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Exploiting the point spread function for optical imaging through a scattering medium based on deconvolution method

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Journal of Innovative Optical health Sciences 2019年第4期12卷 21-31页

作者： hexiang he Xiangsheng Xie Yikun Liu Haowen Liang Jianying Zhou School of Physics and Optoelectronic Engineering Foshan University Foshan 528000 P.R.China Department of Physics College of Science Shantou University Shantou 515063P.R.China School of Physics Sun Yat-sen University Guangzhou 510275 P.R.China

Visual perception of humans penetrating turbid medium is hampered by *** techniques have been prompted recently to recover optical imaging through turbid *** them,speckle correlation based on deconvolution is one of the most attractive methods taking advantage of high imaging quality,robustness,eas-of-use,and *** exploiting the point spread function(PSF)of the scattering system,large Field-of-View,extended Depth-of-Field,noninvasiveness and spectral resoluation are now available as successful solutions for high quality and multifunctional image *** this paper,we review the progress of imaging through a scattering medium based on deconvolution method,including the principle,the breakthrough of the limitation of the optical memory ffect,the improvement of the deconvolution algorithm and innovative applications.

关键词： Speckle correlation deconvolution scattering medium imaging through turbid media

Geometric and defects engineering collaboration for enhanced cascade enzymatic nanoreactors

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Nano Research 2024年第4期17卷 2451-2461页

作者： Zhichao Yu Ruijin Zeng hexiang Gong Yuan Gao Shuyun Chen Yunsen Wang Dianping Tang Key Laboratory for Analytical Science of Food Safety and Biology(MOE&Fujian Province) Department of ChemistryFuzhou UniversityFuzhou 350108China

Highly evolved multi-enzyme cascade catalytic reactions in organisms facilitate rapid transfer of substrates and efficient conversion of intermediates in the catalytic unit,thus rationalizing their efficient *** this study,pore-ordered mesoporous single-atom(Fe)nitrogen-doped carbon nanoreactors(Mp-Fe-CN)were designed,in which a reasonable pore size was designed as a natural enzyme trap coupled to a simulated enzyme center.A polarity-mediated strategy was developed to obtain atomically dispersed nanoporous substrates,with the finding that polarity-guided engineering of the nitrogen-ligand environment and vacancy cluster defects clearly affects nanoporous activity,accompanied by appreciable mesoporous pore size *** active center and distal N atom coordination of Fe-N_(4) affect the catalytic process of the nanozyme exposed by density functional theory(DFT),determining the contribution of hybridized orbitals to electron transfer and the decisive step.A cascade nanoreactor-based domain-limited sarcosine oxidase developed for non-invasive monitoring of sarcosine levels in urine for evaluation of potential prostate carcinogenesis as a proof of *** on the design of surface mesoporous channels of nanocatalytic units,a bridge was built for the interaction between nanozymes and natural enzymes to achieve cascade nanocatalysis of natural enzymatic products.

关键词： nanozyme single-atom catalyst bioreactor cascade catalysis non-Invasive sensing

基于相位共轭实现散射成像及光学幻像的双功能散射光调控方法(特邀)

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红外与激光工程 2022年第8期51卷 88-99页

作者：和河向黎永耀黄锦圣佛山科学技术学院物理与光电工程学院广东佛山528225 粤港澳智能微纳光电技术联合实验室广东佛山528225 香港科技大学物理学系中国香港九龙

近年来,人们对散射光调控的研究取得了极大的进展,产生了许多有趣的应用。其中透过散射介质的成像和光学幻像是两个极为引人注目的方向,但它们不经常同时被研究。文中将深入探索散射光成像和光学幻像的内在联系,在此基础上提出一种新颖... 详细信息

近年来,人们对散射光调控的研究取得了极大的进展,产生了许多有趣的应用。其中透过散射介质的成像和光学幻像是两个极为引人注目的方向,但它们不经常同时被研究。文中将深入探索散射光成像和光学幻像的内在联系,在此基础上提出一种新颖的双功能散射光调控方法以在同一实验装置中根据需求实现散射成像和光学幻像。通过优化光路,结合相位恢复技术检测散射波前,利用相位共轭技术和高分辨率的纯相位液晶空间光调制器可以实现补偿散射的影响或实现特定衍射波前的产生。该系统只需要数秒即可完成散射光调控,因此可以对变化缓慢的散射环境实现动态散射成像或对缓慢变化的物体实现稳定的动态光学幻像。理论分析和实验演示证实了该调控方法的可行性。这一散射光调控方法有望在浑浊介质中的光学成像、光学伪装、反侦察、复杂光场调控等领域找到潜在的应用。

关键词：散射光调控散射成像光学幻像相位恢复相位共轭

Modification of food protein fibrils: During and after fibrillization

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Food Science and Human Wellness 2024年

作者： Kefan Ouyang hexiang Xie Hua Xiong Qiang Zhao Wenjun Wang State Key Laboratory of Food Science and Resources Nanchang University Jiangxi Key Laboratory of Natural Products and Functional Food College of Food Science and Engineering Jiangxi Agricultural University

Fibrillization endows food proteins with anisotropic nanostructures， significantly enhancing their functional properties. The resultant food protein fibrils (FPFs) have garnered attention for their diverse applications across the food industry. However， the full potential of FPFs is hindered by inherent challenges， particularly their limited stability. This review critically examines the formation of FPFs in food processing， the new protein sources， and on the modification strategies of FPFs， thereby unlocking new avenues for FPF utilization in food processing. In particular， the strategies during and after fibrillization are highlighted. The first strategy is to modify the structure and function of protein fibrils by influencing fibrillization， such as through pretreatment， incubation conditions， nuclei induction， and ingredient interactions. The second strategy is to modify the mature FPFs by regulating their properties and interactions with other components. The review also discusses the potential applications and challenges of FPFs in food systems， such as food preservation， functional food design， and novel delivery carriers.

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Screening and identifying natural products with SARS-CoV-2 infection inhibitory activity from medicinal fungi

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Biosafety and health 2024年第1期6卷 12-20页

作者： Shuang Zhao Amelia Siqi Huang Weibo Zhang Lili Ren hexiang Wang Jianbin Wang Xinyang Shao Guanbo Wang Institute of Agri-Food Processing and Nutrition Institute of Plant ProtectionBeijing Academy of Agriculture and Forestry SciencesBejing 100097China Bejing Key Laboratory of Fruits and Vegetable Storage and Processing Key Laboratory of Vegetable Postharvest ProcessingMinistry of AgricultureBejing 100097China Dalton Academy The Affliated High School of Peking UniversityBeijing 100190China NHC Key Laboratory of Systems Biology of Pathogens and Christophe Merieux Laboratory National Institute of Pathogen BiologyBejing 100730China Key Laboratory of Respiratory Disease Pathogenomics Chinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100730China College of Biological Sciences China Agricultural UniversityBejing 100193China School of Life Sciences Tsinghua UniversityBeijing 100084China Changping Laboratory Beijing 102206China Institute for Cell Analysis Shenzhen Bay LaboratoryShenzhen 518132China

The coronavirus disease of 2019(COVID‐19),a global pandemic caused by the severe acute respiratory syndrome coronavirus 2(SARS‐CoV‐2),can result in severe health *** addition to physical preventative measures,pharmaceutical intervention is also *** natural products from medicinal fungi have shown promise as potential antiviral drugs and may serve as a source of effective components with antiviral activity against SARS‐CoV‐2 and other *** this study,we developed a workflow that integrates viral infection inhibition assays at both cellular and molecular levels,as well as molecular separation and characterization,to screen and identify natural products with antiviral *** this workflow,we screened 167 extracts extracted from 36 medicinal fungi using optimized extraction *** assessed the antiviral effects of these extracts by measuring their ability to inhibit SARS‐CoV‐2 infection and receptor binding domain‐human angiotensin‐converting enzyme 2(RBD‐hACE2)binding in *** charge‐and size‐based characterization of the active compounds through filtration and chromatographic fractionation,mass spectrometry characterization of the fractionated compounds revealed that the active components are polysaccharides and determined their monosaccharide residue *** findings provide new insights into the antiviral potential of natural products and their screening strategies and may contribute to the development of effective antiviral therapeutics against COVID‐19 and other diseases.

关键词： Medicinal fungi Natural products Antiviral activity COVID‐19 Polysaccharides

Method for the extraction of circulating nucleic acids based on MOF reveals cell-free RNA signatures in liver cancer

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National Science Review 2024年第1期11卷 94-106页

作者： Yuqing Sun Haixin Yu Shaoqing Han Ruoxi Ran Ying Yang Yongling Tang Yuhao Wang Wenhao Zhang heng Tang Boqiao Fu Boshi Fu Xiaocheng Weng Song-Mei Liu hexiang Deng Shuang Peng Xiang Zhou College of Chemistry and Molecular Sciences Key Laboratory of Biomedical Polymers-Ministry of Education Wuhan University Department of Digestive Surgical Oncology Union Hospital Tongji Medical College Huazhong University of Science and Technology Cancer Center Union HospitalTongji Medical CollegeHuazhong University of Science and Technology Department of Clinical Laboratory Center for Gene Diagnosis and Program of Clinical Laboratory Zhongnan Hospital of Wuhan University College of Chemistry and Materials Science Hubei Engineering University Department of Pharmacology School of Pharmacy China Medical University Taikang Center for Life and Medical Sciences Wuhan University Department of hematology Zhongnan Hospital of Wuhan University

Cell-free RNA(cf RNA) allows assessment of health, status, and phenotype of a variety of human organs and is a potential biomarker to non-invasively diagnose numerous diseases. Nevertheless, there is a lack of highly efficient and bias-free cf RNA isolation technologies due to the low abundance and instability of cf ***, we developed a reproducible and high-efficiency isolation technology for different types of cell-free nucleic acids(containing cf RNA and viral RNA) in serum/plasma based on the inclusion of nucleic acids by metal-organic framework(MOF) materials, which greatly improved the isolation efficiency and was able to preserve RNA integrity compared with the most widely used research kit method. Importantly, the quality of cf RNA extracted by the MOF method is about 10-fold that of the kit method, and the MOF method isolates more than three times as many different RNA types as the kit method. The whole transcriptome mapping characteristics of cf RNA in serum from patients with liver cancer was described and a cf RNA signature with six cf RNAs was identified to diagnose liver cancer with high diagnostic efficiency(area under curve = 0.905 in the independent validation cohort) using this MOF method. Thus, this new MOF isolation technique will advance the field of liquid biopsy, with the potential to diagnose liver cancer.

关键词： MOF circulating cell-free RNA biomarker liver cancer diagnosis

艾司氯胺酮对大鼠内毒素性急性肺损伤时TLR4/NF-κB信号通路的影响

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中华麻醉学杂志 2024年第6期44卷 729-732页

作者：何旋陈鹤翔孔倩袁敏肖兴鹏吴晓静武汉大学人民医院麻醉科武汉430060

目的:评价艾司氯胺酮对大鼠内毒素性急性肺损伤时Toll样受体4(TLR4)/NF-κB信号通路的影响。方法:SPF级健康成年雄性SD大鼠30只,体质量200~220 g,8周龄,采用随机数字表法分为3组( n=10):对照组(Con组)、内毒素性急性肺损伤组(ALI组)和... 详细信息

目的:评价艾司氯胺酮对大鼠内毒素性急性肺损伤时Toll样受体4(TLR4)/NF-κB信号通路的影响。方法:SPF级健康成年雄性SD大鼠30只,体质量200~220 g,8周龄,采用随机数字表法分为3组( n=10):对照组(Con组)、内毒素性急性肺损伤组(ALI组)和艾司氯胺酮组(AK组)。采用腹腔注射LPS 10 mg/kg的方法制备大鼠内毒素性急性肺损伤模型。Con组腹腔注射等容量0.9%氯化钠注射液,AK组注射LPS 30 min和12 h时分别腹腔注射艾司氯胺酮10 mg/kg。模型制备后24 h时麻醉大鼠,采集颈动脉血样后处死大鼠取肺组织,测定PaO_(2)并计算PaO_(2)/FiO_(2),he染色光镜下观察肺组织病理学结果并行肺损伤评分,电镜下观察肺组织细胞超微结构,计数支气管肺泡灌洗液(BALF)多形核白细胞(PMN),计算肺组织湿质量/干质量(W/D)比值,比色法测定髓过氧化物酶(MPO)活性,采用Western blot法检测TLR4和NF-κB p65的表达。结果:与Con组比较,ALI组大鼠PaO_(2)和PaO_(2)/FiO_(2)降低,肺组织损伤评分、BALF PMN计数、肺W/D比值、MPO活性、肺组织TLR4和NF-κB p65表达水平升高( P<0.05);与ALI组比较,AK组大鼠PaO_(2)和PaO_(2)/FiO_(2)升高,肺组织损伤评分、BALF PMN计数、肺W/D比值、MPO活性、肺组织TLR4和NF-κB p65表达水平降低( P<0.05),肺组织细胞超微结构改善。结论:艾司氯胺酮减轻大鼠内毒素性急性肺损伤的机制与阻断TLR4/NF-κB信号通路有关。

关键词：环己烷类内毒素类急性肺损伤 Toll样受体4 NF-κB

文旅区域协同发展的法治保障研究——以青海与甘肃为例

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甘肃理论学刊 2024年第4期 83-92页

作者：张强田鹤翔湖南师范大学法学院长沙410081 青海省社会科学院政法所西宁810000

基于环境要素相融、地缘关系紧密、旅游资源环状聚集等因素,区域协同是青海与甘肃两地文旅高质量发展的必由之路。只有通过法治思维与法治方法,才能凝聚青甘文旅协同发展之合力,而青甘文旅区域协同需要在厘清文旅属性、调整规制工具、... 详细信息

基于环境要素相融、地缘关系紧密、旅游资源环状聚集等因素,区域协同是青海与甘肃两地文旅高质量发展的必由之路。只有通过法治思维与法治方法,才能凝聚青甘文旅协同发展之合力,而青甘文旅区域协同需要在厘清文旅属性、调整规制工具、推进区域协调三重法治逻辑下进行,才符合文旅高质量发展的新趋势。同时,青甘文旅区域协同发展法治保障还存在政策依据不适配和法治供给不充足两个问题。对此,应通过完善文旅区域协同发展的规范依据、建立激励相容机制、健全协同治理机制的路径,以法治保障青甘文旅区域协同发展。

关键词：区域协同青甘环线文旅融合促进性立法协同立法

14种易霉变饮片微生物污染状况及其表面真菌多样性研究

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中国药学杂志 2024年第7期59卷 571-578页

作者：王燕章红段和祥刘绪平刘卫德江西中医药大学南昌330004 江西省药品检验检测研究院国家药品监督管理局中成药质量评价重点实验室江西省药品与医疗器械质量工程技术研究中心南昌330029

目的考察14种易霉变饮片的微生物污染水平,并对其污染真菌进行多样性研究。方法参考2020年版《中国药典》四部通则1108项中药饮片微生物限度检查法,对易霉变饮片的需氧菌总数(TAMC)、霉菌和酵母菌总数(TYMC)、耐热菌总数(HRMC)及3类控... 详细信息

目的考察14种易霉变饮片的微生物污染水平,并对其污染真菌进行多样性研究。方法参考2020年版《中国药典》四部通则1108项中药饮片微生物限度检查法,对易霉变饮片的需氧菌总数(TAMC)、霉菌和酵母菌总数(TYMC)、耐热菌总数(HRMC)及3类控制菌进行检查并采用平板法培养样品表面真菌,顶端纯化法获得单一菌株,通过菌落形态及菌体显微特征观察、分子鉴定等方法进行菌种鉴定。结果31批次易霉变饮片TAMC分布范围为250~2.45×10^(6)cfu·g^(-1),TYMC分布范围为5~6.6×10^(5)cfu·g^(-1),HRMC分布范围为0~30 cfu·g^(-1),除1批远志和1批甘草样品外,其余样品耐胆盐革兰阴性菌均未超过1×10^(4)cfu·g^(-1),1批陈皮样品中检出大肠埃希菌,所有样品均未检出沙门菌,但控制菌检查项中检出重要条件致病菌,典型菌包括阴沟肠杆菌、肺炎克雷伯菌和阪崎克罗诺杆菌等。通过内转录间隔区(ITS)序列测序比对共鉴定106株真菌,归为16个属,其中曲霉属(Aspergillus)、青霉属(Penicillium)和枝孢属(Cladosporium)为优势菌属,分别占比31%、18%、17%。曲霉属中,鉴定出11株黑曲霉、7株黄曲霉、2株烟曲霉、1株杂色曲霉等致病性真菌。结论通过对易霉变饮片微生物污染及表面真菌多样性研究,可为其潜在的真菌毒素污染提供早期风险预警。

关键词：易霉变饮片微生物污染分子鉴定真菌多样性

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