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Enhancement in antinociceptive and anti-inflammatory effects of tramadol by transdermal proniosome gel

Asian Journal of Pharmaceutical Sciences 2020年第6期15卷 786-796页

作者： Jigar shah Anroop B.Nair hiral shah Shery Jacob Tamer M.Shehata Mohamed Aly Morsy Institute of Pharmacy Nirma UniversityAhmedabad 382481India College of Clinical Pharmacy King Faisal UniversityAl-Ahsa 31982Saudi Arabia Arihant School of Pharmacy&BRI Gandhinagar 382421India College of Pharmacy Gulf Medical UniversityAjman 4184United Arab Emirates Faculty of Pharmacy University of ZagazigZagazig 44519Egypt Faculty of Medicine Minia UniversityEl-Minia 61511Egypt

Oral therapy of tramadol,an opiate analgesic,undergoes extensive hepatic metabolism and requires frequent *** therapy by virtue can overcome these issues and can improve the efficacy and reduce abuse liability of *** aim of this research was to investigate the possibility of transdermal delivery of tramadol by formulating proniosome gel and evaluate its therapeutic potential in *** effect of formulation composition as well as amount of drug on physicochemical characteristics of prepared proniosomes were *** proniosome gel(F4)was selected and evaluated for drug release,stability and transdermal efficacy by ex vivo and in vivo *** vesicles demonstrated optimal properties including spherical shape,nanosize with good entrapment efficiency,adequate zeta potential,higher stability and greater transdermal *** amorphization and dispersion of tramadol in the aqueous core of proniosome vesicles was confirmed by differential scanning *** profile of F4 was distinct(P<0.001)from control and displayed steady and prolonged tramadol release by Fickian *** therapy of F4 showed prominent reduction of induced twitches(P<0.005)in mice and edema(P<0.05)in rats,as compared to oral *** improvement in clinical efficacy of tramadol in transdermal therapy is correlated with the pharmacokinetic data *** conclusion,the observed improvement in antinociceptive and anti-inflammatory effects from proniosome carriers signifies its potential to be a suitable alternative to oral therapy of tramadol with greater efficacy.

关键词： Tramadol Proniosomes Flux Edema Pharmacokinetics Rats

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Yesterday,Today and Future of the Engineering Management Body of Knowledge

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Frontiers of Engineering Management 2015年第1期2卷 60-63+102页

作者： hiral shah Walter Nowocin St. Cloud State University Medtronic Inc.

Young engineers are often promoted to leadership roles such as a team leader or a manager within 3 to 6years of graduating from an undergraduate degree in a technical area. To be competent and successful in their leadership role engineers need to update their engineering management knowledge and learn new skills. The purpose of engineering management body of knowledge(EMBOK)is to delineate the knowledge, skills, and competency areas that are applicable to the engineering management discipline. It basically answers the question, “What does it take to be an effective engineering manager?” The EMBOK is based on a validated study and can be used for curriculum development, certification exams, and professional development programs. This paper describes the 11 domains that are included in the EMBOK and discuss the future publication of the EMBOK Guide. American Society for Engineering Management(ASEM) offers two certification exams based on the EMBOK, Associate Engineering Manager(AEM) and Professional Engineering Manager(PEM).These certification exams can help an individual in the engineering management profession to show that they have kept up in the field and possess the necessary skills and competency to practice in the discipline. A detailed description of this certification program is included in this paper. The future of EMBOK and the certi fication program is also discussed.

关键词： body of knowledge engineering management certification exam engineering manager competency areas

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Experimental investigation and prediction of wear behavior of cotton fiber polyester composites

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Friction 2017年第2期5卷 183-193页

作者： hiral H.PARIKH Piyush P.GOHIL Department of Mechanical Engineering School of Science and Engineering Navrachana University Vadodara 391410 India Department of Mechanical Engineering Faculty of Technology & Engineering the MS University of Baroda Kalabhavan Vadodara 390001 India

The cotton fiber reinforced polyester composites were fabricated with varying amount of graphite fillers (0,3,5 wt.％) with a hand lay-up *** tests were planned by using a response surface (Box Behnken method) design of experiments and conducted on a pin-on-disc machine (POD) test *** effect of the weight percentage of graphite content on the dry sliding wear behavior of cotton fiber polyester composite (CFPC) was examined by considering the effect of operating parameters like load,speed,and sliding *** wear test results showed the inclusion of 5 wt.％ of graphite as fillers in CFPC increase wear resistance compared to 3 wt.％ of graphite *** graphite fillers were recommended for CFPC to increase the wear resistance of the material.A scanning electron microscope (SEM) was used to study the wear *** predict the wear behavior of the composite material,comparisons were made between the general regression technique and an artificial neural network (ANN).The conformation test results revealed the predicted wear with the ANN was acceptable when compared with the actual experimental results and the regression mathematical models.

关键词： wear composites cotton fiber reinforced polyester composites artificial neural network pin-on-disc

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ORGANOMETALLIC PRECURSORS FOR DEPOSITION OF METAL NITRIDE THIN FILMS

ORGANOMETALLIC PRECURSORS FOR DEPOSITION OF METAL NITRIDE TH...

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40th IUPAC Congress

作者： Lisa McElwee-White Benjamin C. Brooks Laurel L. Reitfort Corey B. Wilder David H. Powell Omar J. Bchir hiral M. Ajmera Timothy J. Anderson Departments of Chemistry and Chemical Engineering University of FloridaUSA Departments of Chemistry and Chemical Engineering University of FloridaUSA Departments of Chemistry and Chemical Engineering University of FloridaUSA Departments of Chemistry and Chemical Engineering University of FloridaUSA Departments of Chemistry and Chemical Engineering University of FloridaUSA Departments of Chemistry and Chemical Engineering University of FloridaUSA Departments of Chemistry and Chemical Engineering University of FloridaUSA Departments of Chemistry and Chemical Engineering University of FloridaUSA

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