检索结果-南通市图书馆

Frontiers of Medicine 2015年第3期9卷 322-330页

作者： Daniel wai-Hung ho Alan Ka-Lun Kai Irene Oi-Lin Ng Department of Pathology and State Key Laboratory for Liver Research The University of Hong Kong ttong Kong SAR China

This study systematically evaluates the TCGA whole-transcriptome sequencing data of hepatocellular carcinoma （HCC） by comparing the global gene expression profiles between tumors and their corresponding non- tumorous liver tissue. Based on the differential gene expression analysis, we identified a number of novel dysregulated genes, in addition to those previously reported. Top-listing upregulated （CENPF and FOXM1） and downregulated （CLEC4G, CRHBP, and CLEC1B） genes were successfully validated using qPCR on our cohort of 65 pairs of human HCCs. Further examination for the mechanistic overview by subjecting significantly upregulated and downregulated genes to gene set enrichment analysis showed that different cellular pathways were involved. This study provides useful information on the transcriptomic landscape and molecular mechanism of hepatocarcinogenesis for development of new biomarkers and further in-depth characterization.

关键词： TCGA whole-transcriptome sequencing HCC liver cancer

Prevalence, correlates, attitude and treatment seeking of erectile dysfunction among type 2 diabetic Chinese men attending primary care outpatient clinics

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Asian Journal of Andrology 2014年第5期16卷 755-760,I0010页

作者： wai hon Lo Sau Nga Fu Carlos King ho Wong Ee San Chen Department of Family Medicine and Primary Health Care Kowloon West Cluster Hospital Authority Hong Kong China Department of Family Medicine and Primary Care Li Ka Shing Faculty of Medicine University of Hong Kong Hong Kong China Department of Linguistics School of Humanities University of Hong Kong Hong Kong China

To investigate the prevalence, correlates, attitude and treatment seeking behavior of erectile dysfunction （ED） in type 2 diabetes mellitus （T2DM） patients in the primary care setting, a multi-center cross-sectional survey using a structured anonymous self-administered questionnaire was performed in 10 general outpatient clinics. Of the 603 subjects （91% response rate）, the prevalence of ED men, as defined by the International Index of Erectile Function, was 79.1%. Most subjects had mild ED （28.9%）, followed by mild-to-moderate ED （27.9%）, then moderate ED （13.4%） and severe ED （9%）. Nearly 55% of those with ED did not consider themselves as having ED. Less than 10% of them had ever sought medical treatment, although 76.1% of them wished to receive management from doctor（s） should they be diagnosed with ED. They considered the most important management from doctors to be clinical assessment （41.7%）, followed by management of potential underlying cause （37.8%）, referral to specialist （27.5%）, education （23.9%）, prescription of phosphodiesterase type 5 inhibitors （16.9%） and referral to ~：ounseling service （6.7%）. The prevalence of ED was strongly associated with subjects who thought they had ED （odds ratio （OR） = 90.49 （20.00-409.48, P 〈 0.001）） and were from the older age group （OR = 1.043 （1.011-1.076, P = 0.008））. In conclusion, ED is highly prevalent among T2DM men. The majority of them wanted management from doctors should they have ED, but only a minority would actually voice out the request. Screening of ED among T2DM men using structural questionnaire allowed the diagnosis of more than half of the ED cases, which otherwise would have gone undiagnosed.

关键词： diabetes mellitus erectile dysfunction prevalence risk factors

A new species of genus Phraortes St?l and the first description of female *** Chen & He from China(Phasmatodea:Phasmatidae)

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Zoological Systematics 2016年第3期41卷 332-336页

作者： wai-Chun George ho hong Kong Entomological Society P.O.Box No.73749Kowloon Central Post Office

A new species, Phraortes lii sp. nov., from Guangxi, China, is described and illustrated. The female of P. corniformis Chen＆ He, 1993 is firstly described. The examined material including types and non-types are depo... 详细信息

关键词： Lonchodinae Phraortes new species China.

Single cell analysis informing therapy response in hepatocellular carcinoma and intrahepatic cholangiocarcinoma

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Hepatobiliary Surgery and Nutrition 2022年第1期11卷 126-128页

作者： Daniel wai-Hung ho Irene Oi-Lin Ng Department of Pathology The University of Hong KongHong KongChina State Key Laboratory of Liver Research The University of Hong KongHong KongChina

Liver cancer is known to have significant degree of intra-tumoral heterogeneity(ITH)(1).Hepatocellular carcinoma(HCC)and intrahepatic cholangiocarcinoma(ICC)are major forms of primary liver cancer,accounting for>95%of *** is linked,as least in part,to the aggressiveness and refractoriness of liver cancer,rendering its high lethality among human malignancies(2).The complex tumor microenvironment promotes tumor progression and contributes to poor treatment ***,it is vital to address the biological mechanisms underlying liver cancer progression and treatment response analyzing the cells in high resolution rather than the mixture of many cell *** advances in single-cell RNA sequencing(scRNA-seq)provide an avenue to dissect liver cancer in an unprecedented degree of high resolution to characterize the underlying pathogenesis and heterogeneity.

关键词： cancer intrahepatic Liver

The Impact of COVID-19 on the Mental-Emotional Wellbeing of Primary Healthcare Professionals: A Descriptive Correlational Study

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

International Journal of Mental Health Promotion 2023年第3期25卷 327-342页

作者： Regina Lai-Tong lee Anson Chiu-Yan Tang ho-Yu Cheng Connie Yuen-Yu Chong Wilson wai-San Tam wai-Tong Chien Sally wai-Chi Chan The Nethersole School of Nursing Faculty of MedicineThe Chinese University of Hong KongHong Kong518172China School of Nursing and Midwifery College of HealthMedicine and WellbeingUniversity of NewcastleCallaghanNew South Wales2325Australia School of Nursing Tung Wah CollegeHong Kong200051China Alice lee Centre for Nursing Studies National University of Singapore079903Singapore Tung Wah College Hong Kong200051China

The present study aimed to examine work environment related factors and frontline primary healthcare profes-sionals’mental-emotional wellbeing during the COVID-19 pandemic in school communities of hong Kong.A total of 61(20%)school health nurses(frontline primary healthcare professionals)participated in a cross-sec-tional online survey from March to June *** of mental-emotional health were measured using the Mental Health Continuum-Short Form(14-item scale with three subscales related to emotional,social and psychological wellbeing);the Perceived Stress Scale(10-item scale with two subscales related to perceived help-lessness and lack of self-efficacy);and the Coping Orientation to Problems Experienced Inventory(Brief COPE),a 28-item inventory with two subscales related to adaptive and maladaptive *** half(42.6%)of par-ticipants experienced mental health *** employed in government subsidized schools had signifi-cantly lower scores in mental health wellbeing than those who worked in private *** relating to increased mental health problems included lack of emotional support,inadequate training relating to infection prevention and control measures,disengagement and self-blame.A variety of factors inﬂuencing school health nurses’social,emotional and psychological wellbeing in their work environment during the COVID-19 pandemic were also *** mental-emotional wellbeing of school nurses may relate to their subjective feeling of lone-liness as participants were the sole frontline primary healthcare professional working in the school community during the COVID-19 *** provide relevant evidence for management teams to build a cul-ture of psychological and social support into workplace policies and *** staff development and adequate social support are important to promote the mental-emotional wellbeing of primary healthcare pro-fessionals in school communities as they play a significant

关键词： Primary healthcare professionals school nurses impact of COVID-19 pandemic stress coping mental health emotional wellbeing

Optical Network Optimization(Invited Paper)

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

光学学报 2003年第S1期23卷 681-682页

作者： Kwok-wai Cheung Michael K.S. ho Department of Information Engineering The Chinese University of Hong Kong Shatin N.T. Hong Kong SAR ChinaDepartment of Information Engineering The Chinese University of Hong Kong Shatin N.T. Hong Kong SAR China

A novel low-complexity framework for designing survivable optical mesh networks with undetermined topology is presented. By jointly optimizing the topology planning, working- and spare-capacity planning, a cost saving... 详细信息

关键词： link or Optical Network Optimization Invited Paper with been into length of

1D-2D nanohybrid-based textile strain sensor to boost multiscale deformative motion sensing performance

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Nano Research 2022年第9期15卷 8398-8409页

作者： Xiaoting Li Keng Huat Koh Jiaqi Xue Chun ho So Na Xiao Chung Tin King wai Chiu Lai Department of Biomedical Engineering City University of Hong KongKowloon TongHong KongChina

The development of strain sensors with both superior sensitivity(gauge factor(GF)>100)and broad strain-sensing range(>50%strain)is still a grand ***,which demonstrate significant structural deformation under microscale motion,are required to offer high *** connection of materials upon large-scale motion is demanded to widen strainsensing ***,it is hard to achieve both features ***,we design a crepe roll structure-inspired textile yarn-based strain sensor with one-dimensional(1D)-two-dimensional(2D)nanohybrid strain-sensing sheath,which possesses superior *** ultrastretchable strain sensor exhibits a wide and stable strain-sensing range from microscale to large-scale(0.01%–125%),and superior sensitivity(GF of 139.6 and 198.8 at 0.01%and 125%,respectively)*** strain sensor is structurally constructed by a superelastic 1D-structured core elastomer polyurethane yarn(PUY),a novel high conductive crepe roll-structured(CRS)1D-2D nanohybrid multilayer sheath which assembled by 1D nanomaterials silver nanowires(AgNWs)working as bridges to connect adjacent layers and 2D nanomaterials graphene nanoplates(GNPs)offering brittle lamellar structure,and a thin polydopamine(PDA)wrapping layer providing protection in exterior *** the stretching/deformation process,microcracks originate and propagate in the GNPs lamellar structure enable resistance to change significantly,while AgNWs bridge adjacent GNPs to accommodate applied stress partially and boost *** 1D crepe roll structure-inspired strain sensor demonstrates multifunctionality in multiscale deformative motion detection,such as respiratory motions of Sprague–Dawleyw rat,flexible digital display,and proprioception of multi-joint finger bending and antagonistic flexion/extension motions of its flexible continuum body.

关键词： crepe roll-inspired multifunctional yarn strain sensor one-dimensional silver nanowires/two-dimensional graphene nanoplates(1D AgNWs/2D GNPs)nanohybrid multi-scale motion detection e-textiles tactile sensing proprioception of the endoscopic robot

Revisiting oral fluoropyrimidine with cetuximab in metastatic colorectal cancer: Real-world data in Chinese population

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

World Journal of Gastrointestinal Oncology 2019年第11期11卷 1031-1042页

作者： Ka-On Lam Man-Chi Fu Kin-Sang Lau Kam-Mo Lam Cheuk-wai Choi Wan-Hang Chiu Cheng-Man Yuen Lai-Han Kwok Fong-Kit Tam Wing-Lok Chan Sum-Yin Chan Pui-Ying ho To-wai Leung ho-Fun lee Department of Clinical Oncology LKS Faculty of MedicineThe University of Hong KongHong KongChina Department of Clinical Oncology Queen Mary HospitalHong KongChina Clinical Oncology Centre The University of Hong Kong-Shenzhen HospitalShenzhen 518053Guangdong ProvinceChina Department of Pharmacy Queen Mary HospitalHong KongChina Department of Diagnostic Radiology LKS Faculty of MedicineThe University of Hong KongHong KongChina

BACKGROUND Cetuximab in combination with oral fluoropyrimidine(FP)remains controversial in metastatic colorectal cancer(mCRC).In view of the regional variation in the tolerability of FP,we conducted a retrospective analysis to compare oral FP with infusional FP in combination with cetuximab in Chinese *** To compare the efficacy and safety profile of cetuximab in combination with oral FP and infusional FP in Chinese population in the real-world *** A retrospective cohort study was done to analyse consecutive patients with Kras wild-type mCRC who received first-line treatment with cetuximab and FP-based chemotherapy in our unit from January 2010 to December ***-five eligible patients were *** median follow-up of our cohort was 65.0 *** The median progression-free survival(mPFS)and median overall survival(mOS)of the entire cohort were 9.66 mo(95%CI:7.72–12.5)and 25.8 mo(95%CI:18.7–35.6),*** oral FP and infusional FP,there was no statistical significant difference in the mPFS[9.79 mo(95%CI:7.49–12.7)vs 9.63 mo(95%CI:6.34–13.4);P=0.72]and mOS[25.8 mo(95%CI:15.2–35.6)vs 26.3 mo(95%CI:18.7–41.2);P=0.63].Grade 3 or above adverse events were reported in 28.4%of patients,being similar with oral and infusional FP,and included 10.5%of neutropenia and 2.1%of diarrhoea *** The current analysis demonstrates comparable efficacy and safety profiles of cetuximab in combination with oral and infusional FP in Chinese *** results expand treatment options for Chinese patients and invite revision of existing treatment guidelines to incorporate oral FP-based chemotherapy plus cetuximab.

关键词： Capecitabine 5-Fluorouracil Cetuximab Metastatic colorectal cancer Chinese

Bevacizumab for neovascular age-related macular degeneration in Chinese patients in a clinical setting

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

International Journal of Ophthalmology(English edition) 2016年第3期9卷 424-430页

作者： Danny Siu-Chun Ng Alvin Kwan-ho Kwok Justin Man-Kit Tong Clement wai-Nang Chan Walton wai-Tat Li Department of Ophthalmology & Visual Sciences the Chinese University of Hong Kong Department of Ophthalmology Hong Kong Sanatorium and Hospital Department of Ophthalmology United Christian Hospital

AIM：To determine the outcome of non-investigational treatment with intravitreal bevacizumab（IVB） in neovascular age-related macular degeneration（AMD）patients.· METhoDS：Retrospective chart review of 81 eyes with neovascular AMD followed-up for at least 12 mo and received 3-monthly loading IVB ***-treat was based upon the individual clinician＇s *** visual acuity（BCVA） and optical coherence tomography measurements of central foveal thickness outcomes were evaluated at 12,24 mo.· RESULTS：Eighty-one eyes（of 75 patients） completed12 mo of follow-up and 44 eyes（of 41 patients） completed24 mo of *** mean baseline logMAR BCVA significantly improved from 0.94±0.69 to 0.85±0.68 at12mo（P〈0.001） and from 0.91±0.65 to 0.85±0.60（P=0.004）at 24 *** proportion of eyes that lost 〈15 logMAR letters at 12 mo was 90.1%and at 24 mo was 81.8%.IVB was effective in improving visual acuity in both treatment naive and previous photodynamic therapy（PDT）-treated *** naive patients required significantly fewer injections than patients with prior *** regression analysis identified that poorer baseline visual acuity was associated with greater improvement in visual acuity（P=0.015）.· CONCLUSION：Fewer injections in clinical practice may result in suboptimal visual outcomes compared with clinical trials of IVB in neovascular AMD *** baseline visual acuity and prior PDT treatment may also improve vision after *** safety and durability of effect was maintained at 24 mo.

关键词： bcvacizumab age-related maculardegeneration Chinese

Breast reconstruction:Review of current autologous and implantbased techniques and long-term oncologic outcome

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

World Journal of Clinical Cases 2023年第10期11卷 2201-2212页

作者： Mahdi Malekpour Fatemeh Malekpour howard Tz-ho Wang Department of Plastic and Reconstructive Surgery University of Texas Health San AntonioSan AntonioTX 78229United States

Implant-based reconstruction is the most common method of breast *** breast reconstruction is an indispensable option for breast reconstruction demanding keen microsurgical skills and robust anatomical *** reconstructive choice is made by the patient after a discussion with the plastic surgeon covering all the available *** and disadvantages of each technique along with long-term oncologic outcome are reviewed.

关键词： Breast Reconstruction Mammaplasty Breast Implant Autologous Reconstruction Oncologic Outcome Breast Neoplasms