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Development of Epstein-Barr virus-associated gastric cancer:Infection,inflammation,and oncogenesis

World Journal of Gastroenterology 2022年第44期28卷 6249-6257页

作者： Hisashi Iizasa Andy Visi Kartika Sintayehu Fekadu Shunpei Okada Daichi Onomura Afifah Fatimah Azzahra Ahmad Wadi Mosammat Mahmuda Khatun Thin Myat Moe Jun Nishikawa hironori yoshiyama Department of Microbiology Shimane University Faculty of MedicineIzumo 693-8501ShimaneJapan Faculty of Medicine Muslim University of IndonesiaMakassar 90231Indonesia Department of Medical Microbiology and Parasitology Hawassa UniversityCollege of Medicine and Health ScienceHawassa 1560Ethiopia Faculty of Laboratory Science Yamaguchi University Graduate School of MedicineUbe 755-8505Japan

Epstein-Barr virus(EBV)-associated gastric cancer(EBVaGC)cells originate from a single-cell clone infected with ***,more than 95%of patients with gastric cancer have a history of Helicobacter pylori(***)infection,and *** is a major causative agent of gastric ***,it has long been argued that *** infection may affect the development of EBVaGC,a subtype of gastric *** gastrointestinal inflammation,a symptom of *** infection,is observed in the gastric mucosa of ***,it remains unclear whether *** infection is a cofactor for gastric carcinogenesis caused by EBV infection or whether *** and EBV infections act independently on gastric cancer *** has been reported that EBV infection assists in the oncogenesis of gastric cancer caused by *** *** contrast,several studies have reported that *** infection accelerates tumorigenesis initiated by EBV *** reviewing both clinical epidemiological and experimental data,we reorganized the role of *** and EBV infections in gastric cancer formation.

关键词： Helicobacter pylori Epstein-Barr virus Epstein-Barr virus-associated gastric cancer Coreceptor Inflammation Oncogenesis

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Dysbiotic infection in the stomach

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World Journal of Gastroenterology 2015年第40期21卷 11450-11457页

作者： Hisashi Iizasa Shyunji Ishihara Timmy Richardo Yuichi Kanehiro hironori yoshiyama Department of Microbiology Shimane University Faculty of Medicine Department of Internal Medicine II Shimane University Faculty of Medicine

Microbiota in human alimentary tract plays important roles for homeostatic maintenance of the body. Compositional difference of gut microbiota is tightly associated with susceptibility of many diseases,including inflammatory diseases,obesity,diabetes mellitus,cancer,and atherosclerosis. "Dysbiosis" refers to a state of imbalance among the colonies of microorganisms within the body,which brings abnormal increase of specific minor components and decrease in the normally dominant species. Since stomach secrets strong acid for its digestive role,this organ has long been thought a sterile organ. However,the discovery of Helicobacter pylori(H. pylori) has changed the concept. This bacterium has proven to cause gastritis,peptic ulcer,and gastric cancer. However,recent cross-sectional studies revealed that H. pylori carriers had a decreased risk of developing immunological diseases,such as asthma. H. pylori coinfection also suppresses inflammatory bowel diseases. This review describes human gastric microbiota by discussing its mutual interaction and pathogenic enrollment. Gastric "dysbiosis" may affect host inflammatory response and play important role for gastric pathogenesis. We will topically discuss enrollment of dysbiosis for genesis of gastric cancer as well as for disruption of immunological homeostasis affecting oncogenic resistance.

关键词： Stomach Microbiota Dysbiosis Helicobacter pylori E

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