检索结果-南通市图书馆

同方期刊数据库

precision medicine in acute ly.phoblastic leukemia

在线全文

学校读者我要写书评

暂无评论

Frontiers of Medicine 2020年第6期14卷 689-700页

作者： Ching-hon pui Departments of Oncology and pathology St.Jude Children’s Research HospitalMemphisTN 38105USA

The cure rate of childhood acute ly.phoblastic leukemia(ALL)has exceeded 90%in some contemporary clinical ***,the dose intensity of conventional chemotherapy has been pushed to its *** improvement in outcome will need to rely more heavily on molecular therapeutic as well as immuno-and cellular-therapy approaches together with precise risk *** with ETV6-RUNX1 or hyperdiploid>50 ALL who achieve negative minimal residual disease during early remission induction are suitable candidates for reduction in *** with philadelphia chromosome(ph)-positive or ph-like ALL with ABL-class fusion should be treated with ***3 profiling and other preclinical methods have identified several high-risk subtypes,such as hypodiplod,early T-cell precursor,immature T-cell,KMT2A-rearranged,ph-positive and TCF-HLF-positive ALL,that may respond to BCL-2 inhibitor *** are other fusions or mutations that may serve as putative targets,but effective targeted therapy has yet to be *** other high-risk patients or poor early treatment responders who do not have targetable genetic lesions,current approaches that offer hope include blinatumomab,inotuzumab and CAR-T cell therapy for B-ALL,and daratumumab and nelarabine for *** the expanding therapeutic armamentarium,we should start focus on rational combinations of targeted therapy with non-overlapping toxicities.

关键词： acute ly.phoblastic leukemia molecular therapeutics targeted therapy tyrosine kinase inhibitors immunotherapy CAR T-cell therapy

The Value of Traditional Medicine Should not be Underestimated-Traditional Chinese Medicine in Treatment of Autoimmune Diseases

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Chinese Medicine and Culture 2024年第2期7卷 167-173页

作者： yurii O Novikov Anait p Akopyan Bashkir State Medical University Republic of BashkortostanRussia 450008

Autoimmune diseases of the nervous system(ADNS)are characterized by the formation of a pronounced neurologic deficit and often lead to *** attention of doctors and researchers is increasingly attracted by complementary medicine as adjuvant or preventive therapy for various diseases,including autoimmune *** Chinese medicine(TCM)is a combination of treatment methods that include acupuncture,herbal medicine,dietetics,physical exercises,and other methods that are often used in conjunction with recognized approaches of official medical *** article describes the application of TCM techniques in autoimmune diseases of the nervous system,and demonstrates clinical experience in the use of acupuncture,herbal medicine,diets and physical *** and complementary medicine is an important and often underestimated healthcare resource,especially in the prevention and treatment of autoimmune diseases of the nervous system.

关键词： Autoimmune diseases Traditional Chinese medicine Nervous diseases

Niche differentiation among facultative filter feeders: Insights from invasive ponto-Caspian mysids

在线全文

学校读者我要写书评

暂无评论

Current Zoology 2024年第4期70卷 513-521页

作者： péter Borza Varsha Rani Csaba F.Vada Institute of Aquatic Ecology Centre for Ecological ResearchKarolina ut 29.1113 BudapestHungary Doctoral School of Biology Institute of BiologyEotvos Lorand UniversityPazmany Péter sétany 1/C1117 BudapestHungary

The degree of dietary specialization has a fundamental impact on the ecological function and interactions of suspension *** niche differentiation by food particle size is common among obligate suspension feeders,its role is not evident in facultative *** this study,we aimed at providing new insights on the matter by focusing on sy.patric mysid *** mysids use different mechanisms for raptorial and filter-feeding,they represent a more adequate model system than for example,the more extensively studied *** made morpholog-ical measurements on the 4 coexisting invasive ponto-Caspian mysid species to determine the areas and mesh sizes of their *** also quantified their clearance rates on the microalga Cryptomonas *** a laboratory experiment to reveal how morphological differences manifest in their overall filtering *** found relatively small but consistent differences in the primary filter area among the species,indicating that morphological constraints due to the enclosed position of the setae might limit the possibility for *** primary filter mesh sizes were small in all 4 species(0.69-2.73μm)with moderate but consistent intraspecific differences,suggesting that the benefit of being able to capture small particles might outweigh the pressure for *** observed clearance rates were in accordance with the morphological characteristics of the species,highlighting that auxiliary filters(present in one of the species,Limnomysis benedeni)are needed to increase filtering capacity *** study confirmed that food particle size can contribute to the niche differentiation of facultative filter feeders,but also indicated that they can tolerate a higher overlap than obligate *** observed differences were related to the habitat preferences and predatory.potentials of the species,suggesting that complementarity among the different niche axes might further facilitate theircoexistence.

关键词： clearance rate coexistence filter area filtermesh size.

Bile acid signaling in the regulation of whole body metabolic and immunological homeostasis

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Science China(Life Sciences) 2024年第5期67卷 865-878页

作者： Wei Jia yitao Li Kenneth C.p.Cheung Xiaojiao Zheng School of Chinese Medicine Hong Kong Baptist UniversityHong KongChina Center for Translational Medicine and Shanghai Key Laboratory of Diabetes Mellitus Shanghai Sixth People's Hospital Affiliated to Shanghai JiaoTong University School of MedicineShanghai 200233China

Bile acids(BAs)play a crucial role in nutrient absorption and act as key regulators of lipid and glucose metabolism and immune *** the enterohepatic circulation,BAs are synthesized,metabolized,and reabsorbed,with a portion entering the vascular circulation and distributing *** allows BAs to interact with receptors in all major organs,leading to organ-organ interactions that regulate both local and global metabolic processes,as well as the immune *** review focuses on the whole-body effects of BA-mediated metabolic and immunological regulation,including in the brain,heart,liver,intestine,eyes,skin,adipose tissue,and *** BA synthesis and receptor signaling is a promising strategy for the development of novel therapies for various diseases throughout the body.

关键词： bile acid whole body metabolism immunity

Downstaging strategies for unresectable hepatocellular carcinoma

在线全文

学校读者我要写书评

暂无评论

World Journal of Gastroenterology 2024年第20期30卷 2731-2733页

作者： Georgia Sofia Karachaliou Nikolaos Dimitrokallis Dimitrios p Moris Division of Gastroenterology Department of MedicineDuke University Medical CenterDurhamNC 27710United States First Department of Surgery&Organ Transplant Unit Evangelismos General HospitalAthens 10676Greece Department of Surgery Duke University Medical CenterDurhamNC 27710United States

A significant number of patients with hepatocellular carcinoma(HCC)are usually diagnosed in advanced stages,that leads to inability to achieve *** options are focusing on downstaging a locally advanced *** is wellsupported in the literature that patients with HCC who undergo successful conversion therapy followed by curative-intent surgery may achieve a significant survival benefit compared to those who receive chemotherapy alone or those who are successfully downstaged with conversion therapy but not treated with *** artery infusion chemotherapy can be a potential downstaging strategy,since recent studies have demonstrated excellent outcomes in patients with colorectal liver metastatic disease as well as primary liver malignancies.

关键词： Unresectable hepatocellular carcinoma Hepatic arterial infusion chemotherapy Downstaging Hepatocellular carcinoma

MDCN:Modified Dense Convolution Network Based Disease Classification in Mango Leaves

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Computers, Materials & Continua 2024年第2期78卷 2511-2533页

作者： Chirag Chandrashekar K.p.Vijayakumar K.pradeep A.Balasundaram School of Computer Science and Engineering Vellore Institute of Technology(VIT)ChennaiIndia Center for Cyber physical Systems School of Computer Science and EngineeringVellore Institute of Technology(VIT)ChennaiIndia

The most widely farmed fruit in the world is *** the production and quality of the mangoes are hampered by many *** diseases need to be effectively controlled and ***,a quick and accurate diagnosis of the disorders is *** convolutional neural networks,renowned for their independence in feature extraction,have established their value in numerous detection and classification ***,it requires large training datasets and several parameters that need careful *** proposed Modified Dense Convolutional Network(MDCN)provides a successful classification scheme for plant diseases affecting mango *** model employs the strength of pre-trained networks and modifies them for the particular context of mango leaf diseases by incorporating transfer learning *** data loader also builds mini-batches for training the models to reduce training ***,optimization approaches help increase the overall model’s efficiency and lower computing *** employed on the MangoLeafBD Dataset consists of a total of 4,000 *** the experimental results,the proposed system is compared with existing techniques and it is clear that the proposed algorithm surpasses the existing algorithms by achieving high performance and overall throughput.

关键词： Leaf disease detection deep convolutional neural networks transfer learning optimization MangoLeafBD Dataset

Effect of dry-wet cycles on dynamic properties and microstructures of sandstone:Experiments and modelling

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

International Journal of Mining Science and Technology 2024年第5期34卷 655-679页

作者： Hai pu Qingyu yi Andrey.p.Jivkov Zhengfu Bian Weiqiang Chen Jiangyu Wu State Key Laboratory of Intelligent Construction and Healthy Operation and Maintenance of Deep Earth Engineering China University of Mining and TechnologyXuzhou 221116China Key Laboratory of Xinjiang Coal Resources Green Mining Ministry of EducationXinjiang Institute of EngineeringUrumqi 830023China Department of Solids and Structures School of EngineeringUniversity of ManchesterManchester M139PLUK School of Environment Science and Spatial Informatics China University of Mining and TechnologyXuzhou 221116China Department of Civil and Environmental Engineering Rice UniversityHouston 77005USA State Key Laboratory of High performance Civil Engineering Materials Jiangsu Research Institute of Building Science Co.Ltd.Nanjing 210008China Department of Materials University of OxfordOxford OX13PHUK

Underground pumped storage power plant(UpSp)is an innovative concept for space recycling of abandoned *** realization requires better understanding of the dynamic performance and durability of reservoir *** paper conducted ultrasonic detection,split Hopkinson pressure bar(SHpB)impact,mercury intrusion porosimetry(MIp),and backscatter electron observation(BSE)tests to investigate the dynamical behaviour and microstructure of sandstone with cyclical dry-wet damage.A coupling FEM-DEM model was constructed for reappearing mesoscopic structure *** results show that dry-wet cycles decrease the dynamic compressive strength(DCS)with a maximum reduction of 39.40%,the elastic limit strength is reduced from 41.75 to 25.62 *** sieved fragments obtain the highest crack growth rate during the 23rd dry-wet cycle with a predictable life of 25 cycles for each rock *** pore fractal features of the macropores and micro-meso pores show great differences between the early and late cycles,which verifies the computational statistics analysis of particle *** numerical results show that the failure patterns are governed by the strain in pre-peak stage and the shear cracks are *** dry-wet cycles reduce the energy transfer efficiency and lead to the discretization of force chain and crack fields.

关键词： Underground pumped storage power plant Dry-wet cycles Split Hopkinson pressure bar Macro and micro properties FEM-DEM coupling model Damage characterization

Investigation of Microstructure, Microhardness and Thermal properties of Ag-In Intermetallic Alloys prepared by Vacuum Arc Meltings

在线全文

学校读者我要写书评

暂无评论

Journal of Wuhan University of Technology(Materials Science) 2024年第1期39卷 182-187页

作者： ÇELİK Erçevik ATA ESENER pınar ÖZTÜRK Esra AKSÖZ Sezen Nevşehir HacıBektaşVeli University Department of Physics50300NevşehirTurkey Erciyes University Graduate School of Natural and Applied Sciences38039KayseriTurkey Kocaeli University Department of Physics41380KocaeliTurkey

Ag-In intermetallic alloys were produced by using vacuum arc furnace. Differential Scanning Calorimetry(DSC) and Energy Dispersive X-Ray Spectrometry(EDX) were used to determine the thermal properties and chemical composition of the phases respectively. Microhardness values of Ag-In intermetallics were calculated with Vickers hardness measurement method. According to the experimental results, Ag-34 wt%In intermetallic system generated the best results of energy saving and storage compared to other intermetallic systems. Also from the microhardness results, it was observed that intermetallic alloys were harder than pure silver and Ag-26 wt%In system had the highest microhardness value with 143.45 kg/mm^(2).

关键词： thermal properties microstructure characterization microhardness alloys material characterization

Laser-induced graphene-coated wearable smart textile electrodes for biopotentials signal monitoring

在线全文

学校读者我要写书评

暂无评论

Frontiers of Materials Science 2024年第1期18卷 95-111页

作者： C.M.Vidhya yogita Maithani Sakshi Kapoor J.p.Singh Department of physics Indian Institute of Technology DelhiHauz KhasNew Delhi 110016India

This paper describes how to produce a wearable dry electrode at a reasonable cost and how to use it for the monitoring of biopotentials in *** textiles in wearable technologies have made a great advancement in the health care management and living standards of *** was manufactured using the low-cost single-step process,laser ablation of polyimide,a commercial *** dispersions were made using solvent isopropyl alcohol which has low boiling point,nontoxicity,and environmental *** successive coating of the graphene dispersion on the cotton fabric to make it conductive,the sheet resistance of the resulting fabric dropped to 3% of its initial *** laser-induced graphene(LIG)cotton dry electrodes thus manufactured are comparable to Ag/AgCl wet electrodes in terms of the skin-to-electrode impedance,measuring between 78.0 and 7.2 kΩ for the frequency between 40 Hz and 1 *** LIG cotton electrode displayed a signal-to-noise ratio of 20.17 *** to its comfort,simplicity,and good performance over a longer period of time,the textile electrode appears suited for medical applications.

关键词： biopotential electrocardiogram electromyogram flexible electrode textile porous graphene