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Dosage and utilization of dexamethasone in the management of COVID-19: A critical review

World Journal of Virology 2024年第3期13卷 107-114页

作者： Imran Sethi Asim Shaikh Musa Sethi hira khalid Chohan Sheraz Younus Syed A Khan Salim Surani Department of Critical Care Medicine Marion General HospitalMarionIN 46952United States Department of Medicine Aga Khan UniversityKarachi 74200SindhPakistan Department of Medicine Eman SchoolFishersIN 46038United States Department of Internal Medicine Dow University of Health ScienceKarachi 74200SindhPakistan Department of Hospital Medicine Franciscan HealthIndianapolisIN 46237United States Department of Critical Care Medicine Mayo Clinic Health SystemMankatoMN 56001United States Department of Medicine and Pharmacology Texas A and M UniversityCollege StationTX 77843United States

BACKGROUND The severe respiratory manifestations observed in severe coronavirus disease 2019(COVID-19)cases are often associated with an excessive inflammatory ***,a synthetic glucocorticoid,exerts its anti-inflammatory effects by inhibiting the transcription of pro-inflammatory genes and suppressing the activity of various immune *** mechanism has implications for mitigating the cytokine storm observed in severe COVID-19 *** on in the pandemic,the Recovery Collaborative working group showed a mortality benefit of using dexamethasone in decreasing mortality in patients with COVID-19 requiring respiratory ***,the optimal dosage of corticosteroids remains *** studies that compare different doses of dexamethasone in COVID-19 exist,but the results are *** To review the latest evidence regarding dosage,safety,and efficacy of dexamethasone in severe *** We followed preferred reporting items for systematic reviews and meta-analysis guidelines.A detailed literature search was conducted across PubMed,Google Scholar,and Medline to include publications up to March *** keywords included“COVID-19”“SARS-CoV-2”“dexamethasone”“corticosteroid”“steroid”and“glucocorticoid”-along with their *** employed the Cochrane Risk of Bias Tool and the Newcastle-Ottawa scale to evaluate the integrity and potential of bias in the included studies.A meta-analysis was conducted using a random-effects model,assessing pooled odds ratios and mean differences,with heterogeneity gauged by the I2 statistic and theχ^(2) *** No statistical differences were found in 28-day all-cause mortality[pooled odds ratio(OR)=1.109,95%CI:0.918-1.340],60-day all-cause mortality(OR=0.873,95%CI:0.744-1.024;I2=47.29%),mean length of hospital stay(mean difference=-0.08 days,95%CI:-0.001 to 0.161)and adverse events(OR=0.877,95%CI:0.707-1.087).CONCLUSION Differing doses of corticosteroids have no clinical implication

关键词： COVID-19 Steroids Corticosteroids Steroid dosage Critical care Corona virus

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Sequence modulation of tunneling barrier and charge transport across histidine doped oligo-alanine molecular junctions

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Chinese Chemical Letters 2021年第12期32卷 3782-3786页

作者： Baili Li Xuan Ji Lixian Tian Xianneng Song Ziyan Wang hira khalid Xi Yu Lejia Wang Wenping Hu Department of Chemistry Tianjin Key Laboratory of Molecular Optoelectronic SciencesSchool of ScienceTianjin University and Collaborative Innovation Center of Chemical Science and Engineering(Tianjin)Tianjin 300072China School of Materials and Chemical Engineering Ningbo University of TechnologyNingbo 315211China

Series tunneling across peptides composed of various amino acids is one of the main charge transport mechanisms for realizing the function of protein. Histidine, more frequently found in redox active proteins, has been proved to be efficient tunneling mediator. While how it exactly modulates charge transport in a long peptide sequence remains poorly explored. In this work, we studied charge transport of a model peptide junction, where oligo-alanine peptide was doped by histidine at different position,and the series of peptides were self-assembled into a monolayer on gold electrode with soft EGa In as top electrode to form molecular junction. It was found that histidine increased the overall conductance of the peptide, meanwhile, its position modulated the conductance as well. Quantitative analysis by transport model and ultraviolet photoelectron spectroscopy(UPS) indicated a sequence dependent energy landscape of the tunneling barrier of the junction. Density-functional theory(DFT) calculation on the electronic structure of histidine doped oligo-alanine peptides revealed localized highest occupied molecular orbital(HOMO) on imidazole group of the histidine, which decreased charge transport barrier.

关键词： Charge transport Molecular junction Peptide sequence Self-assembled monolayer Tunneling

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基于混合自组装单分子层的可控分子整流

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化学学报 2019年第10期77卷 1031-1035页

作者：王紫嫣 khalid hira 李柏力李瑶于曦胡文平天津大学理学院天津市分子光电科学重点实验室天津300072 天津大学分子+研究院天津300072

基于自组装单分子层(SAM)的分子器件的性能取决于分子层的超分子结构.而混合自组装单分子层是一种简便易行的调控单分子层组成和结构的方法.将具有整流特性的11-二茂铁基-1-十一烷基硫醇(FUT)和惰性1-十一烷硫醇(C11-SH)通过溶液共混制... 详细信息

基于自组装单分子层(SAM)的分子器件的性能取决于分子层的超分子结构.而混合自组装单分子层是一种简便易行的调控单分子层组成和结构的方法.将具有整流特性的11-二茂铁基-1-十一烷基硫醇(FUT)和惰性1-十一烷硫醇(C11-SH)通过溶液共混制备了混合单分子层,并用液态EGaIn作为顶电极研究了SAM器件的性质.C11-SH与FUT分子的比例可以调节器件的整流性能:随着惰性C11-SH分子比例增高, SAM器件的整流比逐渐降低.有趣的是,当惰性C11-SH的比例小于20%时,器件的整流性能反而随C11-SH的加入而得到了提升.这是由于少量C11-SH分子减弱了由二茂铁分子的排列缺陷引起的漏电流,改善了分子器件的稳定性和重现性,为单分子层器件的性能调控提供了一种简便有效的方法.

关键词：分子电子学自组装单分子层稀释法整流特性混合单分子层

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Phytochemical Study of <i>Glycosmis Mauritiana</i>

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American Journal of Plant Sciences 2011年第5期2卷 657-659页

作者： Javed Intekhab Mohammad Aslam hira khalid 不详

Three quinolinone alkaloids, two acridone alkaloids and a flavones glycoside were isolated from the aerial parts of Glycosmis mauritiana. These compounds were characterized as 7, 8-Dimethoxy-2,2,6-trimethyl-pyrano quinolin-5-one, 4-Methoxy 1-methyl quinolin-2-one, 6-Hydroxy N-methyl 2,3-furo-quinolin-4-one, 1-Hydroxy-10-methyl acridone, 1- Hydroxy-2, 3-dimethoxy-10-methylacridin-9-one and Luteolin-4'-O-[α-L-rhamnopyranosyl-(1→2)-{α-L-rhamnopyra- nosyl-(1→6)}-β-D-glycopyranoside]. The isolated compounds were characterized by UV, IR and N. M. R (1H, 13C) studies.

关键词： Glycosmis Mauritiana Rutaceae Flavanone Glycoside

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Development of Bioinfo-Portal Tool for the Analysis of Genomic and Proteomic Data

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Journal of Life Sciences 2012年第5期6卷 485-488页

作者： Rana Rehan khalid Bilal Hussain Muhammad Ali Muhammad Sajjad Ahmad Asma Haque hira Qamar Department of Bioinformatics and Biotechnology Govt College University Faisalabad Punjab 38000 Pakistan Department of Computer Science Riphah International University Islamabad Punjab 44000 Pakistan

The recent explosion of biological data and the concomitant proliferation of distributed databases make it challenging for biologists and bioinformaticians to discover the best data resources for their needs, and the most efficient way to access and use them For the biologist, running bioinformatics analyses involve a time-consuming management of data and tools. Users need support to organize their work, retrieve parameters and reproduce their analyses. They also need to be able to combine their analytic tools using a safe data flow software mechanism. Finally we have designed a system, Bioinfo-Portal, to provide a flexible and usable web environment for defining and running bioinformatics analyses. It embeds simple yet powerful data management features that allow the user to reproduce analyses and to combine tools using an adobe flex tool. Bioinfo-Portal can also act as a front end to provide a unified view of already-existing collections of bioinformatics resources. Users can analyze genomic and proteomic data by using the tools that has been integrated in the portal （tools for alignments, dotplots, motif detection, domain analysis, profile searching and tertiary structure prediction）. The sequences that user obtained from portal＇s nucleotide and protein databases are easily analyzed by the portal tools on the same interface in no time. User can also take benefit from the animations.

关键词： Bioinfo-Portal analytic tools flexible and usable web environment tertiary structure prediction domain analysis motifdetection alignments.

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