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Effect of calcium on phytochrome-mediated synthesis of amaranthin in Amaranthus caudatus seedlings

Chinese Science Bulletin 1995年第17期40卷 1469-1473页

作者：马力耕周君莉安宜崔国军孙大业 hidakahiroyoshi hidaka hiroyoshi Department of Biology Hebei Normal University. Shijiazhuang 050016 China) Department of Pharmacology College of Medicine Nagoya University Nagoya 466. Japan)

Light plays a critical role in the regulation of plant morphogenetic and physiologicalresponses. As one of the extracellular signals, light signa1 is first received by the plantcells, then it affects the physiological and biochemical status of the cells and the expressionof genetic characters through signal transduction. Tong has pointed out that until recentlythere had been little progress in the intersteps between phytochrome activation and

关键词： calcium phytochrome Amaranthus caudatus amaranthin synthesis.

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Sofosbuvir plus ribavirin is tolerable and effective even in elderly patients 75-years-old and over

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World Journal of Hepatology 2020年第9期12卷 672-684页

作者： Hideyuki Tamai Naoki Shingaki Yoshiyuki Ida Ryo Shimizu Shuya Maeshima Junpei Okamura Akira Kawashima Taisei Nakao Takeshi Hara hiroyoshi Matsutani Izumi Nishikawa Katsuhiko Higashi Department of Hepatology Wakayama Rosai HospitalWakayama 6408505Japan Second Department of Internal Medicine Wakayama Medical UniversityWakayama 6418509Japan Department of Internal Medicine Naga Municipal HospitalWakayama 6496414Japan Department of Gastroenterology Wakayama Rosai HospitalWakayama 6408505Japan Department of Internal Medicine Hidaka General HospitalWakayama 6440002Japan

BACKGROUND Although clinical use of sofosbuvir plus ribavirin has been approved for patients infected with genotype 2 hepatitis C virus,patients≥75-years-old have not been included in previous clinical *** To evaluate the real-world safety and efficacy of sofosbuvir plus ribavirin for elderly patients(≥75-years-old)compared to nonelderly patients,we conducted a post-marketing prospective cohort *** We treated 265 patients with genotype 2 hepatitis C virus using standard approved doses of sofosbuvir(400 mg/d)plus ribavirin adjusted by body weight,administered orally for 12 *** Sustained virological response rates for the overall cohort,patients<65-years-old,≥65-years-old but<75-years-old,and≥75-years-old were 97%(258/265),98%(93/95),97%(84/87),and 98%(81/83),respectively(P=0.842).Logistic regression analyses identified history of hepatocellular carcinoma treatment and alpha-fetoprotein as factors significantly associated with sustained virological ***-fetoprotein was the only independent factor *** virological response rate was significantly lower for patients with hepatocellular carcinoma treatment(91%)than for patients without history of hepatocellular carcinoma treatment(98%,P=0.004).One patient(0.4%)discontinued treatment due to drug-induced *** reduction or interruption of ribavirin was required for 12.1%(32/265)of patients because of anemia,including 7.7%(14/182)of patients<75-years-old and 21.7%(18/83)of patients≥75-years-old(P=0.002).CONCLUSION Although ribavirin dose reduction or interruption was required with advanced age,sofosbuvir plus ribavirin appears tolerable and highly effective even in patients≥75-years-old.

关键词： Hepatitis C virus Genotype 2 Sofosbuvir Ribavirin Elderly patients Cirrhosis

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