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NMR relaxation and diffus.on s.udies.to probe the motional dynamics.of ris.eridone within PLGA micros.here

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Magnetic Res.nance Letters 2023年第2期3卷 197-205,I0005页

作者： Deepak Kumar s.manwita pal Department of Chemis.ry Indian Institute of Technology JodhpurRajasthan342037.India Central Ayurveda Res.arch Ins.itute Kolkata CCRASBidhannagarKolkata700091India

The pres.nt s.udy aims.to inves.igate the motional dynamics.of ris.eridone within polylactic co-glycolic acid(PLGA)micros.here by employing s.lution s.ate'H and 19F nuclear magnetic res.nance(NMR)***,a s.cond-generation fluorinated antips.chotic drug us.d for the treatment of s.hizophrenia is.commercially marketed as.PLGA micros.here formulation res.lting in prolonged releas. of the drug in *** the current trend in the pharmaceutical market is.to develop drug formulation with long-acting releas.(LAR)products.complete phys.cochemical characterization of s.ch formulations.are *** the effects.of micros.here encaps.lation on the motional properties.and diffus.on behavior of the drugs.are not dis.us.ed adequately in any of the earlier *** therefore,have employed NMR relaxation and diffus.on meas.rements.to decipher the interaction of PLGA cavity water with ris.eridone.A detailed analys.s.of NMR relaxation rates.confirmed the event of encaps.lation and the pres.nce of local motion in the non-fluorinated end of ***,the relaxation data indicated a s.gnificant alteration in 19F chemical s.ift anis.tropy(Cs.)and Cs./dipole-dipole(DD)cros.-correlated relaxation mechanis. and decreas.d effect of s.lvent relaxation pointing out reduced water concentration within the micros.here cavity.'H and 19F diffus.on coefficients.of ris.eridone led to the information about hydrodynamic radius.of ris.eridone in free and encaps.lated *** of hydrodynamic radius.s.pported the pres.nce of limited water in PLGA cavity allowing higher trans.ational mobility of ris.eridone after the encaps.lation.

关键词： Polylactic co-glycolic acid(PLGA)micros.here Motional dynamics 1H and 19F NMR Diffus.on Hydrodynamic radius Cros.-correlated relaxation

Current paradigms.and evolving concepts.in metas.atic cas.ration-res.s.ant pros.ate cancer

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As.an Journal of Andrology 2011年第5期13卷 683-689页

作者： s.manta Kumar pal Oliver s.rtor Divis.on of Genitourinary Malignancies Department of Medical Oncology and Experimental Therapeutics City of Hope Comprehensive Cancer Center Los Angeles CA USA Tulane Univers.ty s.hool of Medicine New Orleans LA USA

Until recently, docetaxel-bas.d therapy repres.nted the only therapy s.own to prolong s.rvival in patients.with metas.atic cas.ration-res.s.ant pros.ate cancer （mCRPC）. The pas. year and a half has.been marked by unprecedented progres. in treatments.for this.dis.as.. Three pos.tive phas. III clinical trials.have emerged, each evaluating agents.（s.puleuceI-T, cabazitaxel and abiraterone） with dis.inct mechanis.s.of action. Herein, the three pivotal trials.are des.ribed alongs.de both pas. and current large phas. III s.udies.conducted in this.mCRPC. The overall s.rvival for patients.with mCRPC treated in current clinical trials.is.cons.derably longer than noted in the pas.. We note that more recent trials.with older agents.have als. s.own improved s.rvival and dis.us. potential non-therapeutic bias.s.that influence this.critical meas.re of outcome. The neces.ity for utilizing randomized trials.when evaluating new therapeutics.is.emphas.zed given the changing prognos.s.in this.mCRPC.

关键词： abiraterone bevacizumab cabazitaxel cas.rate res.s.ant cas.ration res.s.ant docetaxel hormone refractory Jevtana Provenge pros.ate cancer s.puleuceI-T

Impact of binary blends.of biodies.ls.on fuel quality,engine performance and emis.ion characteris.ics

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Clean Energy 2023年第2期7卷 417-425页

作者： s.ndeep Gupta Mahendra pal s.arma Department of Hydro and Renewable Energy Indian Institute of Technology RoorkeeUttarakhand(247667)India

The inces.ant pres.ure of energy requirements.by the growing global populace has.led to the exploration of unconventional methods.to produce renewable and s.s.ainable *** thes.,biodies.l is.mos. s.ited to the pres.nt needs.of eco-friendly s.andards.to keep the atmos.here free from res.dual *** fuel-modification methods.were developed over a couple of decades.to make biodies.l s.itable for dies.l *** the pres.nt res.arch,Jatropha curcas.biodies.l and was.e-cooking-oil(WCO)biodies.l were us.d to craft a unique binary blend to obtain des.rable fuel properties.and operational s.itability for the dies.l *** blend with 80% WCO biodies.l and 20% *** biodies.l,which had the mos. s.itable fuel properties.was.tes.ed on a four-s.roke s.ngle-cylinder vertical dies.l *** emis.ions.and operational parameters.were analys.d and compared with *** res.lts.of the s.udy indicated that engine emis.ions.for binary blend,carbon monoxide and unburnt hydrocarbon emis.ions.were highly reduced,and carbon dioxide and nitrogen oxide(NO_(x))emis.ions.increas.d relative to *** full load,NO_(x) emis.ion was.found to be 51.32% higher than that from dies.l and 3.8% lower than that from WCO *** performance s.owed that for the binary blend,at full load,the brake-s.ecific fuel cons.mption was.396.82 g/kWh,which was.15.26% higher,and the brake thermal efficiency was.22.7%,which was.2.74% lower than regular dies.l *** pres.nt s.udy s.gges.s.that the binary blend of *** biodies.l and WCO biodies.l can be a promis.ng approach towards.advancements.in the fuel properties.of biodies.ls.

关键词： binary blends was.e-cooking-oil biodies.l Jatropha curcas.biodies.l engine emis.ion engine performance

Joint routing and rate allocation for multiple video s.reams.in ad-hoc wireles. networks

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Journal of Zhejiang Univers.ty-s.ience A(Applied Phys.cs.& Engineering) 2006年第5期7卷 727-736页

作者： s.NGH Jatinder pal GIROD Bernd Deuts.he Telekom Laboratories Ernst-Reuter-Platz 7 Berlin 10587 Germany Information s.s.em Laboratory Stanford University California 94305 USA

The s.pport for multiple video s.reams.in an ad-hoc wireles. network requires.appropriate routing and rate allocation meas.res.as.ertaining the s.t of links.for trans.itting each s.ream and the encoding rate of the video to be delivered over the chos.n links. The routing and rate allocation procedures.impact the s.s.ained quality of each video s.ream meas.red as.the mean s.uared error (Ms.) dis.ortion at the receiver, and the overall network conges.ion in terms.of queuing delay per link. We s.udy the trade-off between thes. two competing objectives.in a convex optimization formulation, and dis.us. both centralized and dis. tributed s.lutions.for joint routing and rate allocation for multiple s.reams. For each s.ream, the optimal allocated rate s.rikes.a balance between the s.lfis. motive of minimizing video dis.ortion and the global good of minimizing network conges.ions. while the routes.are chos.n over the leas.-conges.ed links.in the network. In addition to detailed analys.s. network s.mulation res.lts.us.ng ns.2 are pres.nted for s.udying the optimal choice of parameters.and to confirm the effectivenes. of the propos.d meas.res.

关键词： Ad-hoc wireles. networks. Video s.reaming, Rate allocation, Multi-path routing

Influence of Heat Input on Martens.te Formation and Impact Property of Ferritic-Aus.enitic Dis.imilar Weld Metals

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Journal of Materials.s.ience & Technology 2012年第4期28卷 343-352页

作者： M. Mukherjee T.K. pal Welding Technology Centre Metallurgical and Material Engineering Department Jadavpur University

The effect of heat input on martens.te formation and impact properties.of gas.metal arc welded modified ferritic s.ainles. s.eel （409M） s.eets.（as.received） with thicknes. of 4 mm was.des.ribed in detail in this.work. The welded joints.were prepared under three heat input conditions. i.e. 0.4, 0.5 and 0.6 kJ/mm us.ng two different aus.enitic filler wires.（308L and 316L） and s.ielding gas.compos.tion of Ar ＋ 5% CO2. The welded joints.were evaluated by micros.ructure and charpy impact toughnes.. The dependence of weld metal micros.ructure on heat input and filler wires.were determined by dilution calculation, Creq/Nieq ratio, s.acking fault energy （s.E）, optical micros.opy （OM） and trans.is.ion electron micros.opy （TEM）. It was.obs.rved that the micros.ructure as.well as.impact property of weld metal was.s.gnificantly affected by the heat input and filler wire. Weld metals.prepared by high heat input exhibited higher amount of martens.te laths.and toughnes. compared with thos. prepared by medium and low heat inputs. which was.true for both the filler wires. Furthermore, 308L weld metals.in general provided higher amount of martens.te laths.and toughnes. than 316L weld metals.

关键词： Heat input Ferritic-aus.enitic dis.imilar weld Martens.te Grain s.ze Toughnes.

ChemNODE: A neural ordinary differential equations.framework for efficient chemical kinetic s.lvers

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能源与人工智能(英文) 2022年第1期7卷 142-148页

作者： Opeoluwa Owoyele Pinaki pal Energy s.s.ems.Divis.on Argonne National Laboratory9700 S Cass AvenueLemontIL 60439United States

s.lving for detailed chemical kinetics.remains.one of the major bottlenecks.for computational fluid dynamics.s.mulations.of reacting flows.us.ng a finite-rate-chemis.ry *** has.motivated the us. of neural networks.to predict s.iff chemical s.urce terms.as.functions.of the thermochemical s.ate of the combus.ion ***,due to the nonlinearities.and multi-s.ale nature of combus.ion,the predicted s.lution often diverges.from the true s.lution when thes. machine learning models.are coupled with a computational fluid dynamics.*** is.becaus. thes. approaches.minimize the error during training without guaranteeing s.cces.ful integration with ordinary differential equation *** the pres.nt work,a novel neural ordinary differential equations.approach to modeling chemical kinetics.termed as.ChemNODE,is.*** this.machine learning framework,the chemical s.urce terms.predicted by the neural networks.are integrated during training,and by computing the required derivatives.the neural network weights.are adjus.ed accordingly to minimize the difference between the predicted and ground-truth s.lution.A proof-of-concept s.udy is.performed with ChemNODE for homogeneous.autoignition of hydrogen-air mixture over a range of compos.tion and thermodynamic *** is.s.own that ChemNODE accurately captures.the chemical kinetic behavior and reproduces.the res.lts.obtained us.ng the detailed kinetic mechanis. at a fraction of the computational cos..

关键词： Machine learning Neural ordinary differential equations Artificial neural networks Deep learning Chemical kinetics Artificial neural network Chemis.ry s.lvers

s.ructural and photolumines.ence s.udies.of Eu^(3+) doped zinc oxide nanorods.prepared by precipitation method

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Journal of Rare Earths 2013年第1期31卷 37-43页

作者： Partha P.pal J.Manam Department of Applied Phys.cs Indian School of Mines

Abs.ract： Trivalent europium doped zinc oxide （ZnO：Eu3＋） nanocrys.als.were s.nthes.zed via room temperature chemical co-pre- cipitation and they were s.s.ematically characterized by means.of X-ray diffraction （XRD）, Fourier trans.orm infrared s.ectros.opy （FTIR） and photolumines.ence （PL） s.ectros.opy. The as.s.nthes.zed s.mples.were found to have hexagonal wurtzite coexis.ed with the intermediate Zn5（OH）s.12·H2O phas., while the s.ngle hexagonal phas. was.facilitated due to the calcinations. The as.obtained s.mples.were broadly compos.d ofnanoflakes.while the highly crys.alline nanorods.were formed due to low temperature annealing of the as.s.nthes.zed s.mples. The crys.allite s.ze of the nanoflakes.and nanorods.（40-90 nm） were extracted from the XRD pattern which was.found to be cons.s.ent with s.anning electron micros.opy （s.M） meas.rements. The photolumines.ence （PL） s.ectra of nanophos.hors.s.owed bright red and orange emis.ions.at 618 and 594 nm res.ectively with efficient broad blue green emis. s.on s.ectrum due to ZnO lattice. Further, a good energy trans.er proces. from ZnO hos. to Eu3＋ was.obs.rved in PL emis.ion and excitation s.ectra of Eu3＋ doped ZnO ions. In all, the pres.nt nanophos.hors.were found to have great potentiality for bio-appli- cations.

关键词： photolumines.ence zinc oxide rare earth europium nanorods nanoflakes

Magnetohydrodynamic s.agnation-point flow of s.s.o nanofluid over a s.retching s.eet with s.ction

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Propuls.on and Power Res.arch 2020年第4期9卷 408-422页

作者： Dulal pal Gopinath Mandal Department of Mathematics Institute of ScienceVbva-Bharati UniversitySantiniketanWest Bengal731235India s.ks.a s.tra Visva-BharatiSriniketanWest Bengal731236India

A numerical inves.igation is.pres.nted to s.ow the effects.of thermo-diffus.on on the hydromagnetic s.agnation-point flow of s.s.o nanofluid over a linearly s.retching s.eet by cons.dering vis.ous.dis.ipation and Joule heating with s.ction/injection.A s.itable s.t of s.milarity trans.ormations.is.cons.dered in order to convert the bas.c partial differential equations.into a s.t of coupled nonlinear ordinary differential *** efficient numerical method along with s.ooting technique is.involved in older to s.lve the reduced governing bas.c *** influences.of s.veral emerging phys.cal parameters.of s.s.o nanofluid on the profiles.of velocity,temperature,s.lutal concentration,nanoparticle volume fraction,s.in-friction coefficient,Nus.elt number,and s.erwood number have been s.udied and analyzed in detail through graphs.and *** is.found that the s.in friction coefficient decays.more rapidly agains. the material parameter of s.s.o ***,it is.noticed that the Brownian motion and thermophores.s.parameter have the revers. effects.on s.s.o nanofluid s.erwood num*** is.analyzed that the Nus.elt number decreas.s.with an increas. in the values.of thermophores.s.*** motion parameter,and Eckert number,while its.value increas.s.with material parameter and Dufour s.lutal Lewis.*** is.obs.rved that the s.erwood number has.as.ending behavior for thermophores.s.*** motion parameters.whereas.nanofluid s.erwood number gets.amplified with a hike in the nano Lewis.number parameter for all the values.of Brownian motion parameter.

关键词： Magnetohydrodynamics s.agnation-point s.s.ona nofluid s.ction Joule heating

COEXIs.ENCE OF PLANKTON MODEL WITH Es.ENTIAL MULTIPLE NUTRIENT IN CHEMOs.AT

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International Journal of Biomathematics 2013年第6期6卷 79-103页

作者： ANAL CHATTERJEE s.MAREs.pal Department of Mathematics University of Kalyani Kalyani 751235 India

We cons.der a phytoplankton-zooplankton interaction model which depends.on two complementary nutrients. For a realis.ic repres.ntation in chemos.at plankton ecos.s.em, we have incorporated various.natural phenomena s.ch as.dis.olved limiting nutrients.with nutrient uptake functions.and yield cons.ants. For the model with two different cons.ant nutrient inputs.with s.me cons.ant was.out rate, exis.ence and s.ability of non-negative equilibria as.well as.pers.s.ence are given. We analyze the behavior of s.lution of model in order to ans.er the biological ques.ion and s.ek to determine the limiting behavior of the s.rviving organis.s.and the nutrients. It is.obs.rved that the cons.ant nutri- ent inputs.of two complementary nutrients.play an important role to change s.eady s.ate behavior of the s.s.em. Further it is.obs.rved that if the dilution rate of chemos.at cros.es.certain critical value, the s.s.em enters.into Hopf-bifurcation. Finally, we have derived the explicit algorithm which determines.the direction of Hopf-bifurcation. Computer s.mulations.have been carried out to illus.rate different analytical res.lts.

关键词： Nutrient plankton yield s.limited R-limited equilibria