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Alloyed nanostructures integrated metal-phenolic nanoplatform for synergistic wound disinfection and revascularization

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Bioactive Materials 2022年第10期7卷 95-106页

作者： Yi Xie Shengqiu Chen Xu Peng Xiaoling Wang Zhiwei Wei Joseph J.Richardson Kang Liang hirotaka Ejima Junling Guo Changsheng Zhao College of Polymer Science and Engineering State Key Laboratory of Polymer Materials EngineeringSichuan UniversityChengduSichuan610065China BMI Center for Biomass Materials and Nanointerfaces College of Biomass Science and EngineeringSichuan UniverisityChengduSichuan610065China Laboratory Animal Center Sichuan UniversityChengduSichuan610065China School of Chemical Engineering Graduate School of Biomedical Engineeringand Australian Centre for NanoMedicineUniversity of New South WalesSydneyNSW2052Australia Department of Materials Engineering School of EngineeringThe University of Tokyo7-3-1 HongoBunkyo-kuTokyo113􀀀8656Japan Bioproducts Institute Departments of Chemical and Biological EngineeringThe University of British ColumbiaVancouverBCV6T 1Z4Canada School of Chemical Engineering Sichuan UniversityChengduSichuan610065China

New materials for combating bacteria-caused infection and promoting the formation of microvascular networks during wound healing are of vital *** antibiotics can be used to prevent infection,treatments that can disinfect and accelerate wound healing are ***,we engineer a coating that is both highly compatible with current wound dressing substrates and capable of simultaneously disinfecting and revascularizing wounds using a metal-phenolic nanoplatform containing an alloyed nanostructured architecture(Ag@Cu-MPNNC).The alloyed nanostructure is formed by the spontaneous co-reduction and catalytic disproportionation reaction of multiple metal ions on a foundation metal-phenolic supramolecular *** synergistic presence of metals greatly improves the antibacterial activity against both Gram-negative and Gram-positive pathogenic bacteria,while demonstrating negligible cytotoxicity to normal *** infected rat models,the Ag@Cu-MPNNC could kill bacteria efficiently,promoting revascularization and accelerate wound closure with no adverse side effects in infected in vivo *** other words,this material acts as a combination therapy by inhibiting bacterial invasion and modulating bio-nano interactions in the wound.

关键词： Metal-phenolic network Wound healing Antibacterial activity Revascularization

Role of the Na^+/K^+/2Cl^- cotransporter NKCC1 in cell cycle progression in human esophageal squamous cell carcinoma

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World Journal of Gastroenterology 2014年第22期20卷 6844-6859页

作者： Atsushi Shiozaki Yoshito Nako Daisuke Ichikawa hirotaka Konishi Shuhei Komatsu Takeshi Kubota Hitoshi Fujiwara Kazuma Okamoto Mitsuo Kishimoto Yoshinori Marunaka Eigo Otsuji Division of Digestive Surgery Department of SurgeryKyoto Prefectural University of MedicineKyoto 602-8566Japan Department of Pathology Kyoto PrefecturalUniversity of MedicineKyoto 602-8566Japan Departments of Molecular Cell Physiology and Bio-Ionomics Graduate School of Medical ScienceKyoto Prefectural University of MedicineKyoto 602-8566Japan Japan Institute for Food Education and Health St. Agnes’ UniversityKyoto 602-8013Japan

AIM: To investigate the role of Na+/K+/2Cl- cotransporter 1 (NKCC1) in the regulation of genes involved in cell cycle progression and the clinicopathological significance of its expression in esophageal squamous cell ... 详细信息

关键词： Na+/K+/2Cl- cotransporter 1 Esophageal cancer Cell cycle

Comparison of Chromatographic Performance for L-Phenylalanine-Derived Organic Phases on Silica by “Grafting from” and “Grafting to” Strategies

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American Journal of Analytical Chemistry 2011年第7期2卷 795-808页

作者： Mohammed Mizanur Rahman Makoto Takafuji hirotaka Ihara 不详

L-phenylalanine-derived polymerizable organogel, N’-octadecyl-Nα-(4-vinyl)-benzoyl-L-phenylalanineami- de (4) has been prepared according to the procedure described elsewhere. Compound 4 was successfully polymerized by surface initiated atom transfer radical polymerization (ATRP) from the initiator grafted silica particles (sil-poly4). It was also telomerized with 3-mercaptopropyltrimethoxysilane (MPS) and the telomer (T4) was grafted on to silica (sil-T4). TGA and elemental analysis measurement revealed that higher amount of polymer can graft by ATRP process than that of “grafting to” strategy. The results of 13C CP/MAS NMR measurement showed that the N-alkyl chain of the grafted polymers for both sil-poly4 and sil-T4 remained as less ordered gauche conformational form on silica surface and no inversion to trans form was occurred until temperature is increased up to 50?C. The retention of alkylbenzene samples showed that sil-poly4 prepared by “grafting from” method yielded extremely higher retention than conventional C18 phase however, sil-T4 prepared by conventional “grafting to” method showed lower retention than C18 phase. Aspects of molecular recognition were evaluated by the retention studies of a series of polycyclic aromatic hydrocarbons (PAHs) and aromatic positional isomers. We have observed sil-T4 yielded slightly higher selectivity for PAHs than sil-poly4 regardless the fact that it has low surface coverage and lower hydrophobic interactions. The enhanced selectivity observed for sil-T4 than C18 phases and sil-poly4 can be explained by the π - π interactions between the guest PAHs and carbonyl groups present in the polymer chain. In addition the aromatic moieties of compound 4 that aggregates through π - π interactions also contribute to the separation of PAHs for both sil-poly4 and sil-T4. The minimal π - π interactions between the carbonyl groups and guest molecules for sil-poly4 probably due to the presence of long chain initiator which restrict the p

关键词： Polymerizable Organogel Atom Transfer Radical Polymerization Grafting from Grafting to HPLC Molecular Recognition

Natural history of major complications in hepatitis C virus-related cirrhosis evaluated by per-rectal portal scintigraphy

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World Journal of Gastroenterology 2005年第25期11卷 3882-3886页

作者： Etsushi Kawamura Daiki Habu Takehiro Hayashi Ai Oe Jin Kotani hirotaka Ishizu Kenji Torii Joji Kawabe Wakaba Fukushima Takashi Tanaka Shuhei Nishiguchi Susumu Shiomi Department of Nuclear Medicine Department of Hepatology Department of Public Health

AIM: To examine the correlation between the porto-systemic hypertension evaluated by portal shunt index (PSI) and life-threatening complications, including hepatocellular carcinoma (HCC), liver failure (Child-Pugh stage progression), and esophagogastric varices. METHODS: Two hundred and twelve consecutive subjects with HCV-related cirrhosis (LC-C) underwent per-rectal portal scintigraphy. They were allocated into three groups according to their PSI: group Ⅰ, PSI≤10%; group Ⅱ, 10%

关键词： Portal shunt index Porto-systemic shunting Per-rectal portal sdntigraphy Natural history Liver cirrhosis HCV Hepatocellular carcinoma Liver failure Varix

Heat-Killed <i>Lactobacillus brevis</i>SBC8803 Induces Serotonin Release from Intestinal Cells

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Food and Nutrition Sciences 2013年第8期4卷 767-771页

作者： Yasukazu Nakaita hirotaka Kaneda Tatsuro Shigyo Corporate Planning Department Sapporo Holdings Ltd. Tokyo Japan. Frontier Laboratories of Value Creation Sapporo Breweries Ltd. Shizuoka Japan

Previously, we reported that changes induced in autonomic neurotransmission in rats by Lactobacillus brevis SBC8803 may be mediated by serotonin 3 (5-HT3) receptors. In this study, we evaluated the effects of heat-killed L. brevis SBC8803 on serotonin (5-HT) releasing from intestinal cells. In the in vitro study, L. brevis SBC8803 stimulated 5-HT release from cultured rat endocrine RIN-14B cells (SBC8803 vs. sterile water;P in vivo study, 2 mg of heat-killed L. brevis SBC8803 was administered using a stomach sonde (feeding needle) to C57BL/6J mice. Analysis of plasma by ELISA showed gradually increase in 5-HT concentrations (0 min vs. 60 min;P ex vivo cultured intestinal loops composed of duodenum and part of the jejunum, from C3H/HeN and C57BL/6J male mice indicated that L. brevis SBC8803 effectively induced 5-HT release (SBC8803 vs. sterile water;P L. brevis SBC8803 may stimulate 5-HT release from mouse intestinal cells such as enterochromaffin cells.

关键词： Serotonin Lactobacillus Brevis Mice Intestinal Cells 5-HT3 Receptors

Transmembrane serine protease 4 expression in the prognosis of radical resection for biliary tract cancer

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World Journal of Gastrointestinal Surgery 2024年第8期16卷 2555-2564页

作者： Yoshiyuki Shibata Takeshi Sudo Sho Tazuma Naoki Tanimine Takashi Onoe Yosuke Shimizu Atsushi Yamaguchi Kazuya Kuraoka Shinya Takahashi hirotaka Tashiro Department of Surgery National Hospital Organization Kure Medical Center and Chugoku Cancer CenterHiroshima 737-0023Japan Department of Gastroenterology National Hospital Organization Kure Medical Center and Chugoku Cancer CenterHiroshima 737-0023Japan Department of Diagnostic Pathology National Hospital Organization Kure Medical Centerand Chugoku Cancer CenterHiroshima 737-0023Japan Department of Surgery Graduate School of Biochemical and Health ScienceHiroshima UniversityHiroshima 734-8551Japan

BACKGROUND Recent advancements in biliary tract cancer(BTC)treatment have expanded beyond surgery to include adjuvant therapy,yet the prognosis remains *** prognostic biomarkers could enhance the assessment of patients who have undergone radical resection for *** To determine transmembrane serine protease 4(TMPRSS4)utility as a prognostic biomarker of radical resection for *** Medical records of patients who underwent radical resection for BTC,excluding intrahepatic cholangiocarcinoma,were retrospectively *** associations between TMPRSS4 expression and clinicopathological factors,overall survival,and recurrence-free survival were *** Among the 85 patients undergoing radical resection for BTC,46(54%)were *** TMPRSS4-positive group exhibited significantly higher preoperative carbohydrate antigen 19-9(CA19-9)values and greater lymphatic invasion than the TMPRSS4-negative group(P=0.019 and 0.039,respectively).Postoperative overall survival and recurrence-free survival were significantly worse in the TMPRSS4-positive group(median survival time:25.3 months vs not reached,P<0.001;median survival time:28.7 months vs not reached,P=0.043,respectively).Multivariate overall survival analysis indicated TMPRSS4 positivity,pT3/T4,and resection status R1 were independently associated with poor prognosis(P=0.032,0.035 and 0.030,respectively).TMPRSS4 positivity correlated with preoperative CA19-9 values≥37 U/mL and pathological tumor size≥30 mm(P=0.016 and 0.038,respectively).CONCLUSION TMPRSS4 is a potential prognostic biomarker of radical resection for BTC.

关键词： Biliary tract cancer Biomarker Prognosis Radical resection Transmembrane serine protease 4

Metabolism for cyclosporin A during liver regeneration after partial hepatectomy in rats

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World Journal of Gastroenterology 2008年第41期14卷 6355-6359页

作者： Shigeki Nagayoshi Yujo Kawashita Susumu Eguchi Yukio Kamohara Mitsuhisa Takatsuki Shungo Miyamoto Satoshi Mochizuki Akihiko Soyama hirotaka Tokai Masaaki Hidaka Yoshitsugu Tajima Takashi Kanematsu Department of Transplantation and Digestive Surgery Graduate School of Biomedical Sciences Nagasaki University School of Medicine

AIM： To elucidate the metabolism and the effect of the cyclosporin A （CyA） as a representative immuno- suppressive drug used in transplantation in a partially hepatectomized rat model. METHODS： CyA was administered to rats that underwent a 70% hepatectomy. These rats were randomly assigned into three groups according to the dose of CyA administration as follows; （group I） water, （group 2） 5 mg/kg CyA, （group 3） 10 mg/kg CyA. On postoperative days-1, 3, 7 and 14, the rats were killed to analyze the serum concentration of CyA, the liver regeneration ratio, biochemical or histological markers, and mRNA expression using reverse transcriptase-poly- merase chain reaction method to determine albumin and cytochrome p450 expression. RESULTS： The serum concentration of CyA in group 3 was significantly higher than group 2 during liver regeneration. CyA enhanced the liver regeneration in a dose dependent manner. The mRNA expression associated with CyA metabolism was significantly decreased on day 14, while preserving the albumin producing activity. CONCLUSION： These data indicate that the p-450 activity required to metabolize the CyA may be reduced during regeneration of the remnant liver after a hepatectomy, which may, therefore, be linked to difficulty in controlling the optimal dose of CyA during early period of LDLT.

关键词： Cyclosporin A Liver regeneration Partial hepatectomy Rat

Integrated Arrays of Palladium ＆ Platinum Nanotubules on Aluminum for Electrolysis

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Integrated Arrays of Palladium ＆ Platinum Nanotubules on Al...

A force measurement platform for a vitreoretinal surgical simulator using an artificial eye module integrated with a quartz crystal resonator

2006年上海电子电镀学术报告会

作者： hirotaka KAWAMURA Masashi MORI MaterialsScienceLab. CentralResearchInstituteofElectricPowerIndustry(CRIEPI)Nagasaka2-6-1.YokosukaKanagawa240-0196Japan MaterialsSeiceceLab. CentralResearchInstituteofElectricPowerIndustry(CRIEPI)Nagasaka2-6-1.YokosukaKanagawa240-0196Japan

＜正＞Introduction This study is aimed at fabricating integrated arrays of Pd and Pt nanotubules with large surface areas on Al by combining anodization and electroless deposition, towards high-performance catalytic e...

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Microsystems & Nanoengineering 2022年第4期8卷 137-149页

作者： Yuta Taniguchi hirotaka Sugiura Toshiro Yamanaka Shiro Watanabe Seiji Omata Kanako Harada Mamoru Mitsuishi Tomoyasu Shiraya Koichiro Sugimoto Takashi Ueta Kiyohito Totsuka Fumiyuki Araki Muneyuki Takao Makoto Aihara Fumihito Arai Department of Mechanical Engineering The University of Tokyo7-3-1 HongoBunkyo-kuTokyo 113-8656Japan Faculty of Advanced Science and Technology Kumamoto University2-39-1 KurokamiChuo-kuKumamoto-shiKumamoto 860-8555Japan Center for Disease Biology and Integrative Medicine The University of Tokyo7-3-1 HongoBunkyo-kuTokyo 113-0033Japan Department of Ophthalmology The University of Tokyo7-3-1 HongoBunkyo-kuTokyo 113-8655Japan

To provide quantitative feedback on surgical progress to ophthalmologists practicing inner limiting membrane(ILM)peeling,we developed an artificial eye module comprising a quartz crystal resonator(QCR)force sensor and a strain body that serves as a uniform force transmitter beneath a retinal *** a sufficiently large initial force must be loaded onto the QCR force sensor assembly to achieve stable contact with the strain body,the highly sensitive and wide dynamic-range property of this sensor enables the eye module to detect the slight forceps contact force.A parallel-plate strain body is used to achieve a uniform force sensitivity over the 4-mm-diameter ILM peeling *** these two components allowed for a measurable force range of 0.22 mN to 29.6 N with a sensitivity error within−11.3 to 4.2%over the ILM peeling *** this eye module,we measured the applied force during a simulation involving artificial ILM peeling by an untrained individual and compensated for the long-term drift of the obtained force data using a newly developed *** compensated force data clearly captured the characteristics of several types of motion sequences observed from video recordings of the eye bottom using an ophthalmological *** a result,we succeeded in extracting feature values that can be potentially related to trainee skill level,such as the mean and standard deviation of the pushing and peeling forces,corresponding,in the case of an untrained operator,to 122.6±95.2 and 20.4±13.2 mN,respectively.

关键词： artificial quartz resonator