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Effects of progressive muscular relaxation and stretching exercises combination on blood pressure among farmers in rural areas of Indonesia:a randomized study

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Frontiers of Nursing 2021年第4期8卷 365-374页

作者： Tantut Susanto Retno Purwandari Emi Wuri Wuryaningsih hirohito watanabe Kana Kazawa Michiko Moriyama Family and Geriatric Nursing DepartmentFaculty of NursingUniversitas JemberJawa Timur 68121Indonesia Basic Sciences Nursing and Management Nursing Department Faculty of NursingUniversitas JemberJawa Timur 68121Indonesia Psychiatric Nursing Department Faculty of NursingUniversitas JemberJawa Timur 68121Indonesia Graduate School of Biomedical and Health Sciences Hiroshima UniversityHiroshima 734-8553Japan

Objective:Maintaining blood pressure(BP)could improve the quality of life among farmers in agricultural *** study aims to evaluate the effects of progressive muscular relaxation and stretching exercises(SEs)for BP in farmer subjects in rural ***:A randomized controlled design was applied for this *** performed a method,which is the combination of progressive muscle relaxation(PMR)and SEs for participants(30 in the control group and 60 in the intervention group).The intervention group self-practiced PMR and SEs through a video that providing instructions for 15 *** practiced before going to sleeping in the night,and SEs practiced before going to farms in the morning per day for *** signed-rank test was performed to measure the difference between systolic blood pressure(SBP)and diastolic blood pressure(DBP)as one pre-and post-test comparison of baseline and 3 months data in control and intervention ***:There were no significant differences between SBP and DBP pre-and post-test in control group(P>0.050).Meanwhile,there were significant differences in reducing SBP(M=126.67;SD=18.07;95%CI=120-147.5 mmHg)and DBP(M=80.67;SD=6.91;95%CI=80-90 mmHg)pre-and post-test combination of PMR and SEs in intervention group(P<0.001).After 3-months of follow-up data,number type SBP and DBP still remained at the same levels of baseline and 3-month data in control ***,there was an increased number of normal and prehypertension for SBP and DBP(10%vs.10%and 20%vs.31.6%)and reduced of hypertension stage I for SBP and DBP(30%vs.41.6%).Conclusions:This pilot study demonstrated effectively to reduce SBP and DBP among farmers using the combination of PMR and SEs in the agricultural health setting.

关键词： progressive muscular relaxation stretching exercises blood pressure farmer agricultural

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Usefulness of liver infiltrating CD86-positive mononuclear cells for diagnosis of autoimmune hepatitis

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World Journal of Gastroenterology 2006年第16期12卷 2523-2529页

作者： Kazutaka Kurokohchi Tsutomu Masaki Takashi Himoto Akihiro Deguchi Seiji Nakai Asahiro Morishita hirohito Yoneyama Yasuhiko Kimura Seishiro watanabe Shigeki Kuriyama Third Department of Internal Medicine Kagawa University School of Medicine1750-1 IkenobeMiki-choKita-gunKagawa 761-0793Japan

AIM： Although the pathogenic mechanism underlying autoimmune hepatitis （AIH） remains unclear, the immune system is thought to be critical for the progression of the disease. Cellular immune responses may be linked to the hepatocellular damage in AIH. Recently, much attention has been focused on the critical functions of costimulatory molecules expressed on mononuclear cells in the generation of effective T cell-mediated immune responses. Analysis of costimulatory molecule expressed on mononuclear cells from the patients with AIH may give us insight into the pathogenic mechanism of hepatocellular damage in AIH. METHODS： Peripheral blood mononuclear cells （PBMC） were taken from the patients with AIH （34 cases） and healthy controls （25 cases）. Uver infiltrating mononuclear cells （LIMCs） were taken from the patients with AIH （18 cases）, the patient with chronic hepatitis C （CH-C）（13 cases） and the patients with fatty liver （2 cases）. Using flow cytometry, the cells were analyzed for the expression of costimulatory molecules, such as CD80, CD86, and CD152 （CTLA-4）. The results were compared with clinical data such as the level of gammaglobulin, histological grade, presence or absence of corticosteroids administration and the response to corticosteroids. RESULTS： The levels of CD80＋, CD86＋ and CD152＋ PBMC were significantly reduced in the patients with AIH as compared with healthy controls. By contrast, those cells were significantly higher in LIMC than in PBMC of the patients with AIH. Especially, the level of CD86＋ LIMC showed a marked increase irrespective of the degree of disease activity in the patients with AIH,although CD86＋ cells were rarely present in PBMC. The levels of CD86＋ cells were present in significantly higher frequency in patients with AIH than in the patients with CH-C. Furthermore, the patients with AIH with high levels of CD86＋ LIMC showed good responses to corticosteroids, whereas 2 cases of AIH with low levels of CD86＋ LIMC did not respond well. C

关键词： Autoimmune hepatitis Costimulatory molecule CD86 molecule Peripheral blood mononuclear cells Liver infiltrating mononuclear cells Flow cytometry

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A combination therapy of ethanol injection and radiofrequency ablation under general anesthesia for the treatment of hepatocellular carcinoma

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World Journal of Gastroenterology 2008年第13期14卷 2037-2043页

作者： Kazutaka Kurokohchi Seishiro watanabe hirohito Yoneyama Akihiro Deguchi Tsutomu Masaki Takashi Himoto Hisaaki Miyoshi Hamdy Saad Mohammad Akira Kitanaka Tomohiko Taminato Shigeki Kuriyama Department of Gastroenterology and Neurology Kagawa University School of Medicine 1750-1 Ikenobe Miki-cho Kita-gun Kagawa 761-0793 Japan Department of Laboratory Medicine Kagawa University School of Medicine 1750-1 Ikenobe Miki-cho Kita-gun Kagawa 761-0793 Japan

AIM: To summarize the effects of laparoscopic ethanol injection and radiofrequency ablation (L-EI-RFA), thora- coscopic (T-EI-RFA) and open-surgery assisted EI-RFA (O-EI-RFA) under general anesthesia for the treatment of hepatocellular carcinoma (HCC). METHODS: Time-lag performance of RFA after ethanol injection (Time-lag PEI-RFA) was performed in all cases. The volume of coagulated necrosis and the applied en- ergy for total and per unit volume coagulated necrosis were examined in the groups treated under general (group G) or local anesthesia (group L). RESULTS: The results showed that the total applied energy and the applied energy per unit volume of whole and marginal, coagulated necrosis were significantly larger in group G than those in the group L, resulting in a larger volume of coagulated necrosis in the group G. The rate of local tumor recurrence within one year was extremely low in group G. CONCLUSION: These results suggest that EI-RFA, un- der general anesthesia, may be effective for the treat- ment of HCC because a larger quantity of ethanol and energy could be applied during treatment under pain- free condition for the patients.

关键词： Combination therapy Ethanol injection Radiofrequency ablation General anesthesia, Local anesthesia

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Comparison between combination therapy of percutaneous ethanol injection and radiofrequency ablation and radiofrequency ablation alone for patients with hepatocellular carcinoma

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World Journal of Gastroenterology 2005年第10期11卷 1426-1432页

作者： Kazutaka Kurokohchi Seishiro watanabe Tsutomu Masaki Naoki Hosomi Yoshiaki Miyauchi Takashi Himoto Yasuhiko Kimura Seiji Nakai Akihiro Deguchi hirohito Yoneyama Shuhei Yoshida Shigeki Kuriyama Third Department of Internal Medicine

AIM: In the present study, the characteristics of PEI-RFA treatment were further elucidated by analyzing the relationship between the volume of coagulated necrosis and the energy requirement for ablation or the amount of ethanol injected into ***: The volume of coagulated necrosis, total energy requirement and energy requirement for coagulation of per unit volume were examined in the groups of PEI-RFA and RFA alone using the Cool-tip RF ***: The results showed that the volume of coagulated necrosis induced was significantly larger in PEI-RFA group than in routine RFA group, when the total energy administered was comparable in both *** PEI-RFA, enlargement of coagulated necrosis was admitted in 3 dimensions and the amount of energy requirement per unit volume of coagulated necrosis was negatively correlated with the amount of ethanol injected into ***: These results suggest that, compared to RFA alone, PEI-RFA enables to induce comparable coagulated necrosis with smaller energy requirement, and that PEI-RFA is likely to be less invasive than RFA alone irrespective of inducing enhanced coagulated ***, simple prior injection of ethanol may make RFA treatment more effective and less invasive for the treatment of patients with HCC.

关键词： Combination therapy Percutaneous ethanol injection Radiofrequency ablation Energy requirement

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Percutaneous local therapies for hepatocellular carcinoma impair gastric function

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World Journal of Gastroenterology 2006年第1期12卷 157-158页

作者： Fumihiko Kinekawa Kazuya Matsuda Tsutomu Masaki Kazutaka Kurokohchi hirohito Yoneyama Hideyuki Inoue Hirohide Kurata Yoshihito Uchida Seishiro watanabe Shigeki Kuriyama Third Department of Internal Medicine Kagawa University School of Medicine1750-1 lkenobeMiki-choKita-gunKagawa 761-0793Japan Department of Internal Medicine Matsuda Clinic1-3-20 Fujitsuka-choTakamatsu-cityKagawa 760-0071Japan Department of Internal Medicine Takuma Municipal National Health Insurance Eikoh Hospital1381 TakumaTakuma-choMitoyo-gunKagawa 769-1101Japan

Percutaneous local therapies, such as percutaneous ethanol injection （PEI）, microwave coagulation and radiofrequency ablation （RFA）, are frequently used worldwide for the treatment of hepatocellular carcinoma （HCC） because of their high effectiveness. Although these treatment modalities can induce effectively coagulated tumor necrosis in the liver, they may cause adverse effects on extrahepatic abdominal organs. There are, however, no published reports on the influence of percutaneous local therapies on the gastric myenteric activity. Therefore, it is unclear whether or not gastric function is affected by percutaneous local therapies. In this study, to make clear the effect of PEI and RFA on the gastric function, we continuously recorded the gastric myoelectric activity by electrogastrography （EGG） and estimated the effect of percutaneous local therapies for HCC on gastric function.

关键词： Electrogastrography Gastric myentericactivity Hepatocellular carcinoma, Percutaneous ethanolinjection Radiofrequency ablation

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Prevalence of linked angina and gastroesophageal reflux disease in general practice

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World Journal of Gastroenterology 2009年第14期15卷 1764-1768页

作者： hirohito Kato Takamasa Ishii Tatsuo Akimoto Yoshihisa Urita Motonobu Sugimoto Department of General Medicine and Emergency Care Toho University School of Medicine Omori Hospital 6-11-1 Omori-Nishi Ota-Ku Tokyo 143-8541 Japan

AIM： To evaluate the association between gastroesophageal reflux diseases （GERD） and coronary heart diseases. METHODS： One thousand nine hundred and seventy consecutive patients who attended our hospital were enrolled. All of the patients who first attend our hospital were asked to respond to the F-scale questionnaire regardless of their chief complaints. All patients had a careful history taken, and resting echocardiography （ECG） was performed by physicians if the diagnostic necessity arose. Patients with ECG signs of coronary artery ischemia were defined as ST- segment depression based on the Minnesota code. RESULTS： Among 712 patients （36%） with GERD, ECG was performed in 171 （24%）, and ischemic changes were detected in eight （5%）. Four （50%） of these patients with abnormal findings upon ECG had no chest symptoms such as chest pain, chest oppression, or palpitations. These patients （0.6%; 4/712） were thought to have non-GERD heartburn, which may be related to ischemic heart disease. Of 281 patients who underwent ECG and did not have GERD symptoms, 20 （7%） had abnormal findings upon ECG. In patients with GERD symptoms and ECG signs of coronary artery ischemia, the prevalence of linked angina was considered to be 0.4% （8/1970 patients）.CONCLUSION： The present study suggested that ischemic heart disease might be found although a patient was referred to the hospital with a complaint of GERD symptoms. Physicians have to be concerned about missing clinically important coronary artery disease while evaluating patients for GERD symptoms.

关键词： Linked angina Epidemiology Generalpractice Electrocardiography Gastroesophageal reflexdisease

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Novel concept of endoscopic device delivery station system for rapid and tight attachment of polyglycolic acid sheet

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World Journal of Gastroenterology 2018年第2期24卷 211-215页

作者： hirohito Mori Hideki Kobara Noriko Nishiyama Tsutomu Masaki Departments of Gastroenterology and Neurology Kagawa University

AIM To evaluate appropriate and rapid polyglycolic acid sheet(PGAs) covering time using device delivery station system(DDSS).METHODS This pilot basic study was conducted to evaluate the potential of accurate and rapid PGAs delivery using DDSS. Three 11-month-old female Beagle dogs were used in this study. Two endoscopic submucosal dissections(ESDs) 4 cm in diameter were performed in lesser curvature of middle gastric body and greater curvature of antrum(total 6 ESDs performed). DDSS(3 cm length, 12 mm in outer diameter) has 2 chambers which 16 cm^2 large 2 PGAs were stored, and DDSS was attached post ESD ulcers, respectively. Beriplast P?(CSL Behring K.K., Tokyo, Japan)(combination of fibringlue and thrombin) was applied equally to the artificial ulcer, and tight attachment of 2 PGAs with DDSS were completed. The evaluation items were covering times, post ESD bleeding and perforation during *** The covering time of PGAs(defined as the duration from the beginning of endoscope insertion into the mouth to the end of the fibrin glue coating process) was 6.07(4.86-8.29) min. There was no postESD bleeding(1-7 d after ESD), and there was no perforation during *** DDSS was very useful for rapid delivering and tight attachment of PGAs, and has potentials of multipurpose delivery station system.

关键词： Post-endoscopic submucosal dissection ulcers Bleeding Polyglycolic acid sheet Rapidly delivery Tightly attachment

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PARP inhibitors as precision medicine for cancer treatment

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National Science Review 2017年第4期4卷 576-592页

作者： Yi Du hirohito Yamaguchi Jennifer L.Hsu Mien-Chie Hung Department of Molecular and Cellular Oncology The University of Texas MD Anderson Cancer Center Graduate Institute of Biomedical Sciences and Center for Molecular Medicine China Medical University Department of Biotechnology Asia University Graduate Institute of Biomedical Sciences and Center for Molecular Medicine China Medical UniversityTaichung

Personalized or precision medicine is an emerging treatment approach tailored to individuals or certain groups of patients based on their unique characteristics. These types of therapies guided by biomarkers tend to be more effective than traditional approaches, especially in cancer. The inhibitor against poly(ADP-ribose) polymerase(PARP), olaparib(Lynparza, Astra Zeneca), which was approved by the US Food and Drug Administration(FDA) in 2014, demonstrated efficacy specifically for ovarian cancer patients harboring mutations in BRCA genes, which encode proteins in DNA double-strand break ***, the response to PARP inhibitors has been less encouraging in other cancer types that also carry defects in the BRCA genes. Thus, furthering our understanding of the underlying mechanism of PARP inhibitors and resistance is critical to improve their efficacy. In this review, we summarize the results of preclinical studies and the clinical application of PARP inhibitors, and discuss the future direction of PARP inhibitors as a potential marker-guided personalized medicine for cancer treatment.

关键词： PARP inhibitor kinase DNA damage precision medicine combination therapy

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Difficulty in differentiating two cases of sigmoid stenosis by diverticulitis from cancer

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World Journal of Gastroenterology 2012年第27期18卷 3623-3626页

作者： Noriko Nishiyama hirohito Mori Hideki Kobara Kazi Rafiq Shintarou Fujihara Mitsuyoshi Kobayashi Tsutomu Masaki Department of Gastroenterology and Neurology Faculty of MedicineKagawa UniversityKagawa 761-0793Japan Department of Pharmacology Faculty of MedicineKagawa UniversityKagawa 761-0793Japan

The incidence of colonic diverticulosis with or without diverticulitis has increased in the Japanese population due to the modernization of food and aging. The rate of diverticulitis in colon diverticulosis ranges from 8.1% to 9.6%. However, few cases of stenosis due to diverticulitis have been reported. These reports suggest that the differentiation between sigmoid diverticulitis and colon cancer is difficult. This report describes two cases of colon stenosis due to diverticulitis that were difficult to differentiate from colon cancer. Case i was a 70-year-old woman with narrowed stools for 1 month who underwent colonofiberscopy （CFS）. CFS revealed a diverticulum and circumferential stenosis in the sigmoid colon. Barium enema revealed a marked, hourglass- shaped, 2-cm circumferential stenosis in the sigmoid colon. Fluorodeoxyglucose （FDG）-positron emission tomography computed tomography （CT） revealed an increased FDG uptake at the affected portion of the sigmoid colon. Sigmoid colon cancer was suspected,and laparoscopic sigmoidectomy was performed. Patho- logical examination demonstrated active inflammation with no evidence of malignancy. Case 2 was a 50-year- old man who presented to a nearby clinic with reduced stool output despite the urge to defecate. CFS detected severe stenosis in the sigmoid colon approximately 25 cm from the dentate line. Contrast-enhanced abdomi- nal CT revealed multiple diverticula, wall thickening, and swelling of the lymph nodes around the peritoneal aorta and the inferior mesenteric artery. A partial sig- moidectomy was performed. Pathological examination of the resected specimen revealed no changes in the mucosal epithelial surface, but a marked infiltration of inflammatory cells was observed.

关键词： Diverticulosis Colon cancer Colon stenosisPositron emission tomography-computed tomographyMagnetic resonance imaging

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Bleeding duodenal hemangioma: Morphological changes and endoscopic mucosal resection

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World Journal of Gastroenterology 2012年第22期18卷 2872-2876页

作者： Noriko Nishiyama hirohito Mori Hideki Kobara Shintarou Fujihara Takako Nomura Mitsuyoshi Kobayashi Tsutomu Masaki Department of Gastroenterology and Neurology Faculty of Medicine Kagawa Medical University

Recently, the development of endoscopic procedures has increased the availability of minimally invasive treatments; however, there have been few case reports of duodenal hemangioma treated by endoscopic mucosal resection. The present report describes a case of duodenal hemangioma that showed various endoscopic changes over time and was treated by endoscopic mucosal resection. An 80-year-old woman presented with tarry stools and a loss of appetite. An examination of her blood revealed severe anemia, and her hemoglobin level was 4.2 g/dL. An emergency upper gastrointestinal endoscopy was performed. A red, protrusive, semipedunculated tumor (approximately 20 mm in diameter) with spontaneous bleeding on its surface was found in the superior duodenal angle. Given the semipedunculated appearance of the tumor, it was suspected to be an epithelial tumor with a differential diagnosis of hyperplastic polyp. The biopsy results suggested a telangiectatic hemangioma. Because this lesion was considered to be responsible for her anemia, endoscopic mucosal resection was performed for diagnostic and treatment purposes after informed consent was obtained. A histopathological examination of the resected specimen revealed dilated and proliferated capillary lumens of various sizes, which confirmed the final diagnosis of duodenal hemangioma. Neither anemia nor tumor recurrence has been observed since the endoscopic mucosal resection (approximately 1 year). Duodenal hemangiomas can be treated endoscopically provided that sufficient consideration is given to all of the possible treatment strategies. Interestingly, duodenal hemangiomas show morphological changes that are influenced by various factors, such as mechanical stimuli.

关键词： Duodenal hemangioma Endoscopic muco-sal resection Gastrointestinal bleeding Morphologicalchanges Capillary hemangioma

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