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Type 2 Diabetes Risk Prediction Using Deep Convolutional Neural Network Based-Bayesian Optimization

Computers, Materials & Continua 2023年第5期75卷 3223-3238页

作者： Alawi Alqushaibi Mohd hilmi Hasan Said Jadid Abdulkadir Amgad Muneer Mohammed Gamal Qasem Al-Tashi Shakirah Mohd Taib Hitham Alhussian Computer&Information Sciences Universiti Teknologi PETRONASSeri Iskandar32610PerakMalaysia Centre for Research in Data Science(CERDAS) Universiti Teknologi PETRONASSeri Iskandar32610PerakMalaysia Department of Imaging Physics University of Texas MD Anderson CancerHoustonTXUSA

Diabetes mellitus is a long-term condition characterized by *** could lead to plenty of *** to rising morbidity in recent years,the world’s diabetic patients will exceed 642 million by 2040,implying that one out of every ten persons will be *** is no doubt that this startling figure requires immediate attention from industry and academia to promote innovation and growth in diabetes risk prediction to save individuals’*** to its rapid development,deep learning(DL)was used to predict numerous ***,DLmethods still suffer from their limited prediction performance due to the hyperparameters selection and parameters ***,the selection of hyper-parameters is critical in improving classification *** study presents Convolutional Neural Network(CNN)that has achieved remarkable results in many medical domains where the Bayesian optimization algorithm(BOA)has been employed for hyperparameters selection and parameters *** issues have been investigated and solved during the experiment to enhance the *** first is the dataset class imbalance,which is solved using Synthetic Minority Oversampling Technique(SMOTE)*** second issue is the model’s poor performance,which has been solved using the Bayesian optimization *** findings indicate that the Bayesian based-CNN model superbases all the state-of-the-art models in the literature with an accuracy of 89.36%,F1-score of 0.88.6,andMatthews Correlation Coefficient(MCC)of 0.88.6.

关键词： Type 2 diabetes diabetes mellitus convolutional neural network Bayesian optimization SMOTE

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Sweet plasmonics： Sucrose macrocrystals of metal nanoparticles

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Nano Research 2015年第3期8卷 860-869页

作者： Talha Erdem Zeliha Soran-Erdem Pedro Ludwig Hernandez-Martinez Vijay Kumar Sharma Halil Akcali Ibrahim Akcali Nikolai Gaponik Alexander Eychmeller hilmi Volkan Demir Departments of Electrical and Electronics Engineering Physics UNAM-National Nanotechnology Research Center and Institute ot Materials Science and Nanotechnology Bilkent University Ankara 06800 Turkey School of Electrical and Electronic Engineering and School of Physical and Mathematical Sciences Nanyang Technological University Singapore 639798 Singapore Physical Chemistry TU Dresden Bergstrasse 66b D-O 1062 Dresden Germany

The realization of plasmonic structures generally necessitates expensive fabrication techniques, such as electron beam and focused ion beam lithography, allowing for the top-down fabrication of low-dimensional structures. Another approach to make plasmonic structures in a bottom-up fashion is colloidal synthesis, which is convenient for liquid-state applications or very thin solid films where aggregation problems are an important challenge. The architectures prepared using these methods are typically not robust enough for easy handling and convenient integration. Therefore, developing a new plasmonic robust platform having large-scale dimensions without adversely affecting the plasmonic features is in high demand. As a solution, here we present a new plasmonic composite structure consisting of gold nanoparticles （Au NPs） incorporated into sucrose macrocrystals on a large scale, while preserving the plasmonic nature of the Au NPs and providing robustness in handling at the same time. As a proof of concept demonstration, we present the fluorescence enhancement of green CdTe quantum dots （QDs） via plasmonic coupling with these Au NPs in the sucrose crystals. The obtained composite material exhibits centimeter scale dimensions and the resulting quantum efficiency （QE） is enhanced via the interplay between the Au NPs and CdTe QDs by 58% （from 24% to 38%）. Moreover, a shortening in the photoluminescence lifetime from 11.0 to 7.40 ns, which corresponds to a field enhancement factor of 2.4, is observed upon the introduction of Au NPs into the QD incorporated macrocrystals. These results suggest that such ＂sweet＂ plasmonic crystals are promising for large-scale robust platforms to embed plasmonic nanoparticles.

关键词： plasmonics macrocrystals metal nanoparticles metal enhancedfluorescence colloidal quantum dots

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Kombucha and Health

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Journal of Health Science 2017年第5期5卷 244-250页

作者： Nilgǖn OZDEMIR Ahmet hilmi CON Department of Food Engineering Faculty of Engineering Ondokuz Mayzs University Atakum Samsun 55200 Turkey

Kombucha is a fermented drink produced by fermentation of sweetened black and/or green tea with kombucha culture, it is known to have health benefits. The microflora of this fermented beverage mostly consists of AAB （acetic acid bacteria） and yeasts. Depending on its origin, LAB （lactic acid bacteria） sometimes will also be able to be found in the microflora. The production of kombucha and formation of its beneficial components are the result of the metabolic activities of this microflora. This fermented tea has been produced and consumed in the Far East for hundreds of years as a tradition; it is used as an adjunctive treatment for certain diseases. The interest in this tea has increased recently, and kombucha has spread worldwide. Its microflora diversity and metabolites are becoming important subjects of scientific studies. Although there are a few companies in Turkey that manufacture and market kombucha, there is no comprehensive scientific study on this subject. The liquid portion of kombucha is claimed to have various medicinal effects on human health. Recent studies have suggested that kombucha tea prevents paracetamol induced hepatotoxieity and chromate induced oxidative stress in albino rats. As kombucha tea is rich in compounds known to be strong antioxidants, it is expected to ameliorate liver damage. This beneficial effects of kombucha tea are attributed to the presence of tea polyphenols, gluconic acid, glucuronic acid, lactic acid, vitamins, amino acids, antibiotics and a variety of micronutrients produced during fermentation. The functional character of the kombucha should be investigated by a larger number of scientific studies. Co-use or self-use with various foods of this tea should be widespread.

关键词： Kombucha health food.

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Diagnostic dilemma of coagulation problems in an HIV-positive patient with end-stage liver disease undergoing liver transplantation

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World Journal of Transplantation 2015年第1期5卷 34-37页

作者： Ali Abdullah Ibtesam A hilmi Raymond Planinsic Department of Anesthesiology and Critical Care Medicine Allegheny General Hospital Pittsburgh PA 15212 United States Department of Anesthesiology Clinical and Translational Science Institute University of Pittsburgh School of Medicine UPMC Presbyterian Hospital Pittsburgh PA 15213 United States Department of Anesthesiology University of Pittsburgh School of Medicine UPMC Presbyterian Hospital Pittsburgh PA 15213 United States

Human immunodeficiency virus(HIV) may result in devastating multi-organ complications, including cirrhosis. Consequently, liver transplantation is often required for these patients. We report a case of a 43-year-old female with cryptogenic cirrhosis and HIV on highly active antiretroviral therapy, presenting for non-related living donor liver transplantation. The intraoperative course was complicated by hepatic artery and portal vein thrombosis, requiring thrombectomy. On postoperative day-3, the patient required retransplantation with a cadaveric donor organ due to primary graft failure.

关键词： Hypercoagulation Liver transplant Highly active antiretroviral therapy Human immunodeficiency virus

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INSTRUCTIONS TO AUTHORS

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World Journal of Transplantation 2012年第1期2卷 1-4页

作者： Ibtesam Abbass hilmi Raymond M Planinsic Department of Anesthesiology University of Pittsburgh Medical Center200 Lothrop StreetSuite C-200PittsburghPA 15213United States

Live liver donor transplantation to adult recipients is becoming a common practice,increasing the organ pool and providing an alternative to whole cadaveric liver *** patients are healthy adults without serious medical conditions and typically have normal coagulation profiles *** hepatic lobectomy is usually performed for adult recipients,while left hepatic lobectomy is performed for pediatric *** of the whole right lobe from the donors may expose theses patients to multiple intraoperative and postoperative *** has been identified as a serious complication which leads to thromboembolic phenomena with potential fatal *** primary aim of this review is to look at possible changes in post-operative coagulation dynamics that may increase the risk for development of thromboembolic complications in live liver *** this article,we stress the importance of addressing the issue that conventional clotting tests(PT,INR,PTT)are unable to detect a hypercoagulable state,and therefore,we should examining alternative laboratory tests to improve diagnosis and early detection of thrombotic *** of natural anticoagulant/procoagulant biomarkers combined with conventional coagulation studies and thromboelastography offers a more accurate assessment of coagulation *** allows earlier diagnosis,permitting appropriate intervention sooner,hence avoiding potential morbidity and *** that may be evaluated include,but are not limited to:protein C,soluble P-selectin,antithrombinⅢ,thrombin-antithrombin complex,and thrombin generation complex.

关键词： Live liver donors Hypercoagulability Postoperative thrombotic complications

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Internet and social media usage of orthopaedic patients:A questionnaire-based survey

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World Journal of Orthopedics 2017年第2期8卷 178-186页

作者： Tahir Mutlu Duymus hilmi Karadeniz Mehmet Akif Cacan Baran Komür Abdullah Demirtas Sinan Zehir Ibrahim Azboy Department of Orthopaedics Haydarpasa Numune Training and Research Hospital Department of Orthopaedics and Traumatology Bah?elievler Medikal Park Hospital Department of Orthopaedics Bitlis State Hospital Department of Orthopaedics Kanuni Sultan Süleyman Training and Research Hospital Department of Orthopedics and Traumatology G?ztepe Training and Research HospitalIstanbul Medeniyet University Department of Orthopaedics and Traumatology Hitit University Faculty of Medicine Department of Orthopaedics and Traumatology Dicle University Faculty of Medicine

AIM To evaluate social media usage of orthopaedic patients to search for solutions to their health problems. METHODS The study data were collected using face-to-face questionnaire with randomly selected 1890 patients aged over 18 years who had been admitted to the orthopaedic clinics in different cities and provinces across Turkey. The questionnaire consists of a total of 16 questions pertaining to internet and social media usage and demographics of patients, patients' choice of institution for treatment, patient complaints on admission, online hospital and physician ratings, communication between the patient and the physician and its *** It was found that 34.2%(n = 647) of the participants consulted with an orthopaedist using the internet and 48.7%(n = 315) of them preferred websites that allow users to ask questions to a physician. Of all questionaskers, 48.5%(n = 314) reported having found the answers helpful. Based on the educational level of the participants, there was a highly significant difference between the rates of asking questions to an orthopaedist using the internet(P = 0.001). The rate of questionasking was significantly lower in patients with an elementary education than that in those with secondary, high school and undergraduate education(P = 0.001) The rate of reporting that the answers given was helpful was significantly higher in participants with an undergraduate degree compared to those who were illiterate, those with primary, elementary or high school education(P = 0.001). It was also found that the usage of the internet for health problems was higher among managers-qualified participants than unemployed-housewives, officers, workers-intermediate staff(P < 0.05).CONCLUSION We concluded that patients have been increasingly using the internet and social media to select a specific physician or to seek solution to their health problems in an effective way. Even though the internet and social media offer beneficial effects for physician

关键词： Patient Internet Orthopedist Social media Communication

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Interfacial charge and energy transfer in van der Waals heterojunctions

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InfoMat 2022年第3期4卷 64-84页

作者： Zehua Hu Xue Liu Pedro Ludwig Hernandez-Martínez Shishu Zhang Peng Gu Wei Du Weigao Xu hilmi Volkan Demir Haiyun Liu Qihua Xiong Division of Physics and Applied Physics School of Physical and Mathematical SciencesNanyang Technological UniversitySingaporeSingapore Institutes of Physical Science and Information Technology Anhui UniversityHefeiP.R.China LUMINOUS Center of Excellence for Semiconductor Lighting and DisplaySchool of Electrical and Electronics EngineeringNanyang Technological UniversitySingaporeSingapore State Key Laboratory of Low-Dimensional Quantum Physics Department of PhysicsTsinghua UniversityBeijingP.R.China Beijing Academy of Quantum Information Sciences BeijingP.R.China Institute of Functional Nano and Soft Materials(FUNSOM) Soochow UniversitySuzhouP.R.China Key Laboratory of Mesoscopic Chemistry of MOE School of Chemistry and Chemical EngineeringNanjing UniversityNanjingP.R.China Department of Physics Department of Electrical and Electronics EngineeringUNAM-National Nanotechnology Research Center and Institute of Materials Science and NanotechnologyBilkent UniversityAnkaraTurkey Beijing Innovation Center for Future Chips Tsinghua UniversityBeijingP.R.China

Van der Waals heterojunctions are fast-emerging quantum structures fabricated by the controlled stacking of two-dimensional(2D)*** to the atomically thin thickness,their carrier properties are not only determined by the host material itself,but also defined by the interlayer interactions,including dielectric environment,charge trapping centers,and stacking *** abundant constituents without the limitation of lattice constant matching enable fascinating electrical,optical,and magnetic properties in van der Waals heterojunctions toward next-generation devices in photonics,optoelectronics,and information *** review focuses on the charge and energy transfer processes and their dynamics in transition metal dichalcogenides(TMDCs),a family of quantum materials with strong excitonic effects and unique valley properties,and other related 2D materials such as graphene and hexagonalboron *** the first part,we summarize the ultrafast charge transfer processes in van der Waals heterojunctions,including its experimental evidence and theoretical understanding,the interlayer excitons at the TMDC interfaces,and the hot carrier injection at the graphene/TMDCs *** the second part,the energy transfer,including both Förster and Dexter types,are reviewed from both experimental and theoretical ***,we highlight the typical charge and energy transfer applications in photodetectors and summarize the challenges and opportunities for future development in this field.

关键词： 2-dimensional semiconductors carrier dynamics charge and energy transfer optical spectroscopy optoelectronics

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Unusual complications of spinal surgery: A report of lifethreatening vascular injury

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World Journal of Anesthesiology 2014年第3期3卷 221-224页

作者： Faith J Ross William Donaldson Ibtesam A hilmi Department of Anaesthesiology University of Pittsburgh Medical Center Department of Orthopaedic Surgery University of Pittsburgh Medical Center Department of Anaesthesiology University of Pittsburgh UPMC-Presbyterian Hospital

Kyphoplasty and lumbar spine fusion are rarely associated with significant vascular damage and internal bleeding. However, anaesthesiologists must maintain vigilance in order to detect rare, but potentially lifethreatening haemorrhagic complications of these procedures which may present intra-operatively or in the immediate post-operative period. We present two cases of life-threatening haemorrhagic complications of spine surgery, one from T12 kyphoplasty and the other from a redo lumbar laminectomy and fusion. In both cases, prompt recognition of vascular injuries with internal or covert bleeding which presented shortly after surgery allowed timely and life-saving treatment.

关键词： Post-operative complication Spinal surgery Kyphoplasty

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Alvarado, Eskelinen, Ohhmann and Raja Isteri Pengiran Anak Saleha Appendicitis scores for diagnosis of acute appendicitis

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World Journal of Gastroenterology 2013年第47期19卷 9057-9062页

作者： Hasan Erdem Süleyman etinkünar Koray Das Enver Reyhan Cumhur Deger Mehmet Aziret hilmi Bozkurt Seluk Uzun Selim Szen Oktay rkrücü Department of General Surgery Adana Numune Training and Research HospitalAdana 01240Turkey

AIM:To assess the reliability and practical applicability of the widely used Alvarado,Eskelinen,Ohhmann and Raja Isteri Pengiran Anak Saleha Appendicitis(RIPASA)scoring systems in patients with suspected acute ***:Patients admitted to our tertiary center due to suspected acute appendicitis constituted the study *** were divided into two *** group(Group A)consisted of patients who underwent appendectomy and were histopathologically diagnosed with acute appendicitis,and non-appendicitis group(Group N-A)consisted of patients who underwent negative appendectomy and were diagnosed with pathologies other than appendicitis and patients that were followed *** operative findings for the patients,the additional analyses from follow up of the patients and the results of those analyses were recorded using the follow-up ***:One hundred and thirteen patients with suspected acute appendicitis were included in the *** the 113 patients(62 males,51 females),the mean age was 30.2±10.1(range 18-67)*** the 113patients,94 patients underwent surgery,while the rest were followed *** the 94 patients,77patients were histopathologically diagnosed with acute *** study showed a sensitivity level of81%for the Alvarado system when a cut-off value of 6.5was used,a sensitivity level of 83.1%for the Ohmann system when a cut-off value of 13.75 was used,a sensitivity level of 80.5%for the Eskelinen system when a cut-off value of 63.72 was used,and a sensitivity level of 83.1%for the RIPASA system when a cut-off value of 10.25 was ***:The Ohmann and RIPASA scoring systems had the highest specificity for the diagnosis of acute appendicitis.

关键词： Acute appendicitis Alvarado Eskelinen Ohhmann Raja Isteri Pengiran Anak Saleha Appendicitis

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English Needs＂ EL Programme for Distance Education Learners

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Sino-US English Teaching 2012年第7期9卷 1269-1276页

作者： Shahrier Pawanchik Mohd Faiz hilmi Meor Azli Ayub Anton Abdulbasah Kamil Universiti Sains Malaysia Penang Malaysia

This paper will discuss the findings of students＇ needs for an EL （English language） programme at the SDE （School of Distance Education）, USM （Universiti Sains Malaysia）, Penang. English is offered as a compulsory subject for all its students since the School＇s inception in 1971, and the subject has not moved beyond that status quo. However, in the new millennium, with USM having been selected as a research university with an apex status, the expectation of its stakeholders has increased. SDE needs to keep abreast with what is on and what is up in distance education teaching and learning so that its programmes remain relevant. It cannot remain complacent with its present courses Taking into consideration the current needs of its stakeholders within the realm of distance teaching and learning, the researchers carried out a research on the need for an EL programme. Findings show that the students agree that an English programme will help them improve their language and their upward mobility. Majority of the students will sign up for the course if it is offered. This research will provide insights for curriculum developers and lecturers at the SDE to design a new English programme tailored towards meeting the needs of their adult students

关键词： EL (English language) distance education curriculum adult students

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