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Identification of Model Parameters of Vaporized Hydrogen Peroxide Decomposi-tion Flux on Building Materials for Compu-tational Fluid Dynamics

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Journal of Environmental Protection 2016年第2期7卷 212-229页

作者： Kazuhide Ito Sung-Jun Yoo hirofumi Horata Interdisciplinary Graduate School of Engineering Science Kyushu University Fukuoka Japan

To maintain healthy and sanitary indoor air quality, development of effective decontamination measures for the indoor environment is important and hydrogen peroxide is often used as decontamination agent in healthcare environment. In this study, we focused on the decomposition phenomena of vaporized hydrogen peroxide on wall surfaces in indoor environment and discussed a wall surface decomposition model for vaporized hydrogen peroxide using computational fluid dynamics to simulate the concentration distributions of vaporized hydrogen peroxide. A major drawback to using numerical simulations is the lack of sufficient data on boundary conditions for various types of building materials and hence. We also conducted the fundamental chamber experiment to identify the model parameters of wall surface decomposition model for targeting five types of building materials.

关键词： Vaporized Hydrogen Peroxide Computational Fluid Dynamics Wall Surface Decomposition Model Chamber Experiment

Retrocaval liver lifting maneuver and modifications of total hepatic vascular exclusion for liver tumor resection

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World Journal of Hepatology 2016年第8期8卷 411-420页

作者： Saiho Ko Yuuki Kirihatayfa Yayoi Matsumoto Tadataka Takagi Masanori Matsusaka Tomohide Mukogawa hirofumi Ishikawa Akihiko Watanabe Department of Surgery Nara Prefecture General Medical Center

AIM: To evaluate the efficacy of technical modifications of total hepatic vascular exclusion(THVE) for hepatectomy involving inferior vena cava(IVC).METHODS: Of 301 patients who underwent hepatectomy during the immediate previous 5-year period, 8(2.7%) required THVE or modified methods of IVC cross-clamping for resection of liver tumors with massive involvement of the IVC. Seven of the patients had diagnosis of colorectal liver metastases and 1 had diagnosis of hepatocellular carcinoma. All tumors involved the IVC, and THVE was unavoidable for combined resection of the IVC in all 8 of the patients. Technical modifications of THVE were applied to minimize the extent and duration of vascular occlusion, thereby reducing the risk of ***: Broad dissection of the space behind the IVC coupled with lifting up of the liver from the retrocaval space was effective for controlling bleeding around the IVC before and during THVE. The procedures facilitate modification of the positioning of the cranial IVC cross-clamp. Switching the cranial IVC cross-clamp from supra- to retrohepatic IVC or to the confluence of hepatic vein decreased duration of the THVE while restoring hepatic blood flow or systemic circulation via the IVC. Oblique cranial IVC cross-clamping avoided ischemia of the remnant hemi-liver. With these technicalmodifications, the mean duration of THVE was 13.4 ± 8.4 min, which was extremely shorter than that previously reported in the literature. Recovery of liver function was smooth and uneventful for all 8 patients. There was no case of mortality, re-operation, or severe complication(i.e., Clavien-Dindo grade of Ⅲ or more).CONCLUSION: The retrocaval liver lifting maneuver and modifications of cranial cross-clamping were useful for minimizing duration of THVE.

关键词： Total hepatic vascular exclusion Retrocaval liver lifting maneuver Oblique clamping Switching the clamp Hepatectomy

真菌一氧化氮还原酶细胞色素P-450nor 2 cDNA序列的测定

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生物工程学报 1997年第1期13卷 108-110页

作者：刘德立 hirofumi SHOUN 华中师范大学生命科学学院筑波大学应用生物化学系

真菌一氧化氮还原酶细胞色素Ｐ４５０ｎｏｒ２ｃＤＮＡ序列的测定刘德立（华中师范大学生命科学学院武汉４３００７０）ＨｉｒｏｆｕｍｉＳＨＯＵＮ（筑波大学应用生物化学系日本）在真菌的反硝化作用中，一种细胞色素Ｐ４５０起着... 详细信息

真菌一氧化氮还原酶细胞色素Ｐ４５０ｎｏｒ２ｃＤＮＡ序列的测定刘德立（华中师范大学生命科学学院武汉４３００７０）ＨｉｒｏｆｕｍｉＳＨＯＵＮ（筑波大学应用生物化学系日本）在真菌的反硝化作用中，一种细胞色素Ｐ４５０起着一氧化氮还原酶的作用，被称为细胞色...

关键词：真菌一氧化氮还原酶细胞色素 P-450nor2 cDNA

Brown slits for colorectal adenoma crypts on conventional magnifying endoscopy with narrow band imaging using the X1 system

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World Journal of Gastroenterology 2022年第24期28卷 2748-2757页

作者： Osamu Toyoshima Toshihiro Nishizawa Shuntaro Yoshida Hidenobu Watanabe Nariaki Odawara Kosuke Sakitani Toru Arano Hirotoshi Takiyama Hideyuki Kobayashi hirofumi Kogure Mitsuhiro Fujishiro Department of Gastroenterology Toyoshima Endoscopy ClinicTokyo 157-0066Japan Department of Gastroenterology and Hepatology International University of Health and WelfareNarita HospitalChiba 286-8520Japan Department of Pathology Pathology and Cytology Laboratory JapanTokyo 166-0003Japan Department of Gastroenterology Graduate School of MedicineThe University of TokyoTokyo 113-8655Japan Department of Gastroenterology Sakitani Endoscopy ClinicChiba 275-0026Japan Department of Gastroenterology The Fraternity Memorial HospitalTokyo 130-8587Japan Department of Surgical Oncology The University of TokyoTokyo 113-8655Japan Department of Internal Medicine Umegaoka Ekimae ClinicTokyo 154-0022Japan

BACKGROUND Accurate diagnosis of colorectal premalignant polyps,including adenomas,is vital in clinical *** To investigate the diagnostic yields of novel findings of brown slits for *** Patients who underwent colonoscopy at the Toyoshima Endoscopy Clinic were *** sized≥5 mm suspected of adenomas or clinically significant serrated polyps were included in the *** defined the surface structures of colorectal polyps,which were brown curves inside and along the tubular glands identified using a combination of a new X1 system(Olympus Corporation)and a conventional magnifying colonoscope with non-staining narrow band imaging(NBI),as brown *** brown slits corresponded to slit-like lumens on endocytoscopy and histological crypt openings of an *** evaluated the diagnostic performance of brown slits for *** A total of 108 Lesions from 62 patients were *** average age was 60.4 years and 41.9%were *** mean polyp size was 7.45±2.83 ***-seven lesions were positive for brown *** diagnosis comprised 59 low-grade tubular adenomas,16 sessile serrated lesions,and 33 hyperplastic *** 59 adenomas,56(94.9%)were positive for brown *** 16 sessile serrated lesions,0(0%)was positive for brown *** 33 hyperplastic polyps,1(3.0%)was positive for brown *** sensitivity,specificity,and accuracy of brown slits for adenoma were 94.9%,98.0%,and 96.3%,*** positive predictive value and negative predictive value of brown slits for adenoma were also excellent for 98.2%,and 94.1%,*** Brown slits on conventional magnifying endoscopy with non-staining NBI using the X1 system were useful for diagnosing colorectal *** new endoscopy system could be examined using new standards.

关键词： Adenoma Colonoscopy Narrow band imaging Magnifying endoscopy X1 Serrated polyp Colorectal neoplasm Endocytoscopy

Clinical and radiological feature of lymphoepithelial cyst of the pancreas

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World Journal of Gastroenterology 2014年第45期20卷 17247-17253页

作者： hirofumi Terakawa Isamu Makino Hisatoshi Nakagawara Tomoharu Miyashita Hidehiro Tajima Hirohisa Kitagawa Takashi Fujimura Dai Inoue Kazuto Kozaka Toshifumi Gabata Tetsuo Ohta Department of Gastroenterologic surgery Graduate School of Medical Science Kanazawa University Department of Radiology Graduate School of Medical Science Kanazawa University

A lymphoepithelial cyst(LEC)of the pancreas is a rare benign *** patients with LEC of the pancreas have a good prognosis,it is important that these lesions are accurately differentiated from other more aggressive pancreatic neoplasms for an appropriate treatment *** studies have reported that a definitive diagnosis of LEC often cannot be obtained based solely on the findings of preoperative imaging(e.g.,Computed tomography or Magnetic resonance imaging).In this study,we reviewed four cases of pancreatic LECs to investigate the feature of *** reviewed these cases with regard to symptoms,imaging findings,surgical procedures,and other clinical *** found that LEC was associated with unique characteristics on imaging findings.A preoperative diagnosisof LEC may be possible by comprehensively evaluating its clinical and imaging findings.

关键词： Lymphoepithelial cyst Preoperative diagno-sis Magnetic resonance imaging

Pyogenic liver abscess after choledochoduodenostomy for biliary obstruction caused by autoimmune pancreatitis

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World Journal of Gastroenterology 2006年第39期12卷 6397-6400页

作者： Nobuyuki Toshikuni Kyohei Kai Shizo Sato Motoko Kitano Masayoshi Fujisawa Hiroaki Okushin Kazuhiko Morii Shinjiro Takagi Masahiro Takatani hirofumi Morishita Koichi Uesaka Shiro Yuasa Department of Internal Medicine Himeji Red Cross Hospital Himeji Japan Department of Surgery Himeji Red Cross Hospital Himeji Japan Department of Pathology Himeji Red Cross Hospital Himeji Japan

A 68-year-old man underwent cholecystectomy and choledochoduodenostomy for biliary obstruction and nephrectomy for a renal tumor. Based on clinical and histopathologic findings, autoimmune pancreatitis (AIP) was diagnosed. The renal tumor was diagnosed as a renal cell cancer. Steroid therapy was started and thereafter pancreatic inflammation improved. Five years after surgery, the patient was readmitted because of pyrexia in a preshock state. A Klebsiella pneumoniae liver abscess complicated by sepsis was diagnosed. The patient recovered with percutaneous abscess drainage and administration of intravenous antibiotics. Liver abscess recurred 1 mo later but was successfully treated with antibiotics. There has been little information on long-term outcomes of patients with AIP treated with surgery. To our knowledge, this is the second case of liver abscess after surgical treatment of AIP.

关键词： Autoimmune pancreatitis Biliary reconstruction Liver abscess

Functional transition:Inconsistently parallel to the increase in future liver remnant volume after preoperative portal vein embolization

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World Journal of Gastrointestinal Surgery 2021年第2期13卷 153-163页

作者： Yosuke Tsuruga Toshiya Kamiyama hirofumi Kamachi Tatsuya Orimo Shingo Shimada Akihisa Nagatsu Yoh Asahi Yuzuru Sakamoto Tatsuhiko Kakisaka Akinobu Taketomi Department of Gastroenterological Surgery I Hokkaido University Graduate School of MedicineSapporo 060-8638Japan

BACKGROUND Preoperative portal vein embolization(PVE)is a widely used strategy to enable major hepatectomy in patients with insufficient liver *** induces hypertrophy of the future liver remnant(FLR)and a shift of the functional reserve to the ***,whether the increase of the FLR volume(FLRV)corresponds to the functional transition after PVE remains *** To investigate the sequential relationship between the increase in FLRV and functional transition after preoperative PVE using 3-dimensional(3D)computed tomography(CT)and 99mTc-galactosyl-human serum albumin(99mTc-GSA)singlephoton emission computed tomography(SPECT)fusion *** Thirty-three patients who underwent major hepatectomy following PVE at the Department of Gastroenterological Surgery I,Hokkaido University Hospital between October 2013 and March 2018 were ***-phase dynamic multidetector CT and 99mTc-GSA SPECT scintigraphy were performed at pre-PVE,and at 1 and 2 wk after PVE;3D 99mTc-GSA SPECT CT-fused images were constructed from the Digital Imaging and Communications in Medicine data using 3D image analysis *** FLRV(FFLRV)was defined as the total liver volume×(FLR volume counts/total liver volume counts)on the 3D 99m Tc-GSA SPECT CT-fused *** calculated FFLRV was compared with *** FFLRV increased by a significantly larger extent than FLRV at 1 and 2 wk after PVE(P<0.01).The increase in FFLRV and FLRV was 55.1%±41.6%and 26.7%±17.8%(P<0.001),respectively,at 1 wk after PVE,and 64.2%±33.3%and 36.8%±18.9%(P<0.001),respectively,at 2 wk after *** 3 of the 33 patients,FFLRV levels decreased below FLRV at 2 *** of the three patients showed rapidly progressive fatty changes in *** biopsy at 4 wk after PVE showed macroand micro-vesicular steatosis of more than 40%,which improved to 10%.Radical resection was performed at 13 wk after *** patient recovered uneventfully without any symptoms of pos-toperative liver *** The

关键词： Preoperative portal vein embolization Hepatectomy 99mTc-galactosyl-human serum albumin single-photon emission computed tomography Future liver remnant volume Functional transition Fatty liver change

Serum manganese superoxide dismutase and thioredoxin are potential prognostic markers for hepatitis C virus-related hepatocellular carcinoma

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World Journal of Gastroenterology 2011年第44期17卷 4890-4898页

作者： Tsutomu Tamai hirofumi Uto Yoichiro Takami Kouhei Oda Akiko Saishoji Masashi Hashiguchi Kotaro Kumagai Takeshi Kure Seiichi Mawatari Akihiro Moriuchi Makoto Oketani Akio Ido Hirohito Tsubouchi Department of Digestive and Lifestyle Related Diseases Human and Environmental SciencesHealth ResearchKagoshima University Graduate School of Medical and Dental Sciences

AIM:To evaluate the clinical significance of oxidative stress markers in patients with hepatitis C virus(HCV)related hepatocellular carcinoma(HCC).METHODS:Sixty-four consecutive patients who were admitted to Kagoshima University Medical and Dental Hospital were enrolled in this retrospective *** patients had chronic liver disease(CLD) due to infection with *** patients with HCV-related HCC,34 with HCV-related CLD without HCC(non-HCC),and 20 healthy volunteers(HVs) were *** associations between serum manganese superoxide dismutase(MnSOD) and thioredoxin(TRX) levels and clinical parameters or patient prognosis were analyzed over a mean follow-up period of 31.7 ***:The serum MnSOD levels were significantly higher in patients with HCV-related HCC than in patients without HCC(P = 0.03) or HVs(P < 0.001).Similarly,serum TRX levels were also significantly higher in patients with HCV-related HCC than in patients without HCC(P = 0.04) or HVs(P < 0.01).However,serum levels of MnSOD and TRX were not correlated in patients with *** patients with HCC,the overall survival rate(OSR) was lower in patients with MnSOD levels ≥ 110 ng/mL than in patients with levels < 110 ng/mL(P = 0.01),and the OSR tended to be lower in patients with TRX levels < 80 ng/mL(P = 0.05).In addition,patient prognosis with HCC was poorest with serum MnSOD levels ≥ 110 ng/mL and serum TRX levels < 80 ng/***,a multivariate analysis using a Cox proportional hazard model and serum levels of five factors(MnSOD,prothrombin time,serum albumin,serum α-fetoprotein(AFP),and serum des-γ-carboxy prothrombin) revealed that MnSOD levels ≥ 110 ng/mL(risk ratio:4.12,95% confidential interval:1.22-13.88,P = 0.02) and AFP levels ≥ 40 ng/mL(risk ratio:6.75;95% confidential interval:1.70-26.85,P < 0.01) were independent risk factors associated with a poor patient ***:Serum MnSOD and TRX levels are potential clinical biomarkers that predict patient prognosis in

关键词： Oxidative stress Manganese superoxide dismutase Thioredoxin Hepatitis C virus Hepatocellular carcinoma

Diabetic lipemia associated with acute pancreatitis in a patient with type 2 diabetes

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Journal of Diabetes Mellitus 2011年第3期1卷 54-56页

作者： Daisuke Ogawa Jun Wada hirofumi Makino 不详

We report a 59-year-old man with diabetic lipemia associated with acute pancreatitis. The patient was being treated for type 2 diabetes, but his glycemic control was poor. Although his insulin secretory activity was preserved, acute pancreatitis developed because of hypertriglyceridemia and the patient had type V hyperlipidemia. After hospitalization, his hyperlipidemia and hyperglycemia improved in response to insulin infusion and hydration. It is well known that diabetic lipemia is caused by type 1 diabetes, but is rare in type 2 diabetes. Insulin resistance, as well as insulin deficiency, might play a role in the development of diabetic lipemia.

关键词： Diabetic Lipemia Type 2 Diabetes Acute Pancreatitis