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Neural Regeneration Research 2022年第12期17卷 2682-2684页

作者： Akiko Sakai hideaki matsui Department of Neuroscience of Disease Brain Research InstituteNiigata UniversityNiigataJapan

Mitochondria are important organelles for cellular metabolism and homeostasis,and their abnormalities are implicated in various *** mitochondria originate from protobacterium,their components are easily recognized by pathogen sensors called pattern-recognition receptors as foreign substances in the *** is prominent for mitochondrial DNA(mtDNA)which has different properties from nuclear DNA,such as low,if any,methylation status,vulnerability to oxidation due to the proximity to the oxidative phosphorylation machinery,and its circular *** studies indicate that perturbations in mitochondrial function and homeostasis cause mtDNA to leak into the cytoplasm,where it triggers the innate immune response(West and Shadel,2017).Although inflammatory response is a cellular strategy to resist viral infections,it can also lead to undesirable outcomes by damaging own cells and tissues.

关键词： homeostasis metabolism insight

PROFESSOR BRITTON CHANCE AND THE EARLY TIMES HE LIVED

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Journal of Innovative Optical Health Sciences 2011年第3期4卷 215-219页

作者： hideaki KOIZUMI Hitachi Ltd.

*** Professor Britton Chance passed away on November 16,*** on July 24,1913,he was 97 years old when he died.I was honored to have had the opportunity to meet Professor Chance and have friendly conversation at the ear... 详细信息

关键词： Chance passed conversation

Rebuilding insight into the pathophysiology of Alzheimer’s disease through new blood-brain barrier models

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Neural Regeneration Research 2024年第9期19卷 1954-1960页

作者： Kinya Matsuo hideaki Nshihara Yamaguchi University Graduate School of Medicine YamaguchiJapan Department of Neurotherapeutics Yamaguchi UniversityUbeJapan

The blood-brain barrier is a unique function of the microvasculature in the brain parenchyma that maintains homeostasis in the central nervous ***-brain barrier breakdown is a common pathology in various neurological diseases,such as Alzheimer’s disease,stroke,multiple sclerosis,and Parkinson’s ***,it has been considered a consequence of neuroinflammation or neurodegeneration,but recent advanced imaging techniques and detailed studies in animal models show that blood-brain barrier breakdown occurs early in the disease process and may precede neuronal ***,the blood-brain barrier is attractive as a potential therapeutic target for neurological diseases that lack effective *** elucidate the molecular mechanism underlying blood-brain barrier breakdown and translate them into therapeutic strategies for neurological diseases,there is a growing demand for experimental models of human origin that allow for functional ***,several human induced pluripotent stem cell-derived blood-brain barrier models have been established and various in vitro blood-brain barrier models using microdevices have been *** in the Alzheimer’s disease field,the human evidence for blood-brain barrier dysfunction has been demonstrated and human induced pluripotent stem cell-derived blood-brain barrier models have suggested the putative molecular mechanisms of pathological blood-brain *** this review,we summarize recent evidence of blood-brain barrier dysfunction in Alzheimer’s disease from pathological analyses,imaging studies,animal models,and stem cell ***,we discuss the potential future directions for blood-brain barrier research.

关键词： Alzheimer’s disease blood-brain barrier human induced pluripotent stem cells

Long-Term Effect of TMD on Vibration Control of An MDOF Offshore Fixed Platform

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China Ocean Engineering 2003年第4期18卷 481-494页

作者：石湘 Tetsuya matsui WU Minger Graduate School of Environmental Studies Nagoya University Nagoya 464-8603 Japan Department of Architecture Meijo University Nagoya 468-8503 Japan

A three-dimensional fixed offshore platform in deep water modeled by the finite element method is studied in this paper. Analysis of the dynamic response of the MDOF structure is realized taking the non-linearity of the wave drag force and the wave-structure interaction into account. The structural response statistics, which have Gaussian distributions, are used to evaluate the vibration effect of the structure without TMD and with TMD. And an optimal method to design TMD controlling the first mode of the multi-mode structure is proposed. Moreover, the probabilities of occurrence of sea states at the platform site are considered for prediction of the long-term effect of a TMD. Simulation results demonstrate that the long-term effect of a well-designed TMD is good and the practical use is possible due to the good stability of its optimal parameters under different sea states.

关键词： offshore fixed platform vibration control tuned mass damper multi degree of freedom optimal design

A study of optimal switching problem in limited-cycle with multiple periods

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Journal of Zhejiang University-Science A(Applied Physics & Engineering) 2010年第12期11卷 933-937页

作者： Jing SUN Hisashi YAMAMOTO Masayuki matsui Graduate School of Engineering Nagoya Institute of Technology Gokiso-cho Showa-ku Nagoya Aichi 466-8555 Japan Department of System Design Management Systems Engineering Tokyo Metropolitan University 6-6 Asahigaoka Hino Tokyo 191-0065 Japan Department of lnformatics Graduate School of lnformatics and Engineering The University of Electro-Communications 1-5-1 Chofugaoka Chofu-shi Tokyo 182-8585 Japan

In a social system or production line,the restrictions of the cost and the due-time exist in each ***,whether these restrictions are satisfied is dependent not only on the risks of this period,but also on the risks generated *** consider controlling the production process by switching the processing rate to a faster one at a given *** paper deals with the optimal switching period to minimize the total expected cost of the production *** first propose the optimal switching period model,and then the mathematic formulation of the total expectation is ***,the policy of optimal switching period is investigated in detail by numerical experiments.

关键词： Limited-cycle problem Multi-period Optimal switching period Production seat system Manufacturing line

Mutual regulation between Hippo signaling and actin cytoskeleton

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Protein & Cell 2013年第12期4卷 904-910页

作者： Yurika matsui Zhi-Chun Lai I ntercollege Graduate Degree Program in Cell and Developmental Biology The Pennsylvania State UniversityUniversity ParkPA 16802USA Department of Biology The Pennsylvania State UniversityUniversity ParkPA 16802USA Department of Biochemistry and Molecular Biology The Pennsylvania State UniversityUniversity ParkPA 16802USA

Hippo signaling plays a crucial role in growth control and tumor suppression by regulating cell proliferation,apoptosis,and *** Hippo signaling is regulated has been under extensive *** the past three years,an increasing amount of data have supported a model of actin cytoskeleton blocking Hippo signaling activity to allow nuclear accumulation of a downstream effector,Yki/Yap/*** the other hand,Hippo signaling negatively regulates actin cytoskeleton *** review p rovides insight on the mutual regulatory mechanisms between Hippo signaling and actin cytoskeleton for a tight control of cell behaviors during animal development,and points out outstanding questions for further investigations.

关键词： Hippo signaling actin cytoskeleton negative feedback growth control development

SYSTEMATIC DESIGN OF SINGLE CARRIER OVERLAP FREQUENCY DOMAIN EQUALIZATION

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Journal of Systems Science & Complexity 2010年第1期23卷 50-60页

作者： Wladimir BOCQUET Kazunori HAYASHI hideaki SAKAI Oranqe Labs Tokyo France Telecom Japan Co.Ltd Department of Systems Science Graduate School of InformaticsKyoto University

This paper proposes a systematic design method of overlap frequency domain equalization(FDE) for single carrier (SC) transmission without a guard interval (GI).Based on the analysis of signal-to-interference-plus-noise ratio (SINR) of the equalizer output for each symbol,the authors adaptivelydetermine the block of the overlap FDE,where the block is defined as a set of symbols at the equalizeroutput with sufficiently low error rate,for a certain fixed sliding window size,which corresponds toa fast Fourier transform (FFT) window *** proposed method takes advantage of the fact thatthe utility part of the equalized signal is localized around the center of the FFT *** addition,the authors also propose to adjust the block size in order to control the computational complexity ofthe equalization per processed sample associating with the average bit error rate (BER) of the *** results show that the proposed scheme can achieve comparable BER performance to theconventional SC-FDE scheme with sufficient GI insertion for both the coded and uncoded cases withvarious modulation levels,while requiring lower computational complexity compared to the SC overlapFDE transmission with the fixed block.

关键词： Overlap frequency domain equalization single carrier transmission SINR.

A New Species of Fejervarya(Anura: Dicroglossidae) from Mawphlang,Northeastern India

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Asian Herpetological Research 2012年第1期3卷 31-37页

作者： Jayaditya PURKAYASTHA Masafumi matsui Department of Zoology Arya Vidyapeeth College South Point School Help Earth Graduate School of Human and Environmental Studies Kyoto University

A new Dicroglossid species is described from Mawphlang,Meghalaya,northeastern India. The new species differs from all the congeners occurring in this region in body size and call characteristics. It is larger than Fejervarya syhadrensis and F. nepalensis,but smaller than F. teraiensis. It overlaps F. pierrei in snout-vent length,but clearly differs from it in advertisement call,with much shorter note duration,much longer inter note interval,and much lower dominant frequency. Paucity of genetic information and underestimation of species diversity in this region are discussed.

关键词： new species Fejervarya Amphibia Anura Mawphlang India

Laparoscopic duodenojejunostomy for malignant stenosis as a part of multimodal therapy:A case report

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World Journal of Clinical Cases 2022年第16期10卷 5324-5330页

作者： Teppei Murakami Yugo matsui Department of Surgery Kobe City Hospital Organization Kobe City Center West HospitalKobe 653-0013HyogoJapan

BACKGROUND Laparoscopic duodenojejunostomy(LDJ) has become the standard surgical procedure for superior mesenteric artery syndrome due to its sufficient outcome in terms of safety and symptom relief. However, there are only a few reports about LDJ for malignant stenosis and its indication remains *** SUMMARY A 77-year-old woman with a history of pancreatic cancer(PC) treated with distal pancreatectomy with en bloc resection of the transverse colon 7 mo ago was admitted for recurrent vomiting. Imaging upon admission revealed marked distention of the duodenum and a tumor around the duodenojejunal flexure. She was diagnosed with malignant stenosis caused by local recurrence of PC. LDJ was performed with an uneventful postoperative course, followed by chemotherapy which gave her 10 mo overall *** We think that LDJ is a valuable method for unresectable malignant stenosis around the duodenojejunal flexure as a part of multimodal therapy.

关键词： Duodenojejunostomy Laparoscopic surgery Malignant stenosis Pancreatic cancer Multimodal therapy

A method for estimating the fraction of mineral dust in particulate matter using PM2.5-to-PM10 ratios

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Particuology 2016年第5期14卷 114-120页

作者： Nobuo Sugimoto Atsushi Shimizu Ichiro matsui Masataka Nishikawa Center for Environmental Measurement and Analysis National Institute for Environmental Studies 16-20nogawa Tsukuba 305-8506 Japan Tokyo University of Science Environmental Safety Center 1-3 Kagurazaka Shinjuku-ku Tokyo 162-8601Japan

A simple method for estimating the contributions of mineral dust to PM2.5, PM10, or TSP is presented. The method is based on the assumption of external mixing of two types of particles with different PM2.5/PM10 ratios, The method was applied to local and transported dust events observed in Tsukuba, Japan, and was compared with collocated polarization lidar measurements. The method was then applied to three dust events that occurred in Oki, Rishiri, and Ochiishi,Japan, in 2012. The results showed that the method was useful for detecting mineral dust and for qualitatively describing the mixing of dust with anthropogenic aerosols.

关键词： Mineral dust PM2.5 dust fraction PM2.5 to PM10 ratio Atmospheric mixing Lidar Depolarization ratio