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Hybrid liposome-erythrocyte drug delivery system for tumor therapy with enhanced targeting and blood circulation

Regenerative Biomaterials 2023年第1期10卷 1021-1032页

作者： Kehui Zhu Yingcan Xu Rui Zhong Wanjing Li Hong Wang yee Shan wong Subramanian Venkatraman Jiaxin Liu Ye Cao Institute of Blood Transfusion Chinese Academy of Medical Sciences&Peking Union Medical CollegeChengduChina Biomedical Engineering School of EngineeringTemasek PolytechnicSingaporeSingapore School of Materials Science and Engineering National University of SingaporeSingaporeSingapore

Liposome,a widely used drug delivery system(DDS),still shows several disadvantages such as dominant clearance by liver and poor target organ *** overcome the drawbacks of liposomes,we developed a novel red blood cell(RBC)-liposome combined DDS to modulate the tumor accumulation and extend the blood circulation life of the existing liposomal ***,RBCs,an ideal natural carrier DDS,were utilized to carry liposomes and avoid them undergo the fast clearance in the *** this study,liposomes could either absorbed onto RBCs’surface or fuse with RBCs’membrane by merely altering the interaction time at 37°C,while the interaction between liposome and RBCs would not affect RBCs’*** the in vivo antitumor therapeutic efficacy study,1,2-dipalmitoyl-sn-glycero-3-phosphocholine(DPPC)liposomes attached onto RBCs’surfaces exhibited lung targeting effect(via RBC-hitchhiking approach)and reduced clearance in the liver,while DPPC liposomes fused with RBCs had prolong blood circulation up to 48 h and no enrichment in any ***,20 mol%of DPPC liposomes were replaced with pH-sensitive phospholipid 1,2-dioleoyl-Sn-glycero-3-phosphoethanolamine(DOPE)as it could respond to the low pH tumor microenvironment and then accumulate in the *** DOPE attached/fusion RBCs showed partial enrichment in lung and about 5-8%tumor accumulation,which were significantly higher than(about 0.7%)the conventional liposomal ***,RBC-liposome composite DDS is able to improve the liposomal tumor accumulation and blood circulation and shows the clinical application promises of using autologous RBCs for antitumor therapy.

关键词： liposomes erythrocyte RBC-hitchhiking blood circulation target delivery

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Impact of small-for-size liver grafts on medium-term and long-term graft survival in living donor liver transplantation: A meta-analysis

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World Journal of Gastroenterology 2019年第36期25卷 5559-5568页

作者： Ka Wing Ma Kelly hiu Ching wong Albert Chi Yan Chan Tan To Cheung Wing Chiu Dai James Yan Yue Fung wong Hoi She Chung Mau Lo Kenneth Siu Ho Chok Department of Surgery Queen Mary Hospital Hong Kong China Li Ka Shing Faculty of Medicine The University of Hong Kong Hong Kong China Department of Surgery The University of Hong Kong Hong Kong China Department of Medicine Queen Mary Hospital Hong Kong China

BACKGROUND Small-for-size grafts (SFSGs) in living donor liver transplantation (LDLT) could optimize donor postoperative outcomes and also expand the potential donor pool. Evidence on whether SFSGs would affect medium-term and long-term recipient graft survival is lacking. AIM To evaluate the impact of small-for-size liver grafts on medium-term and longterm graft survival in adult to adult LDLT. METHODS A systematic review and meta-analysis were performed by searching eligible studies published before January 24, 2019 on PubMed, EMBASE, and Web of Science databases. The primary outcomes were 3-year and 5-year graft survival. Incidence of small-for-size syndrome and short term mortality were also extracted. RESULTS This meta-analysis is reported according to the guidelines of the PRISMA 2009 Statement. Seven retrospective observational studies with a total of 1821 LDLT recipients were included in the meta-analysis. SFSG is associated with significantly poorer medium-term graft survival. The pooled odds ratio for 3-year graft survival was 1.58 [95% confidence interval 1.10-2.29, P = 0.014]. On the other hand, pooled results of the studies showed that SFSG had no significant discriminatory effect on 5-year graft survival with an odds ratio of 1.31 (95% confidence interval 0.87-1.97, P = 0.199). Furthermore, incidence of small-for-size syndrome detected in recipients of SFSG ranged from 0-11.4% in the included studies. CONCLUSION SFSG is associated with inferior medium-term but not long-term graft survival. Comparable long-term graft survival based on liver graft size shows that smaller grafts could be accepted for LDLT with appropriate flow modulatory measures. Close follow-up for graft function is warranted within 3 years after liver transplantation.

关键词： Living donor liver transplantation Small-for-size grafts Small-for-size syndrome Graft survival

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Imaging of the anterior cruciate ligament

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World Journal of Orthopedics 2011年第8期2卷 75-84页

作者： Wing Hung Alex Ng James Francis Griffith Esther hiu yee Hung Bhawan Paunipagar Billy Kan Yip Law Patrick Shu Hang Yung Department of Imaging and Interventional Radiology Prince of Wales HospitalChinese University of Hong KongHong KongChina Department of Orthopedics and Traumatology Prince of Wales HospitalChinese University of Hong KongHong KongChina

The anterior cruciate ligament(ACL)is an important structure in maintaining the normal biomechanics of the knee and is the most commonly injured knee ***,the oblique course of the ACL within the intercondylar fossa limits the visualization and assessment of the pathology of the *** pictorial essay provides a comprehensive and illustrative review of the anatomy and biomechanics as well as updated information on different modalities of radiological investigation of ACL,particularly magnetic resonance imaging.

关键词： Magnetic resonance Knee Anterior cruciate ligament Tear

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Antiviral activity of traditional Chinese medicinal plants Dryopteris crassirhizoma and Morus alba against dengue virus

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Journal of Integrative Agriculture 2020年第4期19卷 1085-1096页

作者： Maqsood MARYAM Kian Keong TE Fai Chu wong Tsun Thai CHAI Gary K K LOW Seng Chiew GAN Hui yee CHEE Department of Medical Microbiology and Parasitology Faculty of Medicine and Health SciencesUniversiti Putra MalaysiaSerdang 43400Malaysia Faculty of Natural Sciences SBK Women's University QuettaBalochistan 87300Pakistan Department of Chinese Medicine Faculty of Medicine and Health SciencesUniversiti Tunku Abdul RahmanSungai Long CampusKajang 43000Malaysia Department of Chemical Science Faculty of ScienceUniversiti Tunku Abdul Rahman(Kampar Campus)Kampar 31900Malaysia Department of Population Medicine Faculty of Medicine and Health SciencesUniversiti Tunku Abdul Rahman(Sungai Long Campus)Kajang 43000Malaysia Department of Pre-Clinical Sciences Faculty of Medicine and Health SciencesUniversiti Tunku Abdul Rahman(Sungai Long Campus)Kajang 43000Malaysia

Dengue virus(DENV) has emerged as a major virus that is spread by mosquitoes. Recently, it has spread to more than a hundred nations but continues to lack specific treatable medication. Many traditional Chinese medicinal(TCM) plants are in practice for dengue fever in dengue endemic regions. These traditional medicines persevere with treatments, which modern medicines lack. The study aims to substantiate the anti-dengue potential of some traditional herbs and make them available for further studies to facilitate TCM users. Twelve TCM plants aqueous extracts were evaluated, which are described as cool herbs used for the diseases with high fever. Lead plants were established through detailed in vitro foci forming unit reduction analysis(FFURA) against all four serotypes and validated through quantitative real-time RT-PCR(q RT-PCR). Four plants potentially inhibited the virus in primary phenotypic in vitro evaluation. Two lead plants Dryopteris crassirhizoma(DC) and Morus alba(MA) were identified with half minimal inhibitory concentration(IC50) 130 and 221 μg m L^-1, respectively, while the selectivity indices(SI) were 4.21 and 4.62, respectively. Lead plants equally inhibited all four serotypes of DENV. Time-of-addition analysis suggested that, DC was active at later stages of viral replication, whereas MA was active during the early stages and even showed some prophylactic activity. Liquid chromatography-mass spectrometry(HPLC/MS) analysis revealed presence of flavonoids. DC and MA are identified as potential anti-dengue plants, active against varied stages of dengue virus replication cycle. These results may serve as the base knowledge for further investigation on their combined treatments or integrative treatment with western medicines, which may improve the overall anti-dengue activity in future.

关键词： dengue virus traditional Chinese medicines TCM complementary medicines plant extracts anti-dengue

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Establishing a treatment protocol for concomitant major burn and trauma patients:a tropical Asian hospital's experience

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Burns & Trauma 2017年第3期5卷 215-217页

作者： yee Onn Kok Nadia Sim Priya Tiwari Ting Hway wong Si Jack Chong Department of Plastic Reconstructive and Aesthetic Surgery Singapore General Hospital Level 5 Academia Singapore 169865 Singapore Department of Plastic Reconstructive and Aesthetic Surgery Singapore General Hospital Level 5 Academia Singapore 169865 Singapore Yong Loo Lin School of Medicine National University of Singapore 1E Kent Ridge Road Level 11 NUHS Tower Block Singapore 119228 Singapore Division of Plastic Reconstructive and Aesthetic Surgery Department of Surgery National University Health System Level 8 NUHS Tower Block 1E Kent Ridge Road Singapore 119228 Singapore Department of General Surgery Singapore General Hospital Level 5 Academia Singapore 169865 Singapore

Dear Editor,Burns and trauma represent two of the most severe injuries that both developing and developed countries face today. Concomitant burn and traumatic injuries are significant in terms of disease burden and co... 详细信息

关键词： Burns Trauma Protocol

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Quality of life after laparoscopic vs open sphincter-preserving resection for rectal cancer

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World Journal of Gastroenterology 2013年第29期19卷 4764-4773页

作者： Simon Siu-Man Ng Wing-Wa Leung Cherry yee-Ni wong Sophie Sok-Fei Hon Tony Wing-Chung Mak Dennis KwokYu Ngo Janet Fung-yee Lee Division for Colorectal Surgery Department of Surgery The Chinese University of Hong Kong Prince of Wales Hospital

AIM: To compare quality of life (QoL) outcomes in Chinese patients after curative laparoscopic vs open surgery for rectal cancer. METHODS: Eligible Chinese patients with rectal cancer undergoing curative laparoscopic or open sphincterpreserving resection between July 2006 and July 2008 were enrolled in this prospective study. The QoL outcomes were assessed longitudinally using the validated Chinese versions of the European Organization for Research and Treatment of Cancer QLQ-C30 and QLQCR38 questionnaires before surgery and at 4, 8, and 12 mo after surgery. The QoL scores at the different time points were compared between the laparoscopic and open groups. A higher score on a functional scale indicated better functioning, whereas a higher score on a symptom scale indicated a higher degree of ***: Seventy-four patients (49 laparoscopic and 25 open) were enrolled. The two groups of patients were comparable in terms of sociodemographic data, types of surgery, tumor staging, and baseline mean QoL scores. There was no significant decrease from baseline in global QoL for the laparoscopic group at different time points, whereas the global QoL was worse compared to baseline beginning at 4 mo but returned to baseline by 12 mo for the open group (P = 0.019, Friedman test). Compared to the open group, the laparoscopic group had significantly better physical (89.9±1.4 vs 79.2±3.7, P = 0.016), role (85.0±3.4 vs 63.3±6.9, P = 0.005), and cognitive (73.5±3.4 vs 50.7±6.2, P = 0.002) functioning at 8 mo, fewer micturition problems at 4-8 mo (4 mo: 32.3±4.7 vs 54.7±7.1, P = 0.011; 8 mo: 22.8±4.0 vs 40.7±6.9, P = 0.020), and fewer male sexual problems from 8 mo onward (20.0±8.5 vs 76.7±14.5, P = 0.013). At 12 mo after surgery, no significant differences were observed in any functional or symptom scale between the two groups, with the exception of male sexual problems, which remained worse in the open group (29.2±11.3 vs 80.0±9.7, P = 0.026). CONCLUSION: Laparoscopic sphin

关键词： Quality of life Rectal cancer Laparoscopic surgery Sphincter-preserving surgery European Organization for Research and Treatment of Cancer QLQ-C30 European Organization for Research and Treatment of Cancer QLQ-CR38

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Sustainable green technology on wastewater treatment:The evaluation of enhanced single chambered up-flow membrane-less microbial fuel cell

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Journal of Environmental Sciences 2018年第4期30卷 295-300页

作者： Wei-Eng Thung Soon-An Ong Li-Ngee Ho yee-Shian wong Fahmi Ridwan Yoong-Ling Oon Yoong-Sin Oon Harvinder Kaur Lehl Water Research Group (WAREG) School of Environmental Engineering Universiti Malaysia Perlis School of Materials Engineering Universiti Malaysia Perlis

This study demonstrated the potential of single chamber up-flow membrane-less microbial fuel cell（UFML-MFC） in wastewater treatment and power generation. The purpose of this study was to evaluate and enhance the performance under different operational conditions which affect the chemical oxygen demand（COD） reduction and power generation,including the increase of KCl concentration（MFC1） and COD concentration（MFC2）. The results showed that the increase of KCl concentration is an important factor in up-flow membrane-less MFC to enhance the ease of electron transfer from anode to cathode. The increase of COD concentration in MFC2 could led to the drop of voltage output due to the prompt of biofilm growth in MFC2 cathode which could increase the internal resistance. It also showed that the COD concentration is a vital issue in up-flow membrane-less *** the COD reduction was up to 96%, the power output remained constrained.

关键词： MFC Up-flow Membrane-less KCl concentration COD Ionic strength Biocathode Biofilm

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Novel role of STAT3 in microglia-dependent neuroinflammation after experimental subarachnoid haemorrhage

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Stroke & Vascular Neurology 2022年第1期7卷 62-70页

作者： Zhiyuan Vera Zheng Junfan Chen Hao Lyu Sin Yu Erica Lam Gang Lu Wai yee Chan George K C wong Department of Surgery The Chinese University of Hong KongShatinHong Kong Department of Surgery Hainan General HospitalHaikouHainanChina School of Biomedical Science The Chinese University of Hong KongShatinHong Kong

Background and purpose Signal transducer and activator of transcription 3(STAT3)may contribute to the proinflammation in the central nervous system diseases by modulating the microglial ***,this study was intended to investigate the effect of STAT3 on microglia-dependent neuroinflammation and functional outcome after experimental subarachnoid haemorrhage(SAH).Methods The SAH model was established by endovascular perforation in the ***-time PCR(RtPCR)and western blot were used to examine the dynamic STAT3 signalling pathway responses after *** clarify the role of the STAT3 signalling pathway in the microglia-dependent neuroinflammation after SAH,the microglia-specific STAT3 knockout(KO)mice were generated by the Cre-LoxP *** neurological functions were assessed by Catwalk and Morris water maze *** loss after SAH was determined by immunohistochemistry *** polarisation status after STAT3 KO was then examined by RtPCR and *** The STAT3 and Janus kinase-signal transducer 2 activated immediately with the upregulation and phosphorylation after *** factors and related mediators altered dynamically and *** STAT3 deletion ameliorated the neurological impairment and alleviated the early neuronal loss after *** investigate the underlying mechanism,we examined the microglial reaction after STAT3 ***3 deletion reversed the increase of microglia after *** of STAT3 triggered the early morphological changes of microglia and primed microglia from M1 to M2 ***,microglial STAT3 deletion suppressed the SAH-induced proinflammation and promoted the anti-inflammation in the early *** STAT3 is closely related to the microglial polarisation transition and modulation of microglia-dependent *** STAT3 deletion improved neurological function and neuronal survival probably through promoting M2 polarisation and anti-inf

关键词： STAT3 inflammation reversed

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Need of integrated dietary therapy for persons with diabetes mellitus and “unhealthy” body constitution presentations

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Journal of Integrative Medicine 2016年第4期14卷 255-268页

作者： yee Chi Peggy wong Dietetic Department Tuen Mun Hospital

From a perspective of Chinese medicine （CM）, persons with unregulated ＂unhealthy＂ body constitution （BC） will further develop chronic diseases, such as diabetes mellitus （DM）. Conventional dietary therapy with nutrition component has its limitations in the regulation of ＂unhealthy＂ BC. However, empirical evidence supports that ＂unhealthy＂ BC can be regulated with food natures and flavors from a perspective of CM. Presentations of ＂unhealthy＂ BC types, such as Yin-deficiency, Yang-deficiency and Yin-Yangdeficiency were found in persons with DM. It would be necessary to regulate the ＂unhealthy＂ BC presentations with integration of conventional dietary therapy and Chinese food therapy. The ultimate goal is to either stabilize glycaemic control or prevent the development of other chronic diseases leading to reduction of disease burden, such as disease-related poor quality of life, stress of healthcare professionals and the rising of healthcare cost.

关键词： body constitution diabetes mellitus Yin deficiency Yang deficiency dietary therapy

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Quality indicators in pediatric colonoscopy in a low-volume center:Implications for training

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World Journal of Gastroenterology 2018年第9期24卷 1013-1021页

作者： Way-Seah Lee Chun-Wei Tee Zhong-Lin Koay Tat-Seng wong Fatimah Zahraq Hee-Wei Foo Sik-Yong Ong Shin-yee wong Ruey-Terng Ng Department of Paediatrics University Malaya Medical CentreKuala Lumpur 59100Malaysia Paediatric and Child Health Research Group University MalayaKuala Lumpur 50603Malaysia

AIM To study implications of measuring quality indicators on training and trainees' performance in pediatric colonoscopy in a low-volume training *** We reviewed retrospectively the performance of pediatric colonoscopies in a training center in Malaysia over 5 years(January 2010-December 2015), benchmarked against five quality indicators: appropriateness of indications, bowel preparations, cecum and ileal examination rates, and complications. The European Society of Gastrointestinal Endoscopy guideline for pediatric endoscopy and North American Society for Pediatric Gastroenterology, Hepatology and Nutrition training guidelines were used as *** Median(± SD) age of 121 children [males = 74(61.2%)] who had 177 colonoscopies was 7.0(± 4.6) years. On average, 30 colonoscopies were performed each year(range: 19-58). Except for investigations of abdominal pain(21/177, 17%), indications for colonoscopies were appropriate in the remaining 83%. Bowel preparation was good in 87%. One patient(0.6%) with severe Crohn's disease had bowel perforation. Cecum examination and ileal intubation rate was 95% and 68.1%. Ileal intubation rate was significantly higher in diagnosing or assessing inflammatory bowel disease(IBD) than non-IBD(72.9% vs 50.0%; P = 0.016). Performance of four trainees was consistent throughout the study period. Average cecum and ileal examination rate among trainees were 97% and 77%.CONCLUSION Benchmarking against established guidelines helps units with a low-volume of colonoscopies to identify area for further improvement.

关键词： Pediatric colonoscopies Quality indicators Performance

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