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Droplet morphology analysis of drop-on-demand inkjet printing

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China Foundry 2024年第1期21卷 20-28页

作者： Hu-xiang Xia Takechi Kensuke tajima Shin Kawamura Yoshiumi Qing-yan Xu Key Laboratory for Advanced Materials Processing Technology(MOE) School of Materials Science and EngineeringTsinghua UniversityBeijing 100084China Toyota Central R&D Labs. Inc.41-1 Yokomichi NagakuteAichi 480-1192Japan Frontier Research Center Toyota Motor Corporation1 Toyota-ChoToyotaAichi 471-8572Japan

As an accurate 2D/3D fabrication tool,inkjet printing technology has great potential in preparation of micro electronic *** morphology of droplets produced by the inkjet printer has a great impact on the accuracy of *** this study,the drop-on-demand(DoD)inkjet simulation model was established,and the accuracy of the simulation model was verified by corresponding *** simulation result shows that the velocity of the droplet front and tail,as well as the time to disconnect from the nozzle is mainly affected by density(ρ),viscosity(μ)and surface tension(σ)of *** the liquid filament is about to disconnect from the nozzle,the filament length and filament front velocity are found to have a linear correlation withσ/ρμand ln(ρ/(μσ1/2)).

关键词： microdevice fabrication inkjet printing droplet morphology modeling and simulation

Immunotherapy for esophageal cancer:Where are we now and where can we go

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World Journal of Gastroenterology 2024年第19期30卷 2496-2501页

作者： Yoshiaki Shoji Kazuo Koyanagi Kohei Kanamori Kohei tajima Mika Ogimi Yamato Ninomiya Miho Yamamoto Akihito Kazuno Kazuhito Nabeshima Takayuki Nishi Masaki Mori Department of Gastroenterological Surgery Tokai University School of MedicineKanagawa 259-1193Japan

Immune checkpoint inhibitor therapy has dramatically improved patient prognosis,and thereby transformed the treatment in various cancer types including esophageal squamous cell carcinoma(ESCC)in the past *** antibodies that selectively inhibit programmed cell death-1(PD-1)activity has now become standard of care in the treatment of ESCC in metastatic settings,and has a high expectation to provide clinical benefit during perioperative ***,anti-cytotoxic T-lymphocyte–associated protein 4(CTLA-4)monoclonal antibody has also been approved in the treatment of recurrent/metastatic ESCC in combination with anti-PD-1 *** understanding of the existing evidence of immune-based treatments for ESCC,as well as recent clinical trials on various combinations with chemotherapy for different clinical settings including neoadjuvant,adjuvant,and metastatic diseases,may provide future prospects of ESCC treatment for better patient outcomes.

关键词： Esophageal cancer Immunotherapy Immune checkpoint inhibitor Programmed cell death-1 Anti-cytotoxic T-lymphocyte-associated protein 4 Neoadjuvant therapy Adjuvant therapy Clinical trials Combination therapy

Coprecipitation mechanisms of Zn by birnessite formation and its mineralogy under neutral pH conditions

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Journal of Environmental Sciences 2022年第11期34卷 136-147页

作者： Shota tajima Shigeshi Fuchida Chiharu Tokoro Graduate School of Creative Science and Engineering Waseda University3-4-1 OkuboShinjuku-kuTokyo 169-8555Japan Faculty of Science and Engineering Waseda University3-4-1 OkuboShinjuku-kuTokyo 169-8555Japan Faculty of Engineering The University of Tokyo7-3-1 HongoBunkyo-kuTokyo 113-8656Japan

Birnessite(δ-Mn(IV)O_(2))is a great manganese(Mn)adsorbent for dissolved divalent *** this study,we investigated the coprecipitation mechanism of δ-MnO_(2) in the presence of Zn(II)and an oxidizing agent(sodium hypochlorite)under two neutral pH values(6.0 and 7.5).Themineralogical characteristics and Zn–Mn mixed products were compared with simple surface complexation by adsorption modeling and structural *** coprecipitation experiments at different Zn/Mn molar ratios showed a Langmuir-type isotherm at pH 6.0,which was similar to the result of adsorption experiments at pH 6.0 and 7.5.X-ray diffraction and X-ray absorption fine structure analysis revealed triple-corner-sharing innersphere complexation on the vacant sites was the dominant Zn sorption mechanism on δ-MnO_(2) under these experimental conditions.A coprecipitation experiment at pH 6.0 produced some hetaerolite(ZnMn(Ⅲ)_(2)O_(4))and manganite(γ-Mn(Ⅲ)OOH),but only at low Zn/Mn molar ratios(<1).These secondary precipitates disappeared because of crystal dissolution at higher Zn/Mn molar ratios because they were thermodynamically ***(ZnMn(IV)_(3)O_(7)•2H_(2)O)was produced in the coprecipitation experiment at pH 7.5 with a high Zn/Mn molar ratio of *** resulted in a Brunauer–Emmett–Teller(BET)-type sorption isotherm,in which formation was explained by transformation of the crystalline structure ofδ-MnO_(2) to a tunnel *** experiments demonstrate that abiotic coprecipitation reactions can induce Zn–Mn compound formation on theδ-MnO_(2) surface,and that the pH is an important controlling factor for the crystalline structures and thermodynamic stabilities.

关键词： δ-MnO2 Zinc removal Surface complexation X-ray absorption fine structure

Comment on“Perihilar cholangiocarcinoma-novel benchmark values for surgical and oncological outcomes from 24 expert centers”

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Hepatobiliary Surgery and Nutrition 2022年第2期11卷 314-316页

作者： Yasunari Kawabata Yoshitsugu tajima Department of Digestive and General Surgery Shimane University Faculty of MedicineIzumoShimaneJapan

Perihilar cholangiocarcinoma(PHC)is an aggressive malignancy of the biliary tracts with a dismal *** the primary goal of surgery for PHC is complete tumor removal with negative resection margins and regional lymphadenectomy,surgery for PHC with curative intent remains a challenge for surgeons because it involves complex surgical procedures such as bile duct resection,major hepatectomy,and/or vascular *** intensive procedures are often associated with postoperative complications,including severe morbidity and 30-day mortality with incidences of 40%and 5%,respectively(1).From the perspective of surgical and oncological safety,the standardization of aggressive surgical approaches and the establishment of standardized benchmark values that secure the best achievable outcomes are warranted in the treatment of patients with PHC.

关键词： surgical surgery mortality

Control of Snow Falling Flow around NACA0015 Blade using a Plasma Electrode with Weather Resistant Design

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Journal of Thermal Science 2022年第1期31卷 72-81页

作者： MATSUDA Hisashi CHIBA Takahiro YAGAMI Masaki tajima Yusuke WATANABE Nobuyoshi SATO Hideaki TAKEYAMA Masafumi Hokkaido University of Science Hokkaido 006-8585Japan Asahi Rubber Inc. Saitama 330-0801Japan

The plasma actuation (PA) effect on the snow falling flow was investigated using a plasma electrode with weather resistant design and the natural snow wind facility of the Hokkaido University of Science. NACA0015 test blade with chord length c of 300 mm was used. Wind tunnel tests were carried out under the angle of the attack of the blade was fixed at 15 degrees, and the main flow velocity is U=5 m/s. PIV (Particle image velocimetry) measurements were conducted on various PA conditions using natural dry snowflakes as a tracer. When the actuator was driven under the condition of the fundamental frequency of F=50 kHz, and the pulsed modulated frequency f of fc/U=1 and Duty ratio (Ratio of plasma ON time to pulse duration time) =1%, movement of snowflakes was controlled the most effectively tested. It was clarified that the fundamental frequency of PA also affects the control of snow flow. Under snowfall conditions, the weather resistant designed plasma electrode has suffered no damage and operated successfully.

关键词： plasma actuator weather resistant design snow falling flow control experiment PIV

Successful resection of colonic metastasis of lung cancer after colonic stent placement:A case report and review of the literature

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World Journal of Gastrointestinal Surgery 2023年第7期15卷 1549-1558页

作者： Yoko Nakayama Minekazu Yamaguchi Keisuke Inoue Shunichi Hamaguchi Yoshitsugu tajima Department of Surgery Oda Municipal HospitalOda 694-0063ShimaneJapan Department of General Medicine Shimane University Faculty of MedicineIzumo 693-8501Japan Department of Digestive and General Surgery Shimane University Faculty of MedicineIzumo 693-8501Japan

BACKGROUND Lung cancer is the leading cause of cancer deaths *** lung cancer can metastasize to various organs such as the liver,lymph nodes,adrenal gland,bone,and brain,metastases to the digestive organs,especially the colon,are *** SUMMARY An 83-year-old man diagnosed with lung cancer received radiation and chemoimmunotherapy,resulting in a complete clinical *** year after the initial lung cancer diagnosis,the patient presented with obstructive ileus caused by a tumor in the descending *** elective left hemicolectomy was successfully performed after the endoscopic placement of a self-expandable metallic stent(SEMS).Pathologically,the tumor of the descending colon was diagnosed as lung cancer *** postoperative course was uneventful,and the patient is in good condition 13 mo after surgery,with no signs of *** previous 23 cases of surgical resection of colonic metastasis from lung cancer were reviewed using PubMed to characterize their clinicopathological features and *** SEMS is useful for obstructive colonic metastasis as a bridge to surgery to avoid emergency operations.

关键词： Colonic metastasis Colonic obstruction Lung cancer Self-expandable metallic stent Surgical resection Case report

Plastid KEA-type cation/H+ antiporters are required for vacuolar protein trafficking in Arabidopsis

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植物学报:英文版 2023年第9期65卷 2157-2174页

作者： Xiao Zhang Lu Wang Ting Pan Xuexia Wu Jinbo Shen Liwen Jiang Hiromi tajima Eduardo Blumwald Quan-Sheng Qiu MOE Key Laboratory of Cell Activities and Stress Adaptations School of Life SciencesLanzhou UniversityLanzhou 73000China Academy of Plateau Science and Sustainability School of Life SciencesQinghai Normal UniversityXining 810000China College of Coastal Agricultural Sciences Guangdong Ocean UniversityZhanjiang 524088China State Key Laboratory of Herbage Improvement and Grassland Agro‐ecosystems Lanzhou UniversityLanzhou 730000China State Key Laboratory of Subtropical Silviculture Zhejiang A&F UniversityHangzhou 311300China School of Life Sciences Centre for Cell&Developmental Biology and State Key Laboratory of AgrobiotechnologyThe Chinese University of Hong KongHong KongChina Department of Plant Sciences University of CaliforniaDavisCA 95616USA

Arabidopsis plastid antiporters KEA1 and KEA2are critical for plastid development, photosynthetic efficiency, and plant ***, we show that KEA1 and KEA2 are involved in vacuolar protein trafficking. Genetic analyses found that the kea1 kea2 mutants had short siliques, small seeds, and short seedlings. Molecular and biochemical assays showed that seed storage proteins were missorted out of the cell and the precursor proteins were accumulated in kea1 kea2. Protein storage vacuoles(PSVs) were smaller in kea1 kea2. Further analyses showed that endosomal trafficking in kea1 kea2 was compromised. Vacuolar sorting receptor 1(VSR1) subcellular localizations, VSR–cargo interactions, and p24 distribution on the endoplasmic reticulum(ER) and Golgi apparatus were affected in kea1 kea2. Moreover, plastid stromule growth was reduced and plastid association with the endomembrane compartments was disrupted in kea1 kea2. Stromule growth was regulated by the cellular pH and K+homeostasis maintained by KEA1 and KEA2. The organellar pH along the trafficking pathway was altered in kea1 kea2. Overall, KEA1 and KEA2 regulate vacuolar trafficking by controlling the function of plastid stromules via adjusting pH and K+homeostasis.

关键词： Arabidopsis K^(+)homeostasis plastid antiporters plastid stromule pH protein trafficking

Brachiocephalic to left brachial vein thrombotic vasculitis accompanying mediastinal pancreatic fistula:A case report

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World Journal of Clinical Cases 2022年第32期10卷 11882-11888页

作者： Reiji Kokubo Daisuke Yunaiyama Yu tajima Natsumi Kugai Mitsuru Okubo Kazuhiro Saito Takayoshi Tsuchiya Takao Itoi Department of Radiology Tokyo Medical UniversityTokyo 160-0023Japan Department of Gastroenterology and Hepatology Tokyo Medical UniversityTokyo 160-0023Japan

BACKGROUND Pancreatitis is a severe inflammatory pancreatic disease commonly due to bile duct stones or excessive alcohol usage,with clinical manifestations of abdominal pain,nausea,fever,and fluid *** persons with less symptomatic pancreatitis are quite ***,we report a case of a patient with an undetermined onset of pancreatitis mimicking left arm cellulitis due to thrombotic vasculitis of the brachiocephalic *** SUMMARY A 50-year-old woman visited our hospital for tenderness in the left arm over several recent *** was diagnosed with cellulitis on the left arm due to left elbow *** antibiotics administration did not improve symptoms and laboratory data worsened;thus,chest and abdominal computed tomography(CT)was *** demonstrated pancreatitis with pseudocyst around the pancreas extending to the *** vasculitis of the brachiocephalic to left brachial vein was observed,which could be the cause of left elbow pain.A pancreatic fistula was found in the head of the pancreas by endoscopic retrograde cholangiopancreatography,so a pancreatic cyst drainage tube via the duodenum was placed in the *** content culture was positive for Escherichia coli *** symptoms,imaging findings,and inflammatory reactions resolved gradually after starting therapeutic *** mediastinal pancreatic pseudocysts shrunk,and the venous thrombi remained but *** The case of a patient with pancreatitis with an undetermined onset that mimics left arm cellulitis is *** vein thrombosis should be kept in mind when treating patients with severe inflammatory disease.

关键词： Pancreatic fistula Thrombotic vasculitis Pancreatitis Computed tomography Case report

Conjecture with water and rheological control for subducting slab in the mantle transition zone

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Geoscience Frontiers 2015年第1期6卷 79-93页

作者： Fumiko tajima Masaki Yoshida Eiji Ohtani University of California at Irvine 4164 Frederick Reines Hall4IrvineCA 92697USA Institute for Research on Earth Evolution(IFREE) Japan Agency for Marine-Earth Science and Technology(JAMSTEC) Department of Earth and Materials Science Graduate School of ScienceTohoku University

Seismic observations have shown structural variation near the base of the mantle transition zone （MTZ） where subducted cold slabs, as visualized with high seismic speed anomalies （HSSAs）, flatten to form stagnant slabs or sink further into the lower mantle. The different slab behaviors were also accompanied by variation of the ＂660 kin＂ discontinuity depths and low viscosity layers （LVLs） beneath the MTZ that are suggested by geoid inversion studies. We address that deep water transport by subducted slabs and dehydration from hydrous slabs could affect the physical properties of mantle minerals and govern slab dynamics. A systematic series of three-dimensional numerical simulation has been conducted to examine the effects of viscosity reduction or contrast between slab materials on slab behaviors near the base of the MTZ. We found that the viscosity reduction of subducted crustal material leads to a sepa- ration of crustal material from the slab main body and its transient stagnation in the MTZ. The once trapped crustal materials in the MTZ eventually sink into the lower mantle within 20 30 My from the start of the plate subduction. The results suggest crustal material recycle in the whole mantle that is consistent with evidence from mantle geochemistry as opposed to a two-layer mantle convection model. Because of the smaller capacity of water content in lower mantle minerals than in MTZ minerals, dehydration should occur at the phase transformation depth, ~660 kin. The variation of the disconti- nuity depths and highly localized low seismic speed anomaly （LSSA） zones observed from seismic P waveforms in a relatively high frequency band （~ 1 Hz） support the hypothesis of dehydration from hydrous slabs at the phase boundary. The LSSAs which correspond to dehydration induced fluids are likely to be very local, given very small hydrogen （H＋） diffusivity associated with subducted slabs. The image of such local LSSA zones embedded in HSSAs may not be necessarily captured

关键词： Stagnant slab Discontinuity depth variation Deep water transport by subduction Crustal separation Crustal recycling