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Identification of Ca2+ signaling components in neural stem/progenitor cells during differentiation into neurons and glia in intact and dissociated zebrafish neurospheres

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Science China(Life Sciences) 2018年第11期61卷 1352-1368页

作者： Man Kit Tse Ting Shing hung Ching Man chan Tiffany Wong Mike Dorothea Catherine Leclerc Marc Moreau Andrew L.Miller Sarah E.Webb Division of Life Science & State Key Laboratory of Molecular Neuroscience HKUSTClear Water BayHongKongChina Centre de Biologie du Developpement(CBD) Centre de Biologie Integrative(CBI)Universite de ToulouseCNRSUPSToulouse F-31062France

The development of the CNS in vertebrate embryos involves the generation of different sub-types of neurons and glia in a complex but highly-ordered spatio-temporal manner. Zebrafish are commonly used for exploring the development, plasticity and regeneration of the CNS, and the recent development of reliable protocols for isolating and culturing neural stem/progenitor cells(NSCs/NPCs) from the brain of adult fish now enables the exploration of mechanisms underlying the induction/specification/differentiation of these cells. Here, we refined a protocol to generate proliferating and differentiating neurospheres from the entire brain of adult zebrafish. We demonstrated via RT-qPCR that some isoforms of ip3 r, ryr and stim are upregulated/downregulated significantly in differentiating neurospheres, and via immunolabelling that 1,4,5-inositol trisphosphate receptor(IP3 R) type-1 and ryanodine receptor(RyR) type-2 are differentially expressed in cells with neuron-or radial glial-like properties. Furthermore, ATP but not caffeine(IP3 R and RyR agonists, respectively), induced the generation of Ca^(2+) transients in cells exhibiting neuron-or glial-like morphology. These results indicate the differential expression of components of the Ca^(2+) -signaling toolkit in proliferating and differentiating cells. Thus, given the complexity of the intact vertebrate brain, neurospheres might be a useful system for exploring neurodegenerative disease diagnosis protocols and drug development using Ca^(2+) signaling as a read-out.

关键词： Ca^2+ signaling neurospheres zebrafish neural stem/progenitor cells differentiation IP3receptors ryanodine receptors STIM and Orai

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Mathematical Models of Logistics Decision in Slab Yard in an Iron and Steel Complex

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International Journal of Minerals,Metallurgy and Materials 2000年第4期14卷 301-304页

作者： Sujian Li Zhiming chan Mechanical Engineering School University of Science and Technology BeijingBeijing 100083China Hot Strip Mill Plant of Wuhan Iron&Steel(Group)Corp. Wuhan 430083China

The slab yard in a hot strip rolling mill is a key link and a buffer in the production system, which joins continuous rolling process and continuous casting process. There are a large quantity of operations of input and output in the slab yard. Throughout systematic analysis and research on the slab yard, the mathematical models of logistics decision for input, output and restorage operation are built. On the basis of these decision models, the management system for the slab yard is developed. Simulation application to Human Iron & Steel Complex of China shows that they are very effective.

关键词： logistics slab yard model

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Terminal ileum gangrene secondary to a type Ⅳ paraesophageal hernia

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World Journal of Gastroenterology 2016年第8期22卷 2642-2646页

作者： Ching Tsai Hsu Po Jen Hsiao Chih Chien Chiu Jenq Shyong chan Yee Fung Lin Yuan hung Lo Chia Jen Hsiao Department of Internal Medicine Taoyuan Armed Forces General Hospital Tri-Service General Hospital National Defense Medical Center Division of Nephrology Department of Internal Medicine Taoyuan Armed Forces General Hospital Division of General Surgery Department of Surgery Taoyuan Armed Forces General Hospital Division of Gastroenterology Department of Internal Medicine Taoyuan Armed Forces General Hospital

Type Ⅳ paraesophageal hernia(PEH) is very rare, and is characterized by the intrathoracic herniation of the abdominal viscera other than the stomach into the chest. We describe a 78-year-old woman who presented at our emergency department because of epigastric pain that she had experienced over the past 24 h. On the day after admission, her pain became severe and was accompanied by right chest pain and dyspnea. Chest radiography revealed an intrathoracic intestinal gas bubble occupying the right lower lung field. Emergency explorative laparotomy identified a type Ⅳ PEH with herniation of only the terminal ileum through a hiatal defect into the right thoracic cavity. In this report, we also present a review of similar cases in the literature published between 1980 and 2015 in Pub Med. There were four published cases of small bowel herniation into the thoracic cavity during this period. Our patient represents a rare case of an individual diagnosed with type Ⅳ PEH with incarceration of only the terminal ileum.

关键词： Gangrene Hiatal Ileum Paraesophageal hernia Thoracic cavity

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Evolution of microstructure and tensile properties of cold-drawn hyper-eutectoid steel wires during post-deformation annealing

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Journal of Materials Science & Technology 2020年第6期41卷 1-11页

作者： Majid Jafari chan-Woo Bang Jong-chan Han Kyeong-Min Kim Seon-Hyeong Na chan-Gyung Park Byeong-Joo Lee Department of Materials Science and Engineering POSTECH Pohang 37673 South Korea

Manufacturing temperatures of severely cold-drawn hyper-eutectoid steel wires are sufficiently high to influence the mobility of dislocations and alloy elements,thereby affecting the materials’mechanical ***,we describe the evolution of microstructure and tensile strength of the as-drawn 3.45 GPa steel wire during post-deformation annealing for 30 min at 150-450℃.Annealing at 150℃raised the strength to 3.77 GPa by age-hardening through activation of dislocations pinning by carbon,while further temperature rising up to 450℃caused a severe loss of *** was proved that annealing at 300 and 450℃destabilizes the lamellar microstructure,promoting the formation of carbon-deficient(Fe,Mn,Cr)3 C-type cementite particles with preferentially rounded and partially faceted *** at 450℃yielded the accumulation of Mn and Cr at the ferrite/particle interfaces,and their concentrations at the interfaces were dependent on the interface structure;i.e.,lower concentrations at rounded interfaces(formed through capillarity–driven coarsening of the spheroidized cementite),and higher concentrations at faceted interfaces(that are initially existing in the as-drawn state).Our proof-of-principle observations,supported by thermodynamic calculations and kinetic assessments,provide a pathway for understanding the changes in microstructural and tensile properties during manufacturing of the hyper-eutectoid steel wires.

关键词： Three-dimensional atom probe(3DAP) High resolution transmission electron microscopy(HRTEM) Nano-grained low-carbon steel Annealing Tensile behavior

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Anesthetic Management of Neck Trauma with Traumatized Airway: A Case Report and Review

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Open Journal of Anesthesiology 2024年第11期14卷 221-231页

作者： Pou Fong chan hung Ping Li Fai Leong Department of Anesthesiology Centro Hospitalar Conde de So Janurio Macao China

Neck trauma with a traumatized airway can be challenging for airway management, as the neck is a vital structure. Case Report: We are reporting on a 33-year-old male worker who suffered an industrial accident. A steel cord severely hit his neck. He was brought to our ER immediately. Upon arrival, he was conscious with stable vital signs. A physical examination revealed that his Adam’s apple was penetrated, and the adjacent soft tissue and structures were visible. A CT scan showed an anterior and left lateral neck penetrating injury with an open wound, exposure of the thyroid cartilage, a left thyroid cartilage fracture, and pneumoderma. He was urgently taken to the operating theater for airway stabilization and underwent six hours of exploration of the laryngopharyngeal cavity and closure of the laryngopharyngeal defect. He was then sent to the ICU. After two months in the hospital, he regularly follows up in the outpatient department. Conclusion: Effective decision-making for neck trauma with a compromised airway is crucial to ensure the patient’s safety.

关键词： Neck Trauma Traumatized Airway Neck Penetrating Injury Airway Management Surgical Airway

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Urocortin and cardiovascular protection

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Acta Pharmacologica Sinica 2004年第3期25卷 3-11页

作者： Chi-wai LAU,Yau-chi chan,Suk-ying TSANG,Franky Leung chan The Chinese University of Hong Kong Hong Kong China Department of Anatomy The Chinese University of Hong Kong Hong Kong China Department of Anatomy The Chinese University of Hong Kong Hong Kong China Department of Anatomy The Chinese University of Hong Kong Hong Kong China Department of Anatomy

Urocortin and other hypothalamus corticotropin-releasing factor (CRF) polypeptides play biologically diverse roles in the stress, cardiovascular and inflammatory responses by acting on central and peripheral CRF receptors. Urocortin shows a significantly high sequence homology to CRF, and the concurrent expression of type-2 CRF (CRF2) receptors with urocortin in the heart suggests that urocortin may play a physiological role in the cardiac function. Urocortin is thought to be the endogenous agonist producing the cardiovascular actions previously attributed to CRF. This review highlights the current novel findings on the molecular and cellular mechanisms by which urocortin may exert its cardiovascular protective action.

关键词： urocortin corticotropin-releasing hormone vascular smooth muscle heart vasodilaion second messenger system protein kinases

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Highly flexible,mechanically strengthened metallic glass-based composite electrode with enhanced capacitance and cyclic stability

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Rare Metals 2022年第11期41卷 3717-3728页

作者： Yi Xu Pak Man Yiu Yu-Kun Wang Xiao-Meng Qin Tamaki Shibayama Seiichi Watanabe Masato Ohnuma Da-Zhu Chen Hua Cheng chan-hung Shek Zhou-Guang Lu Chen Liu Guangdong Research Center for Interfacial Engineering of Functional Materials College of Materials Science and EngineeringShenzhen UniversityShenzhen518060China Department of Materials Science and Engineering City University of Hong KongHong Kong999077China College of Physics and Optoelectronic Engineering Shenzhen UniversityShenzhen518060China Division of Quantum Science and Engineering Faculty of EngineeringCentre for Advanced Research of Energy and MaterialsHokkaido UniversitySapporo0608628Japan Guangdong-Hong Kong-Macao Joint Laboratory for Photonic-Thermal-Electrical Energy Materials and Devices Department of Materials Science and EngineeringSouthern University of Science and TechnologyShenzhen518060China

The design of flexible composite electrodes has become the top priority in energy storage devices for the development of future wearable intelligent ***,searching for fully integrated,ultrathin flexible composite electrodes with satisfying electrochemical performance is still a major ***,we introduce a nanoporous gold metallic glass(MG) ribbon-based composite electrode with excellent electric conductivity,mechanical flexibility,and extra capacitance by integrating polypyrrole(PPy) into wrinkled nanoporous ribbon(NPG@MG).The freestanding,ultrathin,highly conductive and flexible" nature of the composite electrode prevents the conducting polymer from structural instability resulting from the volume swell and shrink during the charging/discharging circulation,and the packed PPy provides protection for the wrinkled topology on the surface of the MG *** capacitance of pure NPG@MG-PPy composite electrode reached 393 mF·cm^(-2).The ultra-thin all-solid-state flexible supercapacitor demonstrates an excellent capacitance of 172 mF·cM^(-2)(14.8 F·cm^(-3)),accompanied by a superior cycling capability after 8000 charge/discharge cycles attributed to mechanical *** areal energy density also reached 0.74 mWh·cm^(-3)(9μWh·cm^(-2)) at a power density of 1 μW·cm^(-2).This work provides valuable concepts on the design of PPy-based hybrid materials for flexible energy storage systems with greatly enhanced electrochemical performances.

关键词： Metal-matrix composites(MMCs) Thin films Porosity Nano-structures

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Differentially weighted operator splitting Monte Carlo method for simulating complex aerosol dynamic processes

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Particuology 2018年第1期16卷 114-126页

作者： Hongmei Liu Tat Leung chan Department of Mechanical Engineering The Hong Kong Polytechnic University Kowloon Hong Kong China

A differentially weighted operator splitting Monte Carlo （DWOSMC） method is developed to solve com- plex aerosol dynamic processes by coupling the differentially weighted Monte Carlo method and the operator splitting technique. This method is validated by analytical solutions and a sectional method in different aerosol dynamic processes. It is first validated in coagulation and condensation processes, and nucleation and coagulation processes, and then validated through simultaneous nucleation, coagulation, and condensation processes. The results show that the DWOSMC method is a computationally efficient and quantitatively accurate method for simulating complex aerosol dynamic processes.

关键词： Differentially weighted Monte Carlo Operator splitting Aerosol dynamics Particle size distribution

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Impact of small-for-size liver grafts on medium-term and long-term graft survival in living donor liver transplantation: A meta-analysis

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World Journal of Gastroenterology 2019年第36期25卷 5559-5568页

作者： Ka Wing Ma Kelly Hiu Ching Wong Albert Chi Yan chan Tan To Cheung Wing Chiu Dai James Yan Yue Fung Wong hoi She Chung Mau Lo Kenneth Siu Ho Chok Department of Surgery Queen Mary Hospital Hong Kong China Li Ka Shing Faculty of Medicine The University of Hong Kong Hong Kong China Department of Surgery The University of Hong Kong Hong Kong China Department of Medicine Queen Mary Hospital Hong Kong China

BACKGROUND Small-for-size grafts (SFSGs) in living donor liver transplantation (LDLT) could optimize donor postoperative outcomes and also expand the potential donor pool. Evidence on whether SFSGs would affect medium-term and long-term recipient graft survival is lacking. AIM To evaluate the impact of small-for-size liver grafts on medium-term and longterm graft survival in adult to adult LDLT. METHODS A systematic review and meta-analysis were performed by searching eligible studies published before January 24, 2019 on PubMed, EMBASE, and Web of Science databases. The primary outcomes were 3-year and 5-year graft survival. Incidence of small-for-size syndrome and short term mortality were also extracted. RESULTS This meta-analysis is reported according to the guidelines of the PRISMA 2009 Statement. Seven retrospective observational studies with a total of 1821 LDLT recipients were included in the meta-analysis. SFSG is associated with significantly poorer medium-term graft survival. The pooled odds ratio for 3-year graft survival was 1.58 [95% confidence interval 1.10-2.29, P = 0.014]. On the other hand, pooled results of the studies showed that SFSG had no significant discriminatory effect on 5-year graft survival with an odds ratio of 1.31 (95% confidence interval 0.87-1.97, P = 0.199). Furthermore, incidence of small-for-size syndrome detected in recipients of SFSG ranged from 0-11.4% in the included studies. CONCLUSION SFSG is associated with inferior medium-term but not long-term graft survival. Comparable long-term graft survival based on liver graft size shows that smaller grafts could be accepted for LDLT with appropriate flow modulatory measures. Close follow-up for graft function is warranted within 3 years after liver transplantation.

关键词： Living donor liver transplantation Small-for-size grafts Small-for-size syndrome Graft survival

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Progress in self-powered sensors—Moving toward artificial intelligent and neuromorphic system

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Nano Research 2023年第9期16卷 11801-11821页

作者： Feng Wen chan Wang Chengkuo Lee Department of Electrical and Computer Engineering National University of SingaporeSingapore 117583Singapore Center for Intelligent Sensors and MEMS(CISM) National University of SingaporeSingapore 117608Singapore National University of Singapore Suzhou Research Institute(NUSRI) Suzhou 215123China NUS Graduate School-Integrative Sciences and Engineering Programme(ISEP) National University of SingaporeSingapore 119077Singapore

Wearable and flexible electronics are shaping our life with their unique advantages of light weight,good compliance,and desirable *** marching into the era of Internet of Things(IoT),numerous sensor nodes are distributed throughout networks to capture,process,and transmit diverse sensory information,which gives rise to the demand on self-powered sensors to reduce the power ***,the rapid development of artificial intelligence(AI)and fifth-generation(5G)technologies provides an opportunity to enable smart-decision making and instantaneous data transmission in IoT *** to continuously increased sensor and dataset number,conventional computing based on von Neumann architecture cannot meet the needs of brain-like high-efficient sensing and computing applications *** electronics,drawing inspiration from the human brain,provide an alternative approach for efficient and low-power-consumption information ***,this review presents the general technology roadmap of self-powered sensors with detail discussion on their diversified applications in healthcare,human machine interactions,smart homes,*** leveraging AI and virtual reality/augmented reality(VR/AR)techniques,the development of single sensors to intelligent integrated systems is reviewed in terms of step-by-step system integration and algorithm *** order to realize efficient sensing and computing,brain-inspired neuromorphic electronics are next briefly ***,it concludes and highlights both challenges and opportunities from the aspects of materials,minimization,integration,multimodal information fusion,and artificial sensory system.

关键词： wearable and flexible electronics self-powered sensors virtual reality/augmented reality(VR/AR)and artificial intelligence(AI)-enhanced system neuromorphic electronics

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