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Indigenous plant medicines for health care:treatment of Diabetes mellitus and hyperlipidemia

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Chinese Journal of Natural Medicines 2014年第5期12卷 335-344页

作者： Nisha h. parikh Palak K. parikh Charmy Kothari Arihant School of Pharmacy and Bio-Research Institute Institute of Pharmacy Nirma University

Medicinal plants have played an important role in treating and preventing a variety of diseases throughout the world. Metabolic syndrome had become a global epidemic, defined as a cluster of three of five criteria： insulin resistance and glucose intolerance, abdominal obesity, hypertension, low high-density cholesterol, and hypertriglyeeridemia. The current review fo- cuses on Indian medicinal plant drugs and plants used in the treatment of diabetes and hyperlipidemia. Though there are various approaches to reduce the ill-effects of diabetes and hyperlipidemia and its secondary complications, plant-based drugs are preferred due to lesser side effects and low cost. The current review focuses on twenty-three medicinal plants used in the treatment of Diabe- tes mellitus and nine medicinal plants used in the treatment of hyperlipidemia. The wealth of knowledge on medicinal plants points to a great potential for research and the discovery of new drugs to fight diseases, including diabetes and hyperlipidemia.

关键词： Diabetes mellitus hyperlipidemia Medicinal plants Treatment

Quantification of phenolic compounds and antioxidant capacity of an underutilized Indian fruit:Rayan[Manilkara hexandra(Roxb.)Dubard]

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Food Science and human Wellness 2017年第1期6卷 10-19页

作者： Bhumi parikh V.h.Patel Laboratory of Foods and Nutrition P.G.Department of Home ScienceSardar Patel UniversityVallabh Vidyanagar388120 GujaratIndia

The fruit of Manilkara hexandra(Roxb.)Dubard is one of the most underutilized fruits of India and in Gujarat *** is popularly known as‘Rayan’.The fruit and seed of Rayan were analysed for their total phenolic and flavonoid content,phenolic compounds and total antioxidant capacity with six different assay *** results indicated that the methanolic extract of Rayan fruit being a good source of phenolic(811.3 mg GAE/100 g fw)and flavonoid(485.56 mg RE/100 g fw)***,eleven known phenolic compounds were tentatively identified for the first time from the fruit and seed of *** LC–MS/MS analysis of fruit revealed the presence of major phenolic compounds such as gallic acid,quercetin and kaempferol,while quercetin,gallic acid and vanillic acid in *** presence of quercetin suggests health *** fruit of Rayan was also proved to be a better source of antioxidants as measured by FRAP,RPA,DPPhRSA,ABTSRSA and hRSA except NORSA in comparison with that of *** current study explains that *** is a relatively good source of antioxidants such as phenols and flavonoids for diet.

关键词： Manilkara hexandra(Roxb.)Dubard Underutilized fruit high performance liquid chromatography–mass spectrometry Phenolic compounds Total antioxidant capacity

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Migraine and stroke

Stroke & Vascular Neurology 2017年第3期2卷 160-167页

作者： Yonghua Zhang Aasheeta parikh Shuo Qian Edward Neurosciences Institute in affiliation with Northwestern Medicine NapervilleIllinoisUSA Department of Neurology&Rehabilitation University of IllinoisChicagoIllinoisUSA

Migraines are generally considered a relatively benign neurological ***,research has shown an association between migraines and stroke,and especially between migraine with aura and ischaemic *** can also suffer from migrainous infarction,a subset of ischaemic stroke that often occurs in the posterior circulation of younger *** exact pathogenesis of migrainous infarct is not known,but it is theorised that the duration and local neuronal energy level from cortical spreading depression may be a key *** factors contributing to migrainous infarct may include vascular,inflammatory,endothelial structure,patent foramen ovale,gender,oral contraceptive pill use and *** such as the triptan and ergot class are commonly used to treat migraines and may also play a *** is also shown to be correlated to haemorrhagic stroke,although studies do not demonstrate causation versus association,and further studies are *** are also some rare genetic diseases such as cerebral autosomal-dominant arteriopathy with subcortical infarcts and leukoencephalopathy,retinal vasculopathy with cerebral leukodystrophy and others,which can cause both migraines and *** imaging,many migraineurs are found to have white matter changes similar to those seen in patients with *** may be caused in part by alterations in resting cerebral blood flow and vasoconstrictor *** treating patients with migraines,it is important to identify and modify any vascular risk factors such as hypertension,smoking,oral contraceptive pill use and lifestyle *** studies will determine if more aggressive treatment of migraines can ultimately lead to fewer strokes in this population.

关键词： Migraine alterations younger

An uncommon source of upper gastrointestinal bleeding:epiphrenic esophageal diverticulum

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Gastroenterology Report 2017年第4期5卷 313-315,I0003页

作者： Chung Sang Tse Neil D.parikh Department of Internal Medicine Mayo ClinicRochesterMNUSA Division of Gastroenterology Department of Internal MedicineYale School of MedicineNew HavenCTUSA

Esophageal diverticula are rare findings that have an estimated incidence of 1 per 500000 people per year,even though acute upper gastrointestinal bleeding is a relatively common medical emergency with an incidence of up to 150 per 100000 people per year and a mortality rate of 7-14%.An 83-year-old man presented with hematemesis and *** upper endoscopy revealed an esophageal diverticulum,within which was an adherent *** of the clot identified a bleeding vessel within the diverticulum;this was successfully clipped and hemostasis was *** the best of our knowledge,this is the first case report of a bleeding epiphrenic esophageal diverticulum that was successfully managed endoscopically with hemostatic clips *** rare,our case serves as a reminder that bleeding epiphrenic esophageal diverticula can present as massive upper gastrointestinal bleeding and urgent endoscopic therapy can be life-saving.

关键词： upper gastrointestinal bleed epiphrenic esophageal diverticulum esophago-gastroduodenoscopy

Improving intermittent androgen deprivation therapy： lessons learned from basic and translational research

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Asian Journal of Andrology 2014年第4期16卷 505-510页

作者： Rahul A parikh Laura E Pascal Benjamin J Davieses Zhou Wang Division of hematology/OncologyUniversity of Pittsburgh School of Medicine Hillman Cancer Centre University of Pittsburgh Medical Center Pittsburgh Pennsylvania USA. Department of Urology University of Pittsburgh School of Medicine Hillman Cancer Centre University of Pittsburgh Medical Center Pittsburgh Pennsylvania USA. Department of Pharmacology and Chemical Biology University of Pittsburgh School of Medicine Hillman Cancer Centre University of Pittsburgh Medical Center Pittsburgh Pennsylvania USA.

Intermittent androgen deprivation therapy （IADT） is an alternative to continuous androgen deprivation therapy （ADT） in prostate cancer patients with nonmetastatic disease. ADT is associated with numerous side effects such as hot flashes, sexual dysfunction, anemia, fatigue, loss of muscle mass, osteoporosis, metabolic syndrome and premature cardiovascular disease. IADT was developed with the intention of improving the quality of life and to delay progression of prostate cancer to castration resistance. The benefits of slightly improved quality of life by IADT compared to ADT were demonstrated in multiple clinical trials. IADT was noted to be noninferior to ADT in patients with biochemical recurrence of prostate cancer but in studies performed in patients with metastatic prostate cancer, the results were inconclusive. Our recent studies suggested that the administration of 5 alpha-reductase inhibitors during the off-cycle of IADT can significantly prolong the survival of mice bearing androgen-sensitive prostate tumors when off-cycle duration was short. This review discusses the survival benefit of 5 alpha-reductase inhibition in IADT in animal models and the potential translation of this finding into clinic.

关键词： 5 alpha-reductase inhibitor androgen-responsive genes intermittent androgen deprivation therapy (IADT) prostatecancer testosterone

Get Creative! the Digital Video Idea Book

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Efficacy and safety of vedolizumab in elderly patients with inflammatory bowel disease:a matched case-control study

2003年

作者： Todd Stauffer Nina parikh

ISBN: (纸本)9780072229295

Best-selling author Todd Stauffer teams with movie producer Nina parikh to show you what can happen when you apply professional video and film techniques to everything from home movies to corporate projects projects using a digital camcorder, computer-based editing software and a few good ideas. Includes tips on special effects--plus, distributing, marketing, and presenting your work to broad audiences

关键词： Video - Direction Production Video - Multimedia Technology Video Technology Television - Production Professional Cinematography

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Gastroenterology Report 2020年第4期8卷 306-311,I0002页

作者： Preeti Shashi Dharmesh Gopalakrishnan Malav P.parikh Bo Shen Gursimran Kochhar Center for Inflammatory Bowel Disease Digestive Diseases and Surgery InstituteThe Cleveland Clinic FoundationClevelandOHUSA Department of Internal Medicine The Cleveland Clinic FoundationClevelandOHUSA Department of Gastroenterology Allegheny General HospitalPittsburghPAUSA

Background:Vedolizumab was demonstrated to be safe and effective in adults with moderately to severely active inflammatory bowel disease(IBD)in clinical ***,there are limited data regarding its efficacy and safety in elderly ***:This was a case-control study comparing the efficacy(measured by rates of mucosal healing and need for IBD surgery)and safety of vedolizumab in IBD among patients65 years of age(the elderly group)vs thosehe control group).The two groups were matched individually on a 1:4 ratio based on gender and type of *** logistic regression was used for stratified analysis to calculate odds ratios and confidence ***:We included 25 IBD patients in the elderly group and 100 matched patients in the comparison *** patients had Crohn’s disease and 45 had ulcerative *** baseline,the groups were comparable with regard to duration of IBD,prior anti-TNF therapy,and prior IBD *** rate of mucosal healing on follow-up endoscopy was comparable between the elderly and control groups(50%vs 53%,P=0.507).Although more patients in the elderly group required IBD-related surgery while on vedolizumab,the difference did not reach statistical significance(40%vs 19%,P=0.282).Rates of vedolizumab-related adverse effects—rash,arthralgia,infections,infusion reactions,and dyspnea—were comparable between the two groups(all P>0.05).Conclusions:In a real-world setting,vedolizumab was demonstrated to have an efficacy and safety profile among elderly IBD patients that were comparable to younger controls.

关键词： inflammatory bowel disease vedolizumab elderly patients mucosal healing safety

Nano/microscale pyroelectric energy harvesting:challenges and opportunities

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International Journal of Smart and Nano Materials 2013年第4期4卷 229-245页

作者： Devashish Lingam Ankit R.parikh Jiacheng huang Ankur Jain Majid Minary-Jolandan Department of Mechanical Engineering NanoTech InstituteThe University of Texas at DallasRichardsonTX 75080USA Department of Mechanical and Aerospace Engineering The University of Texas at ArlingtonArlingtonUSA

With the ever-growing demand for renewable energy sources,energy harvesting from natural resources has gained much *** sources such as heat and mechanical motion could be easily harvested based on pyroelectric,thermoelectric,and piezoelectric *** energy harvested from otherwise wasted energy in the environment can be utilized in self-powered micro and nano devices,and wearable electronics,which required onlyµW–mW *** article reviews pyroelectric energy harvesting with an emphasis on recent developments in pyroelectric energy harvesting and devices at micro/*** developments are presented and future challenges and opportunities for more efficient materials and devices with higher energy conversion efficiency are also discussed.

关键词： pyroelectricity energy harvesting micro/nanoscale nanowires composites flexible devices self-powered devices

Influence of supports for selective production of 2,5-dimethylfuran via bimetallic copper-cobalt catalyzed 5-hydroxymethylfurfural hydrogenolysis

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Chinese Journal of Catalysis 2017年第4期38卷 699-709页

作者： Sanjay Srivastava G.C.Jadeja Jigisha parikh Department of Chemical Engineering Sardar Vallabhbhai National Institute of Technology Surat‐395007 Gujarat India

The hydrogenolysis of carbon–oxygen bonds is an important model reaction in upgrading biomass‐derived furanic compounds to transportation *** of these model reactions,namelyconversion of5‐hydroxymethylfurfural(hMF)to the gasoline additive2,5‐dimethylfuran(DMF),isespecially *** this study,bimetallic Cu‐Co catalysts supported on CeO2,ZrO2,and Al2O3were used for the selective hydrogenolysis of hMF to *** structures of the fresh and usedcatalysts were studied using X‐ray diffraction,the Brunauer‐Emmett‐Teller method,transmissionelectron microscopy,temperature‐programmed reduction by h2,temperature‐programmed desorptionof Nh3,and ChNS *** structures were correlated with the catalytic ***‐Co/CeO2catalyst produced mainly2,5‐bis(hydroxymethyl)furan via reduction of C=O bonds onlarge Cu *** Cu‐Co/Al2O3catalyst gave the best selectivity for DMF,as a result of a combinationof highly dispersed Cu,mixed copper–cobalt oxides,and suitable weak acidic ***‐Co/ZrO2had low selectivity for DMF and produced a combination of variousover‐hydrogenolysis products,including2,5‐dimethyltetrahydrofuran and5,5‐oxybis(methylene)‐bis(2‐methylfuran),because of the presence of strong acidic *** reaction pathways and effectsof various operating parameters,namely temperature,h2pressure,and time,were studied to enableoptimization of the selective conversion of hMF to DMF over the Cu‐Co/Al2O3catalyst.

关键词： 5‐hydroxymethylfurfural hydrogenation hydrogenolysis Copper‐cobalt Bimetallic Biofuels