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Invariant natural killer T cells and iron metabolism orchestrate skin development and homeostasis

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Cellular & Molecular Immunology 2023年第10期20卷 1095-1097页

作者： hiroshi Nabeshima Takayuki Niitsu Kiyoharu Fukushima hiroshi kida Laboratory of Host Defense World Premier Institute Immunology Frontier Research Center(WPI-IFReC)Osaka University3-1 YamadaokaSuitaOsakaJapan Department of Respiratory Medicine and Clinical Immunology Osaka University Graduate School of Medicine2-2 YamadaokaSuitaOsakaJapan Department of Host Defense Research Institute for Microbial Diseases(RIMD)Osaka University3-1 YamadaokaSuitaOsakaJapan Department of Respiratory Medicine National Hospital Organization Osaka Toneyama Medical Center5-1-1 ToneyamaOsakaJapan Global Center for Medical Engineering and Informatics 2-2 YamadaokaSuitaOsakaJapan

In recent years,innate-like T-cell populations,such as invariant natural killer T(iNKT)cells and mucosal-associated invariant T(MAIT)cells,have been identified[1].These cells are different from conventional T cells in that they reside in tissues such as the liver,lung,and skin,rather than the lymph node and spleen[2].Although iNKT and MAIT cells are abundant in the skin immediately after birth,the detailed functions or the mechanisms regulating their localization have not been clarified[3].In a study published in Nature Immunology,Wang et *** that the early homing of iNKT cells to the skin was dependent on CCR10 expression during the stage of thymic development and was critical for proper commensal bacterial colonization and skin development[4].

关键词： killer metabolism homeostasis

A host lncRNA regulates the innate immune response to an RNA virus

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Cellular & Molecular Immunology 2019年第10期16卷 841-842页

作者： Kiyoharu Fukushima hiroshi kida Department of Respiratory Medicine National Hospital Organization Osaka Toneyama Medical CenterOsakaJapan

TO THE EDITOR Recent studies have shown that more than 70%of the mammalian genome is transcribed into RNAs;however,most of these RNAs do not encode proteins and are thus called noncoding RNAs(ncRNAs).

关键词： immune EDIT innate

Revealing the diversity of neutrophil functions and subsets

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Cellular & Molecular Immunology 2021年第4期18卷 781-783页

作者： Kiyoharu Fukushima hiroshi Nabeshima hiroshi kida Department of Respiratory Medicine National Hospital Organization Osaka Toneyama Medical CenterOsakaJapan Department of Respiratory Medicine and Clinical immunology Osaka University Graduate School of MedicineOsakaJapan Laboratory of Host Defense World Premier Institute Im m unology Frontier Research Center(WPIIFReC)Osaka UniversityOsakaJapan Fujii Memorial Research Institute Otsuka Pharmaceutical CompanyLtdShigaJapan

Several recent studies have shown that diverse neutrophil subsets exhibit distinct phenotypic and functional properties in terms of disease onset and progression.1,2 In a study published in Nature Immunology,Sas et al.3 discovered a new neutrophil subset that promotes neuronal survival and axonal regeneration in the central nervous system(CNS).

关键词： neutrophil Immunology

新城疫病毒某水禽分离株经鸡体传代后由非致病型转变为速发型的研究

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中国预防兽医学报 2003年第1期25卷 59-64页

作者：于圣青丁铲 NORIKO KISHIDA hiroshi ITO hiroshi kida KOICHI OTSUKI YOSHIHIRO KAWAOKA TOSHIHIRO ITO DepatmentofVeterinaryPublicHealth 中国农业科学院家禽科学研究所江苏扬州225003 LaboratoryofMicrobiology DepartmentofDiseaseControlGraduateSchoolofVeterinaryMedicineHokkaidoUniversity DepartmentofVeterinaryMicrobiologyFacultyofAgriculture DepartmentOfPathobiologicalSciences SchoolofVeterinaryMedicineUniversityofWisconsin-Madison

最近 ,一株无毒力的新城疫病毒 (NDV)在鸡体内繁殖时 ,变成了强毒株。但至今尚未能证实 ,经鸡体传代的野生水禽新城疫病毒是否也具有变成速发型毒株的能力。为了通过实验证明从水禽中分离的非致病型NDV可以转变为速发型病毒 ,我们通过... 详细信息

最近 ,一株无毒力的新城疫病毒 (NDV)在鸡体内繁殖时 ,变成了强毒株。但至今尚未能证实 ,经鸡体传代的野生水禽新城疫病毒是否也具有变成速发型毒株的能力。为了通过实验证明从水禽中分离的非致病型NDV可以转变为速发型病毒 ,我们通过在鸡体内传播鹅源性无毒力株 ,经气囊接种连续传代 9次 ,随后再在鸡脑内传代 5次。结果显示 ,该病毒的毒力变得很强 ,致死率可达 1 0 0 %。通过致病性试验证实 ,其具有典型的速发型病毒特征 ;融合蛋白裂解位点的序列分析表明 ,原始的分离株含有无毒力型毒株共有的裂解序列 :E_R_Q_E_R/L,而通过鸡体反复传代后 ,该序列变为致病性毒株共有的序列 :K_R_Q_K_R/F。这些结果表明 ,野生水禽中自然存在的无毒力毒株 ,具有无毒力株相应的序列 ,但当其在鸡群中传播时 ,则具有变成高致病性病毒的能力。同时研究表明 ,鸡体提供了该病毒从非致病型向致病型转变的选择机制。

关键词：水禽分离株鸡体传代新城疫病毒速发型非致病型致病性选择机制 F蛋白

鸡源株与人源株H9N2流感病毒血凝素受体结合位点氨基酸比较与分析

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中国预防兽医学报 2003年第6期25卷 416-418页

作者：刘金华吴清民陈福勇郭玉璞 hiroshi kida 中国农业大学农业部预防兽医学重点开放实验室北京100094 日本北海道大学兽医学部

H9N2病毒可以感染多种禽类和哺乳动物 ,包括人类。流感病毒血凝素受体结合位点的氨基酸可以影响受体结合特性。为了解鸡源株与人源株H9N2病毒受体结合部氨基酸的差异 ,作者对二者进行了比较与分析 ,结果表明 ,鸡源株与人源株血凝素受体... 详细信息

H9N2病毒可以感染多种禽类和哺乳动物 ,包括人类。流感病毒血凝素受体结合位点的氨基酸可以影响受体结合特性。为了解鸡源株与人源株H9N2病毒受体结合部氨基酸的差异 ,作者对二者进行了比较与分析 ,结果表明 ,鸡源株与人源株血凝素受体结合部位氨基酸的第 137、183、190、2 2 6位点存在差异 ,鸡源株在这些位点分别为K、N、AorVorT、LorQ ,而人源株则分别为R、H、E、L。虽然尚不清楚这些位点的改变对病毒与细胞亲和力及宿主范围的影响 ,但由于H9N2在我国养鸡业的普遍存在 ,加强H9N2病毒的分子流行病学监测有重要意义。

关键词：禽流感 H9N2 血凝素受体结合位点

我国与韩国禽流感H9N2病毒血凝素分子特性的区别

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畜牧兽医学报 2004年第1期35卷 79-82页

作者：刘金华吴清民史为民陈福勇郭玉璞 hiroshi kida 中国农业大学农业部预防兽医学重点开放实验室北京100094 日本北海道大学兽医学部

中国与韩国都发生了H9N2亚型禽流感,且都对养禽业造成了严重损失。国际上有不少学者认为韩国的H9N2亚型流感是由中国通过禽肉及其相关产品的输入而引起。本研究针对这一情况对从中国大陆分离的H9N2病毒和自GeneBank读取的韩国H9N2病毒... 详细信息

中国与韩国都发生了H9N2亚型禽流感,且都对养禽业造成了严重损失。国际上有不少学者认为韩国的H9N2亚型流感是由中国通过禽肉及其相关产品的输入而引起。本研究针对这一情况对从中国大陆分离的H9N2病毒和自GeneBank读取的韩国H9N2病毒的血凝素核苷酸序列进行了比较分析,结果表明两者属于不同的进化分支。所有中国H9N2病毒的血凝素裂解位点都为-RSSR/G-,而韩国H9N2病毒的血凝素裂解位点为-ASVR/G-、-ASYR/G-或-ASGR/G-。韩国H9N2病毒血凝素的受体结合位点的氨基酸在第183、190和226位点分别H、E和Q;而中国毒株的变异较大,在第183位点全部为N,190位点为A、T或V,第226位点为L或Q。因此,中韩两国的H9N2病毒血凝素分子特性显著不同。

关键词：中国韩国禽流感 H9N2病毒血凝素分子特性

Current status of endoscopic retrograde cholangiopancreatography in patients with surgically altered anatomy

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World Journal of Gastroenterology 2019年第26期25卷 3313-3333页

作者： Chonlada Krutsri Mitsuhiro kida hiroshi Yamauchi Tomohisa Iwai hiroshi Imaizumi Wasaburo Koizumi Department of Surgery Faculty of MedicineRamathibodi HospitalMahidol UniversityBangkok 10400Thailand Department of Gastroenterology Graduate School of MedicineKitasato University HospitalKanagawa 252-0375Japan

Endoscopic retrograde cholangiopancreatography(ERCP)in patients with surgically altered anatomy must be performed by a highly experienced *** challenges are accessing the afferent limb in different types of reconstruction,cannulating a papilla with a reverse orientation,and performing therapeutic interventions with uncommon endoscopic *** development of endoscopic techniques has led to higher success rates in this group of ***-assisted ERCP is the endoscopic procedure of choice for high success rates in short-limb reconstruction;however,these success rate is lower in long-limb *** assisted by endoscopic ultrasonography is now popular because it can be performed independent of the limb length;however,it must be performed by a highly experienced and skilled *** deployment and small stone removal can be performed immediately after ERCP assisted by endoscopic ultrasonography,but the second session is needed for other difficult procedures such as cholangioscopy-guided electrohydraulic ***-assisted ERCP has an almost 100%success rate in longlimb reconstruction because of the use of a conventional side-view duodenoscope,which is compatible with standard *** requires cooperation between the surgeon and endoscopist and is suitable in urgent situations requiring concomitant *** review focuses on the advantages,disadvantages,and outcomes of various procedures that are suitable in different situations and reconstruction *** new techniques and their outcomes are also discussed.

关键词： Endoscopic retrograde cholangiopancreatography Surgically altered anatomy Endoscopic retrograde cholangiopancreatography in Billroth II Endoscopic retrograde cholangiopancreatography post-Whipple Endoscopic ultrasonography-guided endoscopic retrograde cholangiopancreatography

Clinical implications of doubling time of gastrointestinal submucosal tumors

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World Journal of Gastroenterology 2016年第45期22卷 10015-10023页

作者： Shuko Koizumi Mitsuhiro kida hiroshi Yamauchi Kosuke Okuwaki Tomohisa Iwai Shiro Miyazawa Miyoko Takezawa hiroshi Imaizumi Wasaburo Koizumi Department of Gastroenterology Kitasato University School of Medicine

AIM To evaluate the efficacy of doubling time(DT) of gastrointestinal submucosal tumors(GIST).METHODS From April 1987 through November 2012, a total of 323 patients were given a final histopathological diagnosis of GISTs on surgical resection or endoscopic ultrasound-guided fine-needle aspiration(EUS-FNA) in Kitasato University East Hospital or Kitasato University Hospital. We studied 53 of these patients(34 with resected tumors and 19 with unresected tumors) whose tumors could be measured on EUS on at least two successive occasions. The histopathological diagnosis was GIST in 34 patients, leiomyoma in 5, schwannoma in 3, ectopic pancreas in 1, hamartoma in 1, cyst in 1, Brunner's adenoma in 1, and spindle-cell tumor in 7. We retrospectively calculated the DT of GISTs on the basis of the time course of EUS findings to estimate the growth rate of such *** The DT was 17.2 mo for GIST, as compared with 231.2 mo for leiomyoma, 104.7 mo for schwannoma, 274.9mo for ectopic pancreas, 61.2 mo for hamartoma, 49.0 mo for cyst, and 134.7 mo for Brunner's adenoma. The GISTs were divided into risk classes on the basis of tumor diameters and mitotic figures(Fletcher's classification). The classification was extremely low risk or low risk in 28 patients, intermediate risk in 3, and high risk in 3. DT of GIST according to risk was 24.0 mo for extremely low-risk plus low-risk GIST, 17.1 mo for intermediate-risk GIST, and 3.9 mo for high-risk GIST. DT of GIST was significantly shorter than that of leiomyoma plus schwannoma(P < 0.05), and DT of high-risk GIST was significantly shorter than that of extremely low-risk plus low-risk GIST(P < 0.05).CONCLUSION For GIST, a higher risk grade was associated with a significantly shorter DT. Small SMTs should initially be followed up within 6 mo after detection.

关键词：胃肠的 submucosal 肿瘤双倍工资 Submucosal 肿瘤起始的观察持续时间内视镜的 ultrasonography 内视镜的指导 ultrasonography 的好针渴望 Fletcher’ s 分类

Is Goshinjo therapy effective in cognitive impairment after severe traumatic brain injury?

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Neural Regeneration Research 2013年第12期8卷 1146-1150页

作者： Keiji Hashimoto Kisho kida Hashimoto Cognitive Research Institute Tokyo 156-0051 Japan Kihodo Head Office Clinic Tokyo 151-0065 Japan

We report a case of a 21-year-old man who had severe traumatic brain injury as a result of an accident at the age of 16 years. Two years and 4 months after the trauma, at the age of 19 years, he still had severe right hemiplegia and cognitive dysfunction including aphasia and attention and memory disturbance. Conventional rehabilitation programs cou（d not resolve all of the neuropsychological problems. He started receiving Goshinjo therapy over a period of 22 months. Following the therapy, significant improvements in verbal intelligence quotient （assessed by the Wechsler Adult Intelligence Scale-Third Edition） and attention and concentration function （using the Wechsler Memory Scale-Revised）, and remission of traumatic epilepsy were observed. Goshinjo therapy is suspected to be effective in the treatment of cognitive dysfunction in the chronic stage after severe traumatic brain injury.

关键词： neural regeneration brain injury traumatic brain injury clinical practice Goshinjo therapy rehabilitation cognitive impairment energy field in human body Jaki neuroregeneration