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Chinese Science Bulletin 1997年第2期42卷 147-151页

作者： Seiko Kawano Yoshiyuki Hirayama Masayasu Hiraoka Akihiko Kuniyasu hitoshi Nakayama Department of Cardiovascular Diseases M R 1 Tokyo Medical and Dental University JapanDepartment of Cardiovascular Diseases M R 1 Tokyo Medical and Dental University JapanDepartment of Cardiovascular Diseases M R 1 Tokyo Medical and Dental University JapanFaculty of Pharmaceutical Science Hokkaido University Japan Faculty of Pharmaceutical Science Kumamoto University Japan

RYANODINE is a toxic alkaloid from the plant Ryania speciosa Vahl. It selectively binds to the Ca2+ release channel on skeletal and cardiac heavy sarcoplasmic reticulum （HSR） and has

关键词： scorpion Buthus martensi Karsch ryanodine receptor toxic polypeptide.

Application of monoclonal antibody against ginsenoside in ginseng research:a review

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Traditional Medicine Research 2021年第3期6卷 66-77页

作者： Yui Sasaki Koichi Shimizu hitoshi Watanabe Yukihiro Shoyama Association for Health Economics Research and Social Insurance and Welfare Tokyo 105-0003Japan Center for Environment Health and Field SciencesChiba UniversityKashiwa 277-0882Japan Faculty of Pharmacy Nagasaki International UniversityNagasaki 859-3298Japan

Panax genus belonging to a family of Araliaceae grow in Asia(9 species)and in North America(2 species).Especially Panax ginseng was listed in Chinese medical book,Shennong's Classic of Materia Medica approximately 2 thousand years ago and Panax species are now one of the most important natural *** Panax species contain approximately 260 ginsenosides,its quality control and pharmacological movement of ginsenoside in body are not enough *** antibodies against ginsenosides were prepared and set up the enzyme linked immunosorbent assay system for the quality control of natural ***,we developed Eastern blotting system using monoclonal antibodies resulted that protopanaxadiol and protopanaxatriol group ginsenosides can be separately stained by two corresponding monoclonal antibodies,*** became evident that the ginseng slice was stained by Eastern blotting *** staining of ginseng can make clear the ginsenoside-Rb1 distribution in cells and *** Eastern blotting system facilitated by two monoclonal antibodies like anti-ginsenoside-Rb1 and anti-ginsenoside-Rg1 monoclonal antibodies gives several information such as sugar number,structure,and qualitative/quantitative *** column combined with monoclonal antibodies succeeded one-step isolation of ginsenoside and make it possible to prepare knockout extract of which only antigen molecule was removed suggesting the pharmacological and biological value of antigen molecule in the crude extract.

关键词： Panax species Ginsenoside Monoclonal antibody Pharmacological activity Eastern blotting Knockout extract

Nano-precision combined process of electrolytic in-process dressing grinding and magnetic assisted polishing on optics glass material

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中国有色金属学会会刊：英文版 2009年第B09期19卷 301-306页

作者： Tae-Soo KWAK Yong-Chul LEE Gyung-Nyun KIM Dae-Bong CHOI Mikio YAMANOI hitoshi OHMORI Department of Mechanical Engineering Jinju National University

This study is focused on the application of an effective fabrication method combining electrolytic in-process dressing(ELID) grinding and magnetic assisted polishing(MAP) to nano-precision mirror surface grinding on the optics glass-ceramic named Zerodure that is commonly used in precision optics components. The results show the variation of surface roughness after MAP processes utilizing Fe+CeO2, Fe+CeO2+diamond paste and Fe+diamond paste are applied to ELID ground surfaces. The MAP surface roughnesses for ELID ground surface roughnesses(Ra) of 52.1, 39.8 and 51.1 nm using #1200 grinding wheel are improved to 6.1, 4.6 and 1.9 nm, respectively. The surface roughness of MAP process using Fe+CeO2+diamond paste is superior to that using other processes. Moreover, it takes less than 10 min to conduct the MAP processes. The combined method suggested effectively reduces the working time to get the required surface qualities.

关键词：在线电解修整光学玻璃纳米相抛光材料电解过程表面粗糙度地面粗糙度磨削

Near-infrared imaging survey of faint companions around young dwarfs in the Pleiades cluster

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Research in Astronomy and Astrophysics 2011年第3期11卷 335-344页

作者： Yoichi Itoh Yumiko Oasa hitoshi Funayama Masahiko Hayashi Misato Fukagawa Toshio Hashiguchi Thayne Currie Graduate School of Science Kobe University1-1 RokkodaiNada-kuKobe 657-8501Japan Faculty of Education Saitama University255 Shimo-OkuboSakura-kuSaitamaSaitama 338-8570Japan Subaru Telescope 650 North A'ohoku PlaceHiloHawaii 96720USA School of Mathematical and Physical Science Graduate University for Advanced Studies(Sokendai)2-21-1 OsawaMitakaTokyo 181-8588Japan Graduate School of Science Osaka UniversityMachikaneyamaToyonakaOsaka 560-0043Japan NASA-Goddard Space Flight Center

We conducted a near-infrared imaging survey of 11 young dwarfs in the Pleiades cluster using the Subaru Telescope and the near-infrared coronagraph imager. We found ten faint point sources,with magnitudes as faint as 20 mag in the K-band,with around seven *** with the Spitzer archive images revealed that a pair of the faint sources around V 1171 Tau is very red in infrared wavelengths,which indicates very low-mass young stellar ***,the results of our follow-up proper motion measurements implied that the central star and the faint sources do not share common proper motions,suggesting that they are not physically associated.

关键词： planetary systems:formation—techniques:high angular resolution

Acquisition of LURE-Binding Activity at the Pollen Tube Tip of Torenia fournied

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Molecular Plant 2013年第4期6卷 1074-1090页

作者： Satohiro Okuda Takamasa Suzuki Masahiro M. Kanaoka hitoshi Moric Narie Sasaki Tetsuya Higashiyama Division of Biological Science Graduate School of Science Nagoya University Furo-cho Chikusa-ku Nagoya Aichi 464-8602 Japan JST ERATO Higashiyama Live-Holonics Project Nagoya University Furo-cho Chikusa-ku Nagoya Aichi 464-8602 Japan Department of Bioengineering Sciences Graduate School of Bioagricultural Sciences Nagoya University Furo-cho Chikusa-ku Nagoya Aichi 464-8602 Japan WPI-ITbM Nagoya University Furo-cho Chikusa-ku Nagoya Aichi 464-8602 Japan

Pollen tube guidance is controlled by multiple complex interactions with the female tissues. Here, we show that pollen tubes of Torenia fournieri are regulated by a stylar tissue in a length-dependent manner to receive and respond to attractant LURE peptides secreted from synergid cells. We developed an immunostaining method to visualize LURE peptides bound at the plasma membrane of the tip region of the pollen tube. Using this method, we found that LURE peptides bound specifically to pollen tubes growing through a cut style. The peptides also bound to pollen tubes growing through a shorter style, which were not competent to respond to these peptides. These observations suggested a possibility that acquisition of the LURE peptide reception ability and acquisition of full competency are separable pro- cesses. RNA-Seq suggested that the transcription profile of pollen tubes was affected by both the length of the style and the cultivation period, consistently with physiological changes in binding activity and LURE response ability. The data- base generated from de novo RNA-Seq of Torenia pollen tubes was shown to be useful to identify pollen tube proteins by mass spectrometry. Our studies provide insight and an effective platform for protein identification to understand pollen tube guidance.

关键词： pollen tube guidance attractants pollen tube de novo transcriptome proteome.

Surgical removal of a large mobile left ventricular thrombus via left atriotomy

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World Journal of Clinical Cases 2014年第2期2卷 32-35页

作者： Daizo Tanaka Shinya Unai James T Diehl hitoshi Hirose Division of Cardiothoracic Surgery Department of Surgery Thomas Jefferson University

Left ventricular(LV) thrombus is a life-threatening complication of severe LV dysfunction. Ventriculotomy has been a commonly performed procedure for LV thrombus; however, it often further decrease LV function after surgery. We present an alternative approach to thrombectomy in order to minimize the postoperative LV dysfunction. A 37-year-old female with a postpartum cardiomyopathy found to have poor LV function and a large left ventricular apical thrombus(3 cm × 3 cm) attached to the apex by a narrow stalk. Given her severe LV dysfunction, the LV thrombus was approached via left atriotomy under cardiopulmonary bypass. The LV thrombus was easily extracted with gentle traction via the mitral valve. Postoperatively, the patient was discharged home without any embolization event or inotropic support. LV thrombectomy via left atriotomy through the mitral valve could be an alternative option for the patients with poor LV function with a mobile LV thrombus.

关键词： Left ventricular thrombus Atriotomy Cardiomyopathy Surgical thrombectomy Pedunculated thrombus

Overexpression of INCREASED CAMBIAL ACTIVITY, a putative methyltransferase, increases cambial activity and plant growth

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Journal of Integrative Plant Biology 2016年第11期58卷 874-889页

作者： Hyunsook Kim Mikiko Kojima Daeseok Choi Soyoung Park Minami Matsui hitoshi Sakakibara Ildoo Hwang Department of Life Sciences Pohang University of Science and Technology Pohang 790-784 Korea Synthetic Genomics Research Team Biomass Research Cooperation Division (BMEP) RIKEN Center for Sustainable Resource Science (CSRS) Tsurumi Yokohama 230-0045 Japan Riken Center for Sustainable Resource Science (CSRS) Tsurumi Yokohama 230-0045 Japan

Cambial activity is a prerequisite for secondary growth in plants; however, regulatory factors controlling the activity of the secondary meristem in radial growth remain elusive. Here, we identified INCREASED CAMBIAL ACTIVITY （ICA）, a gene encoding a putative pectin methyltransferase, which could function as a modulator for the meristematic activity of fascicular and interfascicular cambium in Arabidopsis. An overexpressing transgenic line, 35S：＇1CA, showed accelerated stern elongation and radial thickening, resulting in increased accumulation of biomass, and increased levels of cytokinins （CKs） and gibberellins （GAs）. Expression of genes encoding pectin methylesterases involved in pectin modification together with pectin methyltransferases was highly induced in 355：：ICA, which might contribute to an increase of methanol emission as a byproduct in 35S：ICA. Methanol treatment induced the expression of GA- or CK-responsive genes and stimulated plant growth. Overall, we propose that ectopic expression of ICA increases cambial activity by regulating CK and GA homeostasis, and methanol emission, eventually leading to stem elongation and radial growth in the inflorescence stem.

关键词： Cambial activity cytokinin gibberellin methanol methyltransferase pectin shoot growth

Clinical significance of white gastric crypt openings observed via magnifying endoscopy

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World Journal of Gastroenterology 2013年第48期19卷 9392-9398页

作者： Masashi Kawamura hitoshi Sekine Shu Abe Daisuke Shibuya Katsuaki Kato Takayuki Masuda Department of Gastroenterology Sendai City Hospital Miyagi 984-8501 Japan Department of Gastroenterology JR Sendai HospitalMiyagi 980-0022 Japan Cancer Detection Center Miyagi Cancer Society Miyagi 980-0011 Japan Division of Pathology Tohoku University School of Health Sciences Miyagi 980-8575 Japan

AIM:To evaluate the relationship between Helicobacter pylori(***)-induced gastritis and white gastric mucosal crypt openings(COs)in the gastric ***:A total of 175 consecutive patients(including 69 patients with gastric cancer)were enrolled in this *** used magnifying endoscopy(ME)to observe the mucosa microsurface of the lesser and greater curvature of the gastric corpus(350 areas in all).We focused on areas with a round pit microstructure(primarily observed in non-atrophied areas)and evaluated the white openings of these gastric *** classified the whiteness of the COs as the"white-edged dark spot"type(consisting of a dark spot bordered by white);the"white"type(pure white with no dark spot);and the"dense white pit(DWP)"type(dense white,resembling a snowball).Gastritis was also histologically evaluated according to the updated Sydney ***:We detected round COs using ME in 246 of the 350 areas *** histological examination showed significantly more mononuclear cells and neutrophil infiltration in the"white"and"DWP"types than the"white-edged dark spot"type(P<0.001).Furthermore,significantly high-grade inflammation and evidence of active ***-induced gastritis was observed in the"DWP"type(P<0.001).Significant differences were observed in the whiteness of COs between ***-positive(n=139)and negative(n=36)patients(P<0.001).The sensitivity and specificity of the"white"and"DWP"types for predicting *** infection were78.5%and 81.7%,*** the patients with gastric cancer,22.5%(18/80)had"white-edged dark spots",51.3%(41/80)had"white"COs,and 26.3%(21/80)had"DWP"-type COs."DWPs"were frequently observed among patients with undifferentiated gastric cancer[45.7%(16/35)].CONCLUSION:CO whiteness detected via ME was associated with histological evidence of gastritis and helps to predict the severity of inflammation and *** activity.

关键词： Magnifying endoscopy Helicobacter pylori Gastritis Gastric cancer Inflammation

No Quantum Process Can Explain the Existence of the Preferred Basis: Decoherence Is Not Universal

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Journal of Quantum Information Science 2016年第3期6卷 214-222页

作者： hitoshi Inamori Société Générale Boulevard Franck Kupka Puteaux France

Environment induced decoherence, and other quantum processes, have been proposed in the literature to explain the apparent spontaneous selection—out of the many mathematically eligible bases—of a privileged measurement basis that corresponds to what we actually observe. This paper describes such processes, and demonstrates that—contrary to common belief—no such process can actually lead to a preferred basis in general. The key observation is that environment induced decoherence implicitly assumes a prior independence of the observed system, the observer and the environment. However, such independence cannot be guaranteed, and we show that environment induced decoherence does not succeed in establishing a preferred measurement basis in general. We conclude that the existence of the preferred basis must be postulated in quantum mechanics, and that changing the basis for a measurement is, and must be, described as an actual physical process.

关键词： Quantum Mechanics Measurement Preferred Basis Entanglement

Isolation of the Left Subclavian Artery in D-Transposition of the Great Arteries with Right Aortic Arch

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Congenital Heart Disease 2021年第4期16卷 369-371页

作者： Kotaro Hine Kohei Ogata Keiko Saitou Norio Mizukaki Hiroko Arai hitoshi Yoda Department of Neonatology Toho University Omori Medical CenterTokyo143-8541Japan

Abnormal branching of the aorta associated with the right aortic arch(RAA)has been reported as isolation of left subclavian artery(ILSA),isolation of left common carotid artery,isolation of brachiocephalic *** is a rare aortic branch anomaly that originates in the left subclavian artery from the pulmonary artery via ductus *** reports have described ILSA associated with 22q11.2 deletion syndrome and tetralogy of ***,we present a very unusual case of RAA with ILSA associated with D-transposition of the great arteries and inferior vena cava interrupted with azygos continuation.

关键词： Isolated left subclavian artery transposition of the great arteries RAA ILSA