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Anterolateral rotatory instability in vivo correlates tunnel position after anterior cruciate ligament reconstruction using bone-patellar tendon-bone graft

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World Journal of Orthopedics 2017年第12期8卷 913-921页

作者： Yasutaka Tashiro Ken Okazaki Koji Murakami hirokazu Matsubara Kanji Osaki Yukihide Iwamoto Yasuharu Nakashima Department of Orthopaedic Surgery University of Pittsburgh Department of Orthopaedic Surgery Kyushu University

AIM To quantitatively assess rotatory and anterior-posterior instability in vivo after anterior cruciate ligament(ACL) reconstruction using bone-patellar tendon-bone(BTB) autografts, and to clarify the influence of tunnel positions on the knee *** Single-bundle ACL reconstruction with BTB autograft was performed on 50 patients with a mean age of 28 years using the trans-tibial(TT)(n = 20) and trans-portal(TP)(n = 30) techniques. Femoral and tibial tunnel positions were identified from the high-resolution 3 D-CT bone models two weeks after surgery. Anterolateral rotatory translation was examined using a Slocum anterolateral rotatory instability test in open magnetic resonance imaging(MRI) 1.0-1.5 years after surgery, by measuring anterior tibial translation at the medial and lateral compartments on its sagittal images. Anterior-posterior stability was evaluated with a Kneelax3 *** A total of 40 patients(80%) were finally followed up. Femoral tunnel positions were shallower(P < 0.01) and higher(P < 0.001), and tibial tunnel positions were more posterior(P < 0.05) in the TT group compared with the TP group. Anterolateral rotatory translations in reconstructed knees were significantly correlated with the shallow femoral tunnel positions(R = 0.42, P < 0.01), and the rotatory translations were greater in the TT group(3.2 ± 1.6 mm) than in the TP group(2.0 ± 1.8 mm)(P < 0.05). Side-to-side differences of Kneelax3 arthrometer were 1.5 ± 1.3 mm in the TT, and 1.7 ± 1.6 mm in the TP group(N.S.). Lysholm scores, KOOS subscales and reinjury rate showed no difference between the two *** Anterolateral rotatory instability significantly correlated shallow femoral tunnel positions after ACL reconstruction using BTB autografts. Clinical outcomes, rotatory and anterior-posterior stability were overall satisfactory in both techniques, but the TT technique located femoral tunnels in shallower and higher positions, and tibial tunnels in more p

关键词： Anterior cruciate ligament Patellar tendon Bone-patellar tendon-bone Rotatory instability Magnetic resonance imaging Tunnel position Anatomic Singlebundle

Hypertriglyceridemia is positively correlated with the development of colorectal tubular adenoma in Japanese men

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World Journal of Gastroenterology 2006年第8期12卷 1261-1264页

作者： Masafumi Tabuchi Joji Kitayama hirokazu Nagawa Nakameguro Gastrointestinal Clinic Department of Surgical Oncology.The University of TokyoJapan Department of Surgical Oncology The University of TokyoJapan

瞄准：决定在浆液类脂化合物层次和结肠的息肉形成之间的真实协会。方法：我们执行了大规模分析在表面的腺瘤或癌和禁食浆液在为为结肠癌屏蔽经历了全部的结肠镜检查的病人全部的胆固醇(TC ) 和 triglycerides (TG ) 铺平的肤色的发生... 详细信息

瞄准：决定在浆液类脂化合物层次和结肠的息肉形成之间的真实协会。方法：我们执行了大规模分析在表面的腺瘤或癌和禁食浆液在为为结肠癌屏蔽经历了全部的结肠镜检查的病人全部的胆固醇(TC ) 和 triglycerides (TG ) 铺平的肤色的发生之间的关联的回顾的学习。结果：没有任何肿瘤的损害，两水平显著地作为与病人相比与腺瘤在病人被提高(TC 207.6+/-29.5 对 199.5+/-34.3， n=4883， P<0.001；TG 135.0+/-82.2 对 108.7+/-71.5， n=4874， P<0.001 ) 。差别在有管状腺瘤然而并非在那些与的病人是重要的覆有一层绒毛或 serrated 腺瘤。包括年龄和性别的多重逻辑回归分析表明 TG 是在男性(P<0.01 ) ，然而并非在女病人的一个独立关联因素。在有侵略的癌的病人的 TG 的水平没与腺瘤在病人从那显示出重要举起。这些调查结果建议 hypertriglyceridemia 是为在人的结肠的腺瘤的一个独立风险因素。结论：尽管浆液甘油三酸酯的高水平不看起来机械地涉及癌的发展，有全部的结肠镜检查的浆液 TG 和集中的监视的减小可以与 hypertriglyceridemia 在人有利益。

关键词：高甘油三酯血症直肠腺瘤结肠腺瘤日本

Fluorescent spectrum study of fluorescein binding to the interior of silica nanocapsules in various solvents

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Fluorescent spectrum study of fluorescein binding to the int...

Expression pattern of leptin and leptin receptor (OB-R) in human gastric cancer

第十一次中国生物物理学术大会暨第九届全国会员代表大会

作者： hirokazu Miyoshi Radioisotope Research Center The University of Tokushima

＜正＞Porous silica nanocapsules with 20% 3-aminopropyltrimethoxysilane （APS）-bound 6-carboxy-fluorescein（APS-fluorescein）and 80%APS molecules adsorbed on the surface of

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World Journal of Gastroenterology 2006年第34期12卷 5517-5522页

作者： Makoto Ishikawa Joji Kitayama hirokazu Nagawa Department of Surgery Division of Surgical Oncology theUniversity of Tokyo 7-3-1 Hongo Bunkyo-ku Tokyo 113-8655Japan

AIM: To examine the expression of leptin and its receptor, OB-R, in normal gastric mucosa and neoplasia. METHODS: By immunohistochemical staining using specifi c antibodies, we evaluated the expression of leptin and OB-R in 207 gastric carcinomas (100 early and 107 advanced carcinomas) and analyzed their relationship with clinicopathological features. RESULTS: Both normal gastric epithelium and carci- noma cells expressed a significant level of leptin. In cases with OB-R staining, carcinoma cells showed OB-R- positive expression, but the intensity was weaker than that in normal mucosa. The expression of OB-R showed a signifi cant correlation with the level of leptin expres- sion. The expression levels of both leptin and OB-R tend- ed to increase as the depth of tumor invasion or TMN stage increased (P < 0.01). Lymph node metastasis was detected in 49.5% (47/95) of leptin-strong cases and in 50.5% (48/95) of OB-R-positive cases, and the rate was 33% (37/112) in leptin-weak cases and 17% (19/112) in OB-R-negative cases. Both venous and lymphatic inva- sion also tended to be observed frequently in positive tumors as compared with negative tumors. Interestingly, in the 96 leptin- or OB-R-positive tumors, hematogenous metastasis was detected preoperatively in 3 (3.1%) pa- tients. In contrast, none of the carcinomas that lacked expression of leptin and OB-R showed hematogenous metastasis. CONCLUSION: Overexpression of leptin and expres- sion of OB-R may play a positive role in the process of progression in gastric cancer. Functional upregulation of leptin/OB-R may have a positive role in the development and initial phase of progression in gastric cancer.

关键词：受体基因表达胃癌治疗

Sustained release of methyl viologen from a novel nanoparticle delivery system with double shells of silica and PLGA

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The Regional Comprehensive Economic Partnership and Its Potential Impact on Greenhouse Gas Emissions

第十一次中国生物物理学术大会暨第九届全国会员代表大会

作者： hirokazu Miyoshi Radioisotope Research Center The University of Tokushima

＜正＞The use of nanotechnology in drug delivery is a rapidly expanding *** or nontoxic nanomaterials have the most promising application potentials in nanomedicine.

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Journal of Environmental Protection 2016年第9期7卷 1183-1191页

作者： hirokazu Akahori Daisuke Sawauchi Yasutaka Yamamoto Research Faculty of Agriculture Hokkaido University Sapporo Japan

Whether trade liberalization resulting from mega free trade agreements, such as the Regional Comprehensive Economic Partnership (RCEP), will have an impact on the environment is the subject of ongoing debate and remains an empirical matter. In this paper, we contribute to the debate on the relation between trade and the environment by considering the case of the RCEP and examining whether it will increase or decrease greenhouse gas (GHG) emissions. We measure the impact of the RCEP on GHG emissions using the Global Trade Analysis Project (GTAP) model and the GTAP CO2 and non-CO2 emissions databases. Our results suggest that the RCEP is likely to “increase” the total amount of GHG emissions in the 16 RCEP members and the world.

关键词： RCEP Greenhouse gas Climate Change GTAP

ITSS Overview(Skill Standards for IT Professionals )

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Fluorescent spectrum study of fluorescein binding to the interior of silica nanocapsules in various solvents

第五届中国服务外包产业与人才培养峰会

作者： hirokazu AKIMOTO General Manager Center for Human Resources Development Initiative IT Human Resources Development Headquarters Information-Technology Promotion Agency

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生物物理学报 2009年第S1期25卷 299-300页

作者： hirokazu Miyoshi Radioisotope Research Center The University of Tokushima Kuramoto-cho 3-18-15 Tokushima 770-8503 Japan

Porous silica nanocapsules with 20% 3-aminopropyltrimethoxysilane (APS)-bound 6-carboxy-fluorescein (APS-fluorescein) and 80% APS molecules adsorbed on the surface

关键词： Fluorescent spectrum study of fluorescein binding to the interior of silica nanocapsules in various solvents XL

Is the Two-Color Method Superior to Empirical Equations in Refractive Index Compensation?

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Optics and Photonics Journal 2016年第8期6卷 8-13页

作者： Dong Wei Kiyoshi Takamasu hirokazu Matsumoto Department of Mechanical Engineering Nagaoka University of Technology Nagaoka City Japan Department of Precision Engineering The University of Tokyo Tokyo Japan

The Edlén empirical equations and the two-color method are the commonly used approaches to converting a length measured in air to the corresponding length in vacuum to eliminate the influence of the refractive index of air. However, it is not well known whether the two-color method is superior to empirical equations in refractive index compensation. We investigated the uncertainties of these approaches via numerical calculations of their sensitivity coefficients of environmental parameters. On the basis of a comparison of their uncertainties, we found that in a 0% humidity environment, the two-color method had potential to provide greater measurement accuracy than the empirical equations.

关键词： Two-Color Method Length Measurement Sensitivity Coefficient Uncertainty Empirical Equations