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Gene editing particle system as a therapeutic approach for drug-resistant colorectal cancer

Nano Research 2020年第6期13卷 1576-1585页

作者： Jee-Yeon Ryu You Jung Choi Eun-Jeong Won Emmanuel Hui ho-shik kim Young-Seok Cho Tae-Jong Yoon Laboratory of Nanopharmacy College of PharmacyResearch Institute of Pharmaceutical Science and Technology(RIPST)Ajou UniversitySuwon16499Republic of Korea Division of Gastroenterology Department of Internal MedicineSeoul St.Mary’s HospitalCollege of MedicineThe Catholic University of KoreaSeoul06591Republic of Korea Moogene Medi Co. Ltd.Seongnam13488Republic of Korea

The epidermal growth factor receptor(EGFR)pathway plays an important role in the progression of colorectal cancer(CRC).Anti-EGFR drugs based on antibodies have been widely used for treating CRC through inducing the cell death ***,the majority of CRC patients will inevitably develop drug-resistance during anti-EGFR drug treatment,which is mainly caused by a point mutation in the KRAS *** developed a nanoliposomal(NL)particle containing the Cas9 protein and a single-guide RNA(sgRNA)complex(Cas9-RNP),for genomic editing of the KRAS *** NL particle is composed of bio-compatible lipid compounds that can effectively encapsulate *** modifying the NL particle to include the appropriate antibody,it can specifically recognize EGFR expressing CRC and effectively deliver the gene-editing *** conditions of NL treatment were optimized using a KRAS mutated CRC in vivo mouse *** with KRAS-mutated CRC showed drug resistance against cetuximab,a therapeutic antibody *** treating the mice with the KRAS gene-editing NL particles,the implanted tumors showed a dramatic decrease in *** results demonstrated that this genomic editing complex has great potential as a therapeutic carrier system for the treatment of drug-resistant cancer caused by a point mutation.

关键词： nanoliposome clustered regularly interspaced short palindromic repeat and associated Cas9 nuclease(CRISPR/Cas9) KRAS mutation drug-resistance colorectal cancer

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Data driven computational design of stable oxygen evolution catalysts by DFT and machine learning:Promising electrocatalysts

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Journal of Energy Chemistry 2024年第4期91卷 645-655页

作者： Hwanyeol Park Yunseok kim Seulwon Choi ho Jun kim Department of Display Materials Engineering Soonchunhyang UniversityAsanChung-nam 31538Republic of Korea Department of Electronic Materials Devicesand Equipment EngineeringSoonchunhyang Uni-versityAsanChungnam 31538Republic of Korea Department of Mechanical Engineering Hanyang University ERICA Campus55 Hanyangdaehak-roSangnok-guAnsanGyeonggi-do 15588Republic of Korea

The revolutionary development of machine learning(ML),data science,and analytics,coupled with its application in material science,stands as a significant milestone of the scientific community over the last *** active,stable,and cost-efficient catalysts is crucial for oxygen evolution reaction owing to the significance in a range of electrochemical energy co nversion *** this work,we have demonstrated an efficient approach of high-throughput screening to find stable transition metal oxides under acid condition for high-performance oxygen evolution reaction(OER)catalysts through density functional theory(DFT)calculation and a machine learning algorithm.A methodology utilizing both the Materials Project database and DFT calculations was introduced to assess the acid stability under specific reaction *** upon this,OER catalytic activity of acid-stable materials was examined,highlighting potential OER catalysts that meet the required *** identified IrO_(2),Fe(SbO_(3))_(2),Co(SbO_(3))_(2),Ni(SbO_(3))_(2),FeSbO_(4),Fe(SbO_(3))4,MoWO_(6),TiSnO_(4),CoSbO_(4),and Ti(WO_(4))_(2)as promising catalysts,several of which have already been experimentally discovered for their robust OER performance,while others are novel for experimental exploration,thereby broadening the chemical scope for efficient OER *** of the bond length of TM-O and the first ionization energy were used to unveil the OER activity *** the calculated results,guidance has been derived to effectively execute advanced high-throughput screenings for the discovery of catalysts with favorable ***,the intrinsic correlation between catalytic performance and various atomic and structural factors was elucidated using the ML *** these approaches,we not only streamline the choice of the promising electrocatalysts but also offer insights for the design of varied catalyst models and the discovery of superior c

关键词： Transition metal oxides Oxygen evolution reaction High-throughput screening First-principles calculation Machine learning

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Recent advances in targeted endoscopic imaging:Early detection of gastrointestinal neoplasms

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World Journal of Gastrointestinal Endoscopy 2012年第3期4卷 57-64页

作者： Yong-Soo Kwon Young-Seok Cho Tae-Jong Yoon ho-shik kim Myung-Gyu Choi Department of Applied Bioscience CHA University Department of Gastroenterology Uijeongbu St.Mary's HospitalCollege of MedicineThe Catholic University of Korea Department of Biochemistry College of MedicineThe Catholic University of Korea Department of Gastroenterology Seoul St.Mary's HospitalCollege of MedicineThe Catholic University of Korea

Molecular imaging has emerged as a new discipline in gastrointestinal *** technology encompasses modalities that can visualize disease-specific morphological or functional tissue changes based on the molecular signature of individual *** imaging has several advantages including minimal damage to tissues,repetitive visualization,and utility for conducting quantitative *** in basic science coupled with endoscopy have made early detection of gastrointestinal cancer *** imaging during gastrointestinal endoscopy requires thedevelopment of safe biomarkers and exogenous probes to detect molecular changes in cells with high specificity anda high signal-to-background ***,a high-resolution endoscope with an accurate wide-field viewing capability must be *** endoscopic imaging is expected to improve early diagnosis and individual therapy of gastrointestinal cancer.

关键词： Autofluorescence endoscopy Confocal endomicroscopy Endoscopy Molecular imaging Molecular probes,Near-infrared fluorescence imaging Targeted endoscopic imaging

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Structural insight into palladium-nickel clusters over mordenite zeolite for carbene-insertion reaction

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Frontiers of Chemical Science and Engineering 2024年第9期18卷 89-99页

作者： Guangchao Li Ping-Luen Baron ho Bryan Kit Yue Ng Tai-Sing Wu Pawel Rymarz shik Chi Edman Tsang Department of Applied Biology and Chemical Technology The Hong Kong Polytechnic UniversityHong Kong 999077China Department of Chemistry University of OxfordOxford OX13QRUK Synchrotron Radiation Research Center Hsinchu 30076China

The advancement of heterogeneous catalysts incorporating metal clusters in the nanometric size range has garnered significant attention due to their extraordinary catalytic activity and *** detailed characterization and understanding of the atomic structure of these metal clusters within catalysts is crucial for elucidating the underlying reaction *** the present study,a distinctive three-atom PdNi cluster,characterized by two Pd atoms at terminal positions and a central Ni atom,was synthesized over mordenite *** presence of atomic PdNi clusters within the eight-membered ring side pocket area was confirmed by multiple advanced analytical techniques,including magic-angle spinning nuclear magnetic resonance spectroscopy,synchrotron X-ray powder diffraction,extended X-ray absorption fine structure spectroscopy,and high-angle annular dark-field scanning transmission electron *** catalytic activity of the confined active species was examined by the carbene-mediated reactions of ethyl-2-diazoacetate to ethyl-2-methoxyacetate as a model *** to the Pd-mordenite and Ni-mordenite,the PdNi-mordenite catalyst incorporates a PdNi cluster,which demonstrates a superior performance,achieving 100%conversion and high selectivity under the same reaction *** study elucidates the potential of constructing bimetallic clusters in zeolites,providing valuable insights for developing new heterogeneous catalysts applicable to a wide range of catalytic processes.

关键词： zeolite metal cluster synchrotron X-ray diffraction carbene-mediated reaction

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Ag-GST/HfO_(x)-based unidirectional threshold switching selector with low leakage current and threshold voltage distribution for high-density cross-point arrays

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Rare Metals 2024年第1期43卷 280-288页

作者： Kyoung-Joung Yoo Dae-Yun Kang Nahyun kim ho-Jin Lee Ta-Hyeong kim Taeho kim Tae Geun kim School of Electrical Engineering Korea UniversitySeoul 02841Republic of Korea

The use of electrochemical-metallization-based volatile threshold switching selectors in cross-point arrays has been widely explored owing to their high on-off ratios and simple ***,these devices are unsuitable for cross-point architectures because of the difficulty in controlling the random filament formation that results in large fluctuations in the threshold voltage during *** this study,we investigated the unidirectional threshold transition characteristics associated with an Ag/GST/HfO_(x)/Pt-based bilayer selector and demonstrated the occurrence of a low leakage current(hold voltage(Δ0.11 V).The bilayer structure could control the filament formation in the intermediate state through the insertion of an HfO_(x) tunneling *** stacking a bilayer selector with NiO_(x)based resistive random-access memory,the leakage and programming currents of the device could be significantly *** the crossbar array configuration,we performed equivalent circuit analysis of a one-selector oneresistor(1S1R) devices and estimated the optimal array size to demonstrate the applicability of the proposed *** maximum acceptable crossbar array size of the 1S1R device with the Ag/GST/HfO_(x)/Pt/Ti/NiO_(x)/Pt structure was 5.29×10^(14)(N^(2),N=2.3×10^(7)).

关键词： Selector device Tunneling barrier Threshold switching Sputtering 1S1R Cross-point array

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Construction of a High‑Performance Composite Solid Electrolyte Through In‑Situ Polymerization within a Self‑Supported Porous Garnet Framework

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Nano-Micro Letters 2024年第5期16卷 56-70页

作者： An‑Giang Nguyen Min‑ho Lee Jaekook kim Chan‑Jin Park Department of Materials Science and Engineering Chonnam National University77 Yongbong‑roBuk‑guGwangju 61186South Korea

Composite solid electrolytes(CSEs)have emerged as promising candidates for safe and high-energy–density solid-state lithium metal batteries(SSLMBs).however,concurrently achieving exceptional ionic conductivity and interface compatibility between the electrolyte and electrode presents a significant challenge in the development of high-performance CSEs for *** overcome these challenges,we present a method involving the in-situ polymerization of a monomer within a self-supported porous Li_(6.4)La_(3)Zr_(1.4)Ta_(0.6)O_(12)(LLZT)to produce the *** synergy of the continuous conductive LLZT network,well-organized polymer,and their interface can enhance the ionic conductivity of the CSE at room ***,the in-situ polymerization process can also con-struct the integration and compatibility of the solid electrolyte–solid electrode *** synthesized CSE exhibited a high ionic conductivity of 1.117 mS cm^(-1),a significant lithium transference number of 0.627,and exhibited electrochemical stability up to 5.06 V ***/Li+at 30℃.Moreover,the Li|CSE|LiNi_(0.8)Co_(0.1)Mn_(0.1)O_(2) cell delivered a discharge capacity of 105.1 mAh g^(-1) after 400 cycles at 0.5 C and 30℃,corresponding to a capacity retention of 61%.This methodology could be extended to a variety of ceramic,polymer electrolytes,or battery systems,thereby offering a viable strategy to improve the electrochemical properties of CSEs for high-energy–density SSLMBs.

关键词： Scalable tape-casting method Self-supported porous Li_(6.4)La_(3)Zr_(1.4)Ta_(0.6)O_(12) Composite solid electrolyte LiF-and B-rich interphase layers

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Strengthening mechanisms analysis and tailoring of bimodal grain structures for enhanced strength in CoCrFeMnNi high-entropy alloys

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Rare Metals 2024年第8期43卷 3893-3903页

作者： Jaesoung Lee Seulgi kim Taehyun Kwon Young II kim Suyeon kim Sung ho Song Bin Lee Dongju Lee Department of Urban Energyand Environmental EngineeringChungbuk National UniversityCheongju 28644Republic of Korea Division of Advanced Materials Engineering Kongju National UniversityChungnam 330-717Republic of Korea Department of Advanced Materials Engineering for Information and Electronics Integrated-Education Institute for Frontier Science and Technology(BK21 Four)Kyung Hee UniversityYongin17104Republic of Korea

The CoCrFeMnNi high-entropy alloys(HEAs)with a(face-centered cubic) FCC structure has garnered considerable attention for its exceptional ductility and strain hardening ***,its yield strength is insufficient for structural *** this study,strengthening mechanisms in these HEAs were investigated to gain insight into the mechanical properties according to alloy powder ***,we present a novel approach to achieve both high strength and high ductility through the creation of a bimodal structure consisting of both coarse and fine grains via gas atomization and spark plasma sintering processes.A bimodally structured HEA prepared with a mass ratio of 2:8 between coarse particles(75-106 μm) and fine particles(≤25 μm)yielded optimal results,with a strength of 491.95 MPa and elongation of 19.64%.This strength value represents an~41% increase compared with the sample that displayed a fine single microstructure(347.08 MPa for yield strength).The strength enhancement was attributed to the prevention of plastic deformation initiation from the fine particles during *** innovative approach to the creation of HEAs with bimodal structures shows promise for various applications,such as structural components that require a combination of high strength and high ductility.

关键词： High-entropy alloys CrCoFeMoNi Bimodal Gas atomization Mechanical properties

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Programmable directional color dynamics using plasmonics

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Microsystems & Nanoengineering 2024年第1期10卷 325-334页

作者： Gyurin kim Doeun kim Soeun Ko Jang-Hwan Han Juhwan kim Joo Hwan Ko Young Min Song Hyeon-ho Jeong School of Electrical Engineering and Computer Science Gwangju Institute of Science and TechnologyGwangju 61005Republic of Korea Department of Semiconductor Engineering Gwangju Institute of Science and TechnologyGwangju 61005Republic of Korea Artificial Intelligence(AI)Graduate School Gwangju Institute of Science and TechnologyGwangju 61005Republic of Korea

Adaptive multicolor filters have emerged as key components for ensuring color accuracy and resolution in outdoor visual ***,the current state of this technology is still in its infancy and largely reliant on liquid crystal devices that require high voltage and bulky structural ***,we present a multicolor nanofilter consisting of multilayered‘active’plasmonic nanocomposites,wherein metallic nanoparticles are embedded within a conductive polymer *** nanocomposites are fabricated with a total thickness below 100 nm using a‘lithography-free’method at the wafer level,and they inherently exhibit three prominent optical modes,accompanying scattering phenomena that produce distinct dichroic reflection and transmission ***,a pivotal achievement is that all these colors are electrically manipulated with an applied external voltage of less than 1 V with 3.5 s of switching speed,encompassing the entire visible ***,this electrically programmable multicolor function enables the effective and dynamic modulation of the color temperature of white light across the warm-to-cool spectrum(3250 K-6250 K).This transformative capability is exceptionally valuable for enhancing the performance of outdoor optical devices that are independent of factors such as the sun’s elevation and prevailing weather conditions.

关键词： directional prevailing exceptional

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Comparison of macular changes according to the etiology of optic neuritis:a cross-sectional study

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International Journal of Ophthalmology(English edition) 2024年第4期17卷 686-692页

作者： Yeji Moon Sung-Min kim Jae ho Jung Department of Ophthalmology Asan Medical CenterUniversity of Ulsan College of MedicineSeoul 05505Republic of Korea Department of Neurology Seoul National University HospitalSeoul 03080Republic of Korea Department of Ophthalmology Seoul National University HospitalSeoul 03080Republic of Korea Department of Ophthalmology Seoul National University College of MedicineSeoul 03080Republic of Korea

AIM:To compare the macular structure including foveal thickness among patients with optic neuritis(ON)according to the etiology and to investigate the possible correlation between structural and visual outcomes METhoDS:In this retrospective cross-sectional study,the clinical data of patients with aquaporin-4 immunoglobulin G-related ON(AQP4 group,40 eyes),myelin oligodendrocyte glycoprotein IgG-related ON(MOG group,31 eyes),and multiple sclerosis-related ON(MS group,24 eyes)were *** retinal thickness of the foveal,parafoveal and perifoveal regions were *** acuity(VA),visual field index and mean deviation were measured as visual ***:The AQP4 group showed a significantly thinner fovea(226.4±13.4μm)relative to the MOG(236.8±14.0μm,P=0.015)and MS(238.9±14.3μm,P=0.007)*** thickness in the parafoveal area also was thinner in the AQP4 group,though the difference in perifoveal retinal thickness was not *** thickness was correlated with VA in the AQP4 group(coefficientρ=-0.418,P=0.014),but not in the MOG and MS groups(P=0.218 and P=0.138,respectively).There was no significant correlation between foveal thickness and visual field test in all three ***:The significant thinning in the fovea and parafoveal areas in the AQP4 group compared to the MOG and MS groups are ***,macular changes in AQP4-ON show a significant correlation with *** results provide the possibility that retinal structural damage could reflect functional damage in AQP4-ON,distinct from MOGON and MS-ON.

关键词： foveal thickness optic neuritis aquaporin-4 immunoglobulin myelin oligodendrocyte glycoprotein multiple sclerosis

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Dietary eubiotics of microbial muramidase and glycan improve intestinal villi,ileum microbiota composition and production trait of broiler

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Journal of Animal Science and Biotechnology 2024年第4期15卷 1723-1736页

作者： Sungbo Cho Shanmugam Suresh Kumar Santiago Ramirez Rolando Valientes In ho kim Department of Animal Resource and Science Dankook UniversityCheonanChungnam 31116Korea Smart Animal Bio Institute Dankook University CheonanKorea DSM Nutritional Products Asia Pacific Mapletree Business CitySingapore 117440Singapore

Background Optimal gut health is important to maximize growth performance and feed efficiency in broiler chickens.A total of 1,365 one-day-old male Ross 308 broiler chickens were randomly divided into 5 treatments groups with 21 replicates,13 birds per *** present research investigated effects of microbial muramidase or a precision glycan alone or in combination on growth performance,apparent total tract digestibility,total blood carotenoid content,intestinal villus length,meat quality and gut microbiota in broiler *** included:NC:negative control(basal diet group);PC:positive control(basal diet+0.02%probiotics);MR:basal diet+0.035%microbial muramidase;PG:basal diet+0.1%precision glycan;and MRPG:basal diet+0.025%MR+0.1%PG,*** MRPG group increased the body weight gain and feed intake(Phowed significantly increased in duodenum villus length at end the *** In this study,overall results showed that the synergetic effects of MR and PG showed enhancing growth performance,total serum carotenoid level and altering gut microbiota composition of *** current research indicates that co-supplementation of MR and PG in broiler diets enhances intestinal health,consequently leading to an increased broiler production.

关键词： Broiler Intestinal morphology Microbial muramidase Precision glycan Probiotics

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