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MaI-Uniformity of Two-Phase Flow Distribution in Merged Pipe Distributor under Different Outlet Channel Length

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Journal of Mechanics Engineering and Automation 2013年第2期3卷 107-120页

作者： Muh. Anis Mustaghfirin Ak.o Miyara hirata Yuk. Department of Mechanical Engineering Saga University Saga-shi 840-8502 Japan Department of Marine Engineering Ship Building State Polytechnic of Surabaya Surabaya 60111 Indonesia

Two-phase flow distributions in the merged pipe distributor have still remained mal-uniformity problem and the causes have not clearly discovered yet. Therefore, the enhancement study is needed, absolutely. The experimental was carried out upon the distributor constructed by acrylics resembling merged triple pipe, 8 mm in diameter of inlet channel and two set 5 mm in diameter of each outlet channel, set horizontally sideways. Three flow patterns were fed, i.e., bubble, slug and stratified flow, observed via high speed video camera. The pressure distribution was measured by series of U-tube water gauge manometer. The flow patterns, phase distribution and pressure drop were analyzed by CFD software, validated by experimental data and compared by existing correlation, analytically. The experiment is extended by modeling, in order to vary three inclinations of distributor： horizontally, 45° and vertically up-ward as well as to vary three outlet channel lengths with length ratio lc/dc： 3.2, 10 and 70. It was revealed that the two-phase flow distribution tends to be mal-uniform and to transform to different flow pattern in outlet channels. These are promoted by different： outlet channel length, feeding two-phase flow pattern in inlet distributor and inclination angle. The changing of flow pattern is driven by fluctuating velocity in both upper and lower outlet channel.

关键词： Mal-uniformity two-phase flow pressure drop distributor flow pattern.

Association between Dopamine Transporter Gene (<i>DAT1</i>) Polymorphisms and Eating Disorders with Binge Eating Behavior

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Open Journal of Psychiatry 2017年第4期7卷 329-343页

作者： Tak.shi hirata Tak.ji Uemura Manabu Shinohara Masami Hirano Department of Neuropsychiatry and Clinical Ethics Interdisciplinary Graduate School of Medicine University of Yamanashi Yamanashi Japan Health Care Center University of Yamanashi Yamanashi Japan k.osai Hospital Yamanashi Japan

Objectives: Dyshomeostasis of the dopaminergic system is implicated in the pathophysiology of eating disorders (EDs). We have previously reported an association between 3'-UTR VNTR (three prime untranslated region variable number of tandem repeat) of the Dopamine Transporter 1 (DAT1) gene and ED with binge eating behavior (EDBEB). Here we investigated whether variants in the coding region of the DAT1 gene also associate with EDBEB. Methods: The coding region and exon-intron junctions of the DAT1 gene were screened by direct sequencing using genomic DNA from EDBEB patients (n = 90) and healthy subjects (n = 114) on whom 3'-UTR VNTR variants had been previously determined. Results: rs2270912 and rs28363130, two of five k.own polymorphisms found by this screen, were significantly associated with EDBEB patients by genotype (p = 0.003, p = 0.011, respectively) and allele (p = 0.003, p = 0.012, respectively) frequency compared with healthy subjects. Interestingly, these polymorphisms associate with the risk.3'-UTR VNTR variant of EDBEB. Conclusion: Although our sample size was small, we show here that rs2270912 and rs28363130 associates with EDBEB and might act with 3'-UTR VNTR as a haplotype. These findings support the notion that the DAT1 gene plays a k.y role in the dopaminergic system of EDBEB.

关键词： Eating Disorder Binge Eating Behavior DAT1 Association Study Polymorphism

Effects of Cold Atmospheric Pressure Plasma on Accelerating Acute Wound Healing: A Comparative Study among 4 Different Treatment Groups

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Modern Plastic Surgery 2019年第1期9卷 18-31页

作者： Ak.o Nishijima Tak.hiro Fujimoto Tak.michi hirata Junk. Nishijima Department of Medical Engineering Faculty of Engineering Tokyo City University Tokyo Japan Department of Plastic and Reconstructive Surgery University of Tsukuba Ibaraki Japan Clinic F Tokyo Japan

Cold atmospheric pressure plasma (CAP) has been expected to be effective for wound healing among plasma medicines and has been attracting attention. The aim of this retrospective clinical study was to evaluate and compare the effects of CAP on acute wounds created by a fractional CO2 (FXCO2) laser on four treatment groups. Methods: This study was conducted between September 2017 and November 2018. Radiated surface wounds were created using a FXCO2 laser on four identically-sized regions on the medial side of the left forearm of 12 healthy volunteer subjects, for a total of 48 treatment regions. Each region was then randomly assigned to one of four groups: 1) no treatment (control group), 2) irradiated CAP for 60 seconds (plasma group), 3) topical application of ointment containing betamethasone valerate (steroid group), or 4) two to three sprays of basic fibroblast growth factor (bFGF group). The primary outcome of the sk.n was the change in absolute values of lightness index (L*), redness index (a*I) of L*a*b color space, arithmetical mean roughness (Ra), and mean melanin concentration. The secondary outcome was the clinical condition of the wounds, including inflammation, crust formation, and hyper/hypo-pigmentation on the recovering sk.n surface relative to the surrounding intact sk.n. Each item was evaluated at post-treatment 0, 1, 3, 7, 14, 28 days and 1 year. Results: Although no significant difference was observed among all groups, the CAP group exhibited more rapid recovery regarding a*I and Ra. No side-effects were observed in the CAP group. Conclusion: CAP is considered to accelerate healing of irradiated wounds via anti-inflammatory activity. Our study confirmed the effectiveness and safety of CAP which is devoid of side-effects of conventional therapies, and may aid in future development of medical plasma therapies.

关键词： Cold Atmospheric Pressure Plasma Plasma Medicine New Energy Device Wound Healing Sk.n Activation

System to Control Upright Posture with Alcoholic Intak.

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Journal of Mathematics and System Science 2012年第7期2卷 447-453页

作者： Hirok. Tak.da Shinichi Taniguchi Yuuk. Shimizu Tak.yuk. hirata Graduate School of Engineering University of Fukui Fukui 910-8507 Japan Department of Physiology Aichi Medical University School of Medicine Aichi 480-1195 Japan

Equilibrium function in the cerebellum （vestibulo-cerebellar system） can deteriorate under the influence of alcohol. In the Romberg posture, the center of gravity, which was measured every 50 ms by stabilometry, appeared to shift with alcohol ingestion. In the previous study, a locus in the center of gravity （stabilogram） was converted to values of statistical indices such as area of sway, total locus length, sparse density, and locus length per unit area, although these indices could not always distinguish between the stabilograms sampled from seven healthy young males in sober and intoxicated states. This measurement was made with an AMTI force plate. In this study, ＂translation error＂ was estimated in a d-dimensional embedding space in order to compare stabilograms recorded before and after the ingestion of doubly diluted brandy in 30 s （1 ≤ d ≤ 10）. The authors succeeded in validating stochastic differential equations as a mathematical model of the body sway. Although the postural control system shows different patterns in the lateral and anterior-posterior directions, the randomness in the model was preserved after alcohol intak. and significantly increased in the medial/lateral direction. Visual information referred by the postural conlrol system when standing might be interfered by the effects of intoxication, which was regarded as disturbance. The possibility of detecting alcohol-ingestion-induced reduction of the equilibrium function and its recovery process are also suggested in this paper. This method is considered to be useful to diagnose the disorders of the vestibulo-cerebellar system.

关键词： Stabilogram alcoholic intak. SPD (sparse density) translation error SDE (stochastic differential equation).

Novel technique of abdominal wall nerve block.for laparoscopic colostomy: Rectus sheath block.with transperitoneal approach

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World Journal of Gastrointestinal Surgery 2017年第8期9卷 182-185页

作者： Jun Nagata Jun Watanabe Yusuk. Sawatsubashi Masak. Ak.yama k.ichi Arase Noritak. Minagawa Tak.yuk. Torigoe k.taro Hamada Yoshifumi Nak.yama k.iji hirata Department of Gastroenterological and General Surgery Wakamatsu Hospital University of Occupational and Environmental Health Department of Surgery Yokosuka Kyosai Hospital Department of Surgery University of Occupational and Environmental Health Department of Anesthesiology Wakamatsu Hospital University of Occupational and Environmental Health

A 62-year-old man who had acute rectal obstruction due to a large rectal cancer is presented. He underwent emergency laparoscopic colostomy. We used the laparoscopic puncture needle to inject analgesia with the novel transperitoneal approach. In this procedure, both ultrasound and laparoscopic images assisted with the accurate injection of analgesic to the correct layer. The combination of laparoscopic visualization and ultrasound imaging ensured infiltration of analgesic into the correct layer without causing damage to the bowel. Twentyfour hours postoperatively, the patient's pain intensity as assessed by the numeric rating scale was 0-1 during coughing, and a continuous intravenous analgesic was not needed. Colostomy is often necessary in colon obstruction. Epidural anesthesia for postoperative pain cannot be used in patients with a coagulation disorder. We report the use of a novel laparoscopic rectus sheath block.for colostomy. There has been no literature described about the nerve block.with transperitoneal approach. The laparoscopic rectus sheath block.was performed safely and had enough analgesic efficacy for postoperative pain. This technique could be considered as an optional anesthetic regimen in acute situations.

关键词： Colorectal cancer Rectus sheath block Colon obstruction Postoperative pain

Involvement of TLR2 and TLR4,Chlamydophila pneumoniae and Mycoplasma pneumoniae in adventitial inflammation of aortic atherosclerotic aneurysm

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World Journal of Cardiovascular Diseases 2014年第1期4卷 14-22页

作者： Renata Melo de Assis Maria de Lourdes Higuchi Marcia Martins Reis Suely APPalomino Rosario Dominguez Crespo hirata Mario Hiroyuk. hirata Faculty of Pharmaceutical Sciences University of Sao PauloSao PauloSPBrazil Heart Institute of Clinical Hospital Medical SchoolUniversity of Sao PauloSao PauloSPBrazil

Aortic atherosclerotic aneurysm (AAA) is associated with adventitial inflammation where infection is suggested to have a role. Co-infection with Chlamydophila pneumoniae (Cp) and Mycoplasma pneumoniae (Mp) was link.d with coronary plaque rupture, in association with vessel dilatation and adventitial inflammation. Pathogens are recognized by Toll-lik. receptors (TLRs) development of the inflammatory process. Objective: Here, we studied whether co-infection by Cp and Mp was involved in the increased inflammation present in AAA and if it could be associated with deficient expression of TLRs. We compared human samples of AAA with non-dilated human aortic atherosclerotic lesions, regarding the amount of Cp and Mp antigens, and expression of TLR2 and TLR4. Methods: Two groups of aorta fragments were analyzed: G1 (n = 13) moderate atherosclerosis and G2 (n = 14) AAA samples, through immunohisto-chemistry and in situ hybridization methods. Results: Mp and Cp antigens in intima/medial layer were greater in G2 than G1, with no difference in adventitia. TLR2 and TLR4 were higher in G2 than G1 adventitia fat. There was a correlation between Mp versus TLR2 and of TLR4 in intima/medial layer and in adventitia of G1, but there was a lack.of correlation in G2. In Cp adventitia, the correlation in G1 was high with TLR2 but not with TLR4, and in G2 the correlation was positive for both TLRs. Conclusion: This study favors the concept that symbiotic co-infection by Cp and Mp participates in the pathogenesis of AAA. It also emphasizes that adventitial fat is the initial site for colonization of these bacteria that probably reach the tissue through vasa vasorum. An exacerbated immune reaction is not efficient to control the infection that reaches and proliferates in high levels at the medial and intimal layer, contributing to the development of vessel dilatation.

关键词： Aortic Atherosclerotic Aneurysm Inflammation Co-Infection Chlamydophila pneumoniae Mycoplasma pneumoniae Toll-Lik. Receptors

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A prolonged granitoid formation in Saglek.Block.Labrador:Zonal growth and crustal rework.ng of continental crust in the Eoarchean

第一届中日机械技术史国际学术会议

作者： Masahiro MATSUO Naotsugu ISSIk. Masaru hirata Iwne FUJII Saitama University Nihon University Sibaura Institute of Technology Meiji University

＜正＞Introduction The essence of science and technology can be said to actually touch the thing *** is to say that"mak.ng something"or"touching machines"meets the essence of technical education, and the education thr...

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Geoscience Frontiers 2017年第2期8卷 355-385页

作者： Tsuyoshi k.miya Shinji Yamamoto Shogo Aok. k.ik. k.shida Masanori Shimojo Yusuk. Sawak. k.zumasa Aok. Shuhei Sak.ta Tak.omi D.Yok.yama k.nshi Mak. Ak.ra Ishik.wa Tak.fumi hirata k.nneth D.Collerson Department of Earth Science and Astronomy Graduate School of Arts and SciencesThe University of TokyoTokyo 153-8902Japan Department of Earth and Planetary Sciences Tokyo Institute of Technology2-12-1 OokayamaMeguroTokyo 152-8551Japan Laboratory for Planetary Sciences Kyoto UniversityKitashirakawa OiwakechoKyoto 606-8502Japan School of Earth Sciences The University of QueenslandBrisbaneQueenslandAustralia k.C Consulting 33 Cramond StWitstonQld 4051Australia

The Archean continental crusts account for ca.20% of the present volume,but the thermal history of the Earths＇ mantle suggests much more continental crusts were formed in the early *** the Archean continental crust underwent severe metamorphism,it is important to avoid influence by the later thermal *** carried out a comprehensive geochronological work.of Cathodoluminescence（CL） observation and U-Pb dating of zircons from orthogneisses and supracrustal rock. over the Saglek.Block.to obtain their protolith *** zircons were classified into three domains of core,mantle and rims,and the cores were further classified into three groups of inherited,altered and zoned cores based on the zonation on the CL *** estimated the protolith ages from Pb-Pb ages of the zoned-cores of zircons with low U *** made a detailed sk.tch of a small outcrop in ***＇s Harbour South（SJHS） area,and classified the orthogneisses and mafic enclaves into seven generations based on the geologic *** first and second generations comprise mafic rock. and lack.magmatic *** conducted CL imaging and U-Pb dating of zircons from the third,sixth and seventh generation of the orthogneisses to estimate the protolith ages at 3902 L 25,3892 ± 33 and 3897 ± 33 Ma for each,supporting the presence of the over 3.9 Ca Iqaluk.*** geological occurrence that the mafic rock. occur as enclaves within the 3.9 Ga Iqaluk.Gneiss indicates that they are the oldest supracrustal rock. in the *** geochronological and geological studies show the Uivak.Gneiss is quite varied in lithology and age from 3.6 to 〉3.9 Ga,and tentatively classified into six groups based on their *** oldest Uivak.Gneiss components including the Iqaluk.Gneiss are present around the SJHS area,and the orthogneisses become young as it is *** lines of evidence of overprinting of younger granitoid on older granitoid in small outcrops and geological-map scale as well as presence of in

关键词： Eoarchean Geochronology Uivak.Gneiss Iqaluk.Gneiss Continental recycling The oldest rock.

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机械技术史

机械技术史 1998年 108-112页

作者： Masahiro MATSUO Naotsugu ISSIk. Masaru hirata Iwne FUJII Saitama University Nihon University Sibaura Institute of Technology Meiji University

Introduction The essence of science and technology can be said to actually touch the thing *** is to say that"mak.ng something"or"touching machines"meets the essence of technical education, and the education through t... 详细信息

关键词： essence something touch actually itself machines theoret figure powered automobile