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Digital pathology-based artificial intelligence models for differential diagnosis and prognosis of sporadic odontogenic keratocysts

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International Journal of Oral Science 2024年第2期16卷 349-358页

作者： Xinjia Cai heyu zhang Yanjin Wang Jianyun zhang Tiejun Li Department of Oral Pathology Peking University School and Hospital of Stomatology&National Center of Stomatology&National Clinical Research Center for Oral Diseases&National Engineering Research Center of Oral Biomaterials and Digital Medical DevicesBeijingChina Central Laboratory Peking University School and Hospital of StomatologyBeijingChina Department of Oral Pathology Shanghai Stomatological Hospital&School of StomatologyFudan UniversityShanghaiChina Research Unit of Precision Pathologic Diagnosis in Tumors of the Oral and Maxillofacial Regions Chinese Academy of Medical Sciences(2019RU034)BeijingChina

Odontogenic keratocyst(OKC)is a common jaw cyst with a high recurrence *** combined with basal cell carcinoma as well as skeletal and other developmental abnormalities is thought to be associated with Gorlin ***,OKC needs to be differentiated from orthokeratinized odontogenic cyst and other jaw *** of the different prognosis,differential diagnosis of several cysts can contribute to clinical *** collected 519 cases,comprising a total of 2157 hematoxylin and eosinstained images,to develop digital pathology-based artificial intelligence(AI)models for the diagnosis and prognosis of *** Inception_v3 neural network was utilized to train and test models developed from patch-level ***,whole slide imagelevel AI models were developed by integrating deep learning-generated pathology features with several machine learning *** AI models showed great performance in the diagnosis(AUC=0.935,95%CI:0.898–0.973)and prognosis(AUC=0.840,95%CI:0.751–0.930)of *** advantages of multiple slides model for integrating of histopathological information are demonstrated through a comparison with the single slide ***,the study investigates the correlation between AI features generated by deep learning and pathological findings,highlighting the interpretative potential of AI models in the ***,we have developed the robust diagnostic and prognostic models for *** AI model that is based on digital pathology shows promise potential for applications in odontogenic diseases of the jaw.

关键词： diagnosis pathology prognosis

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Nonlinear Flap-Wise Vibration Characteristics ofWind Turbine Blades Based onMulti-Scale AnalysisMethod

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Energy Engineering 2024年第2期121卷 483-498页

作者： Qifa Lang Yuqiao Zheng Tiancai Cui Chenglong Shi heyu zhang School of Mechanical and Electrical Engineering Lanzhou University of TechnologyLanzhou730050China

This work presents a novel approach to achieve nonlinear vibration response based on the Hamilton *** chose the 5-MW reference wind turbine which was established by the National Renewable Energy Laboratory(NREL),to research the effects of the nonlinear flap-wise vibration *** turbine wheel is simplified by treating the blade of a wind turbine as an Euler-Bernoulli beam,and the nonlinear flap-wise vibration characteristics of the wind turbine blades are discussed based on the simplification ***,the blade’s large-deflection flap-wise vibration governing equation is established by considering the nonlinear term involving the centrifugal ***,it is truncated by the Galerkin method and analyzed semi-analytically using the multi-scale analysis method,and numerical simulations are carried out to compare the simulation results of finite elements with the numerical simulation results using Campbell diagram analysis of blade *** results indicated that the rotational speed of the impeller has a significant impact on blade *** the wheel speed of 12.1 rpm and excitation amplitude of 1.23 the maximum displacement amplitude of the blade has increased from 0.72 to *** the amplitude-frequency curve,it can be seen that the multi-peak characteristic of blade amplitude frequency is under centrifugal *** phase trajectories in blade nonlinear vibration,exhibiting periodic motion characteristics,are found through phase diagrams and Poincare section diagrams.

关键词： Wind turbine blades nonlinear vibration Galerkin method multi-scales method

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Effect of the Filling Liquid Ratio on the Thermal Performance of a Novel Thermal Diode with Wick

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Journal of Thermal Science 2024年第2期33卷 396-407页

作者： LI Zhiyong MING Tingzhen zhang heyu ZHAO Sitong WANG Qinggang CAI Cunjin YIN Kui FANG Yueping WU Yongjia School of Civil Engineering and Architecture Wuhan University of TechnologyWuhan430070China Sanya Science and Education Innovation Park Wuhan University of TechnologySanya572004China Deparment of Four Station Logistics AcademyXuzhou221000China School of Energy Construction and EnvironmentCoventry UniversityPriory StreetCoventryCV15FBUK

The application of thermal diodes,which allow heat to flow more readily in one direction than the other,is an important way to reduce energy consumption in buildings and enhance the battery heat dissipation of electric *** on various factors including the specific design,materials used,and operating conditions,the convective thermal diode can exhibit the best thermal rectification effect in intended applications compared to the other thermal *** this study,a novel convective thermal diode with a wick was proposed based on the phase change heat transfer *** design takes advantage of both capillary forces provided by the wick and gravity to achieve enhanced unidirectional heat transfer performance for the designed convective thermal *** effect of the filling liquid ratio on the thermal performance of the thermal diode was experimentally investigated,which was in good agreement with the theoretical *** research findings showed that with an optimal liquid filling ratio of 140%,the thermal diode with a wick can achieve a better thermal rectification ratio when subjected to a lower heating power,and the maximum thermal rectification ratio of 21.76 was experimentally achieved when the heating power of the thermal diode was 40 W.

关键词： filling liquid ratio thermal diode wick structure gravity

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CD97 inhibits osteoclast differentiation via Rap1a/ERK pathway under compression

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International Journal of Oral Science 2024年第1期16卷 134-144页

作者： Xuan Zhou Xinjia Cai Fengyang Jing Xuefen Li Jianyun zhang heyu zhang Tiejun Li Department of Oral Pathology Peking University School and Hospital of Stomatology&National Center of Stomatology&National Clinical Research Center for Oral Diseases&National Engineering Laboratory for Digital and Material Technology of Stomatology&Beijing Key Laboratory of Digital Stomatology&Research Center of Engineering and Technology for Computerized Dentistry Ministry of Health&NMPA Key Laboratory for Dental MaterialsBeijingChina Research Unit of Precision Pathologic Diagnosis in Tumors of the Oral and Maxillofacial Regions Chinese Academy of Medical Sciences(2019RU034)BeijingChina Central Laboratory Peking University School and Hospital of StomatologyBeijingChina

Acceleration of tooth movement during orthodontic treatment is challenging, with osteoclast-mediated bone resorption on the compressive side being the rate-limiting step. Recent studies have demonstrated that mechanoreceptors on the surface of monocytes/macrophages, especially adhesion G protein-coupled receptors (aGPCRs), play important roles in force ***, its role in the regulation of osteoclast differentiation remains unclear. Herein, through single-cell analysis, we revealed that CD97, a novel mechanosensitive aGPCR, was expressed in macrophages. Compression upregulated CD97 expression and inhibited osteoclast differentiation;while knockdown of CD97 partially rescued osteoclast differentiation. It suggests that CD97 may be an important mechanosensitive receptor during osteoclast differentiation. RNA sequencing analysis showed that the Rap1a/ERK signalling pathway mediates the effects of CD97 on osteoclast differentiation under compression. Consistently, we clarified that administration of the Rap1a inhibitor GGTI298 increased osteoclast activity, thereby accelerating tooth movement. In conclusion,our results indicate that CD97 suppresses osteoclast differentiation through the Rap1a/ERK signalling pathway under orthodontic compressive force.

关键词： CD97 osteoclast inhibited

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Genomic alterations in oral multiple primary cancers

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International Journal of Oral Science 2024年第1期16卷 145-153页

作者： Wen Wang Qian Wang Shiying Sun Pengfei zhang Yuyu Li Weimin Lin Qiwen Li Xiao zhang Zhe Ma Haiyan Lu Hebei Key Laboratory of Stomatology Hebei Clinical Research Center for Oral DiseasesHebei Medical UniversityShijiazhuangChina Department of Orthodontics School and Hospital of StomatologyHebei Medical UniversityShijiazhuangChina State Key Laboratory of Oral Diseases&National Center for Stomatology&National Clinical Research Center for Oral Diseases&West China Hospital of Stomatology Sichuan UniversityChengduChina Department of Preventive Dentistry School and Hospital of StomatologyHebei Medical UniversityShijiazhuangHebeiChina

Oral squamous cell carcinoma (OSCC) is the predominant type of oral cancer, while some patients may develop oral multiple primary cancers (MPCs) with unclear etiology. This study aimed to investigate the clinicopathological characteristics and genomic alterations of oral MPCs. Clinicopathological data from patients with oral single primary carcinoma (SPC, n=202) and oral MPCs (n=34) were collected and compared. Copy number alteration (CNA) analysis was conducted to identify chromosomal-instability differences among oral MPCs, recurrent OSCC cases, and OSCC patients with lymph node metastasis. Whole-exome sequencing was employed to identify potential unique gene mutations in oral MPCs patients. Additionally, CNA and phylogenetic tree analyses were used to gain preliminary insights into the molecular characteristics of different primary tumors within individual patients. Our findings revealed that, in contrast to oral SPC, females predominated the oral MPCs (70.59%), while smoking and alcohol use were not frequent in ***, long-term survival outcomes were poorer in oral MPCs. From a CNA perspective, no significant differences were observed between oral MPCs patients and those with recurrence and lymph node metastasis. In addition to commonly mutated genes such as CASP8, TP53 and MUC16, in oral MPCs we also detected relatively rare mutations, such as HS3ST6 and RFPL4A. Furthermore, this study also demonstrated that most MPCs patients exhibited similarities in certain genomic regions within individuals, and distinct differences of the similarity degree were observed between synchronous and metachronous oral MPCs.

关键词： alterations metastasis oral

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基于主成分分析的城市河流水质时空分布特征研究——以沧州市为例

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环境工程技术学报 2024年第4期14卷 1273-1283页

作者：张贺玉杨莉园卢少勇王永强刘树栋毕斌张静湖泊水污染治理与生态修复技术国家工程实验室中国环境科学研究院国家环境保护洞庭湖科学观测研究站中国环境科学研究院环境基准与风险评估国家重点实验室中国环境科学研究院沧州市生态环境保护科学研究院

客观、综合评价城市河流水质的污染状况对城市河流水污染精准防治具有重要意义。以2022年沧州市13条重要河流的pH、溶解氧(DO)、高锰酸盐指数(COD_(Mn))、化学需氧量(COD_(Cr))、总磷(TP)、氨氮(NH_(3)-N)、氟化物(F−)共7项水质指标数... 详细信息

客观、综合评价城市河流水质的污染状况对城市河流水污染精准防治具有重要意义。以2022年沧州市13条重要河流的pH、溶解氧(DO)、高锰酸盐指数(COD_(Mn))、化学需氧量(COD_(Cr))、总磷(TP)、氨氮(NH_(3)-N)、氟化物(F−)共7项水质指标数据为基础,采用主成分分析法,提取引起河流水质变化的主导指标,诊断河流污染状况,再运用水质指标权重计算各河流监测断面和不同季节综合得分,分析河流水质时空分布特征。结果表明:1)2022年沧州市13条河流水质整体较好,大部分河流水质为GB 3838―2002《地表水环境质量标准》Ⅲ类,少数河流COD_(Mn)、COD_(Cr)达到Ⅳ类水质标准;2)使用主成分分析法,可将7个水质指标转化为2个主成分,累计方差贡献率达78.492%,其中与第一主成分显著相关的水质指标COD_(Mn)、COD_(Cr)、TP和F−主导着研究区域水质变化,且4个水质指标之间呈显著正相关;3)空间分析表明,沧浪渠为13条监测河流中污染程度最高的河流,且沧州市东北区域河流污染程度高于西北区域和中南区域;4)季节分析表明,13条河流不同季节水质污染严重程度表现为夏季>春季>冬季>秋季。研究结果可为沧州市城市河流水污染控制策略的制定提供参考。

关键词：城市河流水质主成分分析污染因子时空分布

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Biomarkers of malignant transformation in oral leukoplakia:from bench to bedside

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Journal of Zhejiang University-Science B(Biomedicine & Biotechnology) 2023年第10期24卷 868-882页

作者： Xinjia CAI Jianyun zhang heyu zhang Tiejun LI Department of Oral Pathology Peking University School and Hospital of Stomatology/National Center of Stomatology/National Clinical Research Center for Oral Diseases/National Engineering Research Center of Oral Biomaterials and Digital Medical DevicesBeijing 100081China Central Laboratory Peking University School and Hospital of StomatologyBeijing 100081China Research Unit of Precision Pathologic Diagnosis in Tumors of the Oral and Maxillofacial Regions Chinese Academy of Medical Sciences(2019RU034)Beijing 100081China

Oral leukoplakia is a common precursor lesion of oral squamous cell carcinoma,which indicates a high potential of *** malignant transformation of oral leukoplakia seriously affects patient survival and quality of life;however,it is difficult to identify oral leukoplakia patients who will develop carcinoma because no biomarker exists to predict malignant transformation for effective clinical *** a major problem in the field of head and neck pathologies,it is imperative to identify biomarkers of malignant transformation in oral *** this review,we discuss the potential biomarkers of malignant transformation reported in the literature and explore the translational probabilities from bench to *** no single biomarker has yet been applied in the clinical setting,profiling for genomic instability might be a promising adjunct.

关键词： Oral leukoplakia Oral squamous cell carcinoma Malignant transformation Biomarker Prognosis

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数字化时代乡村社群记忆构建的困境与出路

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南京邮电大学学报（社会科学版） 2024年第1期26卷 96-104页

作者：魏莉张荷瑜方丽萍南京邮电大学社会与人口学院江苏南京210023 江西省人民政府省委办公厅江西南昌330036

乡村社群记忆承载了乡民的思想观念与认知习惯,是乡村文化的直接凝结和体现。数字技术的普及为乡村社群保留和传承记忆提供了重要的技术保障,但数字技术造成的社交隔离、知识流失和媒介表达受限等问题也给乡村社群记忆的构建带来了诸多... 详细信息

乡村社群记忆承载了乡民的思想观念与认知习惯,是乡村文化的直接凝结和体现。数字技术的普及为乡村社群保留和传承记忆提供了重要的技术保障,但数字技术造成的社交隔离、知识流失和媒介表达受限等问题也给乡村社群记忆的构建带来了诸多新的挑战,使得乡村社群内部记忆相对封闭,存在“茧化”与“失忆”的风险。因此,要借助建立数字化社群平台、构建乡村社群文化数字档案库、组织社群庆典活动等手段解封乡村社群记忆,铭记乡村社群历史,以传承乡村社群文化,推动乡村高质量发展。

关键词：数字化时代乡村社群记忆乡村社群记忆保留文化传承

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A drone‑and feld‑based investigation of the land degradation and soil erosion at an opencast coal mine dump after 5 years’evolution of natural processes

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International Journal of Coal Science & Technology 2022年第3期9卷 50-66页

作者： Wu Xiao He Ren Tao Sui heyu zhang Yanling Zhao Zhenqi Hu Department of Land Management Zhejiang UniversityHangzhou 310058China Institute of Land Reclamation and Ecological Restoration China University of Mining and Technology(Beijing)100083 BeijingChina Guangzhou South China Institute of Natural Resources Science and Technology Guangzhou 510642China

Opencast coal mining has a large impact on the land surface,both at the mining pits themselves and at waste *** artifcial management is stopped,a reclaimed opencast coal mine dump is afected by wind and water erosion from natural processes,resulting in land degradation and even safety *** this paper,the soil erosion and land degradation after 5 years of such natural processes,at the Xilinhot opencast coal mine dump in Inner Mongolia,were investigated.A multisource data acquisition method was applied:the vegetation fraction coverage(VFC)was extracted from GF-1 satellite imagery,high-precision terrain characteristics and the location and degree of soil erosion were obtained using a drone,and the physical properties of the topsoil were obtained by feld *** this basis,the degree and spatial distribution of erosion cracks were identifed,and the causes of soil erosion and land degradation were analyzed using the geographical *** results show that(1)multi-source data acquisition method can provide efective basic data for the quantitative evaluation of the ecological environment at dumps,and(2)slope aspect and VFC are the main factors afecting the degree of degradation and soil *** on above analysis,several countermeasures are proposed to mitigate land degradation:(1)The windward slope be designed to imitate the natural landform.(2)Reasonable engineering measures should be applied at the slope to restrain soil erosion.(3)The Pioneer plants should be widely planted on the platform at the early stage of reclamation.

关键词： Coal mine dump Ecological restoration Drone Soil erosion Ecosystem stability Geographical detector

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冷却贮藏期间滩羊肉氧化应激与线粒体功能损伤的关系

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食品科学 2024年第19期45卷 201-207页

作者：魏志宝罗瑞明高爽杨东松虎瑶张赫宇马佳荣宁夏大学食品科学与工程学院宁夏银川750021

研究宰后冷却贮藏时间中氧化应激和线粒体损伤之间的相互关系,以冷却贮藏期间滩羊背最长肌(*** dorsi)为研究对象,设置N-乙酰-L-半胱氨酸(N-acetyl-L-cysteine,NAC)抑制组和生理盐水对照组,分别测定两个组冷却贮藏0、2、4、6、8 d时的... 详细信息

研究宰后冷却贮藏时间中氧化应激和线粒体损伤之间的相互关系,以冷却贮藏期间滩羊背最长肌(*** dorsi)为研究对象,设置N-乙酰-L-半胱氨酸(N-acetyl-L-cysteine,NAC)抑制组和生理盐水对照组,分别测定两个组冷却贮藏0、2、4、6、8 d时的线粒体膜通透性转换孔(mitochondrial permeability transition pore,MPTP)开放程度、膜电位、活性氧(reactive oxygen species,ROS)含量、复合物(Ⅰ、Ⅱ、Ⅲ、Ⅳ)活性、琥珀酸脱氢酶(succinate dehydrogenase,SDH)活性、过氧化氢酶(catalase,CAT)活性、超氧化物歧化酶(superoxide dismutase,SOD)活性、谷胱甘肽过氧化物酶(glutathione peroxidase,GSH-Px)活性以及丙二醛(malondialdehyde,MDA)含量的变化情况,并对其肌细胞线粒体微观结构进行观察,分析其变化情况。结果表明:在成熟过程中,抑制组和对照组的滩羊肉肌细胞线粒体的MPTP开放程度逐渐增大(P<0.05);ROS、MDA含量呈现上升趋势(P<0.05);线粒体膜电位和复合物(Ⅰ、Ⅱ、Ⅲ、Ⅳ)、SDH、CAT、SOD、GSH-Px活性呈现逐渐下降的趋势(P<0.05)。结论:滩羊在宰杀后,其肌肉组织中发生氧化应激反应,导致ROS含量显著增高,超出机体自身抗氧化防御清除过量ROS能力时,进而导致氧化还原系统失衡,而氧化还原系统的失衡进一步加速肌体内ROS水平的上升,从而引发MPTP开放和线粒体膜电位降低,严重损害线粒体,然而NAC可以缓解此类现象;ROS水平的上升会破坏线粒体电子传递链的正常运行,导致线粒体损伤加重;同时脂质氧化产物MDA也能损伤线粒体功能结构,导致线粒体发生肿胀、变形等,从而引起其生物功能紊乱。

关键词：滩羊氧化应激线粒体功能损伤

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