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Effects of primary glaucoma on sleep quality and daytime sleepiness of patients residing at an equatorial latitude

International Journal of Ophthalmology(English edition) 2020年第9期13卷 1451-1458页

作者： Jacob YH Chin Zhi hong Toh Ying Tai Lo Hannah TY Wang Elizabeth YW Poh Chun Hau Chua Owen Kim Hee Boon Ang Lim Vernon KY Yong Augustinus Laude hon tym wong Leonard WL Yip Department of Ophthalmology National Healthcare Group Eye InstituteTan Tock Seng Hospital308433Singapore Monash School of Medicine Monash UniversityVictoria 3800Australia

AIM:To investigate the impact of primary glaucoma on sleep quality and daytime sleepiness of ***:Prospective cross-sectional study with consecutive sampling in South-East Asian population was *** questionnaires:the Pittsburg Sleep Quality Index(PSQI)and Epworth Sleepiness Scale(ESS)were administered *** with nonglaucomatous optic neuropathy or concomitant retinal pathology were *** severity was based on HVF 24-2 *** single vision was represented based on the better *** of and predictive factors for poor sleep quality and excessive daytime sleepiness were ***:A total of 79 primary open angle glaucoma(POAG),27 primary angle-closure glaucoma(PACG)patients,and 89 controls were *** patients had higher median PSQI scores(P=0.004)and poorer sleep quality(P<0.001).Compared to controls,PACG patients were 3.34 times more likely to have poor sleep quality(P=0.008),which remained significant after adjustment for demographics(P=0.016)and predictive variables(P=0.013).PACG patients have poorer sleep quality when visual acuity(VA)was 6/15 or worse(P=0.009).Univariate and multivariate analysis of predictive variables for poor sleep quality and daytime sleepiness did not find statistical ***:PACG patients have poorer sleep quality but not daytime *** is important in South-East Asian population with heavy disease *** on sleep disturbances can be considered to provide more ho istic care.

关键词： sleep disturbances primary glaucoma intrinsically photosensitive retinal ganglion cells daytime sleepiness sleep quality South-East Asia

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Quantum Realities and Observer-Dependent Universes: An Advanced Observer Model

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Journal of Quantum Information Science 2024年第3期14卷 69-121页

作者： Joseph hon Cheung wong Department of Computing The Hong Kong Polytechnic University Hung Hom Kowloon Hong Kong China

This paper presents a novel observer model that integrates quantum mechanics, relativity, idealism, and the simulation hypothesis to explain the quantum nature of the universe. The model posits a central server transmitting multi-media frames to create observer-dependent realities. Key aspects include deriving frame rates, defining quantum reality, and establishing hierarchical observer structures. The model’s impact on quantum information theory and philosophical interpretations of reality are examined, with detailed discussions on information loss and recursive frame transmission in the appendices.

关键词： Quantum Mechanics Observer Model Frame Rates Quantum Reality Hierarchical Observers Information Theory Simulation Hypothesis Recursive Frame Transmission Information Loss

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急性原发性闭角型青光眼视盘水肿的OCT检查

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美国医学会眼科杂志（中文版） 2005年第4期17卷 229-230页

作者： Leonard W. Yip Vernon K. Y. Yong Sek-Tien Hoh hon-tym wong 陆遥（译）

急性原发性闭角型青光眼（APACG）属于眼科急诊，如果延误首诊诊断和治疗，则预后较差。由于角膜水肿，前房炎症，白内障和缩瞳药物的使用常导致后节体征难以检查。光学相干断层扫描（OCT）是一种非接触式无创性图象技术，可以获得眼后... 详细信息

急性原发性闭角型青光眼（APACG）属于眼科急诊，如果延误首诊诊断和治疗，则预后较差。由于角膜水肿，前房炎症，白内障和缩瞳药物的使用常导致后节体征难以检查。光学相干断层扫描（OCT）是一种非接触式无创性图象技术，可以获得眼后段组织结构高分辨率的断层图像。我们报告1例在APACG后发生视盘水肿和分支静脉阻塞的病例，进行了OCT和荧光素血管造影的检查。我们讨论了OCT图像上视盘的外观，在荧光素血管造影上还发现了静脉循环中的部分血栓。

关键词：急性原发性闭角型青光眼 CT检查视盘水肿荧光素血管造影光学相干断层扫描 OCT图像分支静脉阻塞眼科急诊首诊诊断角膜水肿

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Immunoregulatory and Anti-cancer Activities of Combination Treatment of Novel Four-Herb Formula and Doxorubicin in 4T1-Breast Cancer Bearing Mice

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Chinese Journal of Integrative Medicine 2024年第4期30卷 311-321页

作者： Lea Ling-Yu Kan Ben Chung-Lap Chan Grace Gar-Lee Yue LI Pei-ting Sharon Sze-Man hon HUANG Dan-qi Miranda Sin-Man Tsang Clara Bik-San Lau Ping-Chung Leung Chun-Kwok wong Institute of Chinese Medicine The Chinese University of Hong KongHong Kong SARChina State Key Laboratory of Research on Bioactivities and Clinical Applications of Medicinal Plants The Chinese University of Hong KongHong KongChina Department of Chemical Pathology The Chinese University of Hong KongHong Kong SARChina China-Australia International Research Centre for Chinese Medicine School of Health and Biomedical SciencesSTEM CollegeRMIT UniversityBundooraVictoriaAustralia Li Dak Sum Yip Yio Chin R&D Centre for Chinese Medicine The Chinese University of Hong Kong SARHong KongChina

Objective To investigate the in vivo immunomodulatory and anti-tumor mechanisms of the combined treatment of novel Four-Herb formula(4HF)and doxorubicin in triple-negative breast cancer(TNBC).Methods Murine-derived triple-negative mammary carcinoma cell line,4T1 cells,was cultured and inoculated into mouse mammary ***-six mice were randomly assigned into 6 groups(n=11 in ench):naive,control,LD 4HF(low dose 4HF),HD 4HF(high dose 4HF),LD 4HF+D(low dose and doxorubicin),and D(doxorubicin).Apart from the naive group,each mouse received subcutaneous inoculation with 5×10^(5)4T1 cells resuspended in 100µL of normal saline in the mammary fat *** from the day of tumor cell inoculation,tumors were grown for 6 *** LD and HD groups received daily oral gavage of 658 and 2,630 mg/kg 4HF,*** LD 4HF+D group received daily oral gavage of 658 mg/kg 4HF and weekly intraperitoneal injection of doxorubicin(5 mg/kg).The D group received weekly intraperitoneal injections of doxorubicin(5 mg/kg).The treatment naive mice received daily oral gavage of 0.2 mL double distilled water and 0.1 mL normal saline via intraperitoneal injection once a *** control group received daily oral gavage of 0.2 mL double-distilled *** treatment period was 30 *** the end of treatment,mice organs were harvested to analyze immunological activities via immunophenotyping,gene and multiplex analysis,histological staining,and gut microbiota *** Mice treated with the combination of 4HF and doxorubicin resulted in significantly reduced tumor and spleen burdens(P<0.05),altered the hypoxia and overall immune lymphocyte landscape,and manipulated gut microbiota to favor the anti-tumor immunological ***,immunosuppressive genes,cytokines,and chemokines such as C-C motif chemokine 2 and interleukin-10 of tumors were significantly downregulated(P<0.05).4HF-doxorubicin combination treatment demonstrated synergetic activities and was most effective

关键词： adjunctivetherapy breast cancer cytokines Chinese medicine tumor microenvironment

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Synergistic Effect of Graphdiyne-based Electrocatalysts

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Chemical Research in Chinese Universities 2021年第6期37卷 1242-1256页

作者： wong hon Ho SUN Mingzi HUANG Bolong Department of Applied Biology and Chemical Technology The Hong Kong Polytechnic UniversityHung HomKowloonHong Kong SARP.R.China

The synergistic effect can help improve the electrocatalyst performances by combining the advantages of individual *** particular,such an effect has been more important in the atomic *** this review,we have summarized the synergistic effect of N,X co-doping graphdiyne[X=B,S,F or transition metal(TM)]electrocatalysts and graphdiyne-based dual-atom catalyst(GDY-DAC).In general,the synergistic cooperation between two different dopants in co-doped GDY and adjacent active sites in GDY-DAC not only promotes their catalytic activity but also greatly enhances the thermodynamic stability of the *** the N,X co-doping GDY electrocatalysts,doping the heteroatoms like boron,sulphur,phosphorus,and fluorine with nitrogen can further tune the charge density distribution and electronic ***,the electron exchange between two doping atoms and GDY substrate has been discussed,where the TM-based GDY-DAC is a very promising catalyst for *** importantly,electronic interactions between different elements on GDY have been carefully *** the end,we have also supplied perspectives to the future developments of the GDY-based electrocatalysts.

关键词： Graphdiyne(GDY) Electrocatalyst Synergistic effect Dual-atom catalyst co-Doped GDY

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Effective Common Chinese Herbal Medicines Used in Treating Chronic Cholecystitis with Liver-Gallbladder Dampness-Heat Syndrome: A Review of Clinical Studies in the Past 10 Years

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World Journal of Traditional Chinese Medicine 2023年第1期9卷 8-20页

作者： Desmond Wei Kang Tee hon Foong wong Centrefor Complementary and Alternative Medicine International Medical UniversityKuala LumpurMalaysia

The objective of the study is to identify the effective common Chinese herbal medicines used in treating chronic cholecystitis with liver-gallbladder dampness-heat syndrome(CCLGDHS) through reviewing relevant clinical studies published in the past 10 years. Data were collected from Science Direct and Chinese National Knowledge Infrastructure. Data screening was carried out for the abstracts and full texts of the data. The top 15 Chinese herbal medicines with the highest occurring frequency were selected, statistically analyzed, and classified by their medicinal properties, actions, and indications according to the Chinese Pharmacopoeia 2015 edition. The top 15 effective common Chinese herbal medicines comprise Chai Hu, Huang Qin, Jin Qian Cao, Bai Shao, Yin Chen, Yu Jin, Chuan Lian Zi, Yan Hu Suo, Zhi Shi, Ban Xia, Bai Zhu, Pu Gong Ying, Gan Cao, Zhi Zi, and Qing Pi. The predominant natures were cold, cool, and warm. This combination can clear stagnant heat, warm Yang, and regulate Qi dynamics. In addition, bitter, pungent, and sweet were the predominant flavors. They can clear dampness-heat, regulate Qi dynamics to relieve cramps and pain, as well as tonify the deficiency. Along with entering the liver and gallbladder meridians, these herbal medicines also entered the spleen, stomach, and lung meridians to prevent potential disease transmission. The combinatorial medicinal actions of the effective common Chinese herbal medicine highlight the importance of the holistic concept of traditional Chinese medicine when treating CCLGDHS. In addition, the inclusion of activating blood to promote blood circulation, relieving cramps and alleviating pain, and tonifying the spleen and stomach represents a new finding in the treatment principle for CCLGDHS.

关键词： Chronic cholecystitis common Chinese herbal medicines liver-gallbladder dampness-heat syndrome traditional Chinese medicine treatment

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Rapid testing methods for food contaminants and toxicants

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Journal of Integrative Agriculture 2015年第11期14卷 2243-2264页

作者： Jiachi Chiou Arthur Ho hon Leung Hang Wai Lee Wing-tak wong Department of Applied Biology and Chemical Technology Food Safety and Technology Research CenterThe Hong Kong Polytechnic University Shenzhen Key Laboratory for Food Biological Safety Control Food Safety and Technology Research CentreThe Hong Kong Polytechnic University Shenzhen Research Institute

Food safety is one of the major concerns in every country regardless of the economic and social development. The frequent occurrence of food scandals in the world has led the Chinese government to implement several strategies to fortify the food supply system to a high food safety standard. This relies heavily on laboratory testing services but conventional methods for detection of food contaminants and toxicants are limited by sophisticated sample preparation procedures, long analysis time, large instruments and professional personnel to meet the increasing demands. In this review, we have incorporated most of the current and potential rapid detection methods for many notorious food contaminants and toxicants including microbial agents, toxic ions, pesticides, veterinary drugs and preservatives, as well as detection of genetically modified food genes and adulterated edible oil. Development of rapid, accurate, easy-to-use and affordable testing methods could urge food handlers and the public to actively screen for food contaminants and toxicants instead of passively relying on monitoring by the government examination facility. This review also provides several recommendations including how to encourage the public to engage in the food safety management system and provide optimal education and financial assistance that may improve the current Chinese food safety control system.

关键词： rapid testing food contaminants and toxins microbial agents pesticides veterinary drugs preservatives formaldehyde nitrite nitrate test strips

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Prevalence, correlates, attitude and treatment seeking of erectile dysfunction among type 2 diabetic Chinese men attending primary care outpatient clinics

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Asian Journal of Andrology 2014年第5期16卷 755-760,I0010页

作者： Wai hon Lo Sau Nga Fu Carlos King Ho wong Ee San Chen Department of Family Medicine and Primary Health Care Kowloon West Cluster Hospital Authority Hong Kong China Department of Family Medicine and Primary Care Li Ka Shing Faculty of Medicine University of Hong Kong Hong Kong China Department of Linguistics School of Humanities University of Hong Kong Hong Kong China

To investigate the prevalence, correlates, attitude and treatment seeking behavior of erectile dysfunction （ED） in type 2 diabetes mellitus （T2DM） patients in the primary care setting, a multi-center cross-sectional survey using a structured anonymous self-administered questionnaire was performed in 10 general outpatient clinics. Of the 603 subjects （91% response rate）, the prevalence of ED men, as defined by the International Index of Erectile Function, was 79.1%. Most subjects had mild ED （28.9%）, followed by mild-to-moderate ED （27.9%）, then moderate ED （13.4%） and severe ED （9%）. Nearly 55% of those with ED did not consider themselves as having ED. Less than 10% of them had ever sought medical treatment, although 76.1% of them wished to receive management from doctor（s） should they be diagnosed with ED. They considered the most important management from doctors to be clinical assessment （41.7%）, followed by management of potential underlying cause （37.8%）, referral to specialist （27.5%）, education （23.9%）, prescription of phosphodiesterase type 5 inhibitors （16.9%） and referral to ~：ounseling service （6.7%）. The prevalence of ED was strongly associated with subjects who thought they had ED （odds ratio （OR） = 90.49 （20.00-409.48, P 〈 0.001）） and were from the older age group （OR = 1.043 （1.011-1.076, P = 0.008））. In conclusion, ED is highly prevalent among T2DM men. The majority of them wanted management from doctors should they have ED, but only a minority would actually voice out the request. Screening of ED among T2DM men using structural questionnaire allowed the diagnosis of more than half of the ED cases, which otherwise would have gone undiagnosed.

关键词： diabetes mellitus erectile dysfunction prevalence risk factors

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Cupping,the Past and Present Application

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Chinese Medicine and Culture 2018年第3期1卷 121-126页

作者： Xun Lin hon Foong wong Shih Chau Ng International Education College Shanghai University of Traditional Chinese MedicineChina Department of Chinese Medicine Centre for Complementary and Alternative MedicineInternational Medical UniversityMalaysia

Cupping is a therapy in which a cup is applied to the skin surface to cause local congestion through negative *** has a long history in many places such as China,Greece,Egypt,and the Middle *** ancient Chinese used animal horns as their cupping instrument,whereas in modern days there are a wide variety of choices ranging from bamboo cup to glass *** is simple,inexpensive and yet has wide *** has shown that it can promote blood circulation,stimulate nerve and muscle *** terms of application methods,fire cupping,liquid cupping and vaccum cupping were *** five application techniques(flashing,retaining,moving,needle retention and bleeding)and precautions of cupping are also discussed in ***,pathological reactions observed during the cupping process can be used to support Chinese Medicine diagnosis.

关键词： Application cupping history

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Automatic Video Segmentation Based on Information Centroid and Optimized SaliencyCut

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Journal of Computer Science & Technology 2020年第3期35卷 564-575页

作者： Hui-Si Wu Meng-Shu Liu Lu-Lu Yin Ping Li Zhen-Kun Wen hon-Cheng wong College of Computer Science and Software Engineering Shenzhen UniversityShenzhen 518060China Department of Computing The Hong Kong Polytechnic UniversityHong Kong 999077China Faculty of Information Technology Macao University of Science and TechnologyMacao 999078China

We propose an automatic video segmentation method based on an optimized SaliencyCut equipped with information centroid(IC)detection according to level balance principle in physical *** the existing methods,the image information of another dimension is provided by the IC to enhance the video segmentation ***,our IC is implemented based on the information-level balance principle in the image,and denoted as the information pivot by aggregating all the image information to a *** effectively enhance the saliency value of the target object and suppress the background area,we also combine the color and the coordinate information of the image in calculating the local IC and the global IC in the *** saliency maps for all frames in the video are calculated based on the detected *** applying IC smoothing to enhance the optimized saliency detection,we can further correct the unsatisfied saliency maps,where sharp variations of colors or motions may exist in complex ***,we obtain the segmentation results based on IC-based saliency maps and optimized *** method is evaluated on the DAVIS dataset,consisting of different kinds of challenging *** with the state-of-the-art methods are also conducted to evaluate our *** visual results and statistical comparisons demonstrate its advantages and robustness for automatic video segmentation.

关键词： automatic video segmentation information centroid saliency detection optimized SaliencyCut

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