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CLINICOPATHOLOGICAL CHARACTERISTICS OF ADVANCED COLORECTAL CANCER 30mm OR SMALLER IN DIAMETER

Chinese Medical Sciences Journal 2007年第2期22卷 98-103页

作者： Hong Zhang Chun-sheng Chen Jin-chun Cong Lei Qiao Taisuke hasegawa Shigeki Takashima Department of General Surgery the Second Affiliated Hospital of China Medical University Shenyang 110004 Department of General Gastrointestinal Surgery Kanazawa Medical University Ishikawa 920-0293 Japan

Objective To investigate the clinicopathological characteristics of advanced colorectal cancer which was 30 mm or smaller in diameter. Methods Retrospective analysis documented 80 patients with small advanced colorectal cancer from May 1985 to May 2002. According to the diameter of tumors, all patients were divided into three groups: Group A (10 mm or less), Group B (11-20 mm), Group C (21-30 mm). Considering the number of patients in Group A was smaller, we combined Group A with Group B as Group D. Then various clinicopathological characteristics were compared between Group C and Group D. Results The most common site of small advanced colorectal cancer was sigmoid colon and rectum that accounted for 36.2% and 35.0% of all cases. The average diameter of total tumors was 23.3 mm. Type 2 was the most common macroscopic type (63.7%) and the moderate differentiation was seen in 77.5% of cases. Thirty-eight (47.5%) cases had lymph node metastasis. Three (3.8%) cases had liver metastasis and three (3.8%) cases had peritoneal metastasis. The frequency of lymph node metastasis was found significantly different between Group C and Group D (54.2% vs. 28.6%, P<0.05), as well as between the groups with different depth of invasion (P<0.05). Curability A resection was performed in 69 (86.2%) cases. Conclusions Tumor size and depth of invasion are related to lymph node metastasis in small advanced colorectal cancer. However, the small size of tumor may not always be *** parameter for estimating the risk of lymph node metastasis. Small colorectal cancers also do not always mean the early stage. Surgeons should be aware of the features of small advanced colorectal cancers to select ideal management and perform perfect resection.

关键词：直肠癌临床病理学淋巴结转移直径

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The Association between Sentinel Lymph Node Metastasis and Ki-67 Labeling Index

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Advances in Breast Cancer Research 2013年第3期2卷 60-65页

作者： Yu Koyama hiroshi Ichikawa Jun Sakata Eiko Sakata Kumiko Tatsuda Miki hasegawa Chie Toshikawa Naoko Manba Mayuko Ikarashi Toshifumi Wakai Division of Digestive & General Surgery Niigata University Graduate School of Medical & Dental Sciences Niigata Japan

Background: The purpose of this study was to elucidate the association between sentinel lymph node (SLN) metastasis and Ki67 labeling index and to elucidate whether Ki-67 was useful or not for prediction of SLN metastasis in breast cancer. Methods: We identified 343 invasive breast cancer patients with sentinel lymph node biopsy (SLNB) from 2003 to 2012. The association between SLN status and clinicopathological features, molecular subtypes and Ki-67 labeling index were evaluated. Results: SLN metastasis was detected in 79 patients (23.0%). SLN metastasis was significantly associated with clinical T-stage (p = 0.0003), lymphovascular involvement (LVI) (p 0.0001). Ki-67 labeling index of primary tumor was significantly lower in SLN positive patients (p = 0.0331), and Ki-67 cut-off point of 7.5% was useful for dividing SLN positive from negative (p = 0.0197). Conclusion: Low value of Ki-67 labeling index, in addition to progression of clinical T-stage and presence of LVI, is significantly associated with SLN metastasis, and it seems to be useful to consider Ki-67 labeling index for SLN metastasis prediction.

关键词： Breast Cancer Sentinel Lymph Node Molecular Subtypes Ki-67 Labeling Index

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Large edge magnetism in oxidized few-layer black phosphorus nanomeshes

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Nano Research 2017年第2期10卷 718-728页

作者： Yudai Nakanishi Ayumi Ishi Chika Ohata David Soriano Ryo Iwaki Kyoko Nomura~ Miki hasegawa Taketomo Nakamura Shingo Katsumoto Stephan Roche Junji Haruyama Faculty of Science and Engineering Aoyama Gakuin University 5- I0-1 Fuchinobe Sagamihara Kanagawa 252-5258 Japan Chemistry and Biological Science Aoyama Gakuin University 5-10-1 Fuchinobe Sagamihara Kanagawa 252-5258 Japan Catalan Institute of Nanoscience and Nanotechnology (ICN2) CSIC and The Barcelona Institute of Science and Technology Campus UAB Bellaterra 08193 Barcelona Spain Institucio Catalana de Recercai Estudis Avancats (ICREA) 08010 Barcelona Spain Institute for solid state physics The University of Tokyo 5- I-5 Kashiwanoha Kashiwa Chiba 277-8581 Japan

The formation and control of a room-temperature magnetic order in two- dimensional （2D） materials is a challenging quest for the advent of innovative magnetic- and spintronic-based technologies. To date, edge magnetism in 2D materials has been experimentally observed in hydrogen （H）-terminated graphene nanoribbons （GNRs） and graphene nanomeshes （GNMs）, but the measured magnetization remains far too small to allow envisioning practical applications. Herein, we report experimental evidences of large room-temperature edge ferromagnetism （FM） obtained from oxygen （O）-terminated zigzag pore edges of few-layer black phosphorus （P） nanomeshes （BPNMs）. The magnetization values per unit area are -100 times larger than those reported for H-terminated GNMs, while the magnetism is absent for H-terminated BPNMs. The magnetization measurements and the first-principles simulations suggest that the origin of such a magnetic order could stem from ferromagnetic spin coupling between edge P with O atoms, resulting in a strong spin localization at the edge valence band, and from uniform oxidation of full pore edges over a large area and interlayer spin interaction. Our findings pave the way for realizing high-efficiency 2D flexible magnetic and spintronic devices without the use of rare magnetic elements.

关键词： black phosphorus nanomesh edge magnetism spintronics zigzag edge oxygen termination rare-metal free

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RELATIONSHIP BETWEEN CORONARY ANGIOSCOPIC AND INTRAVASCULAR ULTRASOUND IMAGING AND RESTENOSIS

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中华医学杂志(英文版) 1995年第10期108卷 743-749页

作者：徐世全 Nomura M Kurokawa H Ando T Kimura M Ishii J hasegawa H Kondo T Tadiki S 亓鹏 Beijing No.514 Hospital Fujita Health University.Toyoake Japan

In order to investigate the relationship between restenosis and the morphology detected by coronary angioscopy （CASC） and introvascular ultrasound imaging （IVUS）,17 patients were detected by CASC and IVUS immediately and 3 months after percutaneous transluminai coronary angioscopy （PTCA）.The results showed that the dilation index by IVUS （Dlu） was significantly lower in restenosis patients than in non-restenosis patients （0.42±0.08 versus 0.78±0.16, P<0.01） and that the elastic recoil （ER） was higher in restenosis patients than in non-restenosis patients （4.51±1.42mmversus 1.63±1.20 mm, P<0.01）, and that the elastic recoil rate （ERR） was also higher in restenosis patients than in non-restenosis patients （57.3±8.07% venus 21.80±16.84% P<0.01）,and that coronary dissection,atheromatous plaque and calcification as well as the coiour of inner coronary artery had no relation with chronic *** conclusion,the elastic recoil is one of the important factors of chronic restcnosis after PTCA.

关键词： IVUS CASC PTCA RELATIONSHIP BETWEEN CORONARY ANGIOSCOPIC AND INTRAVASCULAR ULTRASOUND IMAGING AND RESTENOSIS

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Effects of elevated [CO_2] on stem and root lodging among rice cultivars

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Chinese Science Bulletin 2013年第15期58卷 1787-1794页

作者： ZHU ChunWu CHENG WeiGuo SAKAI Hidemitsu OIKAWA Shimpei LAZA Rebecca C USUI Yasuhiro hasegawa Toshihiro National Institute for Agro-Environmental Sciences Ibaraki 305-8604Japan Faculty of Agriculture Yamagata UniversityYamagata 997-8555Japan Faculty of International Agriculture and Food Studies Tokyo University of AgricultureTokyo 156-8502Japan Crop and Environmental Sciences Division International Rice Research InstituteDAPO Box 7777Metro ManilaPhilippines

Studies showed that elevated [CO2] would improve photosynthetic rates and enhance yields of rice;however,few studies have focused on the response of rice lodging,which is a major cause of cereal yield loss and quality reduction,under elevated [CO2].In this study,we examined the effects of elevated [CO2] on stem and root lodging using 4 rice cultivars(86Y8,japonica hybrid;LYP9,2-line indica hybrid;variety 9311,type of indica inbred rice,and SY63,3-line indica hybrid) grown under two [CO2] levels:400 and 680 μmol *** results indicated that under elevated [CO2],the stem-lodging risk(SLR) of 9311 decreased,while in SY63 the SLR increased,86Y8 and LYP9 were not significantly affected;the risk of root lodging was reduced for all cultivars,because root biomass(instead of root number) and bending strength were increased significantly,and then the increase of anti-lodging ability is far higher than that of self-weight mass moment for all *** findings suggested that higher [CO2] can enhance the risk of stem-lodging for cultivars with strong-[CO2]-responses,but may not aggravate the root lodging for all rice cultivars.

关键词： CO2浓度升高倒伏水稻品种间种茎二氧化碳浓度升高水稻品种杂交粳稻两优培九

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日本南部八重山群岛黑冠鳽的食性分析(英文)

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Chinese Birds 2011年第2期02卷 87-93页

作者： Kazuto KAWAKAMI Masaki FUJITA Motohiro hasegawa hiroshi MAKIHARA Forestry and Forest Products Research Institute Okinawa Prefectural Museum and Art Museum

黑冠鳽(Gorsachius melanolophus)分布于南亚、东南亚及东亚的热带和亚热带地区。由于此鸟种常繁殖于密林中,对其生态学特征知之甚少,目前仅有少量关于其食性的信息。我们通过分析日本南部八重山群岛黑冠鳽食丸和胃的内含物,定量分析了... 详细信息

黑冠鳽(Gorsachius melanolophus)分布于南亚、东南亚及东亚的热带和亚热带地区。由于此鸟种常繁殖于密林中,对其生态学特征知之甚少,目前仅有少量关于其食性的信息。我们通过分析日本南部八重山群岛黑冠鳽食丸和胃的内含物,定量分析了该地区黑冠鳽的食性特征。结果表明,黑冠鳽最喜捕食陆地上的蜗牛、蛛形类、淡水蟹类及昆虫等食物,但不包括鱼类。蚯蚓被普遍认为是该鸟种的一个主要食物,但因蚯蚓的易消化性,极少在食丸中残留,所以我们并未观察黑冠鳽捕食蚯蚓的证据。这表明黑冠鳽主要以活动于湿润森林地表的土壤动物为食。虽然黑冠鳽并不直接栖息于水生环境,但它偏好具有溪流及沼泽等湿地生境的潮湿森林。因此,为更好地维持黑冠鳽的种群,需对环境潮湿的森林加以保护。

关键词：食性黑冠(开鳥) 食丸分析土壤动物

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Ileo-ileal intussusception caused by lymphangioma of the small bowel treated by single-incision laparoscopic-assisted ileal resection

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World Journal of Gastroenterology 2017年第1期23卷 167-172页

作者： Atsushi Kohga Akihiro Kawabe Yuto hasegawa Kiyoshige Yajima Takuya Okumura Kimihiro Yamashita Jun Isogaki Kenji Suzuki Akira Komiyama Division of Surgery Fujinomiya City General Hospital Division of Pathology Fujinomiya City General Hospital

Intraabdominal lymphangiomas are uncommon;additionally,those affecting the gastrointestinal tract are rare and account for less than 1%of *** caused by a cystic lymphangioma of the small bowel is extremely *** patient was a20-year-old woman who visited our emergency room with a complaint of abdominal pain.A computed tomography image revealed ileo-ileal intussusception with a leading hypovascular mass measuring 1 cm in a ***-incision laparoscopic-assisted ileal resection was *** surgical specimen consisted of a soft polycystic ***,a pedunculated polyp with a convolutional pattern was ***,the inner surfaces of the cysts were covered with a single layer of endothelial *** immunohistochemical examination,the endothelial cells were partially positive for D2-40 and *** muscle cells were also found around the *** lesion was diagnosed as a cystic *** of cases of small bowel lymphangiomas have previously been *** these,cases with intussusception were very *** is the first case of small bowel intussusception due to lymphangioma treated by singleincision laparoscopic-assisted surgery.

关键词：摄取单个切口的帮助 laparoscopic 的外科淋巴管瘤

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The Relationship between Major Components of PM2.5 and Meteorological Factors in Urban Tokyo, Japan

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Journal of Environmental Science and Engineering(B) 2017年第1期6卷 27-33页

作者： Ping Li Hideo hasegawa Graduate School of Science and Technology Niigata University 8050 Ikarashi 2-no-cho Nishi-ku Niigata 950-2181 Japan College of Chemistry and Chemical Engineering Qiqihaer University No. 42 Wenhua Street Qiqihar 161006 China

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Active Stall Control System on NACA0012 by Using Synthetic Jet Actuator

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Journal of Flow Control, Measurement & Visualization 2019年第1期7卷 61-72页

作者： Hiroaki hasegawa Shigeru Obayashi Department of Mechanical & Intelligent Engineering Utsunomiya University Utsunomiya Japan Institute of Fluid Science Tohoku University Sendai Japan

Flow separation is typically an undesirable phenomenon, and boundary layer control is an important technique for the separation problems on airfoils. The synthetic jet actuator is considered as a promising candidate for flow control applications because of its compact nature and ability to generate momentum without the need for fluidic plumbing. In the present study, an active separation control system using synthetic jets is proposed and practically applied to the stall control of the NACA0012 airfoil in a wind tunnel test. In our proposed system, the flow conditions (stalled or unstalled) can be judged by calculating from two static pressure holes on the airfoil upper surface alone. The experimental results indicate that the maximum lift coefficient increases by 11% and the stall angle rises by 4°in contrast to the case under no control. It is confirmed that our proposed system can suppress the stall on the NACA0012 airfoil and that the aerodynamic performance of the airfoil can be enhanced. The proposed system can also be operated prior to the onset of stall. Therefore, separation control is always attained with no stall for all flow fields produced by changing the angle of attack that were examined.

关键词： Active Control Airfoil Lift Separation Stall Synthetic Jet

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Measurement of Surface SH-Wave Velocities Generated on the Surface of Japanese Cypress Column

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Open Journal of Acoustics 2014年第4期4卷 177-183页

作者： Masumi hasegawa Junji Matsumura Department of Agro-Environmental Science Faculty of Agriculture Kyushu University Fukuoka Japan

Polyetherimide resin wedge transducers were used to generate a shear wave that was obliquely incident relative to the surface of a Japanese cypress column for measuring the surface SH-wave velocity. As the inter-transducer distance increased, the propagation time increased and the am-plitude became smaller. The propagation time and the amplitude were significantly correlated with the inter-transducer distance. The SH-wave velocity ranged from 1270 m/s to 1496 m/s. Surface SH-wave velocity was lower in the central part of the column and higher in the outer part. Velocity was negatively correlated with moisture content at 1% of significance level. These results suggest the accomplishment of the first target for applying the surface SH-wave acoustoelastic technique to nondestructive evaluation of drying stress in wood.

关键词： Surface SH-Wave Moisture Content Acoustoelasticity Velocity Wood

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