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Surgery for gastric cancer patients of age 85 and older: Multicenter survey

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World Journal of Gastroenterology 2017年第7期23卷 1215-1223页

作者： Hirotaka Konishi Daisuke Ichikawa hiroshi Itoh Kenichiro Fukuda Naoki Kakihara Manabu Takemura Kaori Okugawa Kiyoshi Uchiyama Masashi Nakata hiroshi nishi Toshiyuki Kosuga Shuhei Komatsu Kazuma Okamoto Eigo Otsuji Division of Digestive Surgery Department of SurgeryKyoto Prefectural University of Medicine Department of Surgery North Medical CenterKyoto Prefectural University of Medicine Department of Surgery Saiseikai Shigaken Hospital Department of Surgery Japanese Red Cross Kyoto Daini Hospital Department of Surgery Osaka General Hospital of West Japan Railway Company Department of Surgery Omihachiman Community Medical Center Department of Surgery Kyoto Okamoto Memorial Hospital Department of Surgery Kyoto Yamashiro General Medical Center Department of Surgery Saiseikai Kyoto Hospital

AIM To investigate the surgical therapies for gastric cancer(GC) patients of age 85 or older in a multicenter *** Therapeutic opportunities for elderly GC patients have expanded in conjunction with extended life expectancy. However, the number of cases encountered in a single institution is usually very small and surgical therapies for elderly GC patients have not yet been standardized completely. In the present study, a total of 134 GC patients of age 85 or older who underwent surgery in 9 related facilities were retrospectively investigated. The relationships between surgical therapies and clinicopathological or prognostic features were *** Eighty-nine of the patients(66%) presented with a comorbidity, and 26(19% overall) presented with more than two comorbidities. Radical lymphadenectomy was performed in 59 patients(44%), and no patient received pre- or post-operative chemotherapy. Forty of the patients(30%) experienced perioperative complications, but no surgical or perioperative mortality occurred. Laparoscopic surgery was performed in only 12 of the patients(9.0%). Univariate and multivariate analyses of the 113 patients who underwent R0 or R1 resection identified the factors of p T3/4 and limited lymphadenectomy as predictive of worse prognosis(HR = 4.68, P = 0.02 and HR =2.19, P = 0.05, respectively). Non-cancer-specific death was more common in c Stage Ⅰ patients than in c Stage Ⅱ or Ⅲ patients. Limited lymphadenectomy correlated with worse cancer-specific survival(P = 0.01), particularly in c Stage Ⅱ patients(P < 0.01). There were no relationships between limited lymphadenectomy and any comorbidities, except for cerebrovascular disease(P = 0.07). CONCLUSION N o n- c a n c e r- s p e c i f i c d e a t h w a s n o t n e g l i g i b l e, particularly in c Stage Ⅰ, and gastrectomy with radical lymphadenectomy appears to be an effective treatment for cS tage Ⅱ elderly GC patients.

关键词：胃的癌症老超过 85 外科有限 lymphadenectomy Multicenter 调查

自对准结构InGaAsP/InP双异质结构激光器

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微纳电子技术 1983年第2期 35-42页

作者： hiroshi nishi 张华

本文研究了一种横模稳定的InGaAsP/InP双异质结构（DH）激光器的器件参数,即各层的厚度和条宽,这种激光器称为自对准结构（SAS）,发射波长为1.3μm。为了控制平行于结平面的横模以及为了在高温下能稳定工作（尽管阈值电流对温度很灵敏）... 详细信息

本文研究了一种横模稳定的InGaAsP/InP双异质结构（DH）激光器的器件参数,即各层的厚度和条宽,这种激光器称为自对准结构（SAS）,发射波长为1.3μm。为了控制平行于结平面的横模以及为了在高温下能稳定工作（尽管阈值电流对温度很灵敏）,得出最佳条宽为7μm。 SAS激光器显示出稳定的基横模和接近单纵模的工作特性,并且直到3GHz有平坦的频率响应特性,范围在±5dB内。在老化试验中,温度提高到50℃和70℃,在恒定光功率条件下,所有样品都已工作了10000多小时,驱动电流没有明显变化。在50℃,5mW/端面恒定功率条件下的样品,5000小时期间驱动电流增加的平均速率为3.1×10-6/hr。这个数值与GaAlAs/GaAs DH激光器相比几乎一样。在老化试验期间未观察到基横模分布上的变化。

关键词：激光器器件参数热沉双异质结构光激射器电子器件横模激光模式 InGaAsP/InP 驱动电流自对准

Immunotherapy for esophageal cancer:Where are we now and where can we go

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World Journal of Gastroenterology 2024年第19期30卷 2496-2501页

作者： Yoshiaki Shoji Kazuo Koyanagi Kohei Kanamori Kohei Tajima Mika Ogimi Yamato Ninomiya Miho Yamamoto Akihito Kazuno Kazuhito Nabeshima Takayuki nishi Masaki Mori Department of Gastroenterological Surgery Tokai University School of MedicineKanagawa 259-1193Japan

Immune checkpoint inhibitor therapy has dramatically improved patient prognosis,and thereby transformed the treatment in various cancer types including esophageal squamous cell carcinoma(ESCC)in the past *** antibodies that selectively inhibit programmed cell death-1(PD-1)activity has now become standard of care in the treatment of ESCC in metastatic settings,and has a high expectation to provide clinical benefit during perioperative ***,anti-cytotoxic T-lymphocyte–associated protein 4(CTLA-4)monoclonal antibody has also been approved in the treatment of recurrent/metastatic ESCC in combination with anti-PD-1 *** understanding of the existing evidence of immune-based treatments for ESCC,as well as recent clinical trials on various combinations with chemotherapy for different clinical settings including neoadjuvant,adjuvant,and metastatic diseases,may provide future prospects of ESCC treatment for better patient outcomes.

关键词： Esophageal cancer Immunotherapy Immune checkpoint inhibitor Programmed cell death-1 Anti-cytotoxic T-lymphocyte-associated protein 4 Neoadjuvant therapy Adjuvant therapy Clinical trials Combination therapy

A Mixture of Glycosylated proBNP and BNP-32 Is a Suitable Calibrator for BNP Immunoassays

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Open Journal of Clinical Diagnostics 2019年第2期9卷 51-63页

作者： Keiichi Masuta Kenzo Funatsuki Youko Inoue Izuru Masuda Toshio nishikimi Yasuaki Nakagawa Kazukiyo Horii hiroshi nishi Masayo Igarashi Norio Ota Biomarker R & D Department Shionogi & Co. Ltd. Toyonaka Japan Takeda Hospital Medical Examination Center Kyoto Japan Department of Cardiovascular Medicine Kyoto University Graduate School of Medicine Kyoto Japan Department of Medicine Wakakusa-Tatsuma Rehabilitation Hospital Daito Japan Horii Planning Yokohama Japan

Aim: Measurement of B-type natriuretic peptide (BNP) is widely used as a diagnostic and risk assessment tool for cardiovascular disease. Recent studies have demonstrated that BNP-32 and its precursor proBNP circulate in the blood stream, and that most commercial BNP immunoassays measure both forms. However, recombinant or synthetic BNP-32 is used as the standard for those BNP immunoassays. This gap between clinical samples and the standard might be a potential source of variation in BNP measurements among assays. The purpose of this study is to validate a more suitable calibrator for BNP immunoassays. Methods: External BNP calibrators containing both BNP-32 and glycosylated proBNP were prepared at two concentration levels. Target BNP concentrations of the low and high levels were 40 and 160 pg/mL, respectively. And to reflect clinical samples, the molar ratios of BNP-32 to glycosylated proBNP in these concentration levels were adjusted to 50:50 and 25:75, respectively. BNP concentrations of plasma samples along with the external BNP calibrators were measured at two commercial labs and using an automated analyzer MI02 Shionogi®BNP (MI02). These samples and the calibrators were also measured using an immunoradiometric assay (IRMA) as a standard assay procedure. Concentrations of the plasma samples measured at the labs or using the MI02 were adjusted according to a comparison of the measured concentrations of the external BNP calibrators with the IRMA. Results: After measured concentrations of the plasma samples were adjusted using the external BNP calibrators, the correlation between each measurement and the IRMA was improved. The range of the slopes according to Passing-Bablok regression analysis narrowed from 0.628 - 0.955 to 0.911 - 1.005. Conclusions: Our data suggests that a mixture of BNP-32 and glycosylated proBNP at different ratios by concentration level is suitable for calibration to minimize variations in BNP measurements among immunoassays.

关键词： B-Type Natriuretic Peptide (BNP) proBNP Calibrator

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铁路三维电子沙盘搭建及其应用研究

铁道标准设计 2024年第8期68卷 50-57页

作者：赵亮亮董凤翔黄旎诗中铁二院工程集团有限责任公司成都610031

为解决目前铁路行业电子沙盘存在的表达方式不一、应用内容单一、数据泄露风险大、数据加载效率低等问题,研究海量地理地质及BIM模型的数据处理、管理和应用方法,建立以BIM+GIS为技术核心的标准化电子沙盘,从而更好地服务于铁路设计和... 详细信息

为解决目前铁路行业电子沙盘存在的表达方式不一、应用内容单一、数据泄露风险大、数据加载效率低等问题,研究海量地理地质及BIM模型的数据处理、管理和应用方法,建立以BIM+GIS为技术核心的标准化电子沙盘,从而更好地服务于铁路设计和建造。根据鲁南高铁、拉林铁路、成渝中线高铁等项目实践总结,在中国铁路BIM联盟和国铁集团相关标准基础上提出了面向电子沙盘应用的地形、影像、BIM模型、专题图的数据制作标准,从坐标转换、数据转换、数据切片、知识图谱建立、模型发布、前端数据汇集的方法完成了电子沙盘的搭建。最后,在电子沙盘中实现了百公里级、多专业数据的在线高效组织和管理,提出的方法和标准适用于铁路设计、建设过程的管理和分析应用。

关键词：铁路 BIM GIS 智能化电子沙盘专题图高效组织

Treatment of portosystemic shunt-borne hepatic encephalopathy in a 97-year-old woman using balloon-occluded retrograde transvenous obliteration:A case report

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World Journal of Clinical Cases 2023年第4期11卷 945-951页

作者： Akihiro nishi Tsuneaki Kenzaka Misa Sogi Shuichiro Nakaminato Takahiro Suzuki General Medicine Awa Regional Medical CenterTateyama 2940014ChibaJapan Division of Community Medicine and Career Development Kobe University Graduate School of MedicineKobe 6500017HyogoJapan Department of Radiology Kameda Medical CenterKamogawa 2968602ChibaJapan

BACKGROUND Hyperammonemia and hepatic encephalopathy are common in patients with portosystemic *** shunt occlusion has been standard treatment,although recently the less invasive balloon-occluded retrograde transvenous obliteration(B-RTO)has gained increasing *** far,there have been no reports on the treatment of portosystemic shunts with B-RTO in patients aged over 90 *** this study,we present a case of hepatic encephalopathy caused by shunting of the left common iliac and inferior mesenteric veins,successfully treated with *** SUMMARY A 97-year-old woman with no history of liver disease was admitted to our hospital because of disturbance of *** had no jaundice,spider angioma,palmar erythema,hepatosplenomegaly,or *** blood tests showed hyperammonemia,and abdominal contrast-enhanced computed tomography revealed a portosystemic shunt running between the left common iliac vein and the inferior mesenteric *** was diagnosed with hepatic encephalopathy secondary to a portosystemic *** patient did not improve with conservative treatment:Lactulose,rifaximin,and a low-protein diet.B-RTO was performed,which resulted in shunt closure and improvement in hyperammonemia and disturbance of ***,there was no abdominal pain or elevated levels of liver enzymes due to *** patient was discharged without further consciousness *** Portosystemic shunt-borne hepatic encephalopathy must be considered in the differential diagnosis for consciousness disturbance,including abnormal behavior and speech.

关键词： Hepatic encephalopathy Hyperammonemia Portosystemic shunt Balloon-occluded retrograde transvenous obliteration Elderly Case report

Is machine learning redefining the perovskite solar cells?

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Journal of Energy Chemistry 2022年第3期31卷 74-90,I0004页

作者： nishi Parikh Meera Karamta Neha Yadav Mohammad Mahdi Tavakoli Daniel Prochowicz Seckin Akin Abul Kalam Soumitra Satapathi Pankaj Yadav Department of Science School of TechnologyPandit Deendayal Energy UniversityGandhinagar 382007GujaratIndia Department of Electrical Engineering School of TechnologyPandit Deendayal Energy UniversityGandhinagar 382007GujaratIndia Department of Telecommunication Ministry of CommunicationMumbai LSAMumbai 400072MaharashtraIndia Department of Electrical Engineering and Computer Science Massachusetts Institute of TechnologyCambridgeMA 02139USA Institute of Physical Chemistry Polish Academy of SciencesKasprzaka 44/5201-224 WarsawPoland Department of Metallurgical and Materials Engineering Karamanoglu Mehmetbey University70200 KaramanTurkey Department of Chemistry Faculty of ScienceKing Khalid UniversityAbha 61413P.O.Box 9004Saudi Arabia Department of Physics Indian Institute of Technology RoorkeeRoorkeeHaridwarUttarakhand 247667India Department of Solar Energy School of TechnologyPandit Deendayal Energy UniversityGandhinagar 382007GujaratIndia

Development of novel materials with desirable properties remains at the forefront of modern scientific *** learning(ML),a branch of artificial intelligence,has recently emerged as a powerful technology in optoelectronic devices for the prediction of various properties and rational design of *** halide perovskites(MHPs)have been at the centre of attraction owing to their outstanding photophysical properties and rapid development in solar cell ***,the application of ML in the field of MHPs is also getting much attention to optimize the fabrication process and reduce the cost of ***,we comprehensively reviewed different applications of ML in the designing of both MHP absorber layers as well as complete perovskite solar cells(PSCs).At the end,the challenges of ML along with the possible future direction of research are *** believe that this review becomes an indispensable roadmap for optimizing materials composition and predicting design strategies in the field of perovskite technology in the future.

关键词： Machine learning Metal halide perovskites Perovskite solar cell Lead free perovskites

A novel shaft-less double suction mini pump

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Science China(Technological Sciences) 2010年第1期53卷 105-110页

作者： nishi Michihiro Kyushu Institute of Technology Sensui-cho 1TobataKitakyushu 804-8550Japan

A novel double suction shaft-less mini pump was developed for heat control of small energy systems in this *** mini pump impeller with an exit diameter of 40 mm was combined with the motor rotor supported by the hybrid dynamic *** specific speed of the pump was 125 min-1 m3 min-1 *** hydraulic performance of the pump was investigated experimen-tally under four rotational *** the test results,it was recognized that the pump could provide a flow discharge of 5 L/min and head of 1.5 m,which are applicable for the heat control system of a 3 kW fuel cell.A three-dimensional turbulent flow simulation in the pump was also conducted near the design *** numerical results showed that the average hydraulic performance of the mini pump was predicted *** the internal flow simulation,it was revealed that the favorable inflow condition upstream of impeller inlet could be attained by applying the double suction shaft-less design for the mini pump.

关键词： double suction seal-less shaft-less uniform inflow mini pump

ELASTOMERIC SEISMIC-PROTECTION ISOLATORS FOR BUILDINGS AND BRIDGES

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Chinese Journal of Polymer Science 2013年第1期31卷 50-57页

作者： Toshio nishi Nobuo Murota International Division Tokyo Institute of Technology Department of Seismic Isolation &Vibration Control Development

A giant earthquake of magnitude 9.0 occurred in Pacific Ocean off of Tohoku District Japan on March 11,2011. The highest seismic intensity of 7 in JMA scale was recorded in Miyagi. In the Tohoku district, around 230 buildings are seismically isolated （hereafter, SI） mainly by elastomeric isolators （seismic rubber bearings）. According to the official survey reports by several organizations （for example）, the records of those buildings have verified the effectiveness of the seismic isolation. The response acceleration of the SI buildings was reduced by 30% to 50% of the input ground acceleration. Additionally, the difference of the conditions inside the room between SI and the fixed-base buildings was obvious as well as the damage in main structures of the buildings. The displacements of the isolators by the earthquake were around 200 mm according to the records of the instruments. As a result, the performance of SI buildings and the elastomeric isolators in the Tohoku District -- Off the Pacific Ocean Earthquake 2011 were excellent, and the efficiency of the seismic isolation was verified by the records of many buildings in wide area.

关键词： Elastomeric isolator Seismic isolation Rubber bearing.