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Inhibiting scar formation via wearable multilayer stacked electret patch:Self-creation of persistent and customizable DC electric field for fibrogenic activity restriction

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InfoMat 2024年第3期6卷 66-80页

作者： Sung-Won Kim Sumin Cho Donghan Lee Jiyu Hyun Sunmin Jang Inwoo Seo Hyun Su Park Hee jae Hwang Hyung-Seop Han Dae Hyeok Yang heung jae chun Suk Ho Bhang Dongwhi Choi School of Chemical Engineering Sungkyunkwan UniversitySuwonRepublic of Korea Department of Mechanical Engineering(Integrated Engineering Program) Kyung Hee UniversityYonginGyeonggiRepublic of Korea Biomaterials Research Center Biomedical Research DivisionKorea Institute of Science and Technology(KIST)SeoulRepublic of Korea Department of Medical Life Sciences College of MedicineInstitute of Cell and Tissue EngineeringThe Catholic University of KoreaSeoulRepublic of Korea

Electrical stimulation has recently received attention as noninvasive treatment in skin wound healing with its outstanding biological property for clinical set***,the complexity of equipment for applying appropriate electrical stimulation remains an ongoing ***,we proposed a strategy for skin scar inhibition by providing electrical stimulation via a multilayer stacked electret(MS-electret),which can generate direct current(DC)electric field(EF)without any power supply *** addition,the MS-electret can easily control the intensity of EFs by simply stacking electret layers and maintain stable EF with the surface potential of 3400 V over 5 days owing to the injected charges on the electret *** confirmed inhibition of type 1 collagen andα-SMA expression of human dermal fibroblasts(hDFs)by 90%and 44%in vitro,indicating that the transition of hDFs to myofibroblasts was restricted by applying stable electrical *** further revealed a 20%significant decrease in the ratio of myofibroblasts caused by the MS-electret in *** findings present that the MS-electret is an outstanding candidate for effective skin scar inhibition with a battery-free,physiological electrical microenvironment,and noninvasive treatment that allows it to prevent external infection.

关键词： DC electric field dermal fibroblasts electret scar formation restriction self-creation of electrical stimulation

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PagMYB128 regulates secondary cell wall formation by direct activation of cell wall biosynthetic genes during wood formation in poplar

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Journal of Integrative Plant Biology 2024年第8期66卷 1658-1674页

作者： Yuanyuan Hao Fachuang Lu Seung-Won Pyo Min-Ha Kim jae-heung Ko Xiaojing Yan John Ralph Quanzi Li State Key Laboratory of Tree Genetics and Breeding Chinese Academy of ForestryBeijing 100091China Department of Biochemistry and DOE Great Lakes Bioenergy Research Center Wisconsin Energy InstituteUniversity of Wisconsin-MadisonWisconsin 53726USA Department of Plant&Environmental New Resources Kyung Hee UniversityYongin 17104Korea

The biosynthesis of cellulose,lignin,and hemicelluloses in plant secondary cell walls(SCWs)is regulated by a hierarchical transcriptional regulatory *** network features orthologous transcription factors shared between poplar and Arabidopsis,highlighting a foundational similarity in their genetic ***,knowledge on the discrepant behavior of the transcriptional-level molecular regulatory mechanisms between poplar and Arabidopsis remains *** this study,we investigated the function of PagMYB128 during wood formation and found it had broader impacts on SCW formation compared to its Arabidopsis ortholog,*** poplar trees overexpressing PagMYB128 exhibited significantly enhanced xylem development,with fiber cells and vessels displaying thicker walls,and an increase in the levels of cellulose,lignin,and hemicelluloses in the *** contrast,plants with dominant repression of PagMYB128 demonstrated the opposite *** sequencing and reverse transcription–quantitative polymerase chain reaction showed that PagMYB128 could activate SCW biosynthetic gene expression,and chromatin immunoprecipitation along with yeast one-hybrid,and effector–reporter assays showed this regulation was *** analysis revealed that PagSND1(SECONDARY WALL-ASSOCIATED NAC-DOMAIN PROTEIN1)directly regulates PagMYB128 but not cell wall metabolic genes,highlighting the pivotal role of PagMYB128 in the SND1-driven regulatory network for wood development,thereby creating a feedforward loop in SCW biosynthesis.

关键词： cellulose hemicellulose lignin PagMYB128 Populus transcription factor wood formation

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A global-scale multidecadal variability driven by Atlantic multidecadal oscillation

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National Science Review 2020年第7期7卷 1190-1197页

作者： Young-Min Yang Soon-Il An Bin Wang jae heung Park Department of Atmospheric Science Key Laboratory of Meteorological Disaster of Ministry of Education Joint International Research Laboratory of Climate and Environment Change Collaborative Innovation Center on Forecast and Evaluation of Meteorological Disasters and Earth System Modeling Center Nanjing University of Information Science and Technology Department of Atmospheric Sciences and International Pacific Research Center University of Hawaii Department of Atmospheric Sciences and Irreversible Climate Change Research Center Yonsei University Division of Environmental Science and Engineering Pohang University of Science and Technology

Observational analysis shows that there is a predominant global-scale multidecadal variability(GMV) of sea-surface temperature(SST). Its horizontal pattern resembles that of the interdecadal Pacific oscillation(IPO) in the Pacific and the Atlantic multidecadal oscillation(AMO) in the Atlantic Ocean, which could affect global precipitation and temperature over the globe. Here, we demonstrate that the GMV could be driven by the AMO through atmospheric teleconnections and atmosphere–ocean coupling *** reveal a strong negative correlation when AMO leads GMV by approximately 4–8 *** experiments using a climate model driven by observed AMO signals reveal that the tropical Atlantic warm SST anomalies of AMO initiate anomalous cooling in the equatorial central-eastern Pacific through atmospheric teleconnections. Anticyclonic anomalies in the North and South Pacific induce equatorward winds along the coasts of North and South America, contributing to further cooling. The upper-ocean dynamics plays a minor role in GMV formation but contributes to a delayed response of the IPO to the AMO forcing. The possible impact of the GMV on AMO was also tested by prescribing only Pacific SST in the model; however, the model could not reproduce the observed phase relationship between the AMO and the GMV. These results support the hypothesis that the Atlantic Ocean plays a key role in the multidecadal variability of global SST.

关键词： global-scale multidecadal variability Atlantic multidecadal oscillation atmospheric teleconnection interdecadal Pacific oscillation

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Muscular atrophy and weakness in the lower extremities in Behçet’s disease: A case report and review of literature

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World Journal of Clinical Cases 2021年第20期9卷 5647-5654页

作者： Koh-Woon Kim jae-heung Cho Department of Korean Medicine Rehabilitation College of Korean MedicineKyung Hee UniversitySeoul 02447South Korea

BACKGROUND In Behçet’s disease(BD),very few cases of muscular involvement have been reported *** natural history and therapeutic protocol for muscular involvement in BD are obscure due to the low incidence of peripheral neuropathy or myopathy in *** purpose of our study was to report a rare case of BD with chronic,focal forms of neuromyopathy and review the relevant *** SUMMARY We herein report the case of a 54-year-old man who presented with progressive muscular atrophy and weakness of both thighs 2 years after the presentation of the cardinal symptoms of *** past medical history,electrophysiological study,neurological examination,blood tests,magnetic resonance imaging study,and histological exam were performed for the differential *** literature on muscular involvement in BD was *** examination revealed that muscular involvement was predominantly localized in the proximal parts of the lower *** enhancement of several thigh muscles was observed on magnetic resonance imaging,which corresponded with the clinical *** study of one of the enhanced muscles showed denervation atrophy of the muscle with superimposed myopathic changes,while electrophysiological studies only suggested *** To our knowledge,this is the first case of neurogenic muscular atrophy with a specific set of clinical,radiological,electrophysiological,and histological findings reported in BD.

关键词： Behçet’s disease Muscular atrophy Muscular weakness Neuropathy Myopathy Case report

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Iatrogenic giant pseudomeningocele of the cervical spine:A case report

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World Journal of Clinical Cases 2021年第31期9卷 9686-9690页

作者： Koh-Woon Kim jae-heung Cho Department of Korean Medicine Rehabilitation College of Korean MedicineKyung Hee UniversitySeoul 02447South Korea

BACKGROUND Only a few cases of giant pseudomeningoceles have been reported in the ***,we report a giant pseudomeningocele of the cervical spine that was found after cervical laminectomy for an epidural hematoma following epidural *** SUMMARY A 47-year-old man presented with recurrent neck pain and posterior neck swelling after spinal *** resonance imaging of the cervical spine revealed fluid collection(5.6 cm×6.6 cm×11.2 cm)at the C3-6 level;this proved to be a *** related to the pseudomeningocele resolved following dural repair and fat graft *** Although rare,pseudomeningocele is a possibility in patients with recurrent back pain,radicular pain,or a persistent headache following spinal *** attention should be paid throughout the spinal procedure,whether conservative or non-conservative.

关键词： Iatrogenic spinal pseudomeningocele Giant pseudomeningocele Cervical spine C3-6 level Cervical laminectomy Case report

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Microstructure and Mechanical Properties of Hybrid Laser-Friction Stir Welding between AA6061-T6 Al Alloy and AZ31 Mg Alloy

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Journal of Materials Science & Technology 2011年第3期27卷 199-204页

作者： Woong-Seong Chang S.R.Rajesh Chang-Keun chun heung-Ju Kim Welding Research Center Research Institute of Industrial Science and Technology

For the purpose of improving the strength of this dissimilarjoint, the present study was carried out to investigate the improvement in intermetallic layer by using a third material foil between the laying edges of the friction stir welded and hybrid welded AI6061-T6/AZ31 alloy plates. The difference in microstructural and mechanical characteristics of friction stir welded and hybrid welded AI6061-TO/AZ31 joint was compared. Hybrid butt- welding of aluminum alloy plate to a magnesium alloy plate was successfully achieved with Ni foil as filler material, while defect-free laser-friction stir welding （FSW） hybrid welding was achieved by using a laser power of 2 kW. Transverse tensile strength of the joint reached about 66% of the Mg base metal tensile strength in the case of hybrid welding with Ni foil and showed higher value than that of the friction stir welded joint with and without the third material foil. This may be due to the presence of less brittle Ni-based intermetallic phases instead of Al12Mg17.

关键词： Frictions stir welding Laser welding Dissimilar metal joint Hybrid welding Magnesium alloy Aluminum alloy

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Small-scale analysis of brittle-to-ductile transition behavior in pure tungsten

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Journal of Materials Science & Technology 2022年第10期105卷 242-258页

作者： Yeonju Oh Won-Seok Ko Nojun Kwak jae-il Jang Takahito Ohmura heung Nam Han Department of Materials Science and Engineering&Research Institute of Advanced Materials Seoul National UniversitySeoul 08826South Korea School of Materials Science and Engineering University of UlsanUlsan 44610South Korea Division of Materials Science and Engineering Hanyang UniversitySeoul04763South Korea National Institute for Materials Science 1-2-1 SengenTsukubaIbaraki 305-0047Japan

Tungsten as a material exhibits broad and increasingly important applications;however,the characterization of its ductile-to-brittle transition(BDT)is currently limited to large-scale scenarios and destructive *** this study,we overcome this challenge by implementing small-scale techniques to provide a comprehensive understanding of the BDT behavior of pure *** order to predict the failure mode at various temperature ranges,the practical fracture analysis diagram has been proposed to describe the resistance to shear flow and cracking behavior with *** temperature nano-indentation tests have provided the inherent mechanical responses corresponding to the maximum shear stress at various temperatures,which is required for dislocation activities in an atomic scaled activation *** one hand,atomistic simulations have provided the temperature dependence of brittle fracture stress,where the atomic bonds break due to intergranular or intragranular *** considered four tungsten specimens having various microstructures prepared using different processing conditions of cold-rolling and post-annealing,and their BDT ranges were inferred using the obtained fracture analysis diagram with the statistical data *** fracture analysis diagram of each specimen obtained were compared with the direct observation of fracture responses in macroscopic mechanical tests,which conclusively indicated that the small-scale inherent mechanical properties are greatly relevant to the macroscopic BDT behavior in pure *** on the BDT estimations by small-scale characterization,we provided further insights into the factors affecting the BDT behavior of tungsten,focusing on the contributions of different types of dislocations.

关键词： Brittle-to-ductile transition Nano-indentation Molecular dynamics Dislocation Tungsten

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Removal of heavy metals using waste eggshell

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Journal of Environmental Sciences 2007年第12期19卷 1436-1441页

作者： PARK heung Jai JEONG Seong Wook YANG jae Kyu KIM Boo Gil LEE Seung Mok School of Environmental Science and Engineering Inje University 621-749607GyungnamKorea. Department of Environmental Engineering Kwangwoon University SeoulKorea Division of Architecture and Civil Engineering Dong-seo University BusanKorea Department of Environment and Disaster Prevention Kwandong University GangneungKorea

The removal capacity of toxic heavy metals by the reused eggshell was studied. As a pretreatment process for the preparation of reused material from waste eggshell, calcination was performed in the furnace at 800℃ for 2 h after crushing the dried waste eggshell. Calcination behavior, qualitative and quantitative elemental information, mineral type and surface characteristics before and after calcination of eggshell were examined by thermal gravimetric analysis （TGA）, X-ray fluorescence （XRF）, X-ray diffraction （XRD） and scanning electron microscopy （SEM）, respectively. After calcination, the major inorganic composition was identified as Ca （lime, 99.63%） and K, P and Sr were identified as minor components. When calcined eggshell was applied in the treatment of synthetic wastewater containing heavy metals, a complete removal of Cd as well as above 99% removal of Cr was observed after 10 rain. Although the natural eggshell had some removal capacity of Cd and Cr, a complete removal was not accomplished even after 60 rain due to quite slower removal rate. However, in contrast to Cd and Cr, an efficient removal of Pb was observed with the natural eggshell rather than the calcined eggshell. From the application of the calcined eggshell in the treatment of real electroplating wastewater, the calcined eggshell showed a promising removal capacity of heavy metal ions as well as had a good neutralization capacity in the treatment of strong acidic wastewater.

关键词： wasted eggshell CaO removal heavy metals

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Study on the current structure of the thermohaline front in the southeastern entrance of the Yellow Sea during winter

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Acta Oceanologica Sinica 2015年第12期34卷 29-36页

作者： OH Kyung-Hee LEE Seok LIE heung-jae JUNG Kyung Tae QIAO Fangli Korea Institute of Ocean Science and Technology First Institute of Oceanography State Oceanic Administration

A thermohaline front is located at the southeastern entrance of the Yellow Sea in winter, and it is generated by the intrusion of warm saline water into the Yellow Sea caused by a strong northerly wind. Recently, a westward transversal current traveling away from the west coast of Korea toward the open sea area along the front was reported. The westward transversal current is dominant in the surface layer during the temperature inversion period. The formation and structure of this current are examined using a numerical vertical ocean-slice *** two different water masses meet, a front is formed and adjusted geostrophically. In this frontal zone, a horizontal pressure gradient flow by the vertically inclined isopycnal occurs under the thermal wind process in a baroclinic effect, and the cold fresh coastal water moves westward along the front in the upper layer. The barotropic effect across the front and the bottom friction effect strengthen the westward component of the velocity. The velocity of the bottom layer decreases remarkably in the increase of the bottom drag coefficient. This means that the bottom friction with the strong background tidal current causes a reduction in the current in the bottom layer.

关键词： Geostrophic adjustment Southeastern Yellow Sea Thermohaline front Thermal wind Westward transversal current

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The temporal and spatial variability of the Yellow Sea Cold Water Mass in the southeastern Yellow Sea, 2009–2011

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Acta Oceanologica Sinica 2013年第9期32卷 1-10页

作者： OH Kyung-Hee LEE Seok SONG Kyu-Min LIE heung-jae KIM Young-Taeg Marine Environment and Conservation Research Division Korea Institute of Ocean Science and Technology Ocean Research Division Korea Hydrographic and Oceanographic Administration

The Yellow Sea Cold Water Mass （YSCWM） is one of the important water mass in the Yellow Sea （YS）. It is distributed in the lower layer in the Yellow Sea central trough with the temperature less than 10℃ and the salinity lower than 33.0. To understand the variability of the YSCWM, the hydrographic data obtained in April and August during 2009-2011 are analyzed in the southeastern Yellow Sea. In August 2011, relatively warm and saline water compared with that in 2009 and 2010 was detected in the lower layer in the Yellow Sea central area. Although the typhoon passed before the cruise, the salinity in the Yellow Sea central trough is much higher than the previous season. It means that the saline event cannot be explained by the typhoon but only by the intrusion of saline water during the previous winter. In April 2011, actually, warm and saline water （T 〉 10~C, S 〉34） was observed in the deepest water depth of the southeastern area of the Yellow Sea. The wind data show that the northerly wind in 2011 winter is stronger than in 2009 and 2010 winter season. The strong northerly wind can trigger the intrusion of warm and saline Yellow Sea Warm Current. Therefore, it is proposed that the strong northerly wind in winter season leads to the intrusion of the Yellow Sea Warm Current into the Yellow Sea central trough and influenced a variability of the YSCWM in summer.

关键词： Yellow Sea Cold Water Mass interannual variation saline event atmosphere variability Yellow Sea

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