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Melatonin for the treatment of irritable bowel syndrome

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World Journal of Gastroenterology 2014年第10期20卷 2492-2498页

作者： Kewin Tien ho Siah Reuben Kong Min wong Khek Yu ho Division of Gastroenterology and Hepatology University Medicine Cluster National University Hospital Singapore 119228Singapore Yong Loo Lin School of Medicine National University of Singapore Singapore 119228 Singapore

Irritable bowel syndrome(IBS)is a common disorder characterized by recurrent abdominal pain or discomfort,in combination with disturbed bowel habits in the absence of identifiable organic ***(Nacetyl-5-methoxytryptamine)is a hormone produced by the pineal gland and also large number by enterochromaffin cells of the digestive *** plays an important part in gastrointestinal physiology which includes regulation of gastrointestinal motility,local anti-inflammatory reaction as well as moderation of visceral *** is commonly given *** is categorized by the United States Food and Drug Administration as a dietary *** treatment has an extremely wide margin of safety though it may cause minor adverse effects,such as headache,rash and *** was touted as a potential effective candidate for IBS *** role of melatonin in IBS treatment include analgesic effects,regulator of gastrointestinal motility and sensation to sleep ***-controlled studies in melatonin suffered from heterogeneity in *** studies utilized 3 mg at bedtime as the standard dose of ***,all studies had consistently showed improvement in abdominal pain,some showed improvement in quality of life of IBS *** is a relatively safe drug that possesses potential in treating *** studies should focus on melatonin effect on gut mobility as well as its central nervous system effect to elucidate its role in IBS patients.

关键词： Melatonin Irritable bowel syndrome Pain Sleep Analgesia

The Role of Aerosol in Climate Change,the Environment,and Human Health

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Atmospheric and Oceanic Science Letters 2012年第2期5卷 156-161页

作者： Zhang Ren-Jian ho Kin-fai Shen Zhen-Xing Key Laboratory of Regional Climate-Environment for Temperate East Asia Institute of Atmospheric Physics Chinese Academy of Sciences Beijing 100029 China School of Public Health and Primary Care Chinese University of Hong Kong Hong Kong China Department of Environmental Science and Engineering Xi’an Jiaotong University Xi'an 710049 China

Aerosol is an important component of the atmosphere,and its source,composition,distribution,and effects are highly *** and scientists have given much attention to aerosol problems,and it has become a hot topic due to the important role it plays in climate change and the Earth's *** this paper,1) the importance of aerosol in climate change,the atmospheric environment,and human health is summarized;2) the recent serious problems of aerosol pollution and the shortage of current aerosol research in China are pointed out;and 3) the necessity to enhance aerosol research in China is emphasized.

关键词： aerosol climate change environment humanhealth

Overcoming Data Sparseness Problem in Statistical Corpus Based Sense Disambiguation

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Overcoming Data Sparseness Problem in Statistical Corpus Bas...

The occurrence of arthropods in processed rice products in Malaysia

The 10th EPMESC

作者： Francisco Oliveira fai wong Anna ho Faculty of Science and Technology University of Macau Macao China Faculty of Science and Technology University of Macau Macao China Faculty of Science and Technology University of Macau Macao China

The problem of data sparseness is considered as a common problem for Statistical Corpus based Word Sense Disambiguation (WSD) approaches [1]. Usually large amounts of data are required in the corpus t

关键词： Word Sense Disambiguation Data Sparseness problem Singular Value Decomposition

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Asian Pacific Journal of Tropical Medicine 2010年第7期3卷 552-554页

作者： Mariana A Heah SK wong AL ho TM Acarology Unit Infectious Diseases Research CentreInstitute for Medical Research.Jalan Pahang50588 Kuala LumpurMalaysia

Objective:To determine distribution of arthropods in processed rice products such as rice flour and rice cereal-based infant ***:Random samples of rice flour and rice cereal-based infant food purchased from commercial outlets were examined for the presence of arthropods using a modified Berlese Tullgren Funnel *** were mounted prior to identification and weevils were directly ***:For non-expired products, infestation was found in 6.7%of rice flour and none was found in rice cereal-based infant food *** arthropods found in the flour samples were Cheyletus spp.,Suidasia pontifica(S. pontifica),Tarsonemus spp.,Tyrophagus putrescentiae(***),Sitophilus granarius(S. granarius) and Sitophilus oryzae(***).Others which cannot be identified were Oribatid and Prostigmatid *** most common mites in rice flour were Tarsonemus spp.(69.1%),followed by ***(18.2%).For expired products,only one sample of rice cereal-based infant food was infested and the infestation was by mites of the family ***:This study demonstrates the presence of 4 allergenic species of ***,***,*** and *** in rice *** arthropods can contribute to the incidence of anaphylaxis upon consumption by atopic *** was no infestation of arthropods in rice cereal-based infant food surveyed except for an expired product in a moderate rusty tin container.

关键词： Arthropods Mites Processed rice products

超声波无线电能传输系统电气建模方法（英文）

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电工技术学报 2015年第19期30卷 85-89页

作者： Leung ho fai 戴欣呼爱国奥克兰大学电气与计算机工程系重庆大学自动化学院重庆400030

基于等效电路的方法,提出一种适用于超声波无线电能传输系统的电气建模方法。首先采用基本压电方程对压电换能器进行建模,接着推导出系统层面的等效电路模型,并获得系统输出特性。实验结果对所提出的模型进行了验证,实验证明利用一对28 ... 详细信息

基于等效电路的方法,提出一种适用于超声波无线电能传输系统的电气建模方法。首先采用基本压电方程对压电换能器进行建模,接着推导出系统层面的等效电路模型,并获得系统输出特性。实验结果对所提出的模型进行了验证,实验证明利用一对28 k Hz的压电换能器,该系统能通过5 mm厚的铝板向阻性负载传输2.6 W功率的电能。

关键词：超声波电能传输超声波声波能量传输无线电能传输

Synergetic analysis of springtime air pollution episodes over Gwangju,Korea

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Journal of Environmental Sciences 2017年第7期29卷 270-283页

作者： Sung-Kyun Shin Kwon-ho Lee Seung-Shik Park Man Sing wong Research Institute for Radiation-Satellite(RIRS) Gangneung-Wonju National University(GWNU)Gangneung 25457Republic of Korea Department of Atmospheric and Environmental Sciences(DAES) Gangneung-Wonju National University(GWNU)Gangneung 25457Republic of Korea Department of Environment and Energy Engineering Chonnam National UniversityGwangju 61186Republic of Korea Department of Land Surveying and Geo-Informatics The Hong Kong Polytech UniversityKowloonHong Kong

The characteristics of springtime aerosols,including their optical and microphysical properties,were analyzed for the months of March to May of 2009 in Gwangju（35.23°N,126.84°E）,Korea.A high Light Detection and Ranging（LIDAR）-derived aerosol depolarization ratio（δ） of 0.25 ± 0.04 was determined on dust particles during the observation ***？ngstr？m exponent values of the 440–870 nm wavelength pair（？_（440–870）） and single-scattering albedo at 675 nm（Ω_（675）） measured by a CIMEL sun/sky radiometer were 0.77 ± 0.19 and 0.95 ±0.01,*** elevated dust layers reached a maximum elevation of 4 km above sea ***/smoke particles that originated from highly populated/industrialized regions could be distinguished by their relatively smaller particle size（？_（440–870） ranged between1.33 and 1.36） and higher light-absorbing（Ω_（675） of 0.92 ± 0.01） *** aerosols are mostly distributed at altitudes 〈 1.2 *** root-mean-square deviation（RMSD） between the aerosol optical depth（AOD,τ） derived from LIDAR_（（τ_（LIDAR））） and from the CIMEL sun/sky radiometer_（（τ_（CIMEL））） varied with respect to the surface PM10 *** RMSD between τ_（LIDAR） and τ_（CIMEL） was as low as 13% under lower PM_（10） concentration levels（〈 100 μg/m^3）.In contrast,the RMSD between τ_（LIDAR） and τ_（CIMEL） increased three times（~31%） under high surface PM_（10） concentration levels（〉100 μg/m^3）.These results suggest that the accuracy of τ_（LIDAR） is influenced by specific atmospheric conditions,regardless of its uncertainty.

关键词： LIDAR Sun/sky radiometer MODIS Optical/microphysical properties Aerosol optical depth

Association of time to prostate-specific antigen nadir and logarithm of prostate-specific antigen velocity after progression in metastatic prostate cancer with prior primary androgen deprivation therapy

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Asian Journal of Andrology 2017年第1期19卷 98-102页

作者： Jeremy YC Teoh James HL Tsu Steffi KK Yuen Peter KF Chiu Samson YS Chan Ka-Wing wong Kwan-Lun ho Simon SM hou Chi-fai Ng Ming-Kwong Yiu Division of Urology Department of Surgery The Chinese University of Hong Kong Prince of Wales Hospital Shatin Hong Kong China Division of Urology Department of Surgery Queen Mary Hospital University of Hong Kong Hong Kong China.

We investigated the association of time to prostate-specific antigen nadir （TTPN） and logarithm of prostate-specific antigen velocity after progression Log（PSAVAP） in metastatic prostate cancer with prior primary androgen deprivation therapy （ADT）. All metastatic prostate cancer patients treated with primary ADT from 2000 to 2009 were reviewed. Patients who developed disease progression were included in the subsequent analyses. Patients were categorized into three groups according to their TTPN： TTPN of 〈3 months, 3-17 months, and 〉17 months. We compared the Log（PSAVAP） between the different TTPN groups using Mann-Whitney U-test and Kruskal-Wallis test. Further multiple linear regression analyses on Log（PSAVAP） were performed to adjust for other potential confounding factors. Among 419 patients who were treated with primary ADT, 306 patients developed disease progression with a median follow-up of 28 months, Longer TTPN was associated with lower Log（PSAVAP）（P = 0.008） within all subgroup analyses （TTPN of 〈3 vs 3-17 months, P = 0.020; TTPN of 3-17 vs 〉17 months, P = 0.009; and TTPN of 〈3 vs 〉17 months, P = 0.001）. Upon multiple linear regression analyses, baseline PSA （regression coefficient 0.001, P = 0.045）, PSA nadir （regression coefficient 0.002, P = 0.040）, and TTPN （regression coefficient -0.030, P = 0.001） were the three factors that were significantly associated with Log（PSAVAP）. In conclusion, a longer TTPN was associated with lower Log（PSAVAP） in metastatic prostate cancer patients following primary ADT. TTPN cut-offs at 3 months and 17 months appeared to have prognostic significance in predicting Log（PSAVAP）. TTPN may serve as a good prognostic indicator in deciding the treatment strategy in patients with disease progression.

关键词： androgen deprivation therapy prostate cancer prostate-specific antigen velocity after progression ti me to prostate-specific antigen nadir

Effect of Scutellariae Radix extract on experimental dextran-sulfate sodium-induced colitis in rats

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World Journal of Gastroenterology 2007年第42期13卷 5605-5611页

作者： ho-Lam Chung Grace Gar-Lee Yue Ka-fai To Ya-Lun Su Yu Huang Wing-Hung Ko Department of Physiology Faculty of MedicineThe Chinese University of Hong Kong Shatin Hong Kong China Institute of Chinese Medicine The ChineseUniversity of Hong Kong Shatin Hong Kong China Department of Anatomical and Cellular Pathology Faculty of Medicine The Chinese University of Hong KongShatin Hong Kong China Institute of Materia Medica Chinese Academy ofMedical Sciences and Peking Union Medical College Beijing100050 China Department of Physiology and LiKa Shing Institute of Health Sciences Faculty of Medicine TheChinese University of Hong Kong Shatin Hong Kong China

AIM： To investigate the effect of Scutellariae Radix extract （SRE） on ulcerative colitis （UC） in rats induced by dextran-sulfate sodium （DSS）. METhoDS： Colitis was induced in male Sprague-Dawley （SD） rats （170-180 g） by 4% dextran sulfate sodium （DSS, wt/v, MW 54000） in drinking water for 8 d. The treated rats received 4% DSS and SRE orally （100 mg/kg per day）. Control rats received either tap water or SRE only. Macroscopic assessment which included body weight changes, fecal occult blood and stool consistency were determined daily. At the appointed time, the rats were sacrificed and the entire colons were removed. The colon length and the myeloperoxidase （MPO） activity were measured. The severity of colitis was graded by morphological and histological assessments. The ion transport activity of the colonic mucosa was assessed by electrophysiological technique. RESULTS： Rats treated with oral administration of 4% DSS regularly developed clinical and macroscopic signs of colitis. Treatment with SRE relieved the symptoms, including the reduction in body weight, shortening 2nd ulceration of the colon. Administration of SRE also significantly reduced the histological damage induced by DSS. Moreover, the Isc responses of the colonic mucosa to forskolin, were suppressed after the induction of colitis. The stimulated ion transport activity of DSS-rats treated with SRE displayed significant improvement in the secretory responsiveness. CONCLUSION： SRE was effective in treating acute DSS- induced ulcerative colitis, as gauged by reduced clinical disease, improved macroscopic and histological damage scores, and enhanced recovery of normal colonic secretory function.

关键词： Ulcerative colitis Scutellariae Radix Inflammatory bowel disease Colonic ion transport Traditional Chinese medicine

Antiviral activity of traditional Chinese medicinal plants Dryopteris crassirhizoma and Morus alba against dengue virus

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Journal of Integrative Agriculture 2020年第4期19卷 1085-1096页

作者： Maqsood MARYAM Kian Keong TE fai Chu wong Tsun Thai CHAI Gary K K LOW Seng Chiew GAN Hui Yee CHEE Department of Medical Microbiology and Parasitology Faculty of Medicine and Health SciencesUniversiti Putra MalaysiaSerdang 43400Malaysia Faculty of Natural Sciences SBK Women's University QuettaBalochistan 87300Pakistan Department of Chinese Medicine Faculty of Medicine and Health SciencesUniversiti Tunku Abdul RahmanSungai Long CampusKajang 43000Malaysia Department of Chemical Science Faculty of ScienceUniversiti Tunku Abdul Rahman(Kampar Campus)Kampar 31900Malaysia Department of Population Medicine Faculty of Medicine and Health SciencesUniversiti Tunku Abdul Rahman(Sungai Long Campus)Kajang 43000Malaysia Department of Pre-Clinical Sciences Faculty of Medicine and Health SciencesUniversiti Tunku Abdul Rahman(Sungai Long Campus)Kajang 43000Malaysia

Dengue virus(DENV) has emerged as a major virus that is spread by mosquitoes. Recently, it has spread to more than a hundred nations but continues to lack specific treatable medication. Many traditional Chinese medicinal(TCM) plants are in practice for dengue fever in dengue endemic regions. These traditional medicines persevere with treatments, which modern medicines lack. The study aims to substantiate the anti-dengue potential of some traditional herbs and make them available for further studies to facilitate TCM users. Twelve TCM plants aqueous extracts were evaluated, which are described as cool herbs used for the diseases with high fever. Lead plants were established through detailed in vitro foci forming unit reduction analysis(FFURA) against all four serotypes and validated through quantitative real-time RT-PCR(q RT-PCR). Four plants potentially inhibited the virus in primary phenotypic in vitro evaluation. Two lead plants Dryopteris crassirhizoma(DC) and Morus alba(MA) were identified with half minimal inhibitory concentration(IC50) 130 and 221 μg m L^-1, respectively, while the selectivity indices(SI) were 4.21 and 4.62, respectively. Lead plants equally inhibited all four serotypes of DENV. Time-of-addition analysis suggested that, DC was active at later stages of viral replication, whereas MA was active during the early stages and even showed some prophylactic activity. Liquid chromatography-mass spectrometry(HPLC/MS) analysis revealed presence of flavonoids. DC and MA are identified as potential anti-dengue plants, active against varied stages of dengue virus replication cycle. These results may serve as the base knowledge for further investigation on their combined treatments or integrative treatment with western medicines, which may improve the overall anti-dengue activity in future.

关键词： dengue virus traditional Chinese medicines TCM complementary medicines plant extracts anti-dengue