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Si nanowire FET and its modeling

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Science China(Information Sciences) 2011年第5期54卷 1004-1010+1012页

作者： iwai hiroshi NATORI Kenji SHIRAISHI Kenji IWATA Jun-ichi OSHIYAMA Atsushi YAMADA Keisaku OHMORI Kenji KAKUSHIMA Kuniyuki AHMET Parhat Frontier Research Center Tokyo Institute of Technology Yokohama Japan Interdisciplinary Graduate School of Science and Engineering Tokyo Institute of Technology Yokohama Japan Graduate School of Pure and Applied Sciences University of Tsukuba Tsukuba Japan Center for Computational Sciences University of Tsukuba Tsukuba Japan School of Engineering The University of Tokyo Tokyo Japan

Because of its ability to effectively suppress off-leakage current with its gate-around conffguration, the Si nanowire FET is considered to be the ultimate structure for ultra-small CMOS devices to the extent that the devices would be approaching their downsized limits. Recently, several experimental studies of Si nanowire FETs with on-currents much larger than those of planar MOSFETs have been published. Consequently, Si nanowire FETs are now gaining significant attention as the most promising candidate for mainstream CMOS devices in the 2020s. To enable the introduction of the Si nanowire FETs into integrated circuits, good compact models, which circuit designers can easily handle, are essential. However, it is a very challenging task to establish such a compact model, because the ID - VD characteristics of Si nanowire FETs are affected by the band structure of the nanowire, which is very sensitive to the nanowire diameter, cross-sectional shape, crystal orientation, mechanical stress and interface states. In this paper, the recent status of research on Si nanowire FETs in experimental and theoretical studies is described.

关键词： Si nanowire MOSFET modeling

Current status of endoscopic retrograde cholangiopancreatography in patients with surgically altered anatomy

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World Journal of Gastroenterology 2019年第26期25卷 3313-3333页

作者： Chonlada Krutsri Mitsuhiro Kida hiroshi Yamauchi Tomohisa iwai hiroshi Imaizumi Wasaburo Koizumi Department of Surgery Faculty of MedicineRamathibodi HospitalMahidol UniversityBangkok 10400Thailand Department of Gastroenterology Graduate School of MedicineKitasato University HospitalKanagawa 252-0375Japan

Endoscopic retrograde cholangiopancreatography(ERCP)in patients with surgically altered anatomy must be performed by a highly experienced *** challenges are accessing the afferent limb in different types of reconstruction,cannulating a papilla with a reverse orientation,and performing therapeutic interventions with uncommon endoscopic *** development of endoscopic techniques has led to higher success rates in this group of ***-assisted ERCP is the endoscopic procedure of choice for high success rates in short-limb reconstruction;however,these success rate is lower in long-limb *** assisted by endoscopic ultrasonography is now popular because it can be performed independent of the limb length;however,it must be performed by a highly experienced and skilled *** deployment and small stone removal can be performed immediately after ERCP assisted by endoscopic ultrasonography,but the second session is needed for other difficult procedures such as cholangioscopy-guided electrohydraulic ***-assisted ERCP has an almost 100%success rate in longlimb reconstruction because of the use of a conventional side-view duodenoscope,which is compatible with standard *** requires cooperation between the surgeon and endoscopist and is suitable in urgent situations requiring concomitant *** review focuses on the advantages,disadvantages,and outcomes of various procedures that are suitable in different situations and reconstruction *** new techniques and their outcomes are also discussed.

关键词： Endoscopic retrograde cholangiopancreatography Surgically altered anatomy Endoscopic retrograde cholangiopancreatography in Billroth II Endoscopic retrograde cholangiopancreatography post-Whipple Endoscopic ultrasonography-guided endoscopic retrograde cholangiopancreatography

Clinical implications of doubling time of gastrointestinal submucosal tumors

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World Journal of Gastroenterology 2016年第45期22卷 10015-10023页

作者： Shuko Koizumi Mitsuhiro Kida hiroshi Yamauchi Kosuke Okuwaki Tomohisa iwai Shiro Miyazawa Miyoko Takezawa hiroshi Imaizumi Wasaburo Koizumi Department of Gastroenterology Kitasato University School of Medicine

AIM To evaluate the efficacy of doubling time(DT) of gastrointestinal submucosal tumors(GIST).METHODS From April 1987 through November 2012, a total of 323 patients were given a final histopathological diagnosis of GISTs on surgical resection or endoscopic ultrasound-guided fine-needle aspiration(EUS-FNA) in Kitasato University East Hospital or Kitasato University Hospital. We studied 53 of these patients(34 with resected tumors and 19 with unresected tumors) whose tumors could be measured on EUS on at least two successive occasions. The histopathological diagnosis was GIST in 34 patients, leiomyoma in 5, schwannoma in 3, ectopic pancreas in 1, hamartoma in 1, cyst in 1, Brunner's adenoma in 1, and spindle-cell tumor in 7. We retrospectively calculated the DT of GISTs on the basis of the time course of EUS findings to estimate the growth rate of such *** The DT was 17.2 mo for GIST, as compared with 231.2 mo for leiomyoma, 104.7 mo for schwannoma, 274.9mo for ectopic pancreas, 61.2 mo for hamartoma, 49.0 mo for cyst, and 134.7 mo for Brunner's adenoma. The GISTs were divided into risk classes on the basis of tumor diameters and mitotic figures(Fletcher's classification). The classification was extremely low risk or low risk in 28 patients, intermediate risk in 3, and high risk in 3. DT of GIST according to risk was 24.0 mo for extremely low-risk plus low-risk GIST, 17.1 mo for intermediate-risk GIST, and 3.9 mo for high-risk GIST. DT of GIST was significantly shorter than that of leiomyoma plus schwannoma(P < 0.05), and DT of high-risk GIST was significantly shorter than that of extremely low-risk plus low-risk GIST(P < 0.05).CONCLUSION For GIST, a higher risk grade was associated with a significantly shorter DT. Small SMTs should initially be followed up within 6 mo after detection.

关键词：胃肠的 submucosal 肿瘤双倍工资 Submucosal 肿瘤起始的观察持续时间内视镜的 ultrasonography 内视镜的指导 ultrasonography 的好针渴望 Fletcher’ s 分类

Minor Salivary Gland Tumors: A Retrospective Study of 37 Cases

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Open Journal of Stomatology 2022年第12期12卷 363-371页

作者： hiroshi Yamamoto Yukiko Iizuka Erika iwai Shu Fushimi Ryutaro Tsuchimoto Minami Akagi Shina Kato Kunio Hayashi Mitsuko Nakayama Masaaki Suemitsu Tadahiko Utsunomiya Yoshikazu Nakayama Kayo Kuyama Masamichi Komiya Department of Oral Surgery Nihon University School of Dentistry at Matsudo Chiba Japan Nihon University Graduate School of Dentistry at Matsudo Oral and Maxillofacial Surgery Chiba Japan Department of Pathology Nihon University School of Dentistry at Matsudo Chiba Japan Nihon University Graduate School of Dentistry at Matsudo Oral Pathology Chiba Japan

Salivary gland tumors represent 2% - 6.5% of all head and neck tumors. Since salivary gland tumors have various clinical features and histological types, it is often difficult to diagnose and treat them. The aim of this study was to conduct a retrospective clinical-statistical analysis of 37 minor salivary gland tumors (MSGTs) treated in the Department of Oral Surgery at Nihon University School of Dentistry at Matsudo over a 16-year period. The frequencies and distributions of sex, age, occurrence site, preoperative examination (fine needle cytology and/or biopsy), treatment, and prognosis of the tumors were analyzed and compared with previous reports. The average age at diagnosis was 58.1 years (range 22 - 91 years). The peak occurrence of tumors was in the sixties (10 cases, 27.0%), followed by the forties (8 cases, 21.6%) and the seventies (7 cases, 18.9%). The average age of patients with benign tumors was 56.8 years (range 22 - 91 years). For malignant tumors, the average age was 61.7 years (range 42 - 81 years). The male-female ratio was 1:2.1 for all minor salivary gland tumors, 1:2.4 for benign tumors, and 1.5:1 for malignant tumors. There were 27 (73.0%) benign and 10 (27.0%) malignant tumors. Pleomorphic adenoma (PA) was the most common tumor (24 (64.9%) cases). Most salivary gland tumors originated from the palate (21 cases, 56.8%);the second most common site was the buccal mucosa (14 cases, 37.8%). For most patients, an intraoral mass was the primary presentation, and the second most common symptom was swelling. Surgical treatment was performed for all cases, both benign and malignant tumors. There was one case of local recurrence of PA, as well as one of multiple lung metastases after surgery for adenoid cystic carcinoma. Diagnosis and treatment of MSGTs are often delayed because the patients have few symptoms, and it is difficult to distinguish benign from malignant tumors. More cases need to be examined in the future, and the diagnostic accuracy of im

关键词： Minor Salivary Gland Tumor Clinical Statistics Intraoral Japanese

Innovations and techniques for balloon-enteroscopeassisted endoscopic retrograde cholangiopancreatography in patients with altered gastrointestinal anatomy

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World Journal of Gastroenterology 2015年第21期21卷 6460-6469页

作者： hiroshi Yamauchi Mitsuhiro Kida hiroshi Imaizumi Kosuke Okuwaki Shiro Miyazawa Tomohisa iwai Wasaburo Koizumi Department of Gastroenterology Kitasato University Hospital

Endoscopic retrograde cholangiopancreatography(ERCP) remains challenging in patients who have undergone surgical reconstruction of the ***,many studies have reported that balloonenteroscope-assisted ERCP(BEA-ERCP) is a safe and effective ***,further improvements in outcomes and the development of simplified procedures are *** treatment,Laparoscopy-assisted ERCP,endoscopic ultrasoundguided anterograde intervention,and open surgery are effective ***,treatment should be noninvasive,effective,and *** believe that these procedures should be performed only in difficult-to-treat patients because of many potential ***-ERCP still requires high expertiselevel techniques and is far from a routinely performed *** techniques have been proposed to facilitate scope insertion(insertion with percutaneous transhepatic biliary drainage(PTBD) rendezvous technique,Short type single-balloon enteroscopes with passive bending section,Intraluminal injection of indigo carmine,CO2 inflation guidance),cannulation(PTBD or percutaneous transgallbladder drainage rendezvous technique,Dilation using screw drill,Rendezvous technique combining DBE with a cholangioscope,endoscopic ultrasound-guided rendezvous technique),and treatment(overtube-assisted technique,Short type balloon enteroscopes) during *** use of these techniques may allow treatment to be performed by BEA-ERCP in many patients.A standard procedure for ERCP yet to be established for patients with a reconstructed *** present,BEA-ERCP is considered the safest and most effective procedure and is therefore likely to be recommended as firstline *** this article,we discuss the current status of BEA-ERCP in patients with surgically altered gastrointestinal anatomy.

关键词： Balloon enteroscopy Endoscopic retrogradecholangiopancreatography Altered gastrointestinal anatomy Balloon-enteroscope-assisted endoscopicretrograde cholangiopancreatography

Passive-bending,short-type single-balloon enteroscope for endoscopic retrograde cholangiopancreatography in Roux-en-Y anastomosis patients

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World Journal of Gastroenterology 2015年第5期21卷 1546-1553页

作者： hiroshi Yamauchi Mitsuhiro Kida Kosuke Okuwaki Shiro Miyazawa Tomohisa iwai Shuko Tokunaga Miyoko Takezawa hiroshi Imaizumi Wasaburo Koizumi Department of Gastroenterology Kitasato University East HospitalKana-gawa 252--0380Japan

AIM:To evaluate short-type-single-balloon enteroscope(SBE) with passive-bending,high-force transmission functions for endoscopic retrograde cholangiopancreatography(ERCP) in patients with Roux-en-Y ***:Short-type SBE with this technology(SIF-Y0004-V01; working length,1520 mm; channel diameter,3.2 mm) was used to perform 50 ERCP procedures in 37 patients with Roux-en-Y *** rate of reaching the blind end,time required to reach the blind end,diagnostic and therapeutic success rates,and procedure time and complications were studied retrospectively and compared with the results of 34 sessions of ERCP performed using a short-type SBE without this technology(SIF-Y0004; working length,1520 mm; channel diameter,3.2 mm) in 25 ***:The rate of reaching the blind end was 90% with SIF-Y0004-V01 and 91% with SIF-Y0004(P = 0.59).The median time required to reach the papilla was significantly shorter with SIF-Y0004-V01 than with SIF-Y0004(16 min vs 24 min,P = 0.04).The diagnostic success rate was 93% with SIFY0004-V01 and 84% with SIF-Y0004(P = 0.17).The therapeutic success rate was 95% with SIF-Y0004-V01 and 96% with SIF-Y0004(P = 0.68).The median procedure time was 40 min with SIF-Y0004-V01 and 36 min with SIF-Y0004(P = 0.50).The incidence of hyperamylasemia was 6.0% in the SIF-Y0004-V01 group and 14.7% in the SIF-Y0004 group(P = 0.723).The incidence of pancreatitis was 0% in the SIFY0004-V01 group and 5.9% in the SIF-Y0004 group(P > 0.999).The incidence of gastrointestinal perforation was 2.0%(1/50) in the SIF-Y0004-V01 group and 2.9%(1/34) in the SIF-Y0004 group(P > 0.999).CONCLUSION:SIF-Y0004-V01 is useful for ERCP inpatients with Roux-en-Y anastomosis and may reduce the time required to reach the blind end.

关键词： Passive bending Roux-en-Y anastomosis Endoscopic r

First case of IgG4-related sclerosing cholangitis associated with autoimmune hemolytic anemia

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World Journal of Gastroenterology 2014年第26期20卷 8740-8744页

作者： Hironori Masutani Kosuke Okuwaki Mitsuhiro Kida hiroshi Yamauchi hiroshi Imaizumi Shiro Miyazawa Tomohisa iwai Miyoko Takezawa Wasaburo Koizumi Department of Gastroenterology Kitasato University East Hospital

To our knowledge,patients with immunoglobulin G4-related sclerosing cholangitis(IgG4-SC)associated with autoimmune hemolytic anemia(AIHA)have not been reported *** patients with IgG4-SC have autoimmune pancreatitis(AIP)and respond to steroid ***,isolated cases of IgG4-SC are difficult to *** describe our experience with a patient who had IgG4-SC without AIP in whom the presence of AIHA led to *** patient was a73-year-old man who was being treated for *** dysfunction was diagnosed on blood tests at another *** studies suggested the presence of carcinoma of the hepatic hilus and primary sclerosing cholangitis,but a rapidly progressing anemia developed *** the diagnosis of AIHA,steroid treatment was begun,and the biliary stricture ***4-SC without AIP was thus diagnosed.

关键词： IgG4-related sclerosing cholangitis Immunoglobulin

Short-type single balloon enteroscope for endoscopic retrograde cholangiopancreatography with altered gastrointestinal anatomy

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World Journal of Gastroenterology 2013年第11期19卷 1728-1735页

作者： hiroshi Yamauchi Mitsuhiro Kida Kosuke Okuwaki Shiro Miyazawa Tomohisa iwai Miyoko Takezawa Hidehiko Kikuchi Maya Watanabe hiroshi Imaizumi Wasaburo Koizumi Department of Gastroenterology Kitasato University East HospitalSagamiharaKanagawa 252-0380Japan

AIM:To evaluate the effectiveness of a short-type single-balloon-enteroscope(SBE) for endoscopic retrograde cholangiopancreatography(ERCP) in patients with a reconstructed ***:Short-type SBE was developed to perform ERCP in postoperative patients with a reconstructed ***-type SBE is a direct-viewing endoscope with the following specifications:working length,1520 mm;total length,1840 mm;channel diameter,3.2 *** addition,short-type SBE has a water-jet *** study group comprised 22 patients who underwent 31 sessions of short-type SBE-assisted ERCP from June 2011 through May *** was performed by Billroth-Ⅱ(B-Ⅱ) gastrectomy in 6 patients(8 sessions),Roux-en-Y(R-Y) gastrectomy in 14 patients(21 sessions),and R-Y hepaticojejunostomy in 2 patients(2 sessions).We retrospectively studied the rate of reaching the blind end(papilla of Vater or choledochojejunal anastomosis),mean time required to reach the blind end,diagnostic success rate(defined as the rate of successfully imaging the bile and pancreatic ducts),therapeutic success rate(defined as the rate of successfully completing endoscopic treatment),mean procedure time,and ***:Among the 31 sessions of ERCP,the rate of reaching the blind end was 88% in B-Ⅱ gastrectomy,91% in R-Y gastrectomy,and 100% in R-Y *** mean time required to reach the papilla was 18.3 min in B-Ⅱ gastrectomy,21.1 min in R-Y gastrectomy,and 32.5 min in R-Y *** diagnostic success rates in all patients and those with an intact papilla were respectively 86% and 86% in B-Ⅱ gastrectomy,90% and 87% in R-Y gastrectomy,and 100% in R-Y *** therapeutic success rates in all patients and those with an intact papilla were respectively 100% and 100% in B-Ⅱ gastrectomy,94% and 92% in R-Y gastrectomy,and 100% in R-Y *** the channel diameter was 3.2 mm,stone extraction could be performed with a wire-guided basket in 12

关键词： Endoscopic retrograde cholangiopancreatography Single-balloon-enteroscope Short type BillrothII gastrectomy Roux-en-Y gastrectomy

Usefulness of serum lipase for early diagnosis of post-endoscopic retrograde cholangiopancreatography pancreatitis

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World Journal of Gastrointestinal Endoscopy 2019年第9期11卷 477-485页

作者： Masayoshi Tadehara Kosuke Okuwaki hiroshi Imaizumi Mitsuhiro Kida Tomohisa iwai hiroshi Yamauchi Toru Kaneko Rikiya Hasegawa Eiji Miyata Yusuke Kawaguchi Hironori Masutani Wasaburo Koizumi Department of Gastroenterology Kitasato University School of Medicine

BACKGROUND Post-endoscopic retrograde cholangiopancreatography(ERCP)pancreatitis(PEP)is new onset acute pancreatitis after *** complication is sometimes *** such,PEP should be diagnosed early so that therapeutic interventions can be carried *** lipase(s-Lip)is useful for diagnosing acute ***,its usefulness for diagnosing PEP has not been sufficiently *** This study aimed to retrospectively examine the usefulness of s-Lip for the early diagnosis of *** We retrospectively examined 4192 patients who underwent ERCP at our two hospitals over the last 5 *** primary outcomes were a comparison of the areas under the receiver operating characteristic(ROC)curves(AUCs)of s-Lip and serum amylase(s-Amy),s-Lip and s-Amy cutoff values based on the presence or absence of PEP in the early stage after ERCP via ROC curves,and the diagnostic properties[sensitivities,specificities,positive predictive values(PPV),and negative predictive value(NPV)]of these cutoff values for PEP *** Based on the eligibility and exclusion criteria,804 cases were *** the entire course,PEP occurred in 78 patients(9.7%).It occurred in the early stage after ERCP in 40 patients(51.3%)and in the late stage after ERCP in 38 patients(48.7%).The AUCs were 0.908 for s-Lip[95%confidence interval(CI):0.880-0.940,P<0.001]and 0.880 for s-Amy(95%CI:0.846-0.915,P<0.001),indicating both are useful for early *** comparing the AUCs,s-Lip was found to be significantly more useful for the early diagnosis of PEP than s-Amy(P=0.023).The optimal cutoff values calculated from the ROC curves were 342 U/L for s-Lip(sensitivity,0.859;specificity,0.867;PPV,0.405;NPV,0.981)and 171 U/L for s-Amy(sensitivity,0.859;specificity,0.763;PPV,0.277;NPV,0.979).CONCLUSION S-Lip was significantly more useful for the early diagnosis of *** s-Lip after ERCP could help diagnose PEP earlier;hence,therapeutic interventions can be provided earlier.

关键词： Endoscopic retrograde cholangiopancreatography Post-endoscopic retrograde cholangiopancreatography pancreatitis Pancreatitis Lipase Amylase