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褪黑素对大鼠妊娠结局的影响(英文)

生理学报 2013年第2期65卷 149-157页

作者： Harbindar Jeet Singh hisham Ibrahim Saleh Sergey Gupalo Effat Omar MARA工艺大学医学系

褪黑素能调节多项生理功能，但其对妊娠结局的影响所知甚少。本研究旨在探讨补充褪黑素对12～1aN龄的Wistar-Kyoto（WKY）和Sprague-Dawley（SD）大鼠妊娠结局的影响。动情前期确认后，每只雌性大鼠与一只同品种雄性大鼠同笼饲养过夜，... 详细信息

褪黑素能调节多项生理功能，但其对妊娠结局的影响所知甚少。本研究旨在探讨补充褪黑素对12～1aN龄的Wistar-Kyoto（WKY）和Sprague-Dawley（SD）大鼠妊娠结局的影响。动情前期确认后，每只雌性大鼠与一只同品种雄性大鼠同笼饲养过夜，第二天阴道涂片确认交配后，雌性大鼠转移至单独的代谢笼，WKY大鼠每天给予含0、25、50或100mg／kg褪黑素的饮水，SD大鼠则每天给予含0或100mg／kg褪黑素的饮水，从怀孕第一天持续至产后21天。记录母鼠体重、孕期、窝产仔数、仔鼠出生体重和出生后7～42d体重及仔鼠死亡率，使用重复测量的方差分析对数据进行分析。结果显示，与对照组相比，褪黑素组母鼠孕期体重增长较小（P〈0．01），窝产仔数减少（尸〈0．01），仔鼠平均出生体重仅在100mg／kg褪黑素组显著降低（P〈0．001），出生后7～42d仔鼠平均体重显著降低（P〈0．01）。25和100mg／kg褪黑素组WKY仔鼠死亡率分别为9．5％和21．6％，且都发生在断奶21天后。以上结果提示，产前和产后补充褪黑素会严重影响WKY和SD大鼠窝产仔数、仔鼠生长和死亡率。

关键词：褪黑素死亡率体重增长妊娠幼崽生长

Primary Study of the Use of Laser-Induced Plasma Spectroscopy for the Diagnosis of Breast Cancer

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Optics and Photonics Journal 2012年第3期2卷 193-199页

作者： hisham Imam Raeesa. Mohamed Ashraf A. Eldakrouri College of Applied Medical Science King Saud University Kingdom of Saudi Arabia College of Medicine Cairo University Egypt National Institute of Laser Enhanced Sciences Cairo University Giza Egypt

Breast cancer, or malignant breast neoplasm, is a type of cancer that originates from breast tissue, most commonly from the inner lining of the milk ducts or the lobules that supply the ducts with milk. It is one of the most widespread diseases, especially in women. Thus far, large efforts have been towards the early diagnosis of cancer in general, and breast cancer specifically. Most of these techniques deal with malignant tissues without inducing or increasing pathological tissue changes or causing major side effects for the patient. This paper proposes a new technique for diagnosing the presence or occurrence of cancer and assessing its grade early, accurately, and safely. The presented technique depends on the interaction between the laser and the soft tissue in order to induce plasma, and allows us to classify the cancer by studying the difference in the intensity ratio of the trace elements in normal and malignant tissues. The results presented here are show that only four patients out of the total sample of 30 have erroneous trace elements and that this does not affect the overall decision. Hence, the performance of LIPS can be measured as 87%, while retaining 100% accuracy. Furthermore, LIPS technique is a simple and promising technique that is capable of diagnosing malignant cells and tissues.

关键词： LIPS Malignant Breast

Variceal hemorrhage:Saudi tertiary center experience of clinical presentations,complications and mortality

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World Journal of Hepatology 2012年第9期4卷 268-273页

作者： Hind I Fallatah Haifaa Al Nahdi Maan Al Khatabi hisham O Akbar Yousif A Qari Abdul Rahman Sibiani Salim Bazaraa Department of Medical King Abdul Aziz University Hospital Jeddah Saudi ArabiaJeddah 21423Saudi Arabia

AIM:To determine the clinical presentation,underlying etiology and short-and long-term outcomes of acute variceal bleeding(AVB).METHODS:A retrospective descriptive cohort study of cirrhotic patients with AVB who were admitted to King Abdul Aziz University Hospital between January 2005 and December *** obtained demographic data for all *** each patient we also obtained the clinical data at presentation;cause of liver cirrhosis,bleeding presentation(hematemesis and/or melena),presence of ascites,hepatic encephalopathy and renal impairment(RI) or hepatorenal *** carried out complete blood count,prothrombin time evaluation,and liver function *** also report all episodes of re-bleeding after the first episode of AVB,both during the initial admission and after *** recorded the length of stay for each patient and thereby calculated the mean duration of stay for all *** length of follow-up after the first AVB and the outcome for each patient at the end of the study period were *** of mortality either related to liver disease or non-liver disease cause were ***:A 125 patients were enrolled in the *** number of episodes of AVB for each patients varied between 1 and *** from the first attack of AVB to death was 20.38 mo(SD 30.86),while the length of follow-up for the living patients was 53.58 mo(SD 24.94).Total number of AVB admissions was *** hepatitis C,the commonest underlying etiology for liver disease,was present in 46(36.8%) *** 35(28%) patients had received a primary prophylactic β-blocker before the first bleeding *** mean hemoglobin level at the time of admission was 8.59 g/dL(SD 2.53).Most patients had Child-Pugh Class C 41(32.8%) or Class B 72(57.6%) *** was the predominant symptom and was found in 119(95.2%) patients,followed by melena in 75(60.0%) *** of variable extent was documented in 93(74.4%) *** identified hepati

关键词： Endoscopy Liver disease Mortality Outcome Varices Variceal bleeding

Accuracy of virtual chromoendoscopy in differentiating gastric antral vascular ectasia from portal hypertensive gastropathy:A proof of concept study

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World Journal of Hepatology 2021年第12期13卷 2168-2178页

作者： Ahmad M Al-Taee Mark P Cubillan Alice Hinton Lindsay A Sobotka Alex S Befeler Christine Y Hachem hisham Hussan Division of Gastroenterology and Hepatology NYU Langone HealthNew YorkNY 10016United States Department of Internal Medicine Saint Louis UniversitySt LouisMO 63110United States Division of Biostatistics The Ohio State UniversityColumbusOH 43210United States Division of Gastroenterology Hepatologyand NutritionThe Ohio State UniversityColumbusOH 43210United States Division of Gastroenterology and Hepatology Saint Louis UniversitySt LouisMO 63110United States

BACKGROUND Accurate detection of gastric antral vascular ectasia(GAVE)is critical for proper management of cirrhosis-related gastrointestinal ***,endoscopic diagnosis of GAVE can be challenging when GAVE overlaps with severe portal hypertensive gastropathy(PHG).AIM To determine the added diagnostic value of virtual chromoendoscopy to high definition white light for real-time endoscopic diagnosis of GAVE and *** We developed an I-scan virtual chromoendoscopy criteria for diagnosis of GAVE and *** tested our criteria in a cross-sectional cohort of cirrhotic adults with GAVE and PHG when high-definition white light endoscopy(HDWLE)diagnosis was in *** then compared the accuracy of I-scan vs HDWLE alone to *** Twenty-three patients were included in this study(65.2%Caucasians and 60.9%males).Chronic hepatitis C was the predominant cause of cirrhosis(43.5%)and seven adults(30.4%)had confirmed GAVE on histology.I-scan had higher sensitivity(100%vs 85.7%)and specificity(75%vs 62.5%)in diagnosing GAVE compared to *** translates into a higher,albeit not statistically significant,accuracy of I-scan in detecting GAVE compared to HDWLE alone(82%vs 70%).I-scan was less likely to lead to an accurate diagnosis of GAVE in patients on dialysis(P<0.05)and in patients with elevated creatinine(P<0.05).Iscan had similar accuracy to HDWLE in detecting *** This pilot work supports that virtual chromoendoscopy may obviate the need for biopsies when the presence of GAVE is in *** studies are needed to assess the impact of virtual chromoendoscopy on success of endoscopic therapy for GAVE.

关键词： Portal hypertensive gastropathy Gastric antral vascular ectasia Virtual chromoendoscopy Endoscopy

Effect of Experimental Parameters on the Fabrication of Gold Nanoparticles via Laser Ablation

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Optics and Photonics Journal 2012年第2期2卷 73-84页

作者： hisham Imam Khaled Elsayed Mohamed A. Ahmed Rania Ramdan Materials Science Laboratory (1) Physics Department Faculty of Science Cairo University Giza Egypt National Institute of Laser Enhanced Sciences Cairo University Giza Egypt

In this study we report the effect of laser parameters such as laser energy, laser wavelength as well as focusing condition of laser beam on the size and morphology of the gold nanoparticles (GNPs) prepared in deionised water by pulsed laser ablation. The optimum conditions at which gold nanoparticles obtained with controllable average size have been reported as these parameters affected on the size, distribution and absorbance spectrum. Effect of energy was studied. The laser energy was divided into three regions (low, middle and high). A noteworthy change was observed at each region, as the average size changed from 5.9 nm at low energy to 14.4 nm at high energy and the gold nanoparticles reached a critical size of 8 nm at 100 mJ. The Effect of the wavelength on the particle size was examined at 1064 nm, 532 nm. It was found that, the optimum ablation laser wavelength was 1064 nm. Finally, significant results obtained when the effect of focusing conditions studied.

关键词： Laser Ablation Goldnanparticle

Malmquist indices of productivity growth for Islamic and conventional banks in Malaysia

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Journal of Modern Accounting and Auditing 2010年第11期6卷 1-10页

作者： Mohamed hisham Yahya Junaina Muhammad Abdul Razak Abdul Hadi Department of Accounting and Finance Universiti Putra Malaysia Selangor 43400 Malaysia International School of Entrepreneurship Universiti Kuala Lumpur Kuala Lumpur 50250 Malaysia

This paper studies the total factor productivity （TFP） of banks in Malaysia with the emphasis on comparing the relative productivities of Islamic and Conventional banks. The Malmquist index approach is used to decompose productivity growth into technical efficiency and technological change. The productivity growth is measured and decomposed into technical change and efficiency change. The efficiency change is further decomposed into pure efficiency change and scale efficiency. It is found that Islamic banks＇ productivity growth is limited by its lack of technological change compared to its conventional counterparts. Nonetheless, both types of banks are operating at the correct level in terms of scale or size.

关键词： Malmquist index DEA (data exchange agreement) Malaysia Islamic banks efficiency productivity

乙腈/碳酸氢钠溶液混合物电嫁接叔丁氧羟基-乙二胺

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电化学 2017年第2期23卷 130-140页

作者： hisham Hamzah Guy Denuault Philip Bartlett Aleksandra Pinczewska Jeremy Kilburn 南安普顿大学化学系英国南安普顿S0171AL 伦敦大学玛丽女王学院生物与化学科学学院英国伦敦E14NS 阿伯丁大学国王学院英国阿伯丁AB243FX

碳电极表面的伯胺电嫁接被广泛地应用于电极表面改性.本文通过比较发现,在比例为4:1的乙腈和0.1mol·L^(-1) 碳酸氢钠溶液混合物中,玻碳电极表面嫁接上叔丁氧羟基-乙二胺的效率比在单纯的乙腈中显著提高.有碳氢酸钠存在时,循环伏安测得... 详细信息

碳电极表面的伯胺电嫁接被广泛地应用于电极表面改性.本文通过比较发现,在比例为4:1的乙腈和0.1mol·L^(-1) 碳酸氢钠溶液混合物中,玻碳电极表面嫁接上叔丁氧羟基-乙二胺的效率比在单纯的乙腈中显著提高.有碳氢酸钠存在时,循环伏安测得电极的初始电流增大,表明电极表面胺嫁接层的形成更快速,从而使得电极表面更容易钝化,导致乙二胺-叔丁氧羟基膜层更严重地阻碍[Fe(CN)_6]^(3-)的反应.通过去除叔丁氧羟基保护层,在蒽醌-2-羧酸上接自由胺,可获得较高的蒽醌表面覆盖度.采用简单动力学模型模拟了电嫁接反应,结果表明,模拟得到的循环伏安曲线与实验测得的循环伏安曲线相一致.对比在单纯乙腈和乙腈/碳酸氢钠溶液混合物中模型拟合得到的参数值可知,胺自由基与碳表面的反应和在均相溶液中的反应相互竞争,更有利于乙腈与碳氢酸钠的表面反应.

关键词：电嫁接叔丁氧羟基-乙二胺胺氧化玻碳电极表面修饰

Miller Fisher Syndrome Induced by Chemotherapy in Known Case of Acute Lymphocytic Leukaemia: A Case Report

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Open Journal of Internal Medicine 2023年第2期13卷 114-119页

作者： Musab Eltayeb Musab Suliman Amna Hajalsayed hisham Alamin Alnour Alagib University Hospital Limerick Limerick Ireland National Ribat University Khartoum Sudan Sudan Medical Specialisation Board Khartoum Sudan National Ribat University Hospital Khartoum Sudan Karary University Khartoum Sudan Omdurman Military Hospital Khartoum Sudan

Introduction: Guillain-Barre Syndrome (GBS) is an acute-onset autoimmune-mediated neuropathy. Guillain-Barre Syndrome can be divided into three subtypes: acute inflammatory demyelinating poly-radiculo-neuropathy (AIDP), acute motor axonal neuropathy (AMAN), and acute motor sensory axonal neuropathy (AMSAN). About 20% of patients with GBS develop respiratory failure and require mechanical ventilation. We are presenting a variant of GBS (Miller Fisher Syndrome, or MFS), which has been confirmed by nerve conduction studies along with the triad of ophthalmoplegia, ataxia, and areflexia. The objective of this study is to present a rare case of chemotherapy-induced GBS. Important clinic findings: A 25-year-old gentleman with acute lymphocytic leukemia on active chemotherapy treatment presented with lower limb weakness. This weakness started after his fifth chemotherapy session. After the sixth chemotherapy, he developed complete paralysis of the left lower limb. Later, he developed right lower limb paralysis. He was also complaining of eye dryness and incomplete closure of both eyes. While inpatient, he developed upper-limb weakness. His chemotherapy consisted of MESNA, cyclophosphamide, doxorubicin, vincristine, cyorabine, and methotrexate. He had ptosis and ophthalmoplegia in the left abducent and right oculomotor regions. He had bilateral facial nerve palsy. He was hypotonic with power grade 3 in the upper limbs and grade 0 in the lower limbs with areflexia. His sensation was intact in the upper limbs but lost in the lower limbs. His planter reflexes were mute. Diagnoses and Management: Intravenous immunoglobulins were given for 5 days. A nerve conduction study showed severe demyelinating sensorimotor polyradoculoneuropathy with secondary axonal loss. The triad of ataxia, ophthalmoplegia, and areflexia was consistent with MFS. The patient improved over the course of the hospital stay but did not reach full recovery. Conclusion: Although GBS is uncommon, it must be take

关键词： Guillain-Barre Syndrome Variant Miller Fisher Syndrome Chemotherapy Acute Lymphocytic Leukaemia

汉语副词“就”的用法和教学研究——以阿拉伯语为母语的汉语学习者为对象

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汉语副词“就”的用法和教学研究——以阿拉伯语为母语的汉语学习...

作者： hisham MOUSAAD MOHAMMAD HARHASH（穆山）西北师范大学

学位级别：硕士

阿语和汉语分属于不同语系和语言类型,差别很大。在汉语和阿拉伯语中,虚词都占据着举足轻重的地位。汉语中的虚词,很难说是纯粹的语法成分,一般在当用的地方也可以不用,用与不用不会影响句子的语法完整性,甚至有些时候认为它们是多余的... 详细信息

阿语和汉语分属于不同语系和语言类型,差别很大。在汉语和阿拉伯语中,虚词都占据着举足轻重的地位。汉语中的虚词,很难说是纯粹的语法成分,一般在当用的地方也可以不用,用与不用不会影响句子的语法完整性,甚至有些时候认为它们是多余的。与汉语法相比,阿语行文中更经常使用虚词,虚词的作用非常重要,尤其是在行文中不能随便省略。本文的研究对象——汉语副词“就”属于这样的虚词。相应的,阿拉伯语的语法有严格的规则,如果不遵守这些规则,往往不符合表达规范,而汉语语法是强制中带有灵活性、灵活中又有强制性,所以以阿拉伯语为母语学习者在学习汉语时会出现副词“就”的种种偏误现象。本论文首先对汉语副词“就”的用法及义项和在阿拉伯语中相应的表达做出分类,并以阿拉伯语为母语的汉语学习者为对象,讨论“就”的不同用法和教学中应注意的问题,尤其讨论了“就”偏误的重要类型及其偏误情况分析和解决偏误的教学建议,为以阿拉伯语为母语的汉语学习和教学提供有益的帮助及参考。

关键词：副词“就” 以阿拉伯语为母语的汉语学习者偏误偏误分析教学建议