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Characteristics of inflammatory bowel diseases in patients with concurrent immune-mediated inflammatory diseases

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World Journal of Gastroenterology 2022年第25期28卷 2843-2853页

作者： Shintaro Akiyama Soma Fukuda Joshua M Steinberg hideo suzuki Kiichiro Tsuchiya Department of Gastroenterology University of TsukubaTsukuba 305-8575IbarakiJapan Inflammatory Bowel Disease Gastroenterology of the RockiesDenverCO 80218United States

Patients with inflammatory bowel disease(IBD)are more likely to have concurrent immune-mediated inflammatory diseases(IMIDs)than those without *** have been observed to alter the phenotype and outcomes of IBD in recent *** studies have found that IBD patients with concurrent IMIDs may have more extensive or severe disease phenotypes,and are considered to be at increased risk of requiring biologics and IBD-related surgeries,suggesting that having multiple IMIDs is a poor prognostic factor for ***,IBD patients with primary sclerosing cholangitis and Takayasu arteritis are reported to have unique endoscopic phenotypes,suggesting concurrent IMIDs can influence IBD phenotype with specific intestinal inflammatory *** this review,we discuss the pathogenesis,disease phenotypes,and clinical outcomes in IBD patients with concomitant IMIDs.

关键词： Inflammatory bowel disease Phenotypes Outcomes Concurrent immunemediated inflammatory diseases

Pregnancy and medications for inflammatory bowel disease:An updated narrative review

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World Journal of Clinical Cases 2023年第8期11卷 1730-1740页

作者： Shintaro Akiyama Joshua M Steinberg Mariko Kobayashi hideo suzuki Kiichiro Tsuchiya Department of Gastroenterology Faculty of MedicineUniversity of TsukubaTsukuba 305-8575IbarakiJapan Department of Inflammatory Bowel Disease Gastroenterology of the RockiesDenverCO 80027United States

Inflammatory bowel disease(IBD)is often diagnosed during the peak reprodu-ctive years of young *** with active IBD around conception are at a significantly increased risk of disease relapse during pregnancy,which is associated with poor pregnancy and neonatal *** these substantial risks,it is prudent that disease remission should ideally be achieved before ***,some patients may experience a disease flare-up even if they are in a state of remission before *** must continue their IBD medications to reduce the risk of disease flare and subsequent poor outcomes during the gestational and postpartum *** treating IBD flare-ups during pregnancy,the management is quite similar to the therapeutic approach for non-pregnant patients with IBD,including 5-aminosalicylate,steroids,calcineurin inhibitors(CNIs),and biologic *** the data regarding the safety of CNIs in pregnant women with IBD is limited,the findings in our recent meta-analysis suggest that CNIs may be safer to use in those with IBD than in solid organ transplant *** are several types of biologics and small-molecule therapies currently approved for IBD,and physicians should thoroughly understand their clinical benefits and safety profiles when utilizing these treatments in the context of *** review highlights recent studies,including our systematic review and meta-analysis,and discusses the clinical advantages and safety considerations of biologics and small molecules for pregnant women with IBD.

关键词： Inflammatory bowel disease Pregnancy Safety Biologics Small molecules

Indicators of sorafenib efficacy in patients with advanced hepatocellular carcinoma

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World Journal of Gastroenterology 2014年第35期20卷 12581-12587页

作者： Masayoshi Yada Akihide Masumoto Kenta Motomura Hirotaka Tajiri Yusuke Morita hideo suzuki Takeshi Senju Toshimasa Koyanagi Department of Hepatology Iizuka Hospital

AIM: To determine significant indicators for the efficacy of sorafenib in patients with advanced hepatocellular carcinoma (HCC).

关键词： Hand-foot syndrome Hepatocellular carcinoma Indicator of efficacy Sorafenib Time to progression

Therapeutic efficacy of the Qing Dai in patients with intractable ulcerative colitis

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World Journal of Gastroenterology 2013年第17期19卷 2718-2722页

作者： hideo suzuki Tsuyoshi Kaneko Yuji Mizokami Toshiaki Narasaka Shinji Endo Hirofumi Matsui Akinori Yanaka Aki Hirayama Ichinosuke Hyodo Department of Gastroenterology Institute of Clinical Medicine University of Tsukuba Graduate School Center of Integrative Medicine Tsukuba University of Technology

Ulcerative colitis (UC) is a chronic inflammatory bowel disease that may become intractable when treated with conventional medications such as aminosalicylates, corticosteroids, and azathioprine. The herbal medicine Qing Dai has traditionally been used in Chinese medicine to treat UC patients, but there is a lack of published data on the efficacy of Qing Dai in UC treatment. We report several cases of patients with intractable UC who take Qing Dai in a retrospective observational study. Furthermore, we explore the mechanisms of action of Qing Dai. Nine patients with active UC who received conventional medications but wished to receive Qing Dai as an alternative medication were included in our analysis. The UC severity level was determined based on the clinical activity index (CAI). Additionally, 5 of the 9 patients were endoscopically evaluated according to the Matts grading system. Each patient received 2 g/d of Qing Dai orally and continued taking other medications for UC as prescribed. Electron spin resonance was applied to explore the mechanisms of action of Qing Dai. After 4 mo of treatment with Qing Dai, the CAI score decreased from 8.3 ± 2.4 to 2.4 ± 3.4 (mean ± SD; P < 0.001). Similarly, the endoscopic Matts grade decreased from 3.4 ± 0.5 to 2.2 ± 0.8 (P = 0.02). Six of 7 patients who were on prednisolone upon enrollment in the study were able to discontinue this corticosteroid. Electron spin resonance revealed that Qing Dai possesses strong hydroxyl radical scavenging activity. Qing Dai showed significant clinical and endoscopic efficacy in patients who failed to respond to conventional medications. Scavenging of hydroxyl radicals appears to be a potential mechanism through which Qing Dai acts, but the significance of the scavenging ability of Qing Dai with respect to the anti-inflammatory effect in UC patients warrants further investigation.

关键词： Qing Dai Herbal medicine Ulcerative colitis Hydroxyl radical Electron spin resonance

A new sophisticated GPC/SEC instrument for high-throughput and semi-micro SEC

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A new sophisticated GPC/SEC instrument for high-throughput a...

Effects of uniaxial compressive strain on the electronic- transport properties of zigzag carbon nanotubes

2007年全国高分子学术论文报告会

作者： Hiroshi Tomizawa Kuniyuki Tokunaga Teruhiko Tsuda Hiroyuki Moriyama Yoichi Yasuda Toru Satoh hideo suzuki Tosoh corporation Shiba-koen First Bldg.3-8-2 Shiba Minato-kuTokyo 105-8623 Japan Tosoh corporation Shiba-koen First Bldg.3-8-2 Shiba Minato-kuTokyo 105-8623 Japan

＜正＞A new sophisticated GPC/SEC instrument was developed for semi-micro and high-throughput SEC measurements. The equipment consists of on-line degasser, auto-sampler, temperature-controlled pumping system, column o... 详细信息

关键词： GPC/SEC semi-micro instrument

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Nano Research 2016年第5期9卷 1267-1275页

作者： Masato Ohnishi Ken suzuki hideo Miura Fracture and Reliability Research Institute Graduate School of Engineering Tohoku University Sendai 980-8579 Japan

Recently, substantial attention has been paid to the strain sensitivity of the carbon nanotubes＇（CNTs＇） electronic properties. In this study, the relationships between the geometric structures and electronic states of zigzag CNTs under uniaxial compressive strain were investigated. We found that different factors dominate the electronic states of zigzag CNTs depending on the strain regions： the initial stage of the strain loading, which lasts until column-buckling deformation begins, and the strain regions corresponding to column- and shell-buckling deformations. Because shell-buckling deformation significantly increases the re-orbital angle, the angle between the π orbital axis vectors of adjacent atoms, strong localization of the density of states （LDOS） occurs in the buckled area. We also analyzed the current able to pass through deformed CNTs using a tight-binding-based Green＇s function approach and determined that the current can be significantly suppressed by applying uniaxial compressive strain. Our method of predicting the electronic state of a deformed CNT based on the π-orbital angle is expected to be useful for predicting the electronic properties of CNT-based electronic devices and sensors.

关键词： carbon nanotube strain buckling deformation Green's function method electronic-transport property

Boundary-representable partition of unity for image magnification

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Science China(Information Sciences) 2013年第11期56卷 216-227页

作者： NAGAI Yukie OHTAKE Yutaka YOKOTA hideo suzuki Hiromasa School of Engineering The University of Tokyo153-8904 Japan Bio-Research Infrastructure Construction Team ASI RIKEN 351-0198 Japan RCAST The University of Tokyo153-8904 Japan

This paper proposes a simple yet efective algorithm to magnify 2D/3D images with preserving discontinuities of *** algorithm is based on the partition of unity(PU)approximation,which ofers many advantages such as smooth representation,noise-robustness,and precise ***,PU encounters difculties when scaling images and maintaining boundaries within images owing to the nature of its *** overcome this problem,we propose an approximation that preserves *** is realized by dividing the local spherical support of PU into two parts along a locally detected discontinuity and by individually approximating intensities on each side of the *** algorithm is suitable for magnifying a variety of images,including scanned documents,pictures,and CT-scanned *** demonstrate the efectiveness of the proposed method,we show some experimental results for 2D/3D images.

关键词： image approximation partition of unity piecewise smooth function volume data magnification

Cyberknife treatment for advanced or terminal stage hepatocellular carcinoma

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World Journal of Gastroenterology 2015年第46期21卷 13101-13112页

作者： Hiroyuki Kato hideo Yoshida Hiroyoshi Taniguch Ryutaro Nomura Kengo Sato Ichiro suzuki Ryo Nakata Department of Gastroenterology Japanese Red Cross Medical Center Cyberknife Center Japanese Red Cross Medical Center

AIM: To investigate the safety and efficacy of the Cyberknife treatment for patients with advanced or terminal stage hepatocellular carcinoma(HCC).METHODS: Patients with HCC with extrahepatic metastasis or vascular or bile duct invasion were enrolled between May 2011 and June 2015. The Cyberknife was used to treat each lesion. Treatment response scores were based on Response Evaluation Criteria in Solid Tumors v1.1. The trends of tumor markers,including alpha fetoprotein(AFP) and proteins induced by vitamin K absence Ⅱ(PIVKA Ⅱ) were assessed. Prognostic factors for tumor response and tumor markers were evaluated with Fisher's exact test and a logistic regression model. Survival was evaluated with the Kaplan-Meier method and multivariate analysis was performed using the Cox proportional hazards ***: Sixty-five patients with 95 lesions were enrolled. Based on the Barcelona Clinic Liver Cancer classification,all patients were either in the advanced or terminal stage of the disease. The target lesions were as follows: 52 were bone metastasis; 9,lung metastasis; 7,brain metastasis; 9,portal vein invasion;4,hepatic vein invasion; 4,bile duct invasion; and 10 other lesion types. The response rate and disease control rate were 34% and 53%,respectively. None of the clinical factors correlated significantly with tumor response. Fiducial marker implantation was associated with better control of both AFP(HR = 0.152; 95%CI: 0.026-0.887; P = 0.036) and PIVKA Ⅱ(HR = 0.035; 95%CI: 0.003-0.342; P = 0.004). The median survival time was 9 mo(95%CI: 5-15 mo). Terminal stage disease(HR = 9.809; 95%CI: 2.589-37.17,P < 0.001) and an AFP of more than 400 ng/m L(HR = 2.548; 95%CI: 1.070-6.068,P = 0.035) were associated with worse survival. A radiation dose higher than 30 Gy(HR = 0.274; 95%CI: 0.093-0.7541,P = 0.012) was associated with better survival. In the 52 cases of bone metastasis,36 patients(69%) achieved pain relief. One patient had cerebral bleeding and another patient ha

关键词： Hepatocellular carcinoma Stereotactic body radioth

Expression levels of K_(ATP)channel subunits and morphological changes in the mouse liver after exposure to radiation

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World Journal of Experimental Medicine 2024年第2期14卷 103-113页

作者： Ming Zhou Tao-Sheng Li Hiroshi Abe hideo Akashi Ryoji suzuki Yoshio Bando Department of Anatomy Akita University Graduate School of MedicineAkita 010-8543Japan Department of Stem Cell Biology Atomic Bomb Disease InstituteNagasaki UniversityNagasaki 852-8523Japan Sendai Old Age Refresh Station A Long-term Care Health FacilitySendai 981-1105Japan

BACKGROUND ATP sensitive K+(K_(ATP))channels are ubiquitously distributed in various of cells and tissues,including the *** play a role in the pathogenesis of myocardial and liver *** To evaluate the radiation-induced changes in the expression of K_(ATP)channel subunits in the mouse liver to understand the potential role of K_(ATP)channels in radiation *** Adult C57BL/6 mice were randomly exposed toγ-rays at 0 Gy(control,n=2),0.2 Gy(n=6),1 Gy(n=6),or 5 Gy(n=6).The livers were removed 3 and 24 h after radiation *** and eosin staining was used for morphological observation;immunohistochemical staining was applied to determine the expression of K_(ATP)channel subunits in the liver *** Compared with the control group,the livers exposed to 0.2 Gyγ-ray showed an initial increase in the expression of Kir6.1 at 3 h,followed by recovery at 24 h after *** to a high dose of 5.0 Gy resulted in decreased expression of Kir6.1 and increased expression of SUR2B at 24 ***,the expression of Kir6.2,SUR1,or SUR2A had no remarkable changes at 3 and 24 h after exposure to any of these *** The expression levels of Kir6.1 and SUR2B in mouse liver changed differently in response to different radiation doses,suggesting a potential role for them in radiation-induced liver injury.

关键词： Radiation exposure ATP-sensitive K^(+)channel Mouse Liver