检索结果-南通市图书馆

Taste masking of ciprofloxacin by ion-exchange resin and sustain release at gastric-intestinal through interpenetrating polymer network

在线全文

学校读者我要写书评

暂无评论

Asian Journal of Pharmaceutical Sciences 2015年第4期10卷 331-340页

作者： A.Michael Rajesh Shreya A.Bhatt Harshad Brahmbhatt Pritpal Singh Anand Kiritkumar Mangaldas popat Reverse Osmosis Membrane Division Central Salt and Marine Chemicals Research InstituteCouncil of Scientific&Industrial Research(CSIR)G.B.MargBhavnagar 364002India Analytical Discipline&Centralized Instrumentation Facility Central Salt and Marine Chemicals Research InstituteCouncil of Scientific&Industrial Research(CSIR)G.B.MargBhavnagar 364002India Academy of Scientific and Innovative Research Central Salt and Marine Chemicals Research InstituteCouncil of Scientific&Industrial Research(CSIR)G.B.MargBhavnagar 364002India

The aim of the study was to taste mask ciprofloxacin(CP)by using ion-exchange resins(IERs)followed by sustain release of CP by forming interpenetrating polymer network(IPN).IERs based on the copolymerization of acrylic acid with different cross linking agents were ***-resin complexes(DRCs)with three different ratios of drug to IERs(1:1,1:2,1:4)were prepared&evaluated for taste masking by following in vivo and in vitro *** volunteers graded ADC 1:4,acrylic acid-divinyl benzene(ADC-3)resin as *** studies such as FTIR,SEM,DSC,P-XRD differentiated ADC 1:4,from physical mixture(PM 1:4)and confirmed the formation of *** vitro drug release of ADC 1:4 showed complete release of CP within 60 min at simulated gastric fluid(SGF)*** *** beads were prepared with ADC 1:4 by using sodium alginate(AL)and sodium alginate-chitosan(AL-CS)for sustain release of CP at SGF pH and followed by simulated intestinal fluid(SIF *** 7.4).FTIR spectra confirmed the formation of IPN *** release of CP was sustain at SGF pH(75%).The kinetic model of IPN beads showed the release of CP was non-Fickian diffusion type.

关键词： Ion exchange resins Biopolymers In vitro&in vivo taste masking Ciprofloxacin Sustain release Release mechanism and kinetics

Data-driven modeling of power generation for a coal power plant under cycling

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

能源与人工智能(英文) 2023年第1期11卷 90-105页

作者： himanshu Sharma Laurentiu Marinovici Veronica Adetola Herbert T.Schaef Pacific Northwest National Laboratory RichlandWA 99354USA

Increased penetration of renewables for power generation has negatively impacted the dynamics of conventional fossil fuel-based power *** power plants operating on the base load are forced to cycle,to adjust to the fluctuating power *** results in an inefficient operation of the coal power plants,which leads up to higher operating *** overcome such operational challenge associated with cycling and to develop an optimal process control,this work analyzes a set of models for predicting power ***,the power generation is intrinsically affected by the state of the power plant components,and therefore our model development also incorporates additional power plant process variables while forecasting the power *** present and compare multiple state-of-the-art forecasting data-driven methods for power generation to determine the most adequate and accurate *** also develop an interpretable attention-based transformer model to explain the importance of process variables during training and *** trained deep neural network(DNN)LSTM model has good accuracy in predicting gross power generation under various prediction horizons with/without cycling events and outperforms the other models for long-term *** DNN memory-based models show significant superiority over other state-of-the-art machine learning models for short,medium and long range *** transformer-based model with attention enhances the selection of historical data for multi-horizon forecasting,and also allows to interpret the significance of internal power plant components on the power *** newly gained insights can be used by operation engineers to anticipate and monitor the health of power plant equipment during high cycling periods.

关键词： Deep learning Interpretable temporal fusion transformer Long short-term memory Coal power plant cycling

Fatigue crack growth simulations of 3-D linear elastic cracks under thermal load by XFEM

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Frontiers of Structural and Civil Engineering 2015年第4期9卷 359-382页

作者： himanshu PATHAK Akhilendra SINGH I.V. SINGH S. K. YADAV Department of Mechanical Engineering Shiv Nadar University Gautam Buddha Nagar 201314 India Department of Mechanical Engineering liT Patna Patna 800013 India Department of Mechanical and Industrial Engineering HT Roorkee Roorkee 247667 India

This paper deals with the fatigue crack growth simulations of three-dimensional linear elastic cracks by XFEM under cyclic thermal load. Both temperature and displacement approximations are extrinsically enriched by Heaviside and crack front enrichment functions. Crack growth is modelled by successive linear extensions, and the end points of these linear extensions are joined by cubic spline segments to obtain a modified crack front. Different crack geometries such as planer, non-planer and arbitrary spline shape cracks are simulated under thermal shock, adiabatic and isothermal loads to reveal the sturdiness and versatility of the XFEM approach.

关键词： 3-D cracks fatigue life Paris law thermal load XFEM

Inflammation and dry eye disease——where are we?

在线全文

学校读者我要写书评

暂无评论

International Journal of Ophthalmology(English edition) 2022年第5期15卷 820-827页

作者： Srinivas K Rao Rishi Mohan Nikhil Gokhale himanshu Matalia Paras Mehta Darshan Eye Care&Surgical Centre ChennaiTamil NaduIndia MM Eyetech Institute of Ophthalmology New DelhiIndia Gokhale Eye Hospital MumbaiMaharashtraIndia Narayana Nethralaya Electronic CityBangaloreKarnatakaIndia Sameep Eye Hospital and Corneal Center VadodaraGujaratIndia

The presence of inflammation in dry eye disease(DED)results in increased patient symptomatology,ocular surface damage and worsening tear *** also affects the health of meibomian glands and their secretions which further aggravates ocular surface *** article reviews current knowledge regarding ocular surface inflammation in DED and explores the relationships between the vicious cycles of DED,inflammation and meibomian gland dysfunction(MGD).The clinical evaluation of eyes with such changes,markers that identify the presence of inflammation on the ocular surface and current treatment options are discussed.

关键词： dry eye disease inflammation meibomian gland dysfunction vicious cycle ocular surface disease

A GFP-based bacterial biosensor with chromosomally integrated sensing cassette for quantitative detection of Hg(Ⅱ) in environment

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Journal of Environmental Sciences 2012年第5期24卷 963-968页

作者： himanshu Priyadarshi Absar Alam Gireesh-Babu P Rekha Das Pankaj Kishore Shivendra Kumar Aparna Chaudhari College of Fisheries (CAU) Lembucherra Tripura 799210 India Department of Fish Genetics and Biotechnology Central Institute of Fisheries Education Department of Fish Processing Technology Central Institute of Fisheries Education Department of Fish Nutrition and Biochemistry Central Institute of Fisheries Education Krishi Vigyan Kendra Rajendra Agricultural University

A mercury biosensor was constructed by integrating biosensor genetic elements into E. coli JM109 chromosome in a single copy number, using the attP/attB recombination mechanism of λ phage. The genetic elements used include a regulatory protein gene （merR） along with operator/promoter （O/P） derived from the mercury resistance operon from pDU1358 plasmid of Serratia marcescens. The expression of reporter gene gfp is also controlled by merR/O/P. Integration of the construct into the chromosome was done to increase the stability and precision of the biosensor. This biosensor could detect Hg（Ⅱ） ions in the concentration range of 100–1700 nmol/L, and manifest the result as the expression of GFP. The GFP expression was significantly different （P 0.05） for each concentration of inducing Hg（Ⅱ） ions in the detection range, which reduces the chances of misinterpretation of results. A model using regression method was also derived for the quantification of the concentration of Hg（Ⅱ） in water samples.

关键词： attP/attB integration E. coli biosensor GFP mercury

Evaluation of Rainfall Tendency for the Twentieth Century over Indira Sagar Region in Central India

在线全文

学校读者我要写书评

暂无评论

Outcome measures following tele-rehabilitation and conventional face to face rehabilitation in paediatric cochlear implant users during COVID-19 pandemic:A pilot study in a tertiary care setup

American Journal of Climate Change（美国气候变化期刊） 2024年第1期 47页

作者： Rituraj Shukla Deepak Khare Ramesh P.Rudra Priti Tiwari himanshu Sharma Prasad Daggupati Pradeep Goel

来源：博看期刊评论

在线全文

博看期刊

学校读者我要写书评

暂无评论

Journal of Otology 2022年第1期17卷 31-38页

作者： himanshu Verma Banumathy N Roshani Mishra Naresh K.Panda Department of Otolaryngology and Head&Neck Surgery Post Graduate Institute of Medical Education and ResearchChandigarh160012India

Background:Following the COVID-19 pandemic,majority of paediatric cochlear implantees(CI)lost follow ups for rehabilitation and tele-therapy was *** study thus compared the outcome measures of paediatric CI users on tele-therapy versus conventional face to face therapy following COVID-19 ***:Twenty seven unilateral paediatric cochlear implantees in the age range of 2e11 years were divided into two groups based on the therapy modality,viz,tele-and face-to-face *** on the hearing age,participants were further divided into three groups,viz,0e2,2e4,and greater than four years.A complete the test battery comprising Integrated Scales of Development,Speech Intelligibility Rating scale,and Revised Categorical Auditory Perception were *** speech&language test battery was performed prior to initiating the rehabilitation and post 12 months of ***:Results of the present study revealed that conventional rehabilitation had better outcomes compared to *** rate of progress after one year of rehabilitation with respect to hearing-age showed a significant difference for the hearing-age group of 0e2 years across the domains of audition,speech and ***:The present study indicates that conventional method of the speech-language and auditory rehabilitation is far better compared to the tele rehabilitation services especially for those visiting tertiary care hospitals as most of them belong to lower and middle socioeconomic *** the results,it can be delineated that with lesser hearing experience,paediatric CI users always need to initially enroll for conventional therapy for better speech-language and auditory outcomes.

关键词： Cochlear implant Tele-therapy Conventional therapy Language outcomes Speech&language rehabilitation

A Note on Some Inequalities of GG-E-Convexity

在线全文

学校读者我要写书评

暂无评论

Journal of Mathematical Research with Applications 2023年第2期43卷 204-212页

作者： himanshu TIWARI D.B.OJHA Department of Mathematics Faculty of Science University of Rajasthan

In this paper, we define GG-E-convexity and GG-E-concavity. We also establish some inequalities in relation to GG-E-convex function using various integral inequalities with enough examples of various categories, which... 详细信息

关键词： convex function E-convex set E-convex function GG-E-convex function

Controlled release of FK506 from micropatterned PLGA films:potential for application in peripheral nerve repair

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

Neural Regeneration Research 2018年第7期13卷 1247-1252页

作者： Brett Davis Susan Wojtalewicz Pratima Labroo Jill Shea himanshu Sant Bruce Gale Jayant Agarwal Department of Bioengineering University of Utah Department of Surgery University of Utah Department of Mechanical Engineering University of Utah

After decades of research,peripheral nerve injury and repair still frequently results in paralysis,chronic pain and neuropathies leading to severe disability in *** clinically available nerve conduits only provide crude guidance of regenerating axons across nerve gap without additional ***506（Tacrolimus）,an FDA approved immunosuppressant,has been shown to enhance peripheral nerve regeneration but carries harsh side-effects when delivered *** objective of this study was to develop and evaluate a bioresorbable drug delivery system capable of local extended delivery of FK506 that also provides topological guidance cues to guide axon growth via *** was used to create micropatterned poly（lactide-co-glycolic acid）（PLGA） films embedded with ***-patterned,10/10 μm（ridge/groove width）,and 30/30 μm patterned films loaded with 0,1,and 3 μg/cm2 FK506 were manufactured and *** vitro FK506 rate of release testing indicated that the films are capable of an extended（at least 56 days）,controlled,and scalable release of *** extension bioactivity assay indicated that FK506 released from the films（concentration of samples tested ranged between 8.46–19.7 ng/m L） maintained its neural bioactivity and promoted neurite extension similar to control FK506 dosages（10 ng/m L FK506）.The multi-functional FK506 embedded,micropatterned poly（lactide-co-glycolic acid） films developed in this study have potential to be used in the construction of peripheral nerve repair devices.

关键词： nerve regeneration FK506 controlled release micropatterns topological cues PLGA