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SARS-coV-2 variants are associated with different clinical courses in children with MIS-c

World Journal of Pediatrics 2024年第2期20卷 143-152页

作者： Andres F.Moreno Rojas Emelia Bainto Helen Harvey Adriana H.Tremoulet Jane c.Burns Kirsten B.Dummer Department of Pediatrics Division of Pediatric CardiologyUniversity of California San Diegoand Rady Children’s Hospital3020 Children’s Way MC 5004San DiegoCA 92123USA Kawasaki Disease Research center La JollaCAUSA Department of Pediatrics Division of Pediatric Critical CareUniversity of California San Diegoand Rady Children’s HospitalSan DiegoCAUSA Department of Pediatrics University of California San Diegoand Rady Children’s HospitalSan DiegoCAUSA

Background Recent infection with SARS‑coV-2 in children has been associated with multisystem inflammatory syndrome in children(MIS-c).SARS‑coV-2 has undergone different *** publications exist about specific variants and their correlation with the severity of *** This was a single-center,retrospective study including all patients admitted with MIS-c at Rady children’s hospital-San Diego between May 2020 and March *** epidemiologic data,including viral genomic information,were obtained from public ***,clinical presentation,laboratory values,and outcomes were obtained from electronic medical *** The analysis included 104 pediatric *** MIS-c waves were *** variants in San Diego during the first wave included clades 20A to *** the second wave,there were variants from clades 20A to c,20G,21c(Epsilon),20I(Alpha),and 20J(Gamma).The third wave had Delta strains(clades 21A,21I,and 21J),and the fourth had Omicron variants(clades 21K,21L,and 22c).MIS-c presented with similar symptoms and laboratory findings across all *** patients were admitted to the pediatric intensive care unit(PIcU)(74%)and required inotropic support(63%)during the second *** of the patients required mec.anical circulatory support,and only two required invasive ventilatory *** was no *** The various strains of SARS-coV-2 triggered MIS-c with differing severities,with the second wave having a more severe clinical *** the differences in disease severity across variants were due to c.anges in the virus or other factors remains unknown.

关键词： complications cOVID-19 MIS-c SARS-coV-2 variants

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A signaling cascade mediating fruit trait development via phosphorylation-modulated nuclear accumulation of JAZ repressor

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Journal of Integrative Plant Biology 2024年第6期66卷 1106-1125页

作者： Wei Wang Jinyao Ouyang Yating Li c.angsheng Zhai Bing He Huahan Si Kunsong chen Jocelyn K.c.Rose Wensuo Jia college of horticulture China Agricultural UniversityBeijing 100193China college of Agriculture and Biotechnology Zhejiang UniversityZijingang CampusHangzhou 310058China Plant Biology Section School of Integrative Plant ScienceCornell UniversityIthaca14853NYUSA Institute of horticulture crops Xinjiang Academy of Agricultural SciencesUrumqi 830000China

It is generally accepted that jasmonate-ZIM domain(JAZ)repressors act to mediate jasmonate(JA)signaling via cORONATINE-INSENSITIVE1(cOI1)-mediated ***,we report a cryptic signaling cascade where a JAZ repressor,FvJAZ12,mediates multiple signaling inputs via phosphorylation-modulated subcellular translocation rather than the cOI1-mediated degradation mec.anism in strawberry(Fragaria vesca).FvJAZ12 acts to regulate flavor metabolism and defense response,and was found to be the target of Fv MPK6,a mitogen-activated protein kinase that is capable of responding to multiple signal ***6 phosphorylates FvJAZ12 at the amino acid residues S179 and T183 adjacent to the PY residues,thereby attenuating its nuclear accumulation and relieving its repression for FvMYc2,which acts to control the expression of lipoxygenase 3(FvLOX3),an important gene involved in JA biosynthesis and a diverse array of cellular *** data reveal a previously unreported mec.anism for JA signaling and decipher a signaling cascade that links multiple signaling inputs with fruit trait development.

关键词： defense response JAZ repressor phosphorylation strawberry subcellular translocation

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Meticulously engineered three-dimensional-printed scaffold with microarchitecture and controlled peptide release for enhanced bone regeneration

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Biomaterials Translational 2024年第1期5卷 69-83页

作者： Yang J. Fatima K. Zhou X. He c. Shanghai Engineering Research center of Nano-Biomaterials and Regenerative Medicine College of Biological Science and Medical Engineering Donghua University Shanghai China

The repair of large load-bearing bone defects requires superior mec.anical strength, a feat that a single hydrogel scaffold cannot achieve. The objective is to seamlessly integrate optimal microarchitecture, mec.anical robustness, vascularisation, and osteoinductive biological responses to effectively address these critical load-bearing bone defects. To confront this challenge, three-dimensional (3D) printing technology was employed to prepare a polycaprolactone (PcL)-based integrated scaffold. Within the voids of 3D printed PcL scaffold, a methacrylate gelatin (GelMA)/methacrylated silk fibroin (SFMA) composite hydrogel incorporated with parathyroid hormone (PTH) peptide-loaded mesoporous silica nanoparticles (PTH@MSNs) was embedded, evolving into a porous PTH@MSNs/GelMA/SFMA/PcL (PM@GS/PcL) scaffold. The feasibility of fabricating this functional scaffold with a customised hierarchical structure was confirmed through meticulous chemical and physical characterisation. compression testing unveiled an impressive modulus of 17.81 ± 0.83 MPa for the composite scaffold. Additionally, in vitro angiogenesis potential of PM@GS/ PcL scaffold was evaluated through Transwell and tube formation assays using human umbilical vein endothelium, revealing the superior cell migration and tube network formation. The alizarin red and alkaline phosphatase staining assays using bone marrow-derived mesenchymal stem cells clearly illustrated robust osteogenic differentiation properties within this scaffold. Furthermore, the bone repair potential of the scaffold was investigated on a rat femoral defect model using micro-computed tomography and histological examination, demonstrating enhanced osteogenic.and angiogenic performance. This study presents a promising strategy for fabricating a microenvironment-matched composite scaffold for bone tissue engineering, providing a potential solution for effective bone defect repair. © 2024, chinese Medical Multimedia Press co Ltd. All rights reserve

关键词： angiogenesis bone regeneration methacrylated gelatin methacrylated silk fibroin osteogenesis PTH

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Generalized autoencoder-based fault detection method for traction systems with performance degradation

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High-speed Railway 2024年第3期2卷 180-186页

作者： cheng c. Liu W. Di L. Wang S. c.angchun University of Technology Changchun 130012 China Jilin Institute of Electronics Information Products Inspection Changchun 130012 China

Fault diagnosis of traction systems is important for the safety operation of high-speed trains. Long-term operation of the trains will degrade the performance of systems, which decreases the fault detection accuracy. To solve this problem, this paper proposes a fault detection method developed by a Generalized Autoencoder (GAE) for systems with performance degradation. The advantage of this method is that it can accurately detect faults when the traction system of high-speed trains is affected by performance degradation. Regardless of the probability distribution, it can handle any data, and the GAE has extremely high sensitivity in anomaly detection. Finally, the effectiveness of this method is verified through the Traction Drive control System (TDcS) platform. At different performance degradation levels, our method's experimental results are superior to traditional methods. © 2024 Beijing Jiaotong University

关键词： Fault detection Generalized autoencoder High-speed trains Performance degradation Traction control systems

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Gouty destruction of a patellar tendon reconstruction and novel revision reconstruction technique: A case report

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World Journal of Orthopedics 2024年第7期15卷 675-682页

作者： carl c Edge Jonathan Widmeyer Omar Protzuk Maya Johnson Robert O’connell Department of Orthopaedic Surgery Division of Sports MedicineVirginia Commonwealth University Health SystemRichmondVA 23298-0153United States Division of Sports Medicine OrthowestCarroltonGA 30117United States

BAcKGROUND Gout is a disease characterized by hyperuricemia,and resultant deposition of uric acid crystals in *** typically manifested as intraarticular crystals or tophi,gout can also cause pathology at *** deposition within tendinous structures put them at risk for traumatic.and degenerative ***,allografts can also be at risk of rupture in the setting of severe *** present the case of a 56-year-old female with severe gouty disease who sustained a re-rupture of a patellar tendon allograft *** SUMMARY A 56-year-old female presented to clinic after feeling her left knee pop and collapse beneath her while descending *** had a history of tophaceous gout and left patellar tendon rupture with reconstruction and multiple revisions over the course of 19 *** patient presented with pain and extensor lag.A magnetic resonance image demonstrated a ruptured patellar tendon allograft reconstruction and avulsion fracture at the tibial *** patient was treated with a novel intervention of Achilles allograft with bone block in a unique configuration with a dermal allograft incorporated into the *** was made non-weight bearing in the operative extremity in extension for the first four weeks postoperatively and was then progressed to active flexion over the course of eight *** twelve weeks,she was able to fully extend her operative knee and at five months she was resuming her normal activities and *** Failed patellar tendon reconstruction due to gouty infiltration is treated with dermal allograft augmented Achilles tendon reconstruction with bone block.

关键词： Gout Patella Reconstruction Dermal allograft Revision case report

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Programmable directional color dynamics using plasmonics

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Microsystems & Nanoengineering 2024年第1期10卷 325-334页

作者： Gyurin Kim Doeun Kim Soeun Ko Jang-Hwan Han Juhwan Kim Joo Hwan Ko Young Min Song Hyeon-ho Jeong School of Electrical Engineering and computer Science Gwangju Institute of Science and TechnologyGwangju 61005Republic of Korea Department of Semiconductor Engineering Gwangju Institute of Science and TechnologyGwangju 61005Republic of Korea Artificial Intelligence(AI)Graduate School Gwangju Institute of Science and TechnologyGwangju 61005Republic of Korea

Adaptive multicolor filters have emerged as key components for ensuring color accuracy and resolution in outdoor visual ***,the current state of this technology is still in its infancy and largely reliant on liquid crystal devices that require high voltage and bulky structural ***,we present a multicolor nanofilter consisting of multilayered‘active’plasmonic nanocomposites,wherein metallic nanoparticles are embedded within a conductive polymer *** nanocomposites are fabricated with a total thickness below 100 nm using a‘lithography-free’method at the wafer level,and they inherently exhibit three prominent optical modes,accompanying scattering phenomena that produce distinct dichroic reflection and transmission ***,a pivotal achievement is that all these colors are electrically manipulated with an applied external voltage of less than 1 V with 3.5 s of switc.ing speed,encompassing the entire visible ***,this electrically programmable multicolor function enables the effective and dynamic modulation of the color temperature of white light across the warm-to-cool spectrum(3250 K-6250 K).This transformative capability is exceptionally valuable for enhancing the performance of outdoor optical devices that are independent of factors such as the sun’s elevation and prevailing weather conditions.

关键词： directional prevailing exceptional

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Macroalgal deep genomics illuminate multiple paths to aquatic,photosynthetic multicellularity

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Molecular Plant 2024年第5期17卷 747-771页

作者： David R.Nelson Alexandra Mystikou Ashish Jaiswal cecilia Rad-Menendez Michael J.Preston Frederik De Boever Diana c.El Assal Sarah Daakour Michael W.Lomas Jean-claude Twizere David H.Green William c.Ratcliff Kourosh Salehi-Ashtiani Division of Science and Math New York University Abu DhabiAbu DhabiUAE center for Genomics and Systems Biology(cGSB) New York University Abu DhabiAbu DhabiUAE Biotechnology Research center Technology Innovation InstitutePO Box 9639Masdar CityAbu DhabiUAE culture collection of Algae and Protozoa Scottish Association for Marine ScienceObanScotlandUK National center for Marine Algae and Microbiota Bigelow Laboratory for Ocean SciencesEast BoothbayMEUSA Laboratory of Viral Interactomes GIGA InstituteUniversity of LiegeLiegeBelgium School of Biological Sciences Georgia Institute of TechnologyAtlantaGAUSA

Macroalgae are multicellular,aquatic autotrophs that play vital roles in global climate maintenance and have diverse applications in biotechnology and eco-engineering,which are directly linked to their multicellularity ***,their genomic diversity and the evolutionary mec.anisms underlying multicellularity in these organisms remain *** this study,we sequenced 110 macroalgal genomes from diverse climates and phyla,and identified key genomic features that distinguish them from their microalgal *** for cell adhesion,extracellular matrix formation,cell polarity,transport,and cell differentiation distinguish macroalgae from microalgae across all three major phyla,constituting conserved and unique gene sets supporting multicellular *** genes show phylum-and climate-specific expansions that may facilitate niche ***,our study reveals genetic determinants of convergent and divergent evolutionary trajectories that have shaped morphological diversity in macroalgae and provides genome-wide frameworks to understand photosynthetic multicellular evolution in aquatic environments.

关键词： macroalgae multicellularity comparative genomics evolution adhesome endogenous viral elements

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Trial characteristics and treatment effect estimates in randomized controlled trials of chinese herbal medicine: A meta-epidemiological study

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Journal of Integrative Medicine 2024年第3期22卷 223-234页

作者： Betty H.Wang Ya-li Lin Yin-yan Gao Jin-lu Song Lang Qin Ling-qi Li Wen-qi Liu claire c.W.Zhong Mary Y.Jiang chen Mao Xiao-bo Yang Vincent c.H.chung Irene X.Y.Wu Jockey club School of Public Health and Primary care the Chinese University of Hong KongHong Kong 999077China Xiangya School of Public Health Central South UniversityChangsha 410006Hunan ProvinceChina School of chinese Medicine the Chinese University of Hong KongHong Kong 999077China School of Public Health Southern Medical UniversityGuangzhou 510080Guangdong ProvinceChina State Key Laboratory of Dampness Syndrome of chinese Medicine the Second Affiliated Hospital of Guangzhou University of Chinese MedicineGuangzhou 510120Guangdong ProvinceChina chinese Medicine Syndrome Research Team the Second Affiliated HospitalGuangzhou University of Chinese MedicineGuangzhou 510120Guangdong ProvinceChina Guangdong Provincial Key Laboratory of clinical Research on Traditional chinese Medicine Syndrome Guangzhou 510120Guangdong ProvinceChina Hunan Provincial Key Laboratory of clinical Epidemiology Central South UniversityChangsha 410006Hunan ProvinceChina

Background:Previously published meta-epidemiological studies focused on Western medicine have identified some trial characteristics that impact the treatment effect of randomized controlled trials(RcTs).Nevertheless,it remains unclear if similar associations exist in RcTs on chinese herbal medicine(cHM).Further,chinese medicine-related characteristics have not been explored ***:To investigate trial characteristics related to treatment effect estimates on cHM *** strategy:This meta-epidemiological study searched 5 databases for systematic reviews on cHM treatment published between January 2011 and July *** criteria:An eligible systematic review should only include RcTs of cHM and conduct at least one *** extraction and analysis:Two reviewers independently conducted data extraction on general characteristics of systematic reviews,meta-analyses and included *** also assessed the risk of bias of RcTs using the cochrane risk of bias tool.A two-step approach was used for data *** ratio of odds ratios(ROR) and difference in standardized mean differences (dSMD) with 95%confidence interval (cI) were applied to present the difference in effect estimates for binary and continuous outcomes,***:Ninety-one systematic reviews,comprising 1338 RcTs were *** binary outcomes,RcTs incorporated with syndrome differentiation (ROR:1.23;95%cI:[1.07,1.39]),adopting chinese medicine formula (ROR:1.19;95%cI:[1.03,1.34]),with low risk of bias on incomplete outcome data (ROR:1.29;95%cI:[1.06,1.52]) and selective outcome reporting (ROR:1.12;95%cI:[1.01,1.24]),as well as a trial size≥100 (ROR:1.23;95%cI:[1.04,1.42]) preferred to show larger effect *** for continuous outcomes,RcTs with chinese medicine diagnostic criteria (dSMD:0.23;95%cI:[0.06,0.41]),judged as high/unclear risk of bias on allocation concealment (dSMD:-0.70;95%cI:[-0.99,-0.42]),with low risk of bias on incomplete outcome data (dSMD:0.30

关键词： chinese herbal medicine Randomized controlled trial Risk of bias Meta-epidemiological study Effect estimates

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Nanoparticle Exsolution on Perovskite Oxides:Insights into Mec.anism,characteristics and Novel Strategies

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Nano-Micro Letters 2024年第2期16卷 312-346页

作者： Yo Han Kim Hyeongwon Jeong Bo‑Ram Won Hyejin Jeon c.an‑ho Park Dayoung Park Yeeun Kim Somi Lee Jae‑ha Myung Department of Materials Science and Engineering Incheon National UniversityIncheon 22012Republic of Korea

Supported nanoparticles have attracted considerable attention as a promising catalyst for achieving unique properties in numerous applications,including fuel cells,chemical conversion,and *** demonstrate high activity by expanding the number of active sites,but they also intensify deactivation issues,such as agglomeration and poisoning,*** for bottomup synthesis of supported nanoparticles has emerged as a breakthrough technique to overcome limitations associated with conventional *** are uniformly exsolved from perovskite oxide supports and socketed into the oxide support by a one-step reduction *** uniformity and stability,resulting from the socketed structure,play a crucial role in the development of novel ***,tremendous research efforts have been dedicated to further controlling exsolution *** effectively address exsolution at a more precise level,understanding the underlying mec.anism is *** review presents a comprehensive overview of the exsolution mec.anism,with a focus on its driving force,processes,properties,and synergetic strategies,as well as new pathways for optimizing nanocatalysts in diverse applications.

关键词： Supported nanoparticle Exsolution In situ growth Mec.anism Perovskite oxide catalyst

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Tilted global solar irradiance in Bahrain: an experimental study

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cLEAN ENERGY 2024年第2期8卷 27-34页

作者： Vasilikos, N. Georgantopoulou, c. Alajaimi, H. Almajed, S. H. Ahmed, M. Mathioulakis, D. Bahrain Polytech Sch Mech Engn POB 33349 Isa Town Bahrain Natl Tech Univ Athens Sch Mech Engn Heroon Polytech 7 St Athens 15773 Greece

In the present work, tilted global solar irradiance data are presented and analysed, measured for a period of 1 year on the campus of Bahrain Polytechnic, Kingdom of Bahrain, from both a fixed photovoltaic panel and a moving one via a two-axis solar tracker. The fixed panel faces south with an angle of 26 degrees with respect to the horizontal, coinciding with the local geographical latitude. The second panel is moved by two motors, controlled by a global positioning system and suitable software so that the Sun's rays are perpendicular to the panel surface. A pyranometer is installed on each panel, recording the tilted global solar irradiance, stored by using a data logger. The analysis of the data obtained shows a 33% solar energy gain on an annual basis for the moving panel (2780 versus 2088 kWh/m2 on the fixed panel). More importantly, in June, when the energy demand in Bahrain is elevated due to the increased residential cooling loads, the solar energy received by the moving panel is 54.7% higher compared with that of the fixed panel. On a percentage basis, the increase in solar energy from the moving panel is profound in the early morning and late evening hours. Moreover, the reduction in the solar energy received by the fixed panel from May to June does not appear in the moving panel because of the adjustable orientation of the latter. Throughout the year, the mean daily solar power varies between 0.37 and 0.56 kW/m2 for the fixed panel, and 0.45 and 0.70 kW/m2 for the moving panel. In winter, solar energy fluctuations are elevated due to erratic weather conditions that present a peak standard deviation of 28% of the corresponding mean. The data presented are useful for potential solar investments in Gulf countries. Tilted global solar irradiance data are measured and analysed for a period of 1 year on the campus of Bahrain Polytechnic, Kingdom of Bahrain, from both a fixed photovoltaic panel and a moving one via a two-axis solar tracker. Graphical Abstract

关键词： tilted solar irradiance renewable energy solar trac.ing photovoltaic Gulf cooperation council countries SUN TRAc.ing ENERGY SYSTEMS PANELS WORLD

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