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Green Energy & Environment 2022年第2期7卷 334-344页

作者： sung ho park Sang Joon Lee Department of Mechanical Engineering Pohang University of Science and Technology(POSTECH)Pohang790-784South Korea

With the rapid increase in the demand for lithium as an energy-critical element,the recovery of Li+ions from seawater is a worldwide challenging ***,we propose a new facile and fast selective recovery approach of Li+using an Al^(3+)-crosslinked poly(N-isopropylacrylamide)(PNIPAAm)/alginate(Alg)(PNP/Alg(Al)) *** in situ TEM images indicate that Alg-Al^(3+)coordination is reorganized via the rearrangement of PNIPAAm and Alg networks,as the temperature *** reorganization eventually leads to the formation of polycrystalline *** in situ FTIR results exhibit that PNP/Alg(Al) composite has peculiar phase transitions,which includes a retrogressive phase change from hydrophobic to *** synergetic effect of the strong repulsion force of Al^(3+) ions and the attractive force of negatively charged polymeric chains enables the efficient adsorption of Li+ions with a low affinity from Li-spiked seawater.7.3% of Li+ions are recovered from Li-spiked seawater although the concentration of Li-spiked seawater is very *** addition,Li+ions can be extracted from PNP/Alg(Al) composite with the use of a small thermal *** proposed thermoresponsive IPN gel provides a strong potential in practical applications for Li+recovery as an innovative energy-material strategy.

关键词： structure seawater lithium

Ischemic colitis secondary to inferior mesenteric arteriovenous fistula and portal vein stenosis in a liver transplant recipient

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World Journal of Gastroenterology 2008年第26期14卷 4249-4252页

作者： In Hee Kim Dae Ghon Kim Hyo sung Kwak Hee Chul Yu Baik Hwan Cho ho sung park Division of Gastroenterology and Hepatology Department of Internal Medicine the Research Institute for Medical Sciences Chonbuk National University Medical School and Hospital Jeonju Jeonbuk 561-712 South Korea Division of Gastroenterology and Hepatology Department of Internal Medicine the Research Institute for Medical SciencesChonbuk National University Medical School and Hospital JeonjuJeonbuk 561-712 South Korea Department of Radiology Chonbuk National University Medical School and Hospital Jeonju Jeonbuk 561-712 South Korea Department of Surgery Chonbuk National University Medical School and Hospital Jeonju Jeonbuk 561-712 South Korea Department of Pathology Chonbuk National University Medical School and Hospital Jeonju Jeonbuk 561-712 South Korea

Arteriovenous fistula （AVF） involving the inferior mesenteric vessels is rare, and the affected patients usually present with abdominal pain, mass, or features of established portal hypertension. Colonic ischemia is a less common and more serious manifestation of AVE We report a case of ischemic colitis secondary to inferior mesentedc AVF in a patient who underwent a previous liver transplantation, subsequently developed portal vein stenosis, and then presented with acute lower gastrointestinal bleeding. He underwent percutaneous transhepatic placement of a portal vein stent and left colectomy.

关键词： Ischemic colitis Inferior mesenteric Arteriovenous fistula Portal vein stenosis

Silent advanced large cell neuroendocrine carcinoma with synchronous adenocarcinoma of the colon:A case report

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World Journal of Gastrointestinal Oncology 2022年第11期14卷 2266-2272页

作者： Hyeon Seok Baek Sang Wook Kim Soo Teik Lee ho sung park Seung Young Seo Department of Internal Medicine Research Institute of Clinical Medicine of Jeonbuk National University-Biomedical Research Institute of Jeonbuk National University HospitalJeonju-si 56445Jeollabuk-doSouth Korea Department of Pathology Jeonbuk National University Medical SchoolJeonjusi 56445Jeollabuk-doSouth Korea

BACKGROUND Large cell neuroendocrine carcinoma(LCNEC)accounts for about 0.25%of colorectal cancer ***,synchronous LCNEC and adenocarcinoma coexistence in the colon is very *** are usually aggressive and have a poor ***,colorectal LCNEC patients complain of abdominal symptoms such as pain,diarrhea or hematochezia because it is often diagnosed as an advanced disease that accompanies metastatic *** SUMMARY We describe a case of relatively asymptomatic synchronous LCNEC and colon adenocarcinoma.A 62-year-old male patient visited our hospital due to anemia detected by a local health *** did not complain of melena,hematochezia or abdominal *** examination was unremarkable and his abdomen was soft,nontender and nondistended with no palpable *** tests revealed anemia with hemoglobin 5.1 g/*** revealed an ulcerofungating lesion in the ascending colon and about a 1.5 cm-sized large sessile polyp in the sigmoid *** biopsy of the ascending colon lesion revealed the ulcerofungating mass that was LCNEC and endoscopic mucosal resection at the sigmoid colon lesion showed a large polypoid lesion that was *** liver,lung,bone and lymph nodes metastasis was found on chest/abdominal computed tomography and positron emission *** patient was diagnosed with advanced colorectal LCNEC with liver,lung,bone and lymph node metastasis(stage IV)and synchronous colonic adenocarcinoma *** this case,no specific symptom except anemia was observed despite the multiple *** patient refused systemic chemotherapy and was discharged after *** We report a case of silent LCNEC of the colon despite the advanced state and synchronous adenocarcinoma.

关键词： Large cell neuroendocrine carcinoma Colon Synchronous Adenocarcinoma Case report

Neural Tract Degeneration Correlates with Functional Impairment in Patients with Anoxic Brain Injury:A Tract-based Spatial Statistics Study

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Neuroscience Bulletin 2020年第8期36卷 932-936页

作者： Ji-Yun park sung ho park Jeong-Hee Yang Han Do Lee Jiho Lee Ki-Hyun Byeon Seo Young park Dongseok Yang Department of Neurology University of Ulsan College of MedicineUlsan University HospitalUlsan 44033Korea Department of Neurosurgery Ulsan University HospitalUlsan 44033Korea Department of Plastic Surgery Biomedical Research InstituteSeoul National University HospitalSeoul 03080Korea Department of Physical Therapy College of UlsanUlsan 44022Korea Department of Occupational and Environmental Medicine University of Ulsan College of MedicineUlsan University HospitalUlsan 44033Korea Physical Medicine and Rehabilitation University of Ulsan College of MedicineUlsan University HospitalUlsan 44033Korea Department of Clinical Epidemiology and Biostatistics Asan Medical CenterSeoul 05505Korea

Dear Editor,Anoxic brain injury(ABI)is a devastating event caused by cardiac arrest,chemical exposure,or *** recent advances in medical diagnostic techniques and treatments,the survival rate after ABI is still very *** studies have reported that 52.6%-64.0%of people who received cardiopulmonary resuscitation after nontraumatic cardiac arrest die,and 9.0%-18.6%remain in a permanent vegetative state within 28 days of treatment[1,2].

关键词： Tract cardiac treatment

Enhanced prediction of anisotropic deformation behavior using machine learning with data augmentation

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Journal of Magnesium and Alloys 2024年第1期12卷 186-196页

作者： Sujeong Byun Jinyeong Yu Seho Cheon Seong ho Lee sung Hyuk park Taekyung Lee School of Mechanical Engineering Pusan National UniversityBusan 46241South Korea School of Materials Science and Engineering Kyungpook National UniversityDaegu 41566South Korea

Mg alloys possess an inherent plastic anisotropy owing to the selective activation of deformation mechanisms depending on the loading *** characteristic results in a diverse range of flow curves that vary with a deformation *** study proposes a novel approach for accurately predicting an anisotropic deformation behavior of wrought Mg alloys using machine learning(ML)with data *** developed model combines four key strategies from data science:learning the entire flow curves,generative adversarial networks(GAN),algorithm-driven hyperparameter tuning,and gated recurrent unit(GRU)*** proposed model,namely GAN-aided GRU,was extensively evaluated for various predictive scenarios,such as interpolation,extrapolation,and a limited dataset *** model exhibited significant predictability and improved generalizability for estimating the anisotropic compressive behavior of ZK60 Mg alloys under 11 annealing conditions and for three loading *** GAN-aided GRU results were superior to those of previous ML models and constitutive *** superior performance was attributed to hyperparameter optimization,GAN-based data augmentation,and the inherent predictivity of the GRU for *** a first attempt to employ ML techniques other than artificial neural networks,this study proposes a novel perspective on predicting the anisotropic deformation behaviors of wrought Mg alloys.

关键词： Plastic anisotropy Compression Annealing Machine learning Data augmentation

RANKL-responsive epigenetic mechanism reprograms macrophages into bone-resorbing osteoclasts

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Cellular & Molecular Immunology 2023年第1期20卷 94-109页

作者： Seyeon Bae Kibyeong Kim Keunsoo Kang Haemin Kim Minjoon Lee Brian Oh Kaichi Kaneko sungkook Ma Jae hoon Choi hojoong Kwak Eun Young Lee sung ho park Kyung-Hyun park-Min Arthritis and Tissue Degeneration Program David Z.Rosensweig Genomics Research CenterHospital for Special SurgeryNew YorkNY10021USA Department of Medicine Weill Cornell Medical CollegeNew YorkNY10065USA Department of Biological Science Ulsan National Institute of Science&Technology(UNIST)Ulsan44919Republic of Korea Department of Life Science College of Natural SciencesResearch Institute for Natural SciencesHanyang UniversitySeoulKorea Department of Microbiology Dankook UniversityCheonan3116Republic of Korea Department of Molecular Biology and Genetics Cornell UniversityIthacaUSA Division of Rheumatology Department of Internal MedicineSeoul National University College of MedicineSeoulKorea BCMB Allied Program Weill Cornell Graduate School of Medical SciencesNew YorkNY10021USA

Monocyte/macrophage lineage cells are highly plastic and can differentiate into various cells under different environmental stimuli. Bone-resorbing osteoclasts are derived from the monocyte/macrophage lineage in response to receptor activator of NF-κB ligand (RANKL). however, the epigenetic signature contributing to the fate commitment of monocyte/macrophage lineage differentiation into human osteoclasts is largely unknown. In this study, we identified RANKL-responsive human osteoclast-specific superenhancers (SEs) and SE-associated enhancer RNAs (SE-eRNAs) by integrating data obtained from ChIP-seq, ATAC-seq, nuclear RNA-seq and PRO-seq analyses. RANKL induced the formation of 200 SEs, which are large clusters of enhancers, while suppressing 148 SEs in macrophages. RANKL-responsive SEs were strongly correlated with genes in the osteoclastogenic program and were selectively increased in human osteoclasts but marginally presented in osteoblasts, CD4+ T cells, and CD34+ cells. In addition to the major transcription factors identified in osteoclasts, we found that BATF binding motifs were highly enriched in RANKL-responsive SEs. The depletion of BATF1/3 inhibited RANKL-induced osteoclast differentiation. Furthermore, we found increased chromatin accessibility in SE regions, where RNA polymerase II was significantly recruited to induce the extragenic transcription of SE-eRNAs, in human osteoclasts. Knocking down SE-eRNAs in the vicinity of the NFATc1 gene diminished the expression of NFATc1, a major regulator of osteoclasts, and osteoclast differentiation. Inhibiting BET proteins suppressed the formation of some RANKL-responsive SEs and NFATc1-associated SEs, and the expression of SE-eRNA:NFATc1. Moreover, SE-eRNA:NFATc1 was highly expressed in the synovial macrophages of rheumatoid arthritis patients exhibiting high-osteoclastogenic potential. Our genome-wide analysis revealed RANKL-inducible SEs and SE-eRNAs as osteoclast-specific signatures, which may contribute to t

关键词： Osteoclasts super-enhancers enhancer RNAs Rheumatoid arthritis

Interesting Dynamic Contrast-Enhanced Magnetic Resonance Imaging Findings of Metaplastic Breast Carcinoma with Skeletal Muscle Metastasis

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Chinese Medical Journal 2018年第7期131卷 881-882页

作者： Sin Ae Choi Eun Jung Choi ho sung park Department of Radiology Research Institute of Clinical Medicine of Chonbuk National University Biomedical Research Institute of Chonbuk National University Hospital Chonbuk National University Medical School Jeonju 561-712 Korea Department of Pathology Research Institute of Clinical Medicine of Chonbuk National University Biomedical Research Institute of Chonbuk National University Hospital Chonbuk National University Medical School Jeonju 561-712 Korea

To the Editor： A 76-year-old woman presented with palpable masses in her right breast and right forearm. Physical examination revealed a 5-cm-sized mass in the lower outer quadrant of the right breast and a hard, fixed mass, measuring 4 cm in the right forearm. Mammography revealed a round, obscured, hyperdense mass without microcalcifications.

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Angiomyofibroblastoma of the vulva: A case report with literature review

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Case Reports in Clinical Medicine 2013年第3期2卷 221-224页

作者： Jung ho park Mi Kyung Shin Maria Lee sung Taek park sung-ho park hong-Bae Kim Department of Obstetrics & Gynecology Hallym University Kangdong Sacred Heart Hospital Seoul Korea Department of Obstetrics & Gynecology Hallym University Kangnam Sacred Heart Hospital Seoul Korea Department of Pathology Hallym University Kangnam Sacred Heart Hospital Seoul Korea Hallym University Collage of Medicine Chuncheon Korea

Angiomyofibroblastoma (AMF) is a rare kind of soft tissue tumor that occurs predominantly in the vulva. Due to their location, clinicians often confuse AMF with Bartholin’s cyst or perineal hernia. Radiological evaluation is performed to rule out perineal hernia and invasive neoplasm. Like other benign mesenchymal tumors of vulva, AMF shows indolent behavior and rarely recurs after complete surgical excision.

关键词： Angiomyofibroblastoma Vulvar Neoplasm

Progress and challenges for replacing n-methyl-2-pyrrolidone/polyvinylidene fluoride slurry formulations in lithium-ion battery cathodes

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Progress in Natural Science:Materials International 2024年第1期34卷 194-206页

作者： sung Cik Mun Yeong hoon Jeon Jong ho Won Battery Materials Research Center LG Chem Department of Energy Engineering Dankook University

With electric vehicles, energy storage systems, and portable electronic devices becoming increasingly popular, the demand for lithium-ion batteries has surged considerably. In the lithium-ion battery industry, n-methyl-2-pyrrolidone(NMP) is widely used as the solvent for cathode slurry, and polyvinylidene fluoride(PVDF) is used as the cathode binder. however, because of the harmful effect of NMP on the environment and human health, the use of NMP and PVDF for lithium-ion batteries will be highly regulated in the future. Therefore, developing eco-friendly alternatives is crucial for formulating systems using new solvents and binders. Despite numerous efforts, these alternatives have not been widely adopted across the lithium-ion battery industry. It is due to their limited ability to compete on price or performance to replace the traditional NMP/PVDF slurry formulations. This review investigates developments in the search for new solvents and binders that can be used in cathode slurry compositions. The new systems can potentially decrease energy consumption and manufacturing costs associated with NMP recovery, energy-intensive drying processes, and material expenses. We discuss key factors and technical challenges from earlier studies and compare them with the current, optimized formulations based on NMP and PVDF.

关键词： Lithium-ion battery Eco-friendly alternative Slurry formulation Chemical regulation Binder performance

Co-operative roles of IL-4Rαand IL-13Rα1 in the progression of ovarian carcinomas and the survival of ovarian carcinoma patients

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Cancer Communications 2023年第7期43卷 850-854页

作者： Won Ku Choi Usama Khamis Hussein Asmaa Gamal Ahmed Junyue Zhang Kyoung Min Kim Ae Ri Ahn ho sung park See-Hyoung park Dong Hyu Cho Kyu Yun Jang Department of Obstetrics and Gynecology Jeonbuk National University Medical SchoolJeonjuRepublic of Korea Department of Pathology Jeonbuk National University Medical SchoolJeonjuRepublic of Korea Faculty of Science Beni-Suef UniversityBeni-SuefEgypt School of Biomedical Informatics The University of Texas Health Science Center at HoustonHoustonTexasUSA Faculty of Postgraduate Studies and Advanced Sciences Beni-Suef UniversityBeni-SuefEgypt Department of Orthopedic Surgery Jeonbuk National University Medical SchoolJeonjuRepublic of Korea Department of Bio and Chemical Engineering Hongik UniversitySejongRepublic of Korea Research Institute of Clinical Medicine of Jeonbuk National University JeonjuRepublic of Korea Biomedical Research Institute of Jeonbuk National University hospital JeonjuRepublic of Korea

Dear Editor,Recently,there has been a rise in interest in the roles of cytokines and cytokine receptors in malignant human *** receptors,especially typeⅡinterleukin-4 receptor(IL-4R),have recently been examined as novel therapeutic targets of human cancers[1-3].The typeⅡIL-4R complex is composed of IL-4Rαand interleukin-13 receptorα1(IL-13Rα1),and the expression of IL-4Rαand IL-13Rα1 was higher in cancer tissues compared with normal counterpart tissues[3,4].

关键词： operative patients cytokines