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Outcomes of endoscopic endonasal dacryocysto-rhinostomy for intractable lacrimal dacryostenosis and associated factors

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International Journal of Ophthalmology(English edition) 2016年第10期9卷 1471-1475页

作者： Tohru Tanigawa hirokazu sasaki Hiroshi Nonoyama Yuichiro Horibe Kunihiro Nishimura Tetsuro Hoshino Tetsuya Ogawa Kenta Murotani Hiromi Ueda Masahiro Kaneda Department of Otolaryngology Aichi Medical University Department of Otolaryngology Tono Kosei Hospital Division of Biostatistics Clinical Research CenterAichi Medical University Department of Ophthalmology Tono Kosei Hospital

AIM：To examine the effects of patient age,canalicular obstruction,mode of anesthesia,and duration of nasolacrimal intubation on the outcomes of endoscopic endonasal dacryocystorhinostomy（DCR）. METHODS： Totally 56 eyes of 46 patients with prolonged epiphora underwent minimally invasive endoscopic endonasal DCR.A successful surgical outcome was defined as a significant improvement in symptoms,adequate water passage from the puncta to the nasal cavity,and patency of the DCR *** outcomes were assessed at least 6mo after ***＇s exact test was used to discuss the factors,and then the logistic regression analysis was made by SAS9.4 ***： The overall success rate was 75.0%,and complete resolution was observed in 27 *** success rate was higher for patients with ≥6mo intubation than for those with 〈6mo ***,there were no significant differences in outcomes between groups stratified by age（〈65 or ≥65y）,presence or absence of canalicular obstruction,mode of anesthesia（local or general）,and use or nonuse of a radiowave *** patient developed subcutaneous emphysema around the eye and nose and one developed subcutaneous hemorrhage after surgery. CONCLUSION： Endoscopic endonasal DCR can be considered safe and minimally invasive with reasonable success rates,particularly when the duration of nasolacrimal intubation is ≥6mo.

关键词： dacryocystorhinostomy endoscopy,, intubation epiphora

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用CCD象传感器检测时变强度分布

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应用光学 1987年第2期 64-67页

作者： Osami sasaki hirokazu Okazaki 张兵

本文提出了用电荷耦合器件(CCD)象传感器检测时变强度分布的方法。已经证实,在电荷存贮周期内对时变强度积分而得到的光电探测器元件的瞬时输出,可以再现时变强度。采用正弦型调相激光时,这种检测方法不同于测量光学表面的轮廓分布。

关键词： CCD 电荷离散傅里叶变换强度分布传感器换能器电子技术激光干涉仪光学干涉仪

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Cancer detection by ubiquitin carboxyl-terminal esterase L1 methylation in pancreatobiliary fluids

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World Journal of Gastroenterology 2013年第11期19卷 1718-1727页

作者： Norihiro Kato Hiroyuki Yamamoto Yasushi Adachi hirokazu Ohashi Hiroaki Taniguchi Hiromu Suzuki Mayumi Nakazawa Hiroyuki Kaneto Shigeru sasaki Kohzoh Imai Yasuhisa Shinomura First Department of Internal Medicine Sapporo Medical University School of MedicineSapporo 060-8543Japan The Section of Antibody Vaccine and Molecular Targeted Therapy ResearchThe Institute of Medical ScienceThe University of TokyoTokyo 108-8639Japan Department of Molecular Biology Sapporo Medical University School of MedicineSapporo 060-8556Japan Division of Gastroenterology Muroran City General HospitalMuroran 051-8512Japan

AIM:To evaluate the utility of measuring epigenetic alterations in pancreatic and biliary fluids in determining molecular markers for pancreatobiliary ***:DNA was extracted from undiluted pancreatic and biliary *** a surrogate for a genomewide hypomethylation assay,levels of long interspersed nuclear element-1(LINE-1) methylation were analyzed using bisulfite *** island hypermethylation of 10 tumor-associated genes,aryl-hydrocarbon receptor repressor,adenomatous polyposis coli,calcium channel,voltage dependent,T type α1G subunit,insulin-like growth factor 2,O-6-methyl-guanine-DNA methyltransferase,neurogenin 1,CDKN2A,runt-related transcription factor 3(RUNX3),secreted frizzled-related protein 1,and ubiquitin carboxyl-terminal esterase L1(UCHL1),was analyzed using *** examine the role of CpG methylation and histone deacetylation in the silencing of UCHL1,human gallbladder carcinoma cell lines and pancreatic carcinoma cell lines were treated with 2 or 5 μmol/L 5-AZA-dC for 72 h or 100 nmol/L Trichostatin A for 24 *** the treatment,UCHL1 expression was analyzed by real-time reverse transcription-polymerase chain ***:Pancreatobiliary cancers exhibited significantly lower LINE-1 methylation levels in pancreatic and biliary fluids than did noncancerous pancreatobiliary disease(58.7% ± 4.3% vs 61.7% ± 2.2%,P = 0.027;53.8% ± 6.6% vs 57.5% ± 1.7%,P = 0.007);however,LINE-1 hypomethylation was more evident in pancreatic cancer tissues than in pancreatic fluids(45.4% ± 5.5% vs 58.7% ± 4.3%,P < 0.001).CpG island hypermethylation of tumor-associated genes was detected at various frequencies,but it was not correlated with LINE-1 *** of the UCHL1 gene was cancer-specific and most frequently detected in pancreatic(67%) or biliary(70%) fluids from patients with pancreatobiliary *** a single marker,hypermethylation of the UCHL1 gene in pancreatic and biliary fluids was most useful for the de

关键词： Pancreatobiliary cancers DNA methylation Pancreatobiliary fluids Ubiquitin carboxyl-terminal esterase L1 Runt-related transcription factor 3

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