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Oocyte Cryopreservation before Tumorectomy in Gorlin-Goltz Syndrome with Recurrent Ovarian Fibroma: A Case Report

Open Journal of Obstetrics and Gynecology 2018年第10期8卷 836-846页

作者： Makoto Chihara Atsushi Fujimoto Kanna Ogi Tatsuya Ishiguro Kunihiko Yoshida Masayuki Sekine Koich Takakuwa hiroki fujikawa Yutaka Shimomura Takayuki Enomoto Department of Dermatology Niigata University Graduate School of Medical and Dental Sciences Niigata Japan Department of Obstetrics and Gynecology Niigata University Graduate School of Medical and Dental Sciences Niigata Japan Department of Dermatology Niigata University Graduate School of Medical and Dental Sciences Niigata Japan Department of Dermatology Yamaguchi University Graduate School of Medicine Yamaguchi Japan

Background: Gorlin-Goltz syndrome is a very rare syndrome that reportedly occurs in 1 of 235,800 people in Japan. The proportion of women with Gorlin-Goltz syndrome complicated with an ovarian fibroma ranges from 12.5% to 17.0%. Some surgical cases of Gorlin-Goltz syndrome with an ovarian tumor have been reported. However, no studies have mentioned subsequent fertility preservation by using oocyte cryopreservation process. Case: In this case report, the patient with Gorlin-Goltz syndrome underwent laparotomy for bilateral ovarian fibrothecoma at 15 years of age. At 20 years of age, a recurrent ovarian tumor was detected in the remaining ovary. During the follow-up, we detected an increase in its size. As tumor torsion requiring left salpingo-oophorectomy was possible, tumorectomy was considered. However, her anti-Müllerian hormone level was low. As she was at risk for premature ovarian failure after tumorectomy, we planned to cryopreserve her oocytes to preserve her fertility before tumorectomy. Outcome: When the patient underwent surgery, the diameter of her left ovarian tumor was found to have increased to 56 mm. Egg collection was performed twice, and two oocytes were cryopreserved. Subsequently, she underwent tumorectomy of the left ovarian tumor. No recurrence has been observed. Conclusion: If a recurrent ovarian tumor is detected in patients with Gorlin-Goltz syndrome and a low anti-Müllerian hormone level, cryopreservation of oocytes before tumorectomy may be effective for preserving their fertility.

关键词： Case Reports Cryopreservation Fibroma Gorlin-Goltz Syndrome Recurrence

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Gastric and enteric anisakiasis successfully treated with Gastrografin therapy: A case report

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World Journal of Gastrointestinal Endoscopy 2018年第3期10卷 69-73页

作者： hiroki fujikawa Toshio Kuwai Toshiki Yamaguchi Ryoichi Miura Yuki Sumida Takeshi Takasago Yuki Miyasako Tomoyuki Nishimura Sumio Iio hiroki Imagawa Atsushi Yamaguchi Hirotaka Kouno Hiroshi Kohno Department of Gastroenterology National Hospital OrganizationKure Medical Center and Chugoku Cancer Center

We report a case of a 59-year-old woman who was diagnosed with gastric and small intestinal anisakiasis, which was successfully treated with endoscopic extraction and Gastrografin therapy. She was admitted to our hospital with epigastric pain and vomiting one day after eating raw fish. She exhibited tenderness in the epigastrium without obvious rebound tenderness or guarding. Computed tomography (CT) demonstrated segmental edema of the intestinal wall with proximal dilatation and a small number of ascites. Because enteric anisakiasis was suspected based on the patient's history of recent raw fish consumption and abdominal CT, we performed gastroscopy and confirmed that nine Anisakis larvae were attached to the gastric mucosa. All of the Anisakis larvae were extracted via endoscopy, and the patient was diagnosed with gastric and enteric anisakiasis. Additionally, in the hospital, we performed ileography twice using Gastrografin, which led to shortened hospital stay. Based on the clinical results of this case, we suggest that Gastrografin therapy is a safe, convenient, and useful method to extract enteric Anisakis larvae.

关键词： Enteric anisakiasis Gastrografin Ileus Endoscopic extraction Anisakis larvae

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Evaluation of Psychological Changes on Women Following Coordination Exercises: Immediate Effects of Life Kinetik® Implementation

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Open Journal of Therapy and Rehabilitation 2024年第3期12卷 256-262页

作者： Yutaro Hyodo Takumi Jiroumaru Hikaru Kitagawa Yasumasa Oka Junko Ochi Nobuko Shichiri Takamitsu fujikawa Department of Physical Therapy Bukkyo University Kyoto City Japan Kanazawa Orthopaedic and Sports Medicine Clinic Ritto Japan Department of Applied Biology Graduate School of Science and Technology Kyoto Institute of Technology Kyoto City Japan

Objective: This study aimed to evaluate the immediate psychological effects of coordination exercises on women in Japan. Methods: The subjects were 17 adult women (height, 160.1 ± 5.1 cm;weight, 54.3 ± 10.5 kg;age, 57.8 ± 8.3 years) living in the community and attending a fitness club. The subjects performed a coordination exercise called Life Kinetik®. The subjects responded to the Two-Dimensional Mood Scale–Short Term before and after performing 30 minutes of Life Kinetik®. The results were tabulated and four psychological states were calculated (i.e., vitality, stability, pleasure, and arousal). The pre- and post-implementation results were statistically analyzed using a corresponding t-test. Results: Significant differences were found in activation and arousal levels, but not in stability and comfort levels. Conclusion: The coordination exercise, Life Kinetik®, was found to be an exercise program with potential psychological benefits, as it could change women’s psychological condition to active and excited states.

关键词： Psychological State Life Kinetik® Mood Scale

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Safety of laparoscopic surgery in digestive diseases with special reference to antithrombotic therapy: A systematic review of the literature

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World Journal of Clinical Cases 2018年第14期6卷 767-775页

作者： Takahisa fujikawa Kenji ando Department of Surgery Kokura Memoria Hospital Department of Cardiology Kokura Memorial Hospital

AIMTo elucidate the effect of antithrombotic therapy （ATT） on bleeding and thromboembolic complications during or after laparoscopic digestive *** articles or internationally accepted abstracts between 2000 and 2017 were searched from PubMed, Cochrane Database, and Google Scholar, and studies involving laparoscopic digestive surgery and antiplatelet therapy （APT） and/or anticoagulation therapy （ACT） were included after careful review of each study. Data such as study design, type of surgical procedures, antithrombotic drugs used, and surgical outcome （both bleeding and thromboembolic complications） were extracted from each *** published articles and two internationally accepted abstracts were eligible for inclusion in the systematic review. Only one study concerning elective laparoscopic cholecystectomy in patients with peri-operative heparin bridging for ACT showed that the risk of postoperative bleeding was higher compared with those without ACT. The remaining 14 studies reported no signifcant differences in the incidence of bleeding complications between the ATT group and the group without ATT. The risk of thromboembolic events （TE） associated with laparoscopic digestive surgery in patients receiving ATT was not signifcantly higher than those with no ATT or interrupted *** T et al . Laparoscopic digestive surgery and antithrombotic therapyCONCLUSIONLaparoscopic digestive surgery in ATT-burdened patients for prevention of bleeding and TE showed satisfactory results. The risk of hemorrhagic complication during or after these procedures in patients with continued APT or heparin bridging was not signifcantly higher than in patients with no ATT or interrupted APT.

关键词： Thromboembolic complication Bleeding complication Laparoscopic surgery Anticoagulation therapy Digestive surgery Antithrombotic therapy Antiplatelet therapy

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Safety of pancreatic surgery with special reference to antithrombotic therapy:A systematic review of the literature

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World Journal of Clinical Cases 2021年第23期9卷 6747-6758页

作者： Takahisa fujikawa Shigetoshi Naito Department of Surgery Kokura Memorial HospitalKitakyushu 802-8555Japan

BACKGROUND Postpancreatectomy hemorrhage(PPH)is the most severe type of complication after pancreatic surgery,although the effect of antithrombotic therapy(ATT)on PPH is largely *** safety and efficacy of chemical thromboprophylaxis for venous thromboembolism(VTE)remains *** To elucidate the effect of ATT on *** Published articles between 2013 and 2020 were searched from PubMed and Google Scholar,and after careful reviewing of all studies,studies concerning ATT and pancreatic surgery were *** such as study design,type of surgical procedures,type of antithrombotic drugs,and surgical outcome were extracted from the *** Nineteen published articles with a total of 37863 patients who underwent pancreatic surgery were included in the systematic *** were cohort studies,with only three being prospective in *** studies demonstrated that in patients receiving chronic ATT,which were mostly managed by heparin bridging,the risk of PPH was higher compared with those without ATT,and one study showed that patients with direct-acting oral anticoagulants managed by heparin bridging had significantly higher postoperative bleeding rates than *** remaining six studies reported that pancreatic surgery can be safely performed in patients receiving chronic ATT,even under preoperative aspirin *** chemical thromboprophylaxis for VTE,most studies have shown a potentially high risk of PPH in patients undergoing chemical thromboprophylaxis;however,its effectiveness against VTE has not been statistically demonstrated,particularly among Asian *** Pancreatic surgery in chronically ATT-received patients can be safely performed without an increase in the occurrence of PPH,although the safety and efficacy of chemical thromboprophylaxis for VTE during pancreatic surgery is still *** investigation using reliable studies with good design is required to establish definite pr

关键词： Antithrombotic therapy Pancreatic surgery Perioperative management Antiplatelet therapy Anticoagulation therapy Pancreaticoduodenectomy

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Role of pleiotrophin-protein tyrosine phosphatase receptor type Z signaling in myelination

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Neural Regeneration Research 2016年第4期11卷 549-551页

作者： Akihiro fujikawa Masaharu Noda Division of Molecular Neurobiology National Institute for Basic BiologyThe Graduate University for Advanced Studies (SOKENDAI) School of Life Science The Graduate University for Advanced Studies (SOKENDAI)

Myelination is an essential feature of the vertebrate nervous system that provides electrical insulation to axons,thereby facilitating the transmission of nerve *** in myelination in diseases such as multiple sclerosi... 详细信息

关键词： Role of pleiotrophin-protein tyrosine phosphatase receptor type Z signaling in myelination type PTP Figure

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Safety of liver resection in patients receiving antithrombotic therapy:A systematic review of the literature

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World Journal of Hepatology 2021年第7期13卷 804-814页

作者： Takahisa fujikawa Department of Surgery Kokura Memorial HospitalFukuoka 802-8555Japan

BACKGROUND Little is unknown about the effect of chronic antithrombotic therapy(ATT)on bleeding complication during or after *** addition,the safety and effectiveness of chemical prevention for venous thromboembolism(VTE)is still *** To clarify the effect of ATT on thromboembolism and bleeding after liver *** Articles published between 2011 and 2020 were searched from Google Scholar and PubMed,and after careful reviewing of all studies,studies concerning ATT and liver resection were *** such as study design,type of surgery,type of antithrombotic agents,and surgical outcome were extracted from the *** Sixteen published articles,including a total of 8300 patients who underwent hepatectomy,were eligible for inclusion in the current *** studies regarding patients undergoing chronic ATT showed that hepatectomy can be performed safely,and three studies have also shown the safety and efficacy of preoperative continuation of *** chemical prevention for VTE,some studies have shown a potentially high risk of bleeding complications in patients undergoing chemical thromboprophylaxis;however,its efficacy against VTE has not been shown statistically,especially among Asian *** Hepatectomy in patients with chronic ATT can be performed safely without increasing the incidence of bleeding complications,but the safety and effectiveness of chemical thromboprophylaxis against VTE during liver resection is still controversial,especially in the Asian *** a clear protocol or guideline requires further research using reliable studies with good design.

关键词： Liver resection Bleeding complication Antithrombotic therapy Thromboembolic complication Thromboprophylaxis

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Preparation of large,ultra-flexible and free-standing nanomembranes of metal oxide-polymer composite and their gas permeation properties

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Clean Energy 2017年第1期1卷 80-89页

作者： Anteneh Mersha Roman Selyanchyn Shigenori fujikawa Graduate School of Engineering Kyushu UniversityFukuoka 819-0395Japan WPI International Institute for Carbon-Neutral Energy Research(WPI-I2CNER) Kyushu UniversityFukuoka 819-0395Japan Center for Molecular Systems(CMS) Kyushu UniversityFukuoka 819-0395Japan Laboratory for Chemistry and Life Science Tokyo Institute of Technology4259 NagatsutachoMidori-kuYokohama226-8503Japan

In this work,fabrication of free-standing nanomembranes of metal oxide(MO_(x))and polymers by simple spin-coating method is ***,double-layer nanomembranes containing MO_(x) and epoxy resin of polyethyleneimine and poly[(o-cresyl glycidyl ether)-co-formaldehyde]were ***-standing nanomembranes were successfully prepared,but defects formed in the metal oxide nanolayer during sharp bending of the *** overcome fragility of MO_(x) nanolayer,poly(vinyl alcohol)nanolayers were introduced between MO_(x) nanolayers by layer-by-layer(LbL)assembly *** LbL nanomembrane was also free-standing and was highly flexible during macroscopic membrane *** after transfer of the LbL nanomembrane onto a porous support,it did not have apparent cracks,confirmed by scanning electron microscopy(SEM).The LbL nanomembrane sustained low gas permeance,confirming the absence of significant defects,although it shows excellent *** believe that the presented LbL nanomembrane could be a platform useful for the design of molecular nanochannels,which is the next challenge for efficient gas separation.

关键词： nanomembranes free-standing film ultrathin film layer-by-layer assembly metal oxide gas permeation

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Tissue pad degradation of ultrasonic device may enhance thermal injury and impair its sealing performance in liver surgery

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World Journal of Hepatology 2022年第7期14卷 1357-1364页

作者： Masatoshi Kajiwara Takahisa fujikawa Suguru Hasegawa Department of Gastroenterological Surgery Fukuoka UniversityFukuoka 814-0180FukuokaJapan Department of Surgery Kokura Memorial HospitalKitakyushu 802-8555FukuokaJapan

BACKGROUND Ultrasonic devices are widely used in many surgical fields,including hepatectomy;however,the negative effects of tissue pad degradation of ultrasonic devices,including those in liver surgery,remain *** Harmonic®1100(H-1100)scalpel has advanced heat control technology than previous models,such as the Harmonic®HD1000i(H-HD1000i).We hypothesized that,because of its advanced temperature-control technology,the H-1100 scalpel would show less tissue pad degradation,resulting in superior sealing performance,compared to that with the H-HD1000i *** To elucidate ultrasonic device tissue pad degradation effects on instrument temperature and sealing performance using ex vivo porcine liver/vessel *** Two different harmonic scalpels were used and compared:A newer model,the H-1100 scalpel,and an older model,the H-HD1000i *** ex vivo porcine livers,each instrument was activated until the liver parenchyma was *** device temperature(passive jaw temperature)was measured after every 10 consecutive activations,until 300 transections of the porcine liver were *** pad degradation was evaluated after 300 *** performance was evaluated using excised porcine carotid vessels;vessel sealing speed and frequency of vessel burst pressure below 700 mmHg were determined after 300 transections of porcine liver *** The temperature of the H-HD1000i scalpel was approximately 10℃higher than that of the H-1100 scalpel,and gradually increased as the number of activations *** median passive jaw temperature of the H-HD1000i scalpel was significantly higher than that of the H-1100 scalpel(73.4℃vs 65.1℃;P<0.001).After 300 transections of porcine liver parenchyma,less tissue pad degradation was observed with the H-1100 scalpel than with the H-HD1000i scalpel(0.08 mm vs 0.51 mm).The H-1100 scalpel demonstrated faster vessel-sealing speed(4.9 *** 5.1 sec.)and less frequent vessel burst pressure<700 mm

关键词： Ultrasonic device Harmonic scalpel Tissue pad degradation Hepatectomy Device temperature Vessel sealing

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Spontaneous regression of gastric gastrinoma after resection of metastases to the lesser omentum:A case report and review of literature

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World Journal of Gastroenterology 2021年第1期27卷 129-142页

作者： Takeshi Okamoto Takaaki Yoshimoto Nobuyuki Ohike Aoi fujikawa Takayoshi Kanie Katsuyuki Fukuda Department of Gastroenterology St.Luke's International HospitalTokyo 104-8560Japan Department of Pathology Shizuoka Cancer CenterShizuoka 411-8777Japan Department of Surgery St.Luke’s International HospitalTokyo 104-8560Japan Department of Cardiology St.Luke’s International HospitalTokyo 104-8560Japan

BACKGROUND Gastric gastrinoma and spontaneous tumor regression are both very rarely *** report the first case of spontaneous regression of gastric *** SUMMARY A 37-year-old man with a 9-year history of chronic abdominal pain was referred for evaluation of an 8 cm mass in the lesser omentum discovered incidentally on abdominal computed *** tumor was diagnosed as grade 2 neuroendocrine neoplasm(NEN)on endoscopic ultrasound-guided fine-needle *** esophagogastroduodenoscopy revealed a 7 mm red polypoid lesion with central depression in the gastric antrum,also confirmed to be a grade 2 *** removal of the abdominal mass confirmed it to be a metastatic gastrinoma *** gastric lesion was subsequently diagnosed as primary gastric *** months later,the gastric lesion had disappeared without *** patient remains symptom-free with normal fasting serum gastrin and no recurrence of gastrinoma during 36 mo of *** Gastric gastrinoma may arise as a polypoid lesion in the gastric *** regression can rarely occur after biopsy.

关键词： Neuroendocrine neoplasm Functional tumor Biopsy Gastrin Stomach Case report

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