detectable GW sources,facilitate multi-messenger follow-up observations and provide constraints on the cosmological constant.

关键词： space-based gravitational wave detection gravitational waves massive black hole binaries

Arthroscopically Assisted Debridement and Ankle Arthrodesis with External Fixation for the Treatment of End-stage Ankle Tuberculosis

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Arthroscopically Assisted Debridement and Ankle Arthrodesis ...

Actin microfilament involved in regulation of pacemaking activity increased by membrane stretch in cultured ICCs from murine intestine

中国药学会全国骨科药物与临床应用学术研讨会

作者： TANG Kang-lai, LI Qi-hong, CHEN Guang-xin, guo Lin, DAI Gang, YANG Liu (Centre for Joint Surgery, Southwest Hospital, Chongqing, 400038 China)

＜正＞Objective To evaluate the clinical outcome of arthroscopically assisted debridement and tibiotalar arthrodesis with half-ring sulcated external fixator for the treatment of end-stage ankle joint tuberculosis （TB）. Type of study: Retrospective study of surgical outcomes. Methods 10 patients of end-stage ankle TB （male, 6;female, 4;mean age, 33 years;range, 28 to 56 years） were treated with arthroscopically assisted debridement and tibiotalar arthrodesis using a half-ring sulcated external fixator. All patients received gold standard of anti-TB drug treatment for at least 3 weeks preoperatively and for at least one year postoperatively. All patients began to walk with partial weight bearing 4 days postoperatively and full weight bearing after the joint was fused. The external fixator was removed at that point. The clinical results were assessed with the American Orthopaedic Foot and Ankle Score. Results All patients were assessed both clinically and radiologically at a mean follow-up of 23.2 months （range, 6 to 46 months）. Clinical and radiological fusion rates were both 100%. The mean time to clinical and radiographic bone fusion was 14.5 weeks （8 - 20 weeks）. The AOFAS score was 66 at the last follow-up. No complications occurred. Conclusion Arthroscopically assisted debridement and tibiotalar arthrodesis with half-ring sulcated external fixator for the treatment of end-stage ankle joint TB is a safe and effective procedure with a high rate of fusion, short fusion time without any complications.

关键词： Arthroscopy External Fixation Ankle Tuberculosis Arthrodesis

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Actin microfilament involved in regulation of pacemaking act...

Constructing Donor–Acceptor‑Linked COFs Electrolytes to Regulate Electron Density and Accelerate the Li^(+)Migration in Quasi‑Solid‑State Battery

中国生理学会第23届全国会员代表大会暨生理学学术大会

作者： Zuo-Yu WANG,Yan-Fei HAN,Xu HUANG,hong-Li LU,xin guo,Wen-Xie XU Department of Physiology,Shanghai Jiaotong University School of Medicine Shanghai,200240,China

Distension is a regular mechanical stimulus in gastrointestinal(GI) *** study is designed to investigate the effect of membrane stretch on pacemaking activity and whether actin microfilament is involved in its mechanism in cultured murine intestinal interstitial cells of Cajal(ICCs) by using whole-cell patch-clamp and calcium imaging *** stretch induced sustained inward holding current from the baseline to(647.38±105.07) pA and significantly decreased amplitudes of pacemaker current from(222.25±51.76) pA to(141.17±46.45) pA(n=6,P<0.05).Membrane stretch increased the intensity of basal F/F0 from baseline to(1.09±0.03) and significantly increased of Ca oscillation amplitude from(0.08±0.01) to(0.19±0.03)(ΔF/F0)(n=6,P<0.05).20μmol/L cytochalasin-B,a disruptor of actin microfilaments,significantly suppressed amplitude of pacemaker currents and calcium oscillations from(491.32±160.33) pA and(0.30±0.06)(ΔF/F0) to(233.12±92.00) pA and(0.09±0.02) (ΔF/F0)(n=6,P<0.05),***-B blocked membrane stretch-induced increase of pacemaker currents and calcium oscillations.20μmol/L phalloidin,a stabilizer of actin microfilaments,significantly enhanced amplitude of pacemaker currents and calcium oscillations from(751.79±282.82) pA and(0.56±0.13)(ΔF/F0) to (1234.34±607.83) pA and(0.72±0.08)(ΔF/F0)(n=6,P<0.05),*** stretch still induced an inward holding current and increased basal fluorescence intensity from baseline to(1.32±0.07) when pretreatment with *** results suggest that membrane stretch potentiates pacemaking activity via actin microfilaments and the process is mediated by altering intracellular basal calcium concentration and calcium oscillation in cultured intestinal ICCs.

关键词： ICCs membrane stretch actin microfilament pacemaking activity calcium oscillation.

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Nano-Micro Letters 2025年第1期17卷 456-471页

作者： Genfu Zhao Hang Ma Conghui Zhang Yongxin Yang Shuyuan Yu Haiye Zhu Yongjiang Sun hong guo School of Materials and Energy International Joint Research Center for Advanced Energy Materials of Yunnan ProvinceYunnan UniversityKunming 650091People’s Republic of China Yunnan Yuntianhua Co. LtdR&D CenterKunming 650228People’s Republic of China Southwest United Graduate School Kunming 650091People’s Republic of China

Regulation the electronic density of solid-state electrolyte by donor–acceptor(D–A)system can achieve highly-selective Li^(+)transportation and conduction in solid-state Li metal *** study reports a high-performance solid-state electrolyte thorough D–A-linked covalent organic frameworks(COFs)based on intramolecular charge transfer *** other reported COFbased solid-state electrolyte,the developed concept with D–A-linked COFs not only achieves electronic modulation to promote highly-selective Li^(+)migration and inhibit Li dendrite,but also offers a crucial opportunity to understand the role of electronic density in solid-state Li metal *** introduced strong electronegativity F-based ligand in COF electrolyte results in highlyselective Li^(+)(transference number 0.83),high ionic conductivity(6.7×10^(-4)S cm^(−1)),excellent cyclic ability(1000 h)in Li metal symmetric cell and high-capacity retention in Li/LiFePO_(4)cell(90.8%for 300 cycles at 5C)than substituted C-and N-based *** is ascribed to outstanding D–A interaction between donor porphyrin and acceptor F atoms,which effectively expedites electron transferring from porphyrin to F-based ligand and enhances Li^(+)***,we anticipate that this work creates insight into the strategy for accelerating Li^(+)conduction in high-performance solid-state Li metal batteries through D–A system.

关键词： Electronic modulation engineering Donor-acceptor-linked covalent organic frameworks Quasi-solid-state Li metal battery

Advances in Graphene‑Based Electrode for Triboelectric Nanogenerator

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Nano-Micro Letters 2025年第1期17卷 378-403页

作者： Bin Xie Yuanhui guo Yun Chen Hao Zhang Jiawei Xiao Maoxiang Hou Huilong Liu Li Ma xin Chen Chingping Wong State Key Laboratory of Precision Electronic Manufacturing Technology and Equipment Guangdong University of TechnologyGuangzhou 510006People’s Republic of China School of Electromechanical Engineering Guangdong University of TechnologyGuangzhou 510006People’s Republic of China School of Materials Science and Engineering Georgia Institute of TechnologyAtlantaGA 30332USA

With the continuous development of wearable electronics,wireless sensor networks and other micro-electronic devices,there is an increasingly urgent need for miniature,flexible and efficient nanopower generation *** nanogenerator(TENG)technology can convert small mechanical energy into electricity,which is expected to address this *** the core component of TENG,the choice of electrode materials significantly affects its *** metal electrode materials often suffer from problems such as durability,which limits the further application of ***,as a novel electrode material,shows excellent prospects for application in TENG owing to its unique structure and excellent electrical *** review systematically summarizes the recent research progress and application prospects of TENGs based on graphene *** precision processing methods of graphene electrodes are introduced,and the applications of graphene electrode-based TENGs in various scenarios as well as the enhancement of graphene electrodes for TENG performance are *** addition,the future development of graphene electrode-based TENGs is also prospectively discussed,aiming to promote the continuous advancement of graphene electrode-based TENGs.

关键词： Triboelectric nanogenerator Precision processing Graphene electrode Self-powered sensor

Inhalable particle matter (PM10) can induce and aggravate asthmatic inflammation in rats

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Inhalable particle matter (PM10) can induce and aggravate as...

The 5th Congress of Toxicology in Developing Countries

作者： Xiao-hong Zhao, xin-Biao guo, Shi-Jie Liu Department of Biology, College of Arts and Sciences of Beijing Union University Department of Occupational and Environmental Health Sciences, School of Public Health, Peking University, Beijing 100083, China

Inhalable particle matter (PM) is considered to play an important role in asthmatic airway inflammation. The aim of the present study was to investigate whether PM can induce or aggravate the asthmatic inflammation in sensitized rats. PM was collected on glass-fibre filters using a high-volume sampler, located nearly ur-

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从风邪致病论述肾病蛋白尿的发生机理

世界中西医结合杂志 2017年第6期12卷 855-857,861页

作者：李鑫洪钦国陈刚毅广州中医药大学广州中医药大学第一附属医院肾内科广东广州510405

蛋白尿是肾病的一个常见临床特征,中医学认为其与多种原因有关。风邪与肾病蛋白尿的关系越来越受到重视。长期以来,多数医家从外风致病出发,阐释其发病机理,由此制定的方药取得了良好的临床疗效。临床观察发现,在肾病蛋白尿中,容易忽略... 详细信息

蛋白尿是肾病的一个常见临床特征,中医学认为其与多种原因有关。风邪与肾病蛋白尿的关系越来越受到重视。长期以来,多数医家从外风致病出发,阐释其发病机理,由此制定的方药取得了良好的临床疗效。临床观察发现,在肾病蛋白尿中,容易忽略内风以及内外风之间的相互影响对其发病的影响。文中分别从外风、内风及内外风的相互影响的角度论述风邪导致肾病蛋白尿的中医发病机理,认为外风袭表,风自内生,内外风邪相召,导致肾脏开泄是风邪引发肾病蛋白尿的中医病机,以期为临床治疗肾病蛋白尿提供有效的中医理论依据。

关键词：肾病蛋白尿风邪内风外风