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Effects of electroacupuncture on the functionality of NG2-expressing cells in perilesional brain tissue of mice following ischemic stroke

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Neural Regeneration Research 2022年第7期17卷 1556-1565页

作者： hong ju lee Da Hee jung Nam Kwen Kim Hwa Kyoung Shin Byung Tae Choi Department of Korean Medical Science School of Korean MedicinePusan National UniversityYangsanRepublic of Korea Graduate Training Program of Korean Medicine for Healthy Aging Pusan National UniversityYangsanRepublic of Korea Department of Korean Ophthalmology Otolaryngology and DermatologySchool of Korean MedicinePusan National UniversityYangsanRepublic of Korea

Neural/glial antigen 2(NG2)-expressing cells has multipotent stem cell activity under cerebral *** study examined the effects of electroacupuncture(EA)therapy(2 Hz,1 or 3 mA,20 minutes)at the Sishencong acupoint on motor function after ischemic insult in the brain by investigating the rehabilitative potential of NG2-derived cells in a mouse model of ischemic *** stimulation alleviated motor deficits caused by ischemic stroke,and 1 mA EA stimulation was more efficacious than 3 mA EA stimulation or positive control treatment with edaravone,a free radical *** properties of NG2-expressing cells were altered with 1 mA EA stimulation,enhancing their survival in perilesional brain tissue via reduction of tumor necrosis factor alpha *** stimulation robustly activated signaling pathways related to proliferation and survival of NG2-expressing cells and increased the expression of neurotrophic factors such as brain-derived neurotrophic factor,tumor growth factor beta,and neurotrophin *** the perilesional striatum,EA stimulation greatly increased the number of NG2-expressing cells double-positive for oligodendrocyte,endothelial cell,and microglia/macrophage markers(CC1,CD31,and CD68).EA therapy also greatly activated brain-derived neurotrophic factor/tropomyosin receptor kinase B and glycogen synthase kinase 3 beta *** results indicate that EA therapy may prevent functional loss at the perilesional site by enhancing survival and differentiation of NG2-expressing cells via the activation of brain-derived neurotrophic factor-induced signaling,subsequently ameliorating motor *** animal experiments were approved by the Animal Ethics Committee of Pusan National University(approval ***2019-2199 and PNU2019-2884)on April 8,2019 and june 19,2019.

关键词： brain-derived neurotrophic factor differentiation electroacupuncture motor function neural/glial antigen 2 perilesional striatum stroke survival

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Tailoring Light–Matter Interactions in Overcoupled Resonator for Biomolecule Recognition and Detection

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Nano-Micro Letters 2025年第1期17卷 262-280页

作者： Dongxiao Li hong Zhou Zhihao Ren Cheng Xu Chengkuo lee Department of Electrical and Computer Engineering National University of SingaporeSingapore 117583Singapore Center for Intelligent Sensors and MEMS(CISM) National University of SingaporeSingapore 117608Singapore

Plasmonic nanoantennas provide unique opportunities for precise control of light–matter coupling in surface-enhanced infrared absorption(SEIRA)spectroscopy,but most of the resonant systems realized so far suffer from the obstacles of low sensitivity,narrow bandwidth,and asymmetric Fano resonance ***,we demonstrated an overcoupled resonator with a high plasmon-molecule coupling coefficient(μ)(OC-Hμresonator)by precisely controlling the radiation loss channel,the resonator-oscillator coupling channel,and the frequency detuning *** observed a strong dependence of the sensing performance on the coupling state,and demonstrated that OC-Hμresonator has excellent sensing properties of ultra-sensitive(7.25%nm^(−1)),ultra-broadband(3–10μm),and immune asymmetric Fano *** characteristics represent a breakthrough in SEIRA technology and lay the foundation for specific recognition of biomolecules,trace detection,and protein secondary structure analysis using a single array(array size is 100×100μm^(2)).In addition,with the assistance of machine learning,mixture classification,concentration prediction and spectral reconstruction were achieved with the highest accuracy of 100%.Finally,we demonstrated the potential of OC-Hμresonator for SARS-CoV-2 *** findings will promote the wider application of SEIRA technology,while providing new ideas for other enhanced spectroscopy technologies,quantum photonics and studying light–matter interactions.

关键词： Plasmonic nanoantennas Light-matter interaction Surface-enhanced infrared absorption Overcoupled Biosensing

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Regulation of sleep by astrocytes in the hypothalamic ventrolateral preoptic nucleus

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Neural Regeneration Research 2025年第4期20卷 1098-1100页

作者： Jae-hong Kim Ruqayya Afridi Il-Sung Jang Maan Gee lee Kyoungho Suk Brain Korea 21 four KNU Convergence Educational Program of Biomedical Sciences for Creative Future Talents School of MedicineKyungpook National UniversityDaeguRepublic of Korea Department of Pharmacology School of MedicineKyungpook National UniversityDaeguRepublic of Korea Department of Pharmacology School of DentistryKyungpook National UniversityDaeguRepublic of Korea Brain Science&Engineering Institute Kyungpook National UniversityDaeguRepublic of Korea

Astrocytes are functionally dynamic cells that support neurons in multiple ways throughout an organism’s *** astrocytic regulation of neuronal activity has been increasingly recognized in recent *** are now recognized as playing a more complex role than mere bystanders in the central nervous ***,their role in regulating the sleep neurocircuitry is not well *** this perspective,we highlight the role of astrocytes in sleep modulation,with a particular focus on regulatory mechanisms related to the ventrolateral preoptic nucleus(VLPO)of the *** briefly discuss recent literature reporting the role of VLPO astrocytes in regulating sleep-associated behaviors.

关键词： sleep ventrolateral astrocytes

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Endoplasmic reticulum stress and autophagy in cerebral ischemia/reperfusion injury:PERK as a potential target for intervention

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Neural Regeneration Research 2025年第5期20卷 1455-1466页

作者： ju Zheng Yixin Li Ting Zhang Yanlin Fu Peiyan Long Xiao Gao Zhengwei Wang Zhizhong Guan Xiaolan Qi Wei hong Yan Xiao Key Laboratory of Endemic and Ethnic Diseases Ministry of Education&Key Laboratory of Medical Molecular Biology of Guizhou ProvinceGuizhou Medical UniversityGuiyangGuizhou ProvinceChina Guizhou Center for Disease Control and Prevention GuiyangGuizhou ProvinceChina Department of Histology and Embryology Guizhou Medical UniversityGuiyangGuizhou ProvinceChina Collaborative Innovation Center for Prevention and Control of Endemic and Ethnic Regional Diseases Co-constructed by the Province and Ministry GuiyangGuizhou ProvinceChina

Several studies have shown that activation of unfolded protein response and endoplasmic reticulum(ER)stress plays a crucial role in severe cerebral ischemia/reperfusion *** occurs within hours after cerebral ischemia,but the relationship between ER stress and autophagy remains *** this study,we established experimental models using oxygen-glucose deprivation/reoxygenation in PC12 cells and primary neurons to simulate cerebral ischemia/reperfusion *** found that prolongation of oxygen-glucose deprivation activated the ER stress pathway protein kinase-like endoplasmic reticulum kinase(PERK)/eukaryotic translation initiation factor 2 subunit alpha(e IF2α)-activating transcription factor 4(ATF4)-C/EBP homologous protein(CHOP),increased neuronal apoptosis,and induced ***,inhibition of ER stress using inhibitors or by si RNA knockdown of the PERK gene significantly attenuated excessive autophagy and neuronal apoptosis,indicating an interaction between autophagy and ER stress and suggesting PERK as an essential target for regulating *** autophagy with chloroquine exacerbated ER stress-induced apoptosis,indicating that normal levels of autophagy play a protective role in neuronal injury following cerebral ischemia/reperfusion *** from this study indicate that cerebral ischemia/reperfusion injury can trigger neuronal ER stress and promote autophagy,and suggest that PERK is a possible target for inhibiting excessive autophagy in cerebral ischemia/reperfusion injury.

关键词： apoptosis ATF4 autophagy C/EBP homologous protein cerebral ischemia/reperfusion injury eIF2α endoplasmic reticulum stress PERK

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Video learning based image classification method for object recognition

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Journal of Central South University 2013年第9期20卷 2399-2406页

作者： lee hong-ro SHIN Yong-ju Department of NTIS Center Korea Institute of Science & Technology Information

Automatic image classification is the first step toward semantic understanding of an object in the computer vision *** key challenge of problem for accurate object recognition is the ability to extract the robust features from various viewpoint images and rapidly calculate similarity between features in the image database or video *** order to solve these problems,an effective and rapid image classification method was presented for the object recognition based on the video learning *** optical-flow and RANSAC algorithm were used to acquire scene images from each video *** the selection of scene images,the local maximum points on comer of object around local area were found using the Harris comer detection algorithm and the several attributes from local block around each feature point were calculated by using scale invariant feature transform （SIFT） for extracting local ***,the extracted local descriptor was learned to the three-dimensional pyramid match *** results show that our method can extract features in various multi-viewpoint images from query video and calculate a similarity between a query image and images in the database.

关键词： image classification multi-viewpoint image feature extraction video learning

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Landscape pattern and its effect on ecosystem functions in Seoul Metropolitan area:Urban ecology on distribution of the naturalized plant species

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Journal of Environmental Sciences 2003年第2期15卷 199-204页

作者： Sun-Kee hong In-ju Song Hyun-Ok Kim Eung-Kyong lee Environmental Planning Institute Seoul National UniversitySeoul Development InstituteTechnical University BerlinEnvironmental Planning Institute Seoul National University Seoul 151-742 Korea Seoul 100-250 KoreaGermanySeoul 151-742 Korea

During land transformation process in the human history, naturalized plants were introduced to several land use patterns by the different ways of plant itself. Including some naturalized plants that had been contribute to land restoration, many naturalized plants have been invaded to original habitat or landscape for native plants. Once the plants were colonized, they extend their area and population size. Urban developed areas often give an important role of source habitat for naturalized plants and expanding their population size. In recent, this situation is appearing as one of environmental problems about the urban landscape management controlling the naturalized plants that invaded in the developed area and conserving the native vegetation. This paper is focusing on relationships between distribution of habitat of naturalized plants and landscape patch in urban area in Seoul. Gangdong-Gu, one of the administrative areas in Seoul was selected for this study. We examined the recent land use change using LANDSAT TM data and spreading of the representative naturalized plants (Robinia pseudoacacia and Eupatorium rugosum) by Seoul Biotope Mapping Project and field survey in 1999. As a result, these two species were often occurred in the same habitat and distributed in forest edge disturbed by man. Their distribution patterns were related to landscape indices (patch size and shape) in the forest edge.

关键词： biotope mapping ecosystem management human impact landscape pattern naturalized plants urban ecology

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Berberine as an Environmental-Friendly Inhibitor for Hot-Dip Coated Steels in Diluted Hydrochloric Acid

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Journal of Materials Science & Technology 2012年第9期28卷 809-816页

作者： hong ju Yulin ju Yan Li College of Mechanic and Electronic Engineering China University of PetroleumQingdao 266555China

The inhibition effect of an excellent environmental-friendly corrosion inhibitor--berberine on hot-dip coated steels in the diluted HCI has been investigated by using quantum chemistry analysis, mass-loss tests, elec- trochemical measurements and scanning electron microscopy （SEM） observation. Calculation results show that berberine has a nearly planar structure with a number of active centers. The value of Mulliken charge, and the distribution of the highest occupied molecular orbital （HOMO） and the lower unoccupied molecular orbital （LUMO） imply that berberine has a good ability of electron exchange with metal surface. The test results indicate that inhibition efficiency （IE%） increases with the inhibitor concentration and the highest IE can reach 99%. Adsorption of berberine on the coating surface follows Langmuir adsorption isotherm with a single molecular layer by chemisorption.

关键词： Berberine Inhibition effects Hot-dip coated steel Corrosion

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Sex hormone-binding globulin impedes hepatocellular carcinoma growth via MERTK regulation

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Genes & Diseases 2022年第3期9卷 579-581页

作者： Sang R.lee Eui-ju hong College of Veterinary Medicine Chungnam National UniversityDaejeon 34134Republic of Korea

Sex hormone-binding globulin(SHBG),a crucial modulator of sex steroids in human blood,regulates androgen bioavailability and homeostasis.1 When androgen or AR signaling is known to be involved in the hepatocellular carcinoma(HCC)and SHBG plays an integral role in regulating the levels of bioavailable androgens,the concern whether SHBG might influence HCC onset or progression by modulating androgen action remains open.

关键词： globulin hepatocellular homeostasis

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Ultrasound-triggered three dimensional hyaluronic acid hydrogel promotes in vitro and in vivo reprogramming into induced pluripotent stem cells

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Bioactive Materials 2024年第8期38卷 331-345页

作者： Deogil Kim Min-ju lee Yoshie Arai Jinsung Ahn Gun Woo lee Soo-hong lee Department of Biomedical Engineering Dongguk University-Seoul04620SeoulSouth Korea

Cellular reprogramming technologies have been developed with different physicochemical factors to improve the reprogramming efficiencies of induced pluripotent stem cells(iPSCs).Ultrasound is a clinically applied noncontact biophysical factor known for regulating various cellular behaviors but remains uninvestigated for cellular ***,we present a new reprogramming strategy using low-intensity ultrasound(LIUS)to improve cellular reprogramming of iPSCs in vitro and in *** 3D microenvironment conditions,increased LIUS stimulation shows enhanced cellular reprogramming of the *** cellular reprogramming process facilitated by LIUS is accompanied by increased mesenchymal to epithelial transition and histone *** stimulation transiently modulates the cytoskeletal rearrangement,along with increased membrane fluidity and mobility to increase HA/CD44 ***,LIUS stimulation with HA hydrogel can be utilized in application of both human cells and in vivo environment,for enhanced reprogrammed cells into ***,LIUS stimulation with a combinatorial 3D microenvironment system can improve cellular reprogramming in vitro and in vivo environments,which can be applied in various biomedical fields.

关键词： Induced pluripotent stem cell Cellular reprogramming Low-intensity ultrasound Biophysical stimulation Cytoskeletal rearrangement

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Stability switches and bifurcation analysis in a coupled neural system with multiple delays

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Science China(Technological Sciences) 2016年第6期59卷 920-931页

作者： GE ju hong XU Jian Department of Mathematics and Information Science Henan University of Economics and Law School of Aerospace Engineering and Applied Mechanics Tongji University

A coupled neural system with multiple delays has been investigated. The number of equilibrium points is analyzed. It implies that the neural system exhibits a unique equilibrium and three ones for the different values of coupling weight by employing the pitchfork bifurcation of the trivial equilibrium point. Further, the local asymptotical stability of the trivial equilibrium point is studied by analyzing the corresponding characteristic equation. Some stability criteria involving multiple delays and coupling weight are obtained. The results show that the neural system exhibits the delay-independent and delay-dependent stability. Increasing delay induces stability switching between resting state and periodic motion in some parameter regions of coupling weight. In addition, the criterion for the global stability of the trivial equilibrium is also derived by constructing a suitable Lyapunov functional. Finally, some numerical simulations are taken to support the theoretical results.

关键词： multiple delays stability switches global stability

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