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Influence of oxygen flow rate and compost addition on reduction of organic matter in aerated waste layer containing mainly incineration residue

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Journal of Environmental Sciences 2013年第1期25卷 53-58页

作者： hiroshi asakura Kei Nakagawa Kazuto Endo Masato Yamada Yusaku Ono Yoshiro Ono Nagasaki University 1-14 Bunkyo-machi Nagasaki 852-8521Japan National Institute for Environmental Studies Onogawa 16-2TsukubaIbaraki 305-8506Japan Nippon Institute of Technology 4-1 GakuendaiMiyashiro-machiMinamisaitama-gunSaitama 345-8501Japan Kyoto Institute of Technology MatsugasakiSakyo-kuKyoto 606-8585Japan

Landfilling municipal solid waste incineration （MSWI） residue alkalizes the waste layer, causing a subsequent decrease in microbial activity and a delay in the decomposition of organic matter. In this study, efficiencies of neutralization of the leachate and organic matter decomposition in the waste layer in a column filled with MSWI residue using aeration and compost addition were evaluated. Total organic carbon （TOC） reduction in the waste layer is large at high oxygen flow rate （OFR）. To effectively accelerate TOC reduction in the waste layer to which compost was added, a high OFR exceeding that by natural ventilation was required. At day 65, the pH of the leachate when OFR was above 102 mol-O2/（day.m3） was lower than that when OFR was below 101 mol-Oz/（day.m3）. At the same OFR, the pH of waste sample was lower than that of waste sample with compost. Although leachate neutralization could be affected by compost addition, TOC reduction in the waste layer became rather small. It is possible that humic substances in compost prevent the decomposition of TOC in MSWI residue.

关键词： waste landfill aeration neutralization acceleration of stabilization

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Prevalence and fuoroquinolone resistance of Campylobacter *** from beef cattle in Japan

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Animal Diseases 2022年第3期2卷 181-186页

作者： Yoshimasa Sasaki hiroshi asakura Tetsuo Asai Division of Biomedical Food Research National Institute of Health Sciences3‑25‑26TonomachiKawasaki‑kuKawasakiKanagawa 210‑9501Japan The United Graduate School of Veterinary Science Gifu University1‑1YanagidoGifu 501‑1193Japan

Beef is a source of human Campylobacter *** treatment is needed when patients are immuno‑compromised or have other ***,we investigated the prevalence and antimicrobial resistance of Campylobacter *** beef cattle in *** swab samples were collected from 164 beef cattle at an abattoir between March 2021 and August 2021,and Campylobacter *** isolated from 94(57.3%)*** and *** were isolated from 68 and 26 cattle,*** Campylobacter jejuni,the resistant rates against ampicillin,tetracycline and ciprofoxacin were 20.6,75.0 and 64.7%,*** ***,the resistant rates against ampicil‑lin,tetracycline and ciprofoxacin were 53.8,76.9 and 88.5%,*** Campylobacter isolates were resistant to *** multilocus sequence typing,*** and *** isolates were classifed into 22 and 2 sequence types(STs).The top three STs of *** were ST806(12 isolates),ST21(nine isolates),and ST459(eight isolates).The most frequent ST of *** was ST1068(23 isolates).The results suggest that Campylobacter *** prevalent in the gastrointestinal tract of beef cattle slaughtered at ***,the administration of erythromycin is efec‑tive against human campylobacteriosis caused by beef *** the prevalence and antimicrobial resistance of Campylobacter *** beef cattle could be useful for managing the risk of human campylobacteriosis.

关键词： Antimicrobial resistance Beef cattle Campylobacter Fluoroquinolone resistance Multilocus sequence typing

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Low Frequency Ultrasonication Induced Antitumor Effect in 5-Aminolevulinic Acid Treated Malignant Glioma

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Journal of Cancer Therapy 2013年第1期4卷 170-175页

作者： Fumio Yamaguchi Takayuki asakura hiroshi Takahashi Takayuki Kitamura Akira Teramoto Department of Neurosurgery Nippon Medical School Tokyo Japan

We investigated the feasibility of sonodynamic therapy for glioma by low frequency ultrasoundwith5-aminolevulinic acid (5-ALA), a precursor of protoporphyrin IX (PpIX) in heme synthetic process. In vivo tumor model was made by inoculating human glioma cell line U87-MG subcutaneously in nude mice. The tumor was sonicated by 25-kHz ultrasound 4 hours following administration of 5-ALA. The tumor size decreased in 5-ALA administered (ALA(+)US(+)) mice, while increased in non-5-ALA administrated (ALA(-)US(+)) mice and non-sonicated mice (ALA(+)US(-)). The immunohistochemical analysis revealed an apoptotic change in tumor tissue of ALA(+)US(+) mice. The results showed the therapeutic effect of 25 kHz ultrasound for the glioma in 5-ALA administered tumor-bearing mice by inducing apoptotic change of tumor cells. This is a first report to elucidate the feasibility of therapeutic use of 25 kHz, relatively low frequency, ultrasound in sonodynamic therapy using 5-ALA as a sonosensitizer precursor. The utilization of this frequency will contribute to the development of sonodynamic therapy for gliomas and the spread of this technique in many hospitals that possess ultrasonic aspirators.

关键词： Glioma Sonodynamic Therapy 5-Aminolevulinic Acid Protoporphyrin IX Ultrasonication

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六国悬浮微粒物的空气质量标准、测量方法及空气污染的研究

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环境科学与管理 1981年第12期 171-174页

作者： Kazuo asakura hiroshi Shikata 包志成

目的在日本,悬浮微粒被限定为直径小于10微米的大气漂尘。对此于1972年制定的空气质量标准规定如下: （1）每小时值……0.20毫克/米3。（2）日平均值……0.10毫克/米3。日本的大气监测网采用小容量法和光散射法测量悬浮微粒环境浓度。... 详细信息

目的在日本,悬浮微粒被限定为直径小于10微米的大气漂尘。对此于1972年制定的空气质量标准规定如下: （1）每小时值……0.20毫克/米3。（2）日平均值……0.10毫克/米3。日本的大气监测网采用小容量法和光散射法测量悬浮微粒环境浓度。曾报导过,符合空气质量标准（0.10毫克/米3）

关键词：悬浮微粒日本容量法空气质量标准测量方法

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Intraductal neoplasm of the intrahepatic bile duct: Clinicopathological study of 24 cases

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World Journal of Gastroenterology 2012年第28期18卷 3673-3680页

作者： Yoshiki Naito Hironori Kusano Osamu Nakashima Eiji Sadashima Satoshi Hattori Tomoki Taira Akihiko Kawahara Yoshinobu Okabe Kazuhide Shimamatsu Jun Taguchi Seiya Momosaki Koji Irie Rin Yamaguchi hiroshi Yokomizo Michiko Nagamine Seiji Fukuda Shinichi Sugiyama Naoyo Nishida Koichi Higaki Munehiro Yoshitomi Masafumi Yasunaga Koji Okuda Hisafumi Kinoshita Masayoshi Kage Masamichi Nakayama Makiko Yasumoto Jun Akiba Hirohisa Yano Departments of Pathology Kurume University School of Medicine Kurume 830-0011 Japan Biostatistics Center Kurume University Kurume 830-0011 Japan Department of Diagnostic Pathology Kurume University Hospital Kurume 830-0011 Japan Division of Gastroenterology Department of Medicine Kurume University School of Medicine Kurume 830-0011 Japan Department of Pathology Omuta City General Hospital Omuta 836-8567 Japan Department of Pathology Asakura Medical Association Hospital Fukuoka 838-0069 Japan Department of Pathology National Hospital Organization Kyushu Medical Center Fukuoka 810-8563 Japan Department of Pathology Shin-Koga Hospital Tenjinkai 120 Tenjincho Kurume 830-0033 Japan Department of Pathology Kurume University Medical Center 155-1 Kokubumachi Kurume 839-0863 Japan Department of Surgery Japanese Red Cross Kumamoto Hospital Kumamoto 861-8520 Japan Department of Pathology Japanese Red Cross Kumamoto Hospital Kumamoto 861-8520 Japan Division of Surgery Saiseikai Kumamoto Hospital Kumamoto 861-4193 Japan Department of Pathology St Mary's Hospital Kurume 830-8543 Japan Department of Surgery Kurume University School of Medicine Kurume 830-0011 Japan

AIM: To investigate the clinicopathological features of intraductal neoplasm of the intrahepatic bile duct (INihB). METHODS: Clinicopathological features of 24 cases of INihB, which were previously diagnosed as biliary papillomatosis or intraductal growth of intrahepatic biliary neoplasm, were reviewed. Mucin immunohistochemistry was performed for mucin (MUC)1, MUC2, MUC5AC and MUC6. Ki-67, P53 and β-catenin immunoreactivity were also examined. We categorized each tumor as adenoma (low grade), borderline (intermediate grade), and malignant (carcinoma in situ , high grade including tumors with microinvasion). RESULTS: Among 24 cases of INihB, we identified 24 tumors. Twenty of 24 tumors (83%) were composed of a papillary structure; the same feature observed in intraductal papillary neoplasm of the bile duct (IPNB). In contrast, the remaining four tumors (17%) showed both tubular and papillary structures. In three of the four tumors (75%), macroscopic mucin secretion was limited but microscopic intracellular mucin was evident. Histologically, 16 tumors (67%) were malignant, three (12%) were borderline, and five (21%) were adenoma. Microinvasion was found in four cases (17%). Immunohistochemical analysis revealed that MUC1 was not expressed in the borderline/adenoma group but was expressed only in malignant lesions (P = 0.0095). Ki-67 labeling index (LI) was significantly higher in the malignant group than in the borderline/adenoma group (22.2 ± 15.5 vs 7.5 ± 6.3, P < 0.01). In the 16 malignant cases, expression of MUC5AC showed borderline significant association with high Ki-67 LI (P = 0.0622). Nuclear expression of β-catenin was observed in two (8%) of the 24 tumors, and these two tumors also showed MUC1 expression. P53 was negative in all tumors. CONCLUSION: Some cases of INihB have a tubular structure, and are subcategorized as IPNB with tubular structure. MUC1 expression in INihB correlates positively with degree of malignancy.

关键词：胆管肿瘤临床病理管内免疫组织化学方法恶性肿瘤管状结构乳头状瘤肝

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