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MiR-125b Expression Affects the Proliferation and Apoptosis of Human Glioma Cells by Targeting Bmf

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MiR-125b Expression Affects the Proliferation and Apoptosis ...

“细胞活动生命活力”——中国细胞生物学学会全体会员代表大会暨第十二次学术大会

作者： hong-fei Xia,tian-Zhu He,Yi Cui,Xu Ma Reproductive and Genetic Center of National Research Institute for Family Planning,Beijing,100081

Background:MicroRNAs(miRNAs) are small noncoding RNAs whose function as modulators of gene expression is crucial for the proper control of cell *** many microRNAs were found to express in central nervous system(CNS),the role of the regulatory networks in which they are involved and their function in the pathological process of nerve cells are only just *** the present study,the possible mechanisms by which one neuronal miRNAs,miR-125b,affected the growth of nervous cells were investigated using in vitro cell line ***:The expression pattern of miR-125b in ATRA-treated human glioma cell lines was detected by Northern blotting and in situ *** effect of miR-125b on the proliferation and apoptosis of human glioma cells was analyzed by MTS assay,TUNEL and Flow cytometry *** addition,the identification of target gene of miR-125b was studied by dualluciferase activity assay and Immunoblot ***:We found differential expression of miR-125b in 1.0 uM all-trans-retinoic acid(ATRA)-treated human glioma cell ***-regulation of miR-125b partially restored cell viability and inhibited cell apoptosis in U343 cells treated by ***-regulation of miR-125b decreased human glioma cells proliferation and enhanced the sensitivity of human glioma cells to ATRA-induced *** addition,we found an inverse relationship between the expression of miR-125b and the cell apoptosis-related protein Bcl-2 modifying factor(Bmf),and miR-125b can interact with 3c-untranslated region(UTR) of ***:These findings indicate that overexpression of miR-l25b promotes human glioma cell proliferation and inhibits ATRA-induced cell apoptosis and low expression of miR-125b sensitizes cells to ATRAinduced *** may play an important role in the process of miR- 125b influencing cell apoptosis.

关键词： miR-125b Human glioma cells Proliferation Apoptosis Bmf

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前红松和红松的系统比较研究

东北师大学报（自然科学版） 2015年第1期47卷 119-123页

作者：由继红陆静梅费虹天东北师范大学生命科学学院吉林长春130024

从结构植物学、植物生物化学、分子生物学三个方面对红松和前红松进行了系统的比较研究.结果表明:前红松叶的角质层内表面的胞间凸缘为浅波浪状,缘厚;红松叶的角质层内表面的胞间凸缘为深波浪状,缘窄.过氧化物同工酶电泳结果可见,前红松... 详细信息

从结构植物学、植物生物化学、分子生物学三个方面对红松和前红松进行了系统的比较研究.结果表明:前红松叶的角质层内表面的胞间凸缘为浅波浪状,缘厚;红松叶的角质层内表面的胞间凸缘为深波浪状,缘窄.过氧化物同工酶电泳结果可见,前红松有8条酶带,红松有7条酶带;前红松的酯酶同工酶电泳有6条酶带,红松的酯酶同工酶电泳有5条酶带.前红松与红松叶绿体基因组中的rbcL基因片段458个核苷酸中有5个不同.

关键词：前红松红松角质层过氧化物同工酶酯酶同工酶叶绿体基因rbcL

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大腹园蛛对小鼠的急毒和亚急毒作用

东北师大学报（自然科学版） 2018年第2期50卷 124-127页

作者：韩旭费虹天姜明明董笑赢郑菲陶冶费瑞吉林大学白求恩医学部基础医学院吉林长春130021

按我国《食品安全性毒理学评价程序和方法》的要求,采用健康昆明小鼠,以灌胃染毒方法进行了大腹园蛛急性毒性、最大耐受剂量和亚急性毒性实验.结果表明:大腹园蛛粉对小鼠的半数致死量大于15g/kg.根据国际卫生组织的标准判定,该大腹园蛛... 详细信息

按我国《食品安全性毒理学评价程序和方法》的要求,采用健康昆明小鼠,以灌胃染毒方法进行了大腹园蛛急性毒性、最大耐受剂量和亚急性毒性实验.结果表明:大腹园蛛粉对小鼠的半数致死量大于15g/kg.根据国际卫生组织的标准判定,该大腹园蛛的毒性分级为无毒.亚急毒实验显示,大腹园蛛组与对照组相比,体重和脏器系数变化及血液和生化指标均无明显差异,表明大腹园蛛粉属于无毒物质,这为大腹园蛛的活性开发奠定了基础.

关键词：大腹园蛛急毒亚急毒

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小鼠肝纤维化模型复制方法的研究进展

中国现代医学杂志 2021年第12期31卷 46-50页

作者：王梓睿田飞鸿饶木艳姚继红李华王丽大连医科大学药学院辽宁大连116044

肝纤维化是肝损伤后修复反应的失衡,其发生机制尚未明确。复制与人类肝纤维化相似的动物模型是深入研究肝纤维化发病机制与药物治疗的重要基础。该文主要针对胆汁淤积、毒物诱导、代谢障碍、酒精损伤、免疫异常及血吸虫等致肝纤维化模... 详细信息

肝纤维化是肝损伤后修复反应的失衡,其发生机制尚未明确。复制与人类肝纤维化相似的动物模型是深入研究肝纤维化发病机制与药物治疗的重要基础。该文主要针对胆汁淤积、毒物诱导、代谢障碍、酒精损伤、免疫异常及血吸虫等致肝纤维化模型复制方法进行综述,以供肝纤维化研究者选择参考。

关键词：肝硬化模型,动物小鼠

“Slope-adsorption & plateau-pore filling” mechanism unlocking the potential of hard carbon anodes for “fast-charging & large-sized”batteries

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Science China Materials 2025年第1期 309-311页

作者： tian Liang Xiaoming Zhu Hubei Key Laboratory of Radiation Chemistry and Functional Materials School of Nuclear Technology and Chemistry & Biology Hubei University of Science and Technology

To date, there has been no report on fast-charging and Ahlevel sodium-ion batteries (SIBs) by utilizing thick hard carbon anodes that demonstrate prolonged cycling life and high areal capacity at high rates. Further, the relationship among the complex structure of hard carbon, storage mechanism, and fastcharging performance in alkali-metal ion batteries has been a subject of ongoing debate [1,2].

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La^(3+)掺杂对纳米ZnO晶粒度及光催化性能的影响

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武汉理工大学学报 2008年第7期30卷 5-9页

作者：吴建锋赵娜徐晓虹邓腾飞田越武汉理工大学材料科学与工程学院武汉430070

以二水合乙酸锌为原料,柠檬酸三铵为改性剂,采用溶胶-凝胶法分别制备了纯纳米ZnO粉体和La3+离子掺杂纳米ZnO粉体。XRD、TEM分析结果表明:所制得的纳米ZnO粒子均为六方晶系红锌矿结构,在热处理温度为550℃时,制得的纯纳米ZnO的晶粒尺寸... 详细信息

以二水合乙酸锌为原料,柠檬酸三铵为改性剂,采用溶胶-凝胶法分别制备了纯纳米ZnO粉体和La3+离子掺杂纳米ZnO粉体。XRD、TEM分析结果表明:所制得的纳米ZnO粒子均为六方晶系红锌矿结构,在热处理温度为550℃时,制得的纯纳米ZnO的晶粒尺寸最小为28.33 nm;La3+离子的掺入抑制了纳米ZnO晶粒的生长,当掺入量为0.2%时,晶粒大小减小了7 nm左右;La3+离子的掺入提高了纳米ZnO的光催化活性,比未掺杂纳米ZnO的光催化降解MB率提高了30%—40%。

关键词： La3+掺杂纳米ZnO 溶胶-凝胶法光催化

Learning Better Word Embedding by Asymmetric Low-Rank Projection of Knowledge Graph

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Journal of Computer Science & Technology 2016年第3期31卷 624-634页

作者： fei tian Bin Gao En-hong Chen Tie-Yah Liu School of Computer Science and Technology University of Science and Technology of China Hefei 230027 China Microsoft Research Asia Beijing 100080 China

Word embedding, which refers to low-dimensional dense vector representations of natural words, has demon- strated its power in many natural language processing tasks. However, it may suffer from the inaccurate and incomplete information contained in the free text corpus as training data. To tackle this challenge, there have been quite a few studies that leverage knowledge graphs as an additional information source to improve the quality of word embedding. Although these studies have achieved certain success, they have neglected some important facts about knowledge graphs： 1） many relationships in knowledge graphs are many-to-one, one-to-many or even many-to-many, rather than simply one-to-one; 2） most head entities and tail entities in knowledge graphs come from very different semantic spaces. To address these issues, in this paper, we propose a new algorithm named ProjectNet. ProjectNet models the relationships between head and tail entities after transforming them with different low-rank projection matrices. The low-rank projection can allow non one- to-one relationships between entities, while different projection matrices for head and tail entities allow them to originate in different semantic spaces. The experimental results demonstrate that ProjectNet yields more accurate word embedding than previous studies, and thus leads to clear improvements in various natural language processing tasks.

关键词： natural language processing word embedding neural network knowledge graph

Preparation of nitrogen-doped graphene by high-gravity technology and its application in oxygen reduction

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Particuology 2017年第5期15卷 110-117页

作者： Jie tian fei Gao Xiangqian Yu Wei Wu hong Meng Stare Key Laboratory of Organic-Inorganic Composites Beijing University of Chemical Technology Beijing 100029. China College of Chemical Engineering Beijing University of Chemical Technology Beijing 100029 China

Electrochemical oxygen reduction is key to many clean and sustainable energy technologies, including proton exchange membrane fuel cells and metal-air batteries. However, the high activation barriers in the oxygen reduction reaction often make it the bottleneck of energy conversion processes; thus, high- performance oxygen reduction electrocatalysts are desired. At present, the best commercially available oxygen reduction catalyst is based on the precious metal Pt. However, it suffers from resource scarcity and unsatisfactory operational stability, hindering its widespread and large-scale application in clean and sustainable technologies. Nitrogen-doped graphene has excellent electrocatalytic properties for oxygen reduction. In this paper, a scalable method to prepare nitrogen-doped graphene with high quality was introduced, in which the graphene oxide prepared by high-gravity technology and urea was reacted under hydrothermal conditions. Accompanying the hydrothermal reaction, graphene oxide reduction and nitrogen doping were accomplished at the same time. The effect of the content of nitrogen on the performance of nitrogen-doped graphene was investigated. When the mass ratio （graphene oxide]urea） was 1：400, the nitrogen-doped graphene had the best oxygen reduction performance, Compared with the undoped samples, the initial reduction voltage of the nitrogen-doped samples distinctly shifted 45 mV to the right. When the voltage was - 1,0 V, the electron transfer number was 4.1, indicating good oxygen reduction activity. The preparation method is feasible, simple, and can be easily scaled up.

关键词： High-gravity technologyC rapheneNitrogen-doped grapheneOxygen reduction reaction

Research status and prospects of the fractal analysis of metal material surfaces and interfaces

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International Journal of Minerals,Metallurgy and Materials 2025年第1期32卷 20-38页

作者： Qinjin Dai Xuefeng Liu Xin Ma Shaojie tian Qinghe Cui Beijing Advanced Innovation Center for Materials Genome Engineering University of Science and Technology BeijingBeijing 100083China Beijing Laboratory of Metallic Materials and Processing for Modern Transportation University of Science and Technology BeijingBeijing 100083China Laboratory for Advanced Materials Processing of Ministry of Education University of Science and Technology BeijingBeijing 100083China School of Mechanical and Electrical Engineering Xinjiang Institute of EngineeringUrumqi 830023China

As a mathematical analysis method,fractal analysis can be used to quantitatively describe irregular shapes with self-similar or self-affine *** analysis has been used to characterize the shapes of metal materials at various scales and *** methods make it difficult to quantitatively describe the relationship between the regular characteristics and properties of metal material surfaces and ***,fractal analysis can be used to quantitatively describe the shape characteristics of metal materials and to establish the quantitative relationships between the shape characteristics and various properties of metal *** the perspective of two-dimensional planes and three-dimensional curved surfaces,this paper reviews the current research status of the fractal analysis of metal precipitate interfaces,metal grain boundary interfaces,metal-deposited film surfaces,metal fracture surfaces,metal machined surfaces,and metal wear *** relationship between the fractal dimensions and properties of metal material surfaces and interfaces is *** from three perspectives of fractal analysis,namely,research scope,image acquisition methods,and calculation methods,this paper identifies the direction of research on fractal analysis of metal material surfaces and interfaces that need to be *** is believed that revealing the deep influence mechanism between the fractal dimensions and properties of metal material surfaces and interfaces will be the key research direction of the fractal analysis of metal materials in the future.

关键词： metal material surfaces and interfaces fractal analysis fractal dimension homogeneity