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Positive Effect of Transcranial Direct Current Stimulation on Visual Verbal Working Memory in Patients with Attention-Deficit/Hyperactivity Disorder

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Open Journal of Psychiatry 2024年第4期14卷 334-346页

作者： Tomoko Uchida Daisuke Matsuzawa Tadashi Shiohama Katsunori Fujii Akihiro Shiina Masamitsu Naka Katsuo Sugita Eiji Shimizu Naoki Shimojo hiromichi hamada Department of Pediatrics Graduate School of Medicine Chiba University Chiba Japan Research Center for Child Mental Development Chiba University Chiba Japan Division of Medical Care and Treatment Center for Forensic Mental Health Chiba University Chiba Japan Department of Cognitive Behavioral Physiology Graduate School of Medicine Chiba University Chiba Japan

Background: Working memory is an executive function that plays an important role in many aspects of daily life, and its impairment in patients with attention-deficit/hyperactivity disorder (ADHD) affects quality of life. The dorsolateral prefrontal cortex (DLPFC) has been a good target site for transcranial direct current stimulation (tDCS) due to its intense involvement in working memory. In our 2018 study, tDCS improved visual-verbal working memory in healthy subjects. Objective: This study examines the effects of tDCS on ADHD patients, particularly on verbal working memory. Methods: We conducted an experiment involving verbal working memory of two modalities, visual and auditory, and a sustained attention task that could affect working memory in 9 ADHD patients. Active or sham tDCS was applied to the left DLPFC in a single-blind crossover design. Results: tDCS significantly improved the accuracy of visual-verbal working memory. In contrast, tDCS did not affect auditory-verbal working memory and sustained attention. Conclusion: tDCS to the left DLPFC improved visual-verbal working memory in ADHD patients, with important implications for potential ADHD treatments.

关键词： Working Memory Attention-Deficit/Hyperactivity Disorder Dorsolateral Prefrontal Cortex Transcranial Direct Current Stimulation

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Granular cell tumor of the pancreas:A case report and review of literature

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World Journal of Gastrointestinal Oncology 2010年第2期2卷 121-124页

作者： Atsushi Kanno Kennichi Satoh Morihisa Hirota Shin hamada Jun Umino hiromichi Itoh Atsushi Masamune Shinichi Egawa Fuyuhiko Motoi Michiaki Unno Kazuyuki Ishida Tooru Shimosegawa Division of Gastroenterology Tohoku University Graduate School of Medicine Department of Hepatobiliary-pancreatic surgery Tohoku University Graduate School of Medicine Department of Pathology Tohoku University Graduate School of Medicine

Granular cell tumors,also called Abrikossof's tumors,were originally described by Abrikossof A in *** f irst case of a pancreatic granular cell tumor was described in 1975 and only 6 cases have been *** describe a case of granular cell tumor in the pancreas showing pancreatic duct *** imaging studies showed f indings compatible with those of pancreatic carcinoma,the patient underwent distal *** examination showed that the tumor consisted of a nested growth of large tumor cells with ample granular cytoplasm and small round *** tumor cells expressed S-100 protein and were stained with neuron-specific enolase and periodic acid-Schiff,but were negative for desmin,vimentin,and *** resected tumor was diagnosed as a granular cell *** our knowledge,this is the seventh case of Granular cell tumor of the pancreas to be reported.

关键词： Granular cell tumor Pancreas Diagnosis Distal pancreatectomy

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Time to re-evaluate effects of renin-angiotensin system inhibitors on renal and cardiovascular outcomes in diabetic nephropathy

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World Journal of Nephrology 2015年第1期4卷 118-126页

作者： hiromichi Suzuki Tomohiro Kikuta Tsutomu Inoue Ukihiro hamada Department of Nephrology and Community Health Science Center Saitama Medical UniversitySaitama 350-0495Japan

The use of renin-angiotensin system(RAS) inhibitors, such angiotensin converting enzyme inhibitors/angiotensin-Ⅱreceptor blockers, to slow progression of chronic kidney disease(CKD) in a large group dominated by elderly people in the real world is not supported by available evidence. Large-scale clinical trials had many faults,among them a lack of focus on the elderly. However,it would be difficult to conduct clinical trials of a similar scale in elderly CKD patients. Besides, progression ofkidney disease is often slow in elderly persons, and the vast majority of older adults with CKD will die before reaching end stage renal disease. Moreover, since it is not clear that progression of kidney disease, and even of proteinuric diabetic nephropathy, is not inhibited through the use of RAS inhibitors, the most patientcentric goal of therapy for many elderly individuals should be individualized.

关键词：肾素血管紧张素治疗方法临床分析

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