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The evolution of cancer genomic medicine in Japan and the role of the National Cancer Center Japan

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Cancer Biology & Medicine 2024年第1期21卷 29-44页

作者： Teruhiko Yoshida Yasushi Yatabe Ken Kato Genichiro Ishii Akinobu hamada hiroyuki Mano Kuniko Sunami Noboru Yamamoto Takashi Kohno Department of Genetic Medicine and Services National Cancer Center HospitalTokyo 104-0045Japan Department of Diagnostic Pathology National Cancer Center HospitalTokyo 104-0045Japan Clinical Research Support Offce Clinical Research Coordinating SectionBiobank Translational Research Support SectionNational Cancer Center HospitalTokyo 104-0045Japan Department of Pathology and Clinical Laboratories National Cancer Center Hospital EastChiba 277-8577Japan Division of Molecular Pharmacology National Cancer Center Research InstituteTokyo 104-0045Japan National Cancer Center Research Institute Tokyo 104-0045Japan Department of Laboratory Medicine National Cancer Center HospitalTokyo 104-0045Japan Department of Experimental Therapeutics National Cancer Center HospitalTokyo 104-0045Japan Division of Genome Biology National Cancer Center Research InstituteTokyo 104-0045Japan

The journey to implement cancer genomic medicine(CGM)in oncology practice began in the 1980s,which is considered the dawn of genetic and genomic cancer *** the time,a variety of activating oncogenic alterations and their functional significance were unveiled in cancer cells,which led to the development of molecular targeted therapies in the 2000s and *** CGM is still a relatively new discipline and it is difficult to predict to what extent CGM will benefit the diverse pool of cancer patients,the National Cancer Center(NCC)of Japan has already contributed considerably to CGM advancement for the conquest of *** back at these past achievements of the NCC,we predict that the future of CGM will involve the following:1)A biobank of paired cancerous and non-cancerous tissues and cells from various cancer types and stages will be *** quantity and quality of these samples will be compatible with omics *** biobank samples will be linked to longitudinal clinical information.2)New technologies,such as whole-genome sequencing and artificial intelligence,will be introduced and new bioresources for functional and pharmacologic analyses(e.g.,a patient-derived xenograft library)will be systematically deployed.3)Fast and bidirectional translational research(bench-to-bedside and bedside-to-bench)performed by basic researchers and clinical investigators,preferably working alongside each other at the same institution,will be implemented;4)Close collaborations between academia,industry,regulatory bodies,and funding agencies will be established.5)There will be an investment in the other branch of CGM,personalized preventive medicine,based on the individual's genetic predisposition to cancer.

关键词： Cancer genomic medicine biobank patient-derived xenograft multi-gene panel test whole genome sequencing

Reactive Compatibilization of Short-Fiber Reinforced Poly(lactic acid)Biocomposites

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Journal of Renewable Materials 2018年第6期6卷 573-583页

作者： Phornwalan Nanthananon Manus Seadan Sommai Pivsa-Art hiroyuki hamada Supakij Suttiruengwong Department of Materials Science and Engineering Faculty of Engineering and Industrial TechnologySilpakorn UniversityNakhon Pathom 73000Thailand Department of Physics Faculty of ScienceSilpakorn UniversityNakhon Pathom 73000Thailand Department of Material and Metallurgical Engineering Faculty of EngineeringRajamangala University of Technology ThanyaburiPathumthani 12110Thailand Kyoto Institute of Technology MatsugasakiSakyo-kuKyoto City 606-8585Japan

Poor interfacial adhesion between biobased thermoplastics and natural fibers is recognized as a major drawback for *** be applicable for the large-scale production,a simple method to handle is of *** work presented poly(lactic acid)(PLA)reinforced with short-fiber and three reactive agents including anhydride and epoxide groups were selected as *** were prepared by one-step meltmixing *** influence of reactive agents on mechanical,dynamic mechanical properties and morphology of PLA biocomposites were *** strength and storage modulus of PLA biocomposites incorporated with epoxide-based reactive agent was increased 13.9%and 37.4%compared to non-compatibilized PLA biocomposite,which was higher than adding anhydride-based reactive *** micrographs and Molau test exhibited an improvement of interfacial fiber-matrix adhesion in the PLA biocomposites incorporated with epoxide-based reactive *** revealed the chemical reaction between the fiber and PLA with the presence of epoxide-based reactive agents.

关键词： Biocomposite poly(lactic acid) Reactive agent in situ compatibilization interfacial adhesion

Reactive ion etching of poly(vinylidene fluoride-trifluoroethylene) copolymer for flexible piezoelectric devices

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Chinese Science Bulletin 2013年第18期58卷 2091-2094页

作者： JIANG YongGang SHIONO Syohei hamada hiroyuki FUJITA Takayuki ZHANG DeYuan MAENAKA Kazusuke School of Mechanical Engineering and Automation Beihang University Graduate School of Engineering University of Hyogo Maenaka Human-Sensing Fusion Project ERATOJapan Science and Technology Agency

A microfabrication process for poly(vinylidene fluoride-trifluoroethylene)(P(VDF-TrFE)) based flexible piezoelectric devices is proposed using heat controlled spin coating and reactive ion etching(RIE) *** etching of P(VDF-TrFE) in CF 4 +O2 plasma is found to be more effective than that using SF 6 +O2 or Ar+O2 feed gas with the same radiofrequency power and pressure conditions.A maximum etching rate of 400 nm/min is obtained using the CF 4 +O2 plasma with an oxygen concentration of 60% at an antenna power of 200 W and a platen power of 20 *** oxygen atoms and fluorine atoms are found to be responsible for the chemical etching *** of P(VDF-TrFE) with a feature size of 10 m is achieved and the patterned films show a high remanent polarization of 63.6mC/m 2.

关键词：反应离子蚀刻压电器件三氟乙烯 P(VDF-TrFE) 偏氟乙烯反应性共聚物 SF6气体

Genomic medicine in clinical practice:national genomic medicine program in Japan

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Cancer Biology & Medicine 2024年第1期21卷 4-9页

Cancer statistics in Japan Cancer is the most common cause of death in Japan based on Statistics 2021~*** statistics were first gathered,infectious diseases,such as tuberculosis,and cerebrovascular disease have been the main causes of death in *** surpassed cerebrovascular disease as the main cause of death in 1981,and the number of cancer deaths has *** 38,000 people died of cancer in *** National Cancer Center(NCC)reported that the 5-year survival rate for patients with cancer was improving(62%for males and 66.9%for females)in a population-based cancer registry.

关键词： Cancer cancer death

Withdraw: Improvement on Adhesion Properties of Insert Injection Molding Composites: Effect of Inserted Parts, Adhesive Lengths and Injection Conditions

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Open Journal of Composite Materials 2017年第4期7卷 197-206页

作者： Badin Pinpathomrat hiroyuki hamada Department of advanced Fibro-Science Kyoto Institute of Technology Kyoto Japan

Short Retraction Notice The paper does not meet the standards of "Open Journal of Composite Materials". This article has been retracted to straighten the academic record. In making this decision the Editorial Board follows COPE's Retraction Guidelines. The aim is to promote the circulation of scientific research by offering an ideal research publication platform with due consideration of internationally accepted standards on publication ethics. The Editorial Board would like to extend its sincere apologies for any inconvenience this retraction may have caused. Editor guiding this retraction: Prof. Chengye Fan (EiC of OJCM) The full retraction notice in PDF is preceding the original paper, which is marked "Withdraw".

关键词： Insert-Injection Molding Adhesive Length Adhesive Normal/Shear Load Injection Molding Condition Polypropylene Glass Fiber Composite

Erratum to “Improvement on Adhesion Properties of Insert Injection Molding Composites: Effect of Inserted Parts, Adhesive Lengths and Injection Conditions” [Open Journal of Composite Materials (2017) 197-206]

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Open Journal of Composite Materials 2019年第2期9卷 197-198页

作者： Badin Pinpathomrat hiroyuki hamada Department of Advanced Fibro-Science Kyoto Institute of TechnologyKyotoJapan

The original online version of this article (Pinpathomrat, B. and hamada, H. (2017) Improvement on Adhesion Properties of Insert Injection Molding Composites: Effect of Inserted Parts, Adhesive Lengths and Injection Conditions. Open Journal of Composite Materials, 7, 197-206. https://***/10.4236/ojcm.2017.74013) unfortunately contains several mistakes in Figures 1-4, and Figure 6.

关键词： Erratum

An Effective Numerical Calculation Method for Multi-Time-Scale Mathematical Models in Systems Biology

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Applied Mathematics 2016年第17期7卷 2241-2268页

作者： Yohei Motomura hiroyuki hamada Masahiro Okamoto Graduate School of Systems Life Sciences Kyushu University Fukuoka Japan Synthetic Systems Biology Research Center Kyushu University Fukuoka Japan

The improvements of high-throughput experimental devices such as microarray and mass spectrometry have allowed an effective acquisition of biological comprehensive data which include genome, transcriptome, proteome, and metabolome (multi-layered omics data). In Systems Biology, we try to elucidate various dynamical characteristics of biological functions with applying the omics data to detailed mathematical model based on the central dogma. However, such mathematical models possess multi-time-scale properties which are often accompanied by time-scale differences seen among biological layers. The differences cause time stiff problem, and have a grave influence on numerical calculation stability. In the present conventional method, the time stiff problem remained because the calculation of all layers was implemented by adaptive time step sizes of the smallest time-scale layer to ensure stability and maintain calculation accuracy. In this paper, we designed and developed an effective numerical calculation method to improve the time stiff problem. This method consisted of ahead, backward, and cumulative algorithms. Both ahead and cumulative algorithms enhanced calculation efficiency of numerical calculations via adjustments of step sizes of each layer, and reduced the number of numerical calculations required for multi-time-scale models with the time stiff problem. Backward algorithm ensured calculation accuracy in the multi-time-scale models. In case studies which were focused on three layers system with 60 times difference in time-scale order in between layers, a proposed method had almost the same calculation accuracy compared with the conventional method in spite of a reduction of the total amount of the number of numerical calculations. Accordingly, the proposed method is useful in a numerical analysis of multi-time-scale models with time stiff problem.

关键词： Finite Difference Method Stiff Equation Multi-Time-Scale Systems Biology Mathematical Analysis

Inference of General Mass Action-Based State Equations for Oscillatory Biochemical Reaction Systems Using <i>k</i>-Step Genetic Programming

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Applied Mathematics 2019年第8期10卷 627-645页

作者： Tatsuya Sekiguchi hiroyuki hamada Masahiro Okamoto Department of Life Sciences and Informatics Faculty of Engineering Maebashi Institute of Technology Maebashi Japan Synthetic Systems Biology Research Center Kyushu University Fukuoka Japan Graduate School of Systems Life Sciences Kyushu University Fukuoka Japan

Systems biology requires the development of algorithms that use omics data to infer interaction networks among biomolecules working within an organism. One major type of evolutionary algorithm, genetic programming (GP), is useful for its high heuristic ability as a search method for obtaining suitable solutions expressed as tree structures. However, because GP determines the values of parameters such as coefficients by random values, it is difficult to apply in the inference of state equations that describe oscillatory biochemical reaction systems with high nonlinearity. Accordingly, in this study, we propose a new GP procedure called “k-step GP” intended for inferring the state equations of oscillatory biochemical reaction systems. The k-step GP procedure consists of two algorithms: 1) Parameter optimization using the modified Powell method—after genetic operations such as crossover and mutation, the values of parameters such as coefficients are optimized by applying the modified Powell method with secondary convergence. 2) GP using divided learning data—to improve the inference efficiency, imposes perturbations through the addition of learning data at various intervals and adaptations to these changes result in state equations with higher fitness. We are confident that k-step GP is an algorithm that is particularly well suited to inferring state equations for oscillatory biochemical reaction systems and contributes to solving inverse problems in systems biology.

关键词： Systems Biology Genetic Programming Inverse Problems Oscillatory Biochemical Reaction Systems GMA-Based State Equations

Effect of Needle Punching Process on a Chopped Strand Mat Composite with an Open Hole

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Open Journal of Composite Materials 2018年第3期8卷 110-123页

作者： Daiki Ichikawa hiroyuki hamada Akio Ohtani Graduate School of Kyoto Institute of Technology Kyoto Japan Future-Applied Conventional Technology Center Kyoto Institute of Technology Kyoto Japan Faculty of Fiber Science and Engineering Kyoto Institute of Technology Kyoto Japan

The easiest and most reliable joining method is the mechanical joint with a bolt and nut or rivet. However, in the case of composite laminates, mechanical joint properties decrease because of lower interlaminar properties compared to in-plane properties around hole.?This study investigated needle punching process with the aim of improving the mechanical properties in the thickness direction of fiber-reinforced plastic composite laminates with an open hole. Needle punching process was applied to glass fiber chopped strand matused as the reinforcement for the composite laminates. Open-hole tensile tests and observations of end cross-sections after the tests were performed. The tensile properties and fracture mechanism of the specimens subjected to needle punching process were investigated. In addition, characteristic distance (a parameter for evaluating resistance to fracture in open-hole tensile test specimens) was also calculated to examine the effects of needle punching process conditions on fracture toughness. Tensile strength was improved by more than 15% by needle punching process. However, when a certain needle punching density was exceeded, the mechanical properties worsened. In addition, characteristic distance increased with increasing needle punching density. Thus, these results suggest that there is an optimal needle punching density with respect to strength and characteristic distance.

关键词： Fiber-Reinforced Plastic Needle Punch Chopped Strand Mat Open Hole Characteristic Distance