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World Journal of Hypertension 2015年第3期5卷 104-106页

作者： Miriam E Pearman hirofumi tanaka Cardiovascular Aging Research Laboratory Department of Kinesiology and Health Education University of Texas at Austin

In cross-sectional and intervention studies, low-fat dairy has proven to be effective in lowering blood pressure in a hypertensive population. Contributing mechanisms include the angiotensin-converting enzyme-inhibiting effects of peptides and possible interplay between calcium and vitamin D. Easily added to the diet, low-fat dairy is an attractive addition to nutritional, lifestyle, and pharmacological interventions to treat hypertension.

关键词： Dairy Blood pressure Hypertension Milk Cardiovascular

Hepatic hydrothorax occurring rapidly after manual abdominal compression

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World Journal of Gastroenterology 2007年第46期13卷 6284-6285页

作者： Kazufumi Dohmen hirofumi tanaka Masatora Haruno Yoshiyuki Niho Internal Medicine Chihaya HospitalFukuoka 813-8501Japan

Hepatic hydrothorax is a relatively infrequent but po- tentially serious complication of liver cirrhosis that often causes respiratory dysfunction. Several hypotheses for the development of hepatic hydrothorax have been sug- gested to explain a transdiaphragmatic shift of ascitic fluid through small defects between the peritoneal cavity and the pleural space. However, the rapid development of hydrothorax within several hours is seldom encoun- tered. In addition, the causal factors for rapid passage of ascitic fluid into the pleural cavity are unknown. This report describes a patient with liver cirrhosis who suf- fered rapid development of a hydrothorax after manual compression of the abdomen.

关键词： Hydrothorax Liver cirrhosis Abdominal compression

Use of Liquid-Based Cytology (LBC) and Cell Blocks from Cell Remnants for Cytologic, Immunohistochemical, and Immunocytochemical Diagnosis of Malignancy

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Open Journal of Pathology 2012年第3期2卷 58-65页

作者： hirofumi Sakamoto Makiyo Takenaka Kazuki Ushimaru Takuji tanaka Department of Cytology The Tohkai Cytopathology Institute Cancer Research and Prevention (TCI-CaRP) Gifu City Japan

Great advances in screening have lowered the death rate from cervical cancer in the advanced countries. The major advances in cervical cancer screening include the Papanicolaou (Pap) test and liquid-based cytology (LBC). In this study, we aimed to use cell remnants from LBC specimens from uterine cervix and endometrium, aspirates from breast and thyroid tumors, and liquid samples (ascites, pleural effusion, and urine). Cell blocks made from cell remnants of LBC specimens were immunohistochemically or immunocytochemically stained for several biomarkers including certain tumor markers such together with hematoxylin and eosin staining for accurate diagnosis of malignancies in different samples. The findings from the cell blocks stained with these biomarkers combined with those from Pap stain led to easily diagnosis of the presence or absence of malignancies. Our findings suggest the utility of LBC and cell blocks from cell remnants in cytologic diagnosis in certain specimens.

关键词： LBC Cell Remnants Cell Block Immunohistohemistry Immunocytochemistry Biomarkers Cancer Accurate Diagnosis

Preliminary Study for Feasibility of Driver Agent in Actual Car Environment<br/>—Driver Agent for Encouraging Safe Driving Behavior (3)

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Journal of Transportation Technologies 2020年第2期10卷 128-143页

作者： Takahiro tanaka Kazuhiro Fujikake Yuki Yoshihara Nihan Karatas hirofumi Aoki Hitoshi Kanamori Institutes of Innovation for Future Society Nagoya University Nagoya Japan

Japan has become a more aged society and there are more drivers, 65 years of age and above. Cars represent an important mode of transportation for the elderly;however, in recent years, the number of traffic accidents caused by elderly drivers has been on the rise, and this has become a social issue. Thus, for the elderly drivers to encourage them to improve their driving, we study a driver agent system which consists of smartphone, communication robot and cloud service and provides the driving support by attention awakening and the feedback support based on driving behavior evaluation. In this paper, we presented a summary of the proposed agent and reported on a set of preliminary experiments using our agent in an actual car environment. From the analysis of subjective evaluations and fixation points during driving, the results revealed the possibility that the drivers accept the agent and supports from the agent during driving and that the agent in an actual car environment did not distract the driver.

关键词： Driving Support Agent Elderly HMI

Effect of Difference in Form of Driving Support Agent to Driver’s Acceptability<br/>—Driver Agent for Encouraging Safe Driving Behavior (2)

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Journal of Transportation Technologies 2018年第3期8卷 194-208页

作者： Takahiro tanaka Kazuhiro Fujikake Takashi Yonekawa Makoto Inagami Fumiya Kinoshita hirofumi Aoki Hitoshi Kanamori Institutes of Innovation for Future Society Nagoya University Nagoya Japan

In recent years, the number of traffic accidents caused by elderly drivers has increased in Japan. However, a car is an important mode of transportation for the elderly. Therefore, to ensure safe driving, a system that can assist elderly drivers is required. In this study, we propose a driver-agent system that provides support to elderly drivers during and after driving and encourages them to improve their driving. This paper describes the prototype system based on the analysis of the teaching records of a human instructor, and the subjective evaluation of driving support to elderly and non-elderly driver from three different agent forms, a voice, visual, and robot. The result revealed that the robot form is more noticeable, familiar, and acceptable to the elderly and non-elderly than other forms.

关键词： Driving support Agent Elderly

Relationship between Senior Drivers’ Cognitive and Physical Functions and Urban Driving Behaviors during Behind-the-Wheel Driving Education Sessions with Driving Instructors

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Journal of Transportation Technologies 2017年第2期7卷 148-166页

作者： Takashi Yonekawa Takahiro tanaka hirofumi Aoki Misako Yamagishi Yuki Yoshihara Eijiro Takeuchi Issey Takahashi Yoshiki Ninomiya Hitoshi Kanamori Tatsuya Suzuki Makoto Inagami Institute of Innovation for Future Society Nagoya University Nagoya Japan

Recently, traffic accidents caused by elderly drivers have been increasing. It is thought that the reasons of accidents are functions such as decline of eyesight, cognition and physical strength caused by aging. In order to assist safe driving for elderly drivers, it is necessary to sufficiently understand any possible relationship of various senior drivers’ cognition, physical strength and driving behavior. In this paper relationship of elderly driver’s cognition, physical strength and driving behaviors were analyzed using the result of driving instructions on urban road by driving school instructors.

关键词： Human Engineering Elderly Person Driver Characteristics Driving Instruction

Purification of enzymatically inactive peptidylarginine deiminase type 6 from mouse ovary that reveals hexameric structure different from other dimeric isoforms

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Advances in Bioscience and Biotechnology 2011年第4期2卷 304-310页

作者： hirofumi Taki Tomoharu Gomi Bryan Knuckley Paul R. Thompson Oliver Vugrek Kazuya Hirata Tatsurou Miyahara Kouichiro Shinoda Hiroyuki Hounoki Eiji Sugiyama Isao Usui Masaharu Urakaze Kazuyuki Tobe Tetsuya Ishimoto Ran Inoue Ayumi tanaka Hiroki Mano hirofumi Ogawa Hisashi Mori 不详

The murine peptidylarginine deiminase (PAD) has five isoforms encoded by different genes and participates in a variety of cellular functions through the citrullination of target proteins. The crystal structure of human PAD4 with a dimeric form was previously solved because of the enzyme’s relevance to rheumatoid arthritis. PAD6, abundant in mouse oocytes and eggs, is believed to take part in early events of embryogenesis, but its biochemical properties are little understood. Here we have purified and characterized a recombinant PAD6. A PAD6 cDNA was cloned from mouse ovary RNA and expressed in Escherichia coli through pET29 and pGEX vectors. When benzoyl-L-arginine ethyl ester was used as a substrate, no appreciable activity was detected with a cell homogenate under conditions where a human PAD4 cDNA caused significant activity. Both proteins were affinity-purified to near homogeneity. The circular dichroism spectra of PAD6 and human PAD4 were similar in the far ultraviolet region. On molecular sieving, PAD6 was eluted faster than human PAD4. The cross-linking of PAD6 with dimethyl suberimidate clearly showed six bands on an sodium dodecyl sulfate-polyacrylamide gel. These results indicate that PAD6 can constitute a hexameric structure. The purified PAD6 still showed no enzymatic activity. This unique structure and loss in enzymatic activity is strongly suggested to favor the formation of egg cytoplasmic sheets as the architectural protein.

关键词： Peptidylarginine deiminase Isoform Dimer Hexamer Mouse Oocytes Cytoplasmic sheets.

Usefulness of Fractional Exhaled Nitric Oxide-Guided Treatment in Patients with Asthma-Chronic Obstructive Pulmonary Disease Overlap

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Open Journal of Respiratory Diseases 2018年第1期8卷 1-12页

作者： Taisuke Akamatsu Toshihiro Shirai Yuko tanaka hirofumi Watanabe Yoshinari Endo Yukiko Shimoda Takahito Suzuki Rie Noguchi Mika Saigusa Akito Yamamoto Yuichiro Shishido Takefumi Akita Satoru Morita Kazuhiro Asada Department of Respiratory Medicine Shizuoka General Hospital Shizuoka Japan

Background: Some patients present clinical features of both asthma and chronic obstructive pulmonary disease (COPD), which has led to the recent proposal of asthma-COPD overlap (ACO) as a diagnosis. Fractional exhaled nitric oxide (FeNO) is a candidate biomarker to diagnose ACO. We assessed the effect of an add-on treatment with budesonide/formoterol (BUD/FM) combination in patients with ACO, which was diagnosed by FeNO. Methods: This was a prospective, single-arm, open-label, before and after comparison study. Subjects included 83 patients with COPD who attended outpatient clinics for routine checkups at Shizuoka General Hospital between June and November 2016. All patients fulfilled the GOLD definition of COPD and were receiving long-acting muscarinic antagonist (LAMA) or LAMA/long-acting β2 agonist (LABA) combinations. After an 8-week run-in period, BUD/FM was added to the patients with FeNO levels of ≥35 ppb, defined as having ACO. For patients receiving LAMA/LABA, BUD/FM was added after the discontinuation of LABA. The modified British Medical Research Council (mMRC) score, COPD assessment test (CAT) score, spirometric indices, forced oscillation parameters, and FeNO were assessed before and after 8 weeks of BUD/ FM add-on treatment. Results: Twenty-four patients (28.9%) had FeNO levels ≥ 35 ppb, and 17 patients completed the study (mean age: 73 years and GOLD I/II/III/IV, 5/10/1/1). The mean CAT scores significantly improved (9.2 to 5.4, p = 0.015) and 10 patients (58.8%) showed ≥2 points improvement, a minimal clinically important difference. The mean FeNO levels significantly decreased from 63.0 to 34.3 ppb (p Conclusions: FeNO-guided treatment with BUD/FM improves symptoms in patients with ACO.

关键词： Asthma-COPD Overlap Budesonide/Formoterol Combination COPD Assessment Test Fractional Exhaled Nitric Oxide

Effects of Direct Switching Dual Bronchodilators between Dry Powder and Soft Mist Inhalers in COPD Patients

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Open Journal of Respiratory Diseases 2020年第1期10卷 11-19页

作者： Taisuke Akamatsu Toshihiro Shirai Hiromasa Nakayasu Kanami Tamura Toshihiro Masuda Shingo Takahashi Yuko tanaka hirofumi Watanabe Yutaro Kishimoto Kyohei Oishi Mika Saigusa Akito Yamamoto Satoru Morita Kazuhiro Asada Department of Respiratory Medicine Shizuoka General Hospital Shizuoka Japan

Objective: Dual bronchodilation with long-acting muscarinic antagonist and long-acting β2-agonist combinations are available worldwide in COPD patients. However, the choice of agents remains under debate. We hypothesized that switching devices between dry powder and soft mist inhalers without a wash-out period to mimic clinical practice would improve clinical symptoms and lung function. The aim of this study was to examine the effects of switching between once-daily glycopyrronium/indacaterol (GLY/IND) or umeclidinium/vilanterol (UMEC/VI), dry powder inhalers, and tiotropium/olodaterol (TIO/OLO), a soft mist inhaler, in COPD patients. Methods: This was a prospective, open-label, 8-week, observational study with follow-up. Subjects included 57 COPD patients, who attended outpatient clinics at Shizuoka General Hospital for routine check-ups between February and December 2015, receiving GLY/IND (50/110 μg) or UMEC/VI (62.5/25 μg). After an 8-week run-in period, medications were switched to TIO/OLO (5/5 μg). Study outcomes included patient’s global rating (PGR), modified MRC (mMRC), COPD assessment test (CAT), and spirometric and forced oscillatory parameters after 8 weeks. PGR used in this study was a 7-point scale ranging from 1 to 7, with 4 in the middle. Patients who consented to switch from TIO/OLO to GLY/IND or UMEC/VI were followed-up thereafter. Results: In total, 53 patients completed the study (mean age, 75 years;48 males and 5 females;GOLD 1/2/3/4 = 19/27/6/1;mMRC 0/1/2/3/4 = 14/22/12/4/1;UMEC/VI 26, GLY/IND 27). PGR, mMRC, and CAT improved in 20 (38%), 9 (17%), and 15 patients (28%), respectively. Respiratory system resistance at 5 Hz (R5), 20 Hz (R20), and the difference between R5 and R20 (R5 - R20) significantly improved. In a follow-up of 16 patients after switching from TIO/OLO to UMEC/VI (9) or GLY/IND (7), PGR, mMRC, and CAT improved in 5 (31%), 3 (12%), and 4 patients (25%), respectively, and R20 significantly improved (p = 0.011). Conclusions: Switc

关键词： Device Dry Powder Inhaler Dual Bronchodilator Soft Mist Inhaler Switching