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Early thrombomodulin-α administration outcome for acute disseminated intravascular coagulopathy in gastrointestinal surgery

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World Journal of Gastroenterology 2017年第5期23卷 891-898页

作者： hirotaka Konishi Kazuma Okamoto Katsutoshi Shoda Tomohiro Arita Toshiyuki Kosuga Ryo Morimura Shuhei Komatsu Yasutoshi Murayama Atsushi Shiozaki Yoshiaki Kuriu Hisashi Ikoma Masayoshi Nakanishi Daisuke Ichikawa Hitoshi Fujiwara Eigo Otsuji Division of Digestive Surgery Department of SurgeryKyoto Prefectural University of MedicineKajii-choKyoto city 6028566Japan

AIMTo investigate the efficacy of thrombomodulin (TM)-α for treatment of disseminated intravascular coagulopathy (DIC) in the field of gastrointestinal ***-six peri-operative DIC patients in the field of gastrointestinal surgery who were treated with TM-α were retrospectively investigated. The relationships between patient demographics and the efficacy of TM-α were examined. Analysis of survival at 28 d was also performed on some parameters by means of the Kaplan-Meier method. Relationships between the initiation of TM-α and patient demographics were also *** formation or bacteremia was the most frequent cause of DIC (33%), followed by digestive tract perforation (31%). Twenty-six patients developed DIC after surgery, frequently within 1 wk (81%). TM-α was most often administered within 1 d of the DIC diagnosis (72%) and was continued for more than 3 d (64%). Although bleeding tendency was observed in 7 patients (19%), a hemostatic procedure was not needed. DIC scores, systemic inflammatory response syndrome (SIRS) scores, quick-sequential organ failure assessment (qSOFA) scores, platelet counts, and prothrombin time ratios significantly improved after 1 wk (P < 0.05, for all). The overall survival rate at 28 d was 71%. The duration of TM-α administration (≥ 4 , ≤ 6) and improvements in DIC-associated scores (DIC, SIRS and qSOFA) at 1 wk were significantly better prognostic factors for 28-d survival (P < 0.05, for all). TM-α was administered significantly earlier to patients with severe clinical symptoms, such as high qSOFA scores, sepsis, shock or high lactate values (P < 0.05, for all).CONCLUSIONEarly administration of TM-α and improvements in each parameter were essential for treatment of DIC. The diagnosis of patients with mild symptoms requires further study.

关键词： Quick-sequential organ failure assessment Thrombomodulin-α Gastrointestinal surgery Systemic inflammatory response syndrome Acute disseminated intravascular coagulopathy

Laparoscopic Choledochoduodenostomy for Biliary Alleviation

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Surgical Science 2017年第2期8卷 65-72页

作者： hirotaka Okamoto Suguru Maruyama Kazunori Takahashi Kenji Kawashima Toshio Fukasawa Hideki Fujii Department of Surgery Tsuru Municipal Hospital Tsuru Japan Gastrointestinal & Breast Endocrine Surgery Faculty of Medicine University of Yamanashi Yamanashi Japan

Choledochoduodenostomy (CDD) was very useful alternatives for treatment for patients with common bile duct (CBD) stones, especially recurrent stones, giant stones with choledochal dilatation, and difficult or failed cases by endoscopic treatment. Furthermore, CDD was also applied to biliary bypass by malignant obstruction. In these days, minimal invasive laparoscopic approach is adapted in these disorders. We have conducted to perform a laparoscopic CDD for biliary alleviation for patients with endoscopic management of difficult CBD stone with choledochal dilatation. A side-to-side CDD was created intra-corporeally using water-tight running absorbable suture by handmade 4-0 monofilament with double side needles, starting from the right side of choledochus, and continued along posterior wall until the left side of the choledochus followed by anterior-wall anastomosis as the same manner. Five patients were treated successfully by this laparoscopic procedure and remained well without bile leakage and reflux cholangitis for the short-term follow-up. The median operative time and intracorporeally anastomosis time were 182 (167 - 209) min and 33 (30 - 38) min, respectively. Median blood loss was 32 (little-90) ml, median hospital stay was 7 (5 - 14) days, and median follow-up time was 18 months. Although this series was relatively small, this laparoscopic technique is feasible and safe for biliary alleviation, especially for endoscopic management of difficult or failed CBD stones, and would also potentially adapt to biliary bypass by malignant obstruction.

关键词： Laparoscopic Choledochoduodenostomy Biliary Alleviation Endoscopic Management Difficult Choledocholithiasis

A Report on Landscape Investigations in Graphic Science Education Aiming at Applying to Town Planning

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A Report on Landscape Investigations in Graphic Science Educ...

Endoventricular Spiral Plication for Ischemic Dilated Cardiomyopathy

第六届中日图学教育研讨会

作者： Akira ONO Haruki MAKIO hirotaka SUZUKI Shizekazu SUGIYAMA Department of Urban Engineering Graduate School of Engineering Osaka City University Osaka Japan Department of Urban Engineering Graduate School of Engineering Osaka City University Osaka Japan Department of Urban Engineering Graduate School of Engineering Osaka City University Osaka Japan Department of Urban Engineering Graduate School of Engineering Osaka City University Osaka Japan

＜正＞ They have, for a long time, cried for town planning with the initiative by residents in order to make landscapes in harmony with existing areas. It needs to reassess local resources. In this research, we selected the Okamoto, district in the Higashinada ward, in the Kobe city where there are regulations for landscaping. The purpose of these regulations was to create it in harmony with relating to town planning with the initiative by residents. We conducted a landscape investigation using the caption evaluation method. In mis sequence, all the participants were students and this was a part of graphic science education. Furthermore, we reported the results of the investigation at a workshop of "Okamoto the Beautiful Town" council, which was followed by a discussion to re-appraise local resources. We explored further into the possibilities of the caption evaluation method in such a sequence.

关键词： Resident-initiated Town Planning Workshops for Town Planning the Caption Evaluation Method

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Open Journal of Thoracic Surgery 2019年第1期9卷 1-7页

作者： Kayo Sugiyama Yasuhiro Futamura hirotaka Watanuki Masaho Okada Genri Tagami Katsuhiko Matsuyama Department of Cardiac Surgery Aichi Medical University Hospital Nagakute Japan

Surgical ventricular restoration (SVR) procedures have been developed;however, their long-term effectiveness remains controversial. Although a series of endoventricular spiral plication (ESP) has been rarely reported and its long prognosis is still unknown;this method has a unique concept of left ventricular (LV) restoration without artificial patch materials. Here, we describe the case of a patient with ischemic cardiomyopathy and ischemic mitral regurgitation who successfully underwent ESP, mitral valve repair, and coronary artery bypass grafting. ESP was effective in papillary muscle approximation for avoiding heart failure;however, the noted improvement of LV wall thickening might be temporary.

关键词： Endoventricular Spiral Plication Ischemic Cardiomyopathy Surgical Ventricular Restoration Ischemic Mitral Regurgitation

Optimal duration of the early and late recurrence of hepatocellular carcinoma after hepatectomy

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World Journal of Gastroenterology 2015年第4期21卷 1207-1215页

作者： Yusuke Yamamoto Hisashi Ikoma Ryo Morimura hirotaka Konishi Yasutoshi Murayama Shuhei Komatsu Atsushi Shiozaki Yoshiaki Kuriu Takeshi Kubota Masayoshi Nakanishi Daisuke Ichikawa Hitoshi Fujiwara Kazuma Okamoto Chouhei Sakakura Toshiya Ochiai Eigo Otsuji Division of Digestive Surgery Department of SurgeryKyoto Prefectural University of MedicineKyoto 6028566Japan Department of Surgery North Medical CenterKyoto Prefectural University of MedicineKyoto 6028566Japan

AIM: To determine the best cut-off value between the early and late recurrence periods after the initial recurrence of hepatocellular carcinoma(HCC).METHODS: The clinical records of 404 patients who underwent macroscopic curative hepatectomy for HCC between 1980 and 2010 were retrospectively examined. We divided the 252 patients experienced a recurrence of HCC into two groups, the early and late recurrence groups using the "minimum P-value" approach. Factors for early recurrence were investigated using all 404 patients, and factors related to late recurrence were investigated in the patients who were confirmed to be recurrence free at the end of the early recurrence ***: For the 252 patients who experienced a recurrence, the optimal cut-off value for differentiating early and late recurrence based on the overall survival after initial recurrence was 17 mo(5-year overall survival after initial recurrence: 15.4% vs 36.3%, P = 0.000018). Cox proportional hazard analysis identified early recurrence(P = 0.003) as one of the independent prognostic factors associated with overall survival after initial recurrence. A logistic regression model showed that an alpha-fetoprotein level > 100 ng/m L(P < 0.001), multiple HCC(P < 0.001), serosal invasion(P = 0.031), and microvascular invasion(P = 0.012) were independent factors associated with early recurrence, whereas the only independent factor related to late recurrence was liver cirrhosis(P = 0.002).CONCLUSION: Seventeen months after hepatectomy is a useful cut-off value between early and late recurrence of HCC based on the prognosis and different etiologies.

关键词： Early recurrence Late recurrence Hepatocellular ca

High-speed playback of spatiotemporal division multiplexing holographic 3D video stored in a solid-state drive using a digital micromirror device

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Chinese Optics Letters 2021年第9期19卷 121-126页

作者： Kohei Suzuki Minori Tao Yuki Maeda hirotaka Nakayama Ren Noguchi Minoru Oikawa Yuichiro Mori Takashi Kakue Tomoyoshi Shimobaba Tomoyoshi Ito Naoki Takada Graduate School of Integrated Arts and Sciences Kochi UniversityKochi 780-8520Japan Faculty of Science Kochi UniversityKochi 780-8520Japan National Astronomical Observatory of Japan Tokyo 181-8588Japan Research and Education Faculty Kochi UniversityKochi 780-8520Japan Graduate School of Engineering Chiba UniversityChiba 263-8522Japan

We propose a high-speed playback method for the spatiotemporal division multiplexing electroholographic three-dimensional(3D)video stored in a solid-state drive(SSD)using a digital micromirror *** spatiotemporal division multiplexing electroholography prevents deterioration in the reconstructed 3D video from a 3D object comprising many object *** the proposed method,the stored data is remarkably reduced using the packing technique,and the computer-generated holograms are played back at high ***,we successfully reconstructed a clear 3D video of a 3D object comprising approximately 1,100,000 points at 60 frames per second by reducing the reading time of the stored data from an SSD.

关键词： spatiotemporal division multiplexing electroholography digital micromirror device computer-generated hologram high-speed playback

Anoctamin 5 regulates the cell cycle and affects prognosis in gastric cancer

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World Journal of Gastroenterology 2022年第32期28卷 4649-4667页

作者： Tomoyuki Fukami Atsushi Shiozaki Toshiyuki Kosuga Michihiro Kudou Hiroki Shimizu Takuma Ohashi Tomohiro Arita hirotaka Konishi Shuhei Komatsu Takeshi Kubota Hitoshi Fujiwara Kazuma Okamoto Mitsuo Kishimoto Yukiko Morinaga Eiichi Konishi Eigo Otsuji Division of Digestive Surgery Department of SurgeryKyoto Prefectural University of MedicineKyoto 602-8566Japan Department of Pathology Kyoto City HospitalKyoto 604-8845Japan Department of Pathology Kyoto Prefectural University of MedicineKyoto 602-8566Japan

BACKGROUND Anoctamin 5(ANO5)/transmembrane protein 16E belongs to the ANO/transmembrane protein 16 anion channel *** comprise a family of plasma membrane proteins that mediate ion transport and phospholipid scrambling and regulate other membrane proteins in numerous cell *** studies have elucidated the roles and mechanisms of ANO5 activation in various cancer ***,it remains unclear whether ANO5 acts as a plasma membrane chloride channel,and its expression and functions in gastric cancer(GC)have not been *** To examine the role of ANO5 in the regulation of tumor progression and clinicopathological significance of its expression in *** Knockdown experiments using ANO5 small interfering RNA were conducted in human GC cell lines,and changes in cell proliferation,cell cycle progression,apoptosis,and cellular movement were *** gene expression profiles of GC cells were investigated following ANO5 silencing by microarray *** staining of ANO5 was performed on 195 primary tumor samples obtained from patients with GC who underwent curative gastrectomy between 2011 and 2013 at our *** Reverse transcription-quantitative polymerase chain reaction(PCR)and western blotting demonstrated high ANO5 mRNA and protein expression,respectively,in NUGC4 and MKN45 *** these cells,ANO5 silencing inhibited cell proliferation and induced *** addition,the knockdown of ANO5 inhibited G1-S phase progression,invasion,and *** results of the microarray analysis revealed changes in the expression levels of several cyclin-associated genes,such as CDKN1A,CDK2/4/6,CCNE2,and E2F1,in ANO5-depleted NUGC4 *** expression of these genes was verified using reverse transcription-quantitative *** staining revealed that high ANO5 expression levels were associated with a poor *** analysis identified high ANO5 expression as an independent prognostic fa

关键词： Anoctamin 5 Gastric cancer Cell cycle G1/S checkpoint Cell proliferation

Visceral Fat Accumulation Is Associated with Increased Mortality Rate after Transcatheter Arterial Chemoembolization in Patients with Hepatocellular Carcinoma

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Journal of Cancer Therapy 2015年第13期6卷 1124-1136页

作者： Masaya Saito Yoshihiko Yano hirotaka Hirano Kenji Momose Yuki Kawano Masaru Yoshida Takeshi Azuma Division of Gastroenterology Department of Internal Medicine Graduate School of Medicine Kobe University Kobe Japan Center for Infectious Diseases Graduate School of Medicine Kobe University Kobe Japan Division of Metabolomics Research Department of Internal Medicine Graduate School of Medicine Kobe University Kobe Japan

Aim: Transcatheter arterial chemoembolization (TACE) is thought to be a safe and effective treatment for hepatocellular carcinoma (HCC). However, in some HCC patients, it potentially shortens survival due to liver damage. We aimed to identify independent factors to predict overall survival of HCC after TACE. Methods: We included a total of 96 consecutive HCC patients who underwent TACE at Kobe University Hospital. Areas of skeletal muscle and fat tissue were measured by computed tomography (CT) scan before TACE. We divided the patients into two groups in terms of the presence or absence of 1-year mortality after TACE. Factors associated with 1-year mortality after TACE were assessed by multivariate analyses, and the optimal cut-off values were evaluated using a propensity score. Results: Multivariate analyses showed that visceral fat accumulation on CT was an independent factor associated with 1-year mortality after TACE (p = 0.033). There were no differences in skeletal muscle area and subcutaneous and intermuscular fat area between the two groups. Cut-off values for visceral fat area associated with 1-year mortality after TACE were defined as 33.3 cm2/m2 for males and 24.4 cm2/m2 for females. Conclusions: High visceral fat area was a prognostic factor associated with increased mortality rate in HCC patients undergoing TACE. Using this value, 1-year mortality risk after TACE would be better estimated before the day TACE was performed.

关键词： Glucose Metabolism Liver Cirrhosis Obesity Overall Survival Sarcopenia

Successful Extracorporeal Membranous Oxygenation with Possible Transfusion-Related Acute Lung Injury after Pulmonary Endarterectomy

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Open Journal of Thoracic Surgery 2018年第3期8卷 57-62页

作者： Kayo Sugiyama hirotaka Watanuki Masaho Okada Yasuhiro Futamura Atomu Tajima Rokuki Kiyosawa Katsuhiko Matsuyama Department of Cardiac Surgery Aichi Medical University Hospital Nagakute Japan

Transfusion-related acute lung injury (TRALI) is characterized by acute severe hypoxemia with bilateral noncardiogenic pulmonary edema after transfusion of a plasma-containing blood component. In patients undergoing cardiac surgery, the incidence of TRALI is high;however, the detailed clinical course is unknown. Here, we report a case of life-threatening TRALI following pulmonary thrombectomy, which was successfully treated with extracorporeal membranous oxygenation (ECMO).

关键词： Transfusion-Related Acute Lung Injury Extracorporeal Membrane Oxygenation Acute Pulmonary Emboli