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Apoptosis-inducing activity of endocrine-disrupting chemicals in cultured PC12 cells

Advances in Biological Chemistry 2012年第2期2卷 92-105页

作者： Harue Sasaya Kazuya Yasuzumi hiroki maruoka Ayumi Fujita Yuichi Kato Taiki Waki Koji Shimoke Toshihiko Ikeuchi Department of Life Science and Biotechnology Faculty of Chemistry Materials and Bioengineering and Strategic Research Base Kansai University Osaka Japan Technology Research Laboratory Kurabo Industries Ltd. Osaka Japan

Endocrine-disrupting chemicals (EDCs) are known to exert estrogen-like effects that are similar to those made by naturally produced hormones or by inhibition of the receptors in the cell receiving the hormones. Recently, several reports have indicated that EDCs can affect the developing central nervous system. In our current study, we report that some EDCs induce apoptosis in cultured PC12 cells and can be classified into three groups. Bisphenol A (BPA), p-nonylphenol (NP) and tributyltin chloride (TBT) were found to induce endoplasmic reticulum (ER) stress-associated apoptosis and activate the unfolded protein response (UPR) system, whereas benomyl (beno) induced non-ER stress-associated apoptosis. The half-maximal apoptosis-inducing concentrations (IC50) of these EDCs were 160 μM for BPA, 25.6 μM for NP, 640 nM for TBT and 48 μM for beno. Although these concentrations are higher than those found in the environment, some EDCs may have apoptotic effects on various cells in the body, including neurons, through their accumulation in the body over time or condensation through the food chain. On the other hand, benzopyrene, fenvalerate, styrene monomer and bis(2-ethylhexyl)phthalate did not induce apoptosis in PC12 cells. We analyzed also whether apoptosis-inducing EDCs had an estrogen-like effect on cultured PC12 cells transfected with a luciferase reporter plasmid, the activity of which is dependent on estrogen receptor α. We found that BPA had an estrogen-like effect (EC50 = 5.9 μM) but that NP, TBT and beno did not in transfected PC12 cells. These results suggest that BPA may predomi-nantly exert estrogenic effects, but others may pre-dominantly have apoptosis-inducing effects on cells in the body exposed to a polluted environment.

关键词： Endocrine-Disrupting Chemicals ER Stress Apoptosis Estrogen Receptor PC12 Cells

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联苯二酚的手性拆分及相转移催化不对称烷基化研究

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有机化学 2020年第7期40卷 1955-1966页

作者：柯翠连徐伟平刘达刘艳 Keiji maruoka 广东工业大学轻工化工学院广州510006 Graduate School of Pharmaceutical Sciences Kyoto UniversitySakyoKyoto606-8501Japan

手性相转移催化剂在手性药物、天然产物核心结构、手性功能分子构建中起着极其重要的作用,因此近年来备受关注.以廉价易得的(R)-α-甲氧基苯乙酸为拆分剂与联苯衍生物进行酯化反应,成功地对联苯衍生物骨架进行了手性拆分,并基于拆分的... 详细信息

手性相转移催化剂在手性药物、天然产物核心结构、手性功能分子构建中起着极其重要的作用,因此近年来备受关注.以廉价易得的(R)-α-甲氧基苯乙酸为拆分剂与联苯衍生物进行酯化反应,成功地对联苯衍生物骨架进行了手性拆分,并基于拆分的光学纯C2轴手性联苯刚性骨架,构建了系列新型联苯类相转移催化剂.对该系列相转移催化剂进行不对称催化烷基化反应,产率高达97%,对映体选择性高达96%.对催化剂进行构效关系研究发现,对2位和2'位的羟基进行甲基化有利于催化反应的选择性,3位和3'位引入叔丁基不利于反应的选择性.催化剂经过结构优化后,在5位和5'位引入3,4,5-三氟苯基和3,5-双(三氟甲基)苯基都显示出较好的反应活性和选择性.

关键词：相转移催化联苯手性拆分不对称烷基化

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Two-week treatment with proton pump inhibitor is sufficient for healing post endoscopic submucosal dissection ulcers

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World Journal of Gastroenterology 2014年第43期20卷 16318-16322页

作者： Makoto Arai Tomoaki Matsumura Kenichiro Okimoto Arata Oyamada Keiko Saito Shoko Minemura Daisuke maruoka Takeshi Tanaka Tomoo Nakagawa Tatsuro Katsuno Osamu Yokosuka Department of Gastroenterology and Nephrology (K1) Graduate School of MedicineChiba UniversityChiba 260-8670Japan

AIM: To investigate the optimum period of treatment for post endoscopic submucosal dissection (ESD) ulcers.

关键词： Proton pump inhibitor Endoscopic submucosal dissection Esomeprazole Rebamipide Randomized control trial

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Study on Properties of Mortar and Concrete Using Belite-Gehlenite Clinker as Fine Aggregate

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材料科学与工程（中英文A版） 2017年第2期7卷 89-96页

作者： Hiromi Fujiwara Takaya Kawato Masanori maruoka Masatoshi Nemoto Kensuke Hayashi Design and Engineering for the Global Environment Graduate School of Utsunomiya University Tochigi 321-0904 Japan Taiheiyo Cement Corporation Central Research Laboratory 2-4-2 Osaku Sakura City Chiba Prefecture 285-8655 Japan

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Platelet count and sustained virological response in hepatitis C treatment

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World Journal of Hepatology 2013年第4期5卷 182-188页

作者： Tatsuo Kanda Keizo Kato Akihito Tsubota Nobuo Takada Takayoshi Nishino Shigeru Mikami Tatsuo Miyamura Daisuke maruoka Shuang Wu Shingo Nakamoto Makoto Arai Keiichi Fujiwara Fumio Imazeki Osamu Yokosuka Department of Gastroenterology and Nephrology Graduate School of MedicineChiba UniversityChiba 260-8677Japan Department of Gastroenterology Narita Red Cross HospitalNarita 286-8523Japan Institute of Clinical Medicine and Research Jikei University School of MedicineKashiwa 277-8567Japan Department of Gastroenterology Toho University Sakura Medical CenterSakura 285-8741Japan Department of Gastroenterology Tokyo Women's Medical University Yachiyo Medical CenterYachiyo 276-8524Japan Department of Medicine Kikkoman HospitalNoda 270-0116Japan

AIM:To examine the epidemiological data,hematological safety and treatment responses of peginterferonalpha 2a plus ribavirin therapy for hepatitis ***:Between March 2008 and February 2011,196 hepatitis C virus(HCV)genotype 1 infected Japanese(127 treatment-naive and 69 treatment-experienced patients)patients treated with peginterferonalpha 2a plus ribavirin were *** examined the epidemiological data and treatment responses were retrospectively analyzed in terms of hematological *** RNA was measured by the COBAS TaqMan HCV ***:Overall sustained virological response(SVR)rates of treatment-naive and treatment-experienced patients were 56% and 39%,*** logistic regression analysis showed that SVR was attained independently of early virological response in both treatment-naive and treatment-experienced *** rates did not differ between the pretreatment hemoglobin < 13 g/dL and ≥ 13 g/dL ***,in treatment-naive patients,the SVR rate of the pretreatment platelet count < 130000/μL group was significantly lower than that of the pretreatment platelet count ≥ 130000/μL ***:Attention should be paid to potential thrombocytopenia in the treatment of chronic hepatitis C patients.

关键词： Anemia Antiviral treatment Chronic hepatitis C Platelet count Sustained virological response

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氧气-水系统中底部气泡条件对表面反应速率的影响

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现代冶金（内蒙古） 2012年第1期 31-35,74页

作者： Nobuhiro maruoka[日本] 张怀军（译）兰岳光（校）

在二次炼钢过程中，增加钢水脱碳过程中低碳时期的反应速率被认为是生产超低碳钢最有效的方法。先前的研究已经说明了在实际精炼过程的最后时期，表面张力起主导作用。为了提高表面反应速率，必须扩大反应区域，通常采用增加流股中心面... 详细信息

在二次炼钢过程中，增加钢水脱碳过程中低碳时期的反应速率被认为是生产超低碳钢最有效的方法。先前的研究已经说明了在实际精炼过程的最后时期，表面张力起主导作用。为了提高表面反应速率，必须扩大反应区域，通常采用增加流股中心面积的方法获取。在此研究中，通过水模试验评价了底部搅拌条件对气体一液体反应速率的影响，为了达到这个目的，测量了底部气泡作用过程中的脱氧速率。采用5种类型的喷嘴布置方式，研究在不同气体流速下，流股中心面积对反应速率的影响。结果表明：表面反应速率受气体流速和流股中心面积影响。开发了反应速率和流股中心面积的经验关系式，采用这种关系式估算了熔池表面的气-液反应速率。

关键词：水模试验二次炼钢超低碳钢流股中心面积反应速率表面反应

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Efficacy of computed image modification of capsule endoscopy in patients with obscure gastrointestinal bleeding

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World Journal of Gastrointestinal Endoscopy 2012年第9期4卷 421-428页

作者： Tomoaki Matsumura Makoto Arai Toru Sato Tomoo Nakagawa Daisuke maruoka Masaru Tsuboi Sachio Hata Eiji Arai Tatsuro Katsuno Fumio Imazeki Osamu Yokosuka Department of Medicine and Clinical Oncology Graduate School of MedicineChiba UniversityChiba 2608670Japan

AIM:To investigate whether flexible spectral color enhancement(FICE) improves diagnostic yields of capsule endoscopy(CE) for obscure gastro-intestinal bleeding(OGIB).METHODS:The study subjects consisted of 81 *** FICE,there were three different sets with different *** randomly selected sets of FICE,images of CE were evaluated again by two individuals who were not shown the conventional CE reports and *** difference between FICE and conventional imaging was ***:The overall diagnostic yields in FICE sets 1,2,3 and conventional imaging(48.1%) were 51.9%,40.7%,51.9% and 48.1%,respectively,which showed no statistical difference compared to conventional *** total numbers of detected lesions per examination in FICE imaging and conventional imaging were 2.5 ± 2.1 and 1.8 ± 1.7,respectively,which showed a significant difference(P = 0.01).CONCLUSION:The diagnostic yield for OGIB is not improved by ***,FICE can detect significantly more small bowel lesions compared to conventional imaging.

关键词： Computed virtual chromoendoscopy Flexible spectral color enhancement Capsule endoscopy Obscure gastro-intestinal bleeding Diagnostic yield

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Malignant Triton Tumor in the Abdominal Wall: A Case Report

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Advances in Molecular Imaging 2013年第2期3卷 9-13页

作者： Yoshiyuki Kitamura Koichiro Abe Shingo Baba Takuro Isoda Yasuhiro maruoka Yoshio Matsuo Yuichiro Kubo Akio Sakamoto Hiroshi Nishimura Masayuki Sasaki Hiroshi Honda Department of Anatomic Pathology Pathological Sciences Graduate School of Medical Sciences Kyushu University Fukuoka Japan Department of Clinical Radiology Kyushu University Hospital Fukuoka Japan Department of Clinical Radiology Saiseikai Futsukaichi Hospital Fukuoka Japan Department of Health Sciences Graduate School of Medical Sciences Kyushu University Fukuoka Japan Department of Orthopaedic Surgery Kyushu University Hospital Fukuoka Japan

Malignant triton tumor (MTT) is a rare variant of malignant peripheral nerve sheath tumor (MPNST) with rhabdomyosarcomatous differentiation. We report the case of a 54-year-old male without a history of neurofibromatosis type 1 (NF1) who had a growing abdominal wall tumor diagnosed as MTT. Computed tomography (CT), magnetic resonance imaging (MRI) and 2-[F-18]-fluoro-2-deoxy-D-glucose positron emission tomography/CT (FDG-PET/CT) were performed. The MRI and FDG-PET/CT indicated that the lateral component of the tumor was composed of many proliferative cells, corresponding to the histopathological finding of a cellular proliferation of spindle-shaped cells. In light of this case and previous reports, it is apparent that FDG-PET/CT is a helpful tool for distinguishing MTT from benign peripheral nerve sheath tumor.

关键词： Malignant Triton Tumor (MTT) Malignant Peripheral Nerve Sheath Tumor (MPNST) 2-[F-18]-Fluoro-2-Deoxy-D-Glucose Positron Emission Tomography/Computed Tomography (FDG-PET/CT)

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O-N型竞争smiles重排反应研究

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广东化工 2018年第10期45卷 51-52,48页

作者：朱伟钦谭嘉燊徐伟平柯翠连刘艳 Keiji maruoka 广东工业大学轻工化工学院广东广州510006

本研究是O-N型竞争smiles重排反应的首次发现和报道。通过对多种底物和多种条件的筛选,发现以2-甲基-5,7-二氟-8-羟基喹啉为底物,在Cs2CO3\Na H\NMP\DMPU\125℃条件下,反应按照竞争smiles重排反应路径进行,产率可达到83%。本论文的研究... 详细信息

本研究是O-N型竞争smiles重排反应的首次发现和报道。通过对多种底物和多种条件的筛选,发现以2-甲基-5,7-二氟-8-羟基喹啉为底物,在Cs2CO3\Na H\NMP\DMPU\125℃条件下,反应按照竞争smiles重排反应路径进行,产率可达到83%。本论文的研究将给芳香环并恶嗪类药物中间体和精细化学品的合成,以及芳香酚类化合物到芳香胺类化合物的转化提供实验依据和理论指导。

关键词： smiles重排竞争smiles重排直接成化反应

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一种3-双烷基化-2-吲哚酮的合成方法

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广东化工 2018年第10期45卷 29-29页

作者：庄桂生卢汉彬何虹运刘艳 Keiji maruoka 广东工业大学轻工化工学院广东广州510006

N-叔丁氧羰基-2-吲哚酮(VI)与(E)-1-(三甲基甲硅烷)戊-1,4-二烯-3-酮(IV)在碱和相转移催化剂下发生双Micheal加成反应,生成N-叔丁氧羰基-3,3-双((E)-3-氧代-5-(三甲基甲硅烷)戊-4-烯-1-基)-2-吲哚酮。该反应具有操作简单,反应条件温和,... 详细信息

N-叔丁氧羰基-2-吲哚酮(VI)与(E)-1-(三甲基甲硅烷)戊-1,4-二烯-3-酮(IV)在碱和相转移催化剂下发生双Micheal加成反应,生成N-叔丁氧羰基-3,3-双((E)-3-氧代-5-(三甲基甲硅烷)戊-4-烯-1-基)-2-吲哚酮。该反应具有操作简单,反应条件温和,原料易得,反应过程中无重金属参与,对环境友好,产率高,副反应少等优点。

关键词： N-Boc-2-吲哚酮相转移催化剂 Micheal加成

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